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Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.

Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R.

Development. 2017 Nov 15;144(22):4148-4158. doi: 10.1242/dev.149914. Epub 2017 Oct 9.


Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.

Manso AM, Okada H, Sakamoto FM, Moreno E, Monkley SJ, Li R, Critchley DR, Ross RS.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6250-E6259. doi: 10.1073/pnas.1701416114. Epub 2017 Jul 11.


LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.

Zacharchenko T, Qian X, Goult BT, Jethwa D, Almeida TB, Ballestrem C, Critchley DR, Lowy DR, Barsukov IL.

Structure. 2016 Jul 6;24(7):1130-41. doi: 10.1016/j.str.2016.04.016. Epub 2016 Jun 2.


Vinculin controls talin engagement with the actomyosin machinery.

Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C.

Nat Commun. 2015 Dec 4;6:10038. doi: 10.1038/ncomms10038.


Talin determines the nanoscale architecture of focal adhesions.

Liu J, Wang Y, Goh WI, Goh H, Baird MA, Ruehland S, Teo S, Bate N, Critchley DR, Davidson MW, Kanchanawong P.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4864-73. doi: 10.1073/pnas.1512025112. Epub 2015 Aug 17.


Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration.

Rainero E, Howe JD, Caswell PT, Jamieson NB, Anderson K, Critchley DR, Machesky L, Norman JC.

Cell Rep. 2015 Jan 20;10(3):398-413. doi: 10.1016/j.celrep.2014.12.037. Epub 2015 Jan 15.


Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.

Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S.

J Clin Invest. 2014 Mar;124(3):1098-113. doi: 10.1172/JCI69778. Epub 2014 Feb 17. Erratum in: J Clin Invest. 2015 Feb;125(2):882.


Talins and kindlins: partners in integrin-mediated adhesion.

Calderwood DA, Campbell ID, Critchley DR.

Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17. Review.


Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.

Goult BT, Xu XP, Gingras AR, Swift M, Patel B, Bate N, Kopp PM, Barsukov IL, Critchley DR, Volkmann N, Hanein D.

J Struct Biol. 2013 Oct;184(1):21-32. doi: 10.1016/j.jsb.2013.05.014. Epub 2013 May 30.


RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.

Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GC, Ballestrem C, Critchley DR, Barsukov IL.

J Biol Chem. 2013 Mar 22;288(12):8238-49. doi: 10.1074/jbc.M112.438119. Epub 2013 Feb 6.


Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.

Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS.

J Biol Chem. 2013 Feb 8;288(6):4252-64. doi: 10.1074/jbc.M112.427484. Epub 2012 Dec 24.


Talin1 and Rap1 are critical for osteoclast function.

Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg MH, Teitelbaum SL.

Mol Cell Biol. 2013 Feb;33(4):830-44. doi: 10.1128/MCB.00790-12. Epub 2012 Dec 10.


Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.

Debrand E, Conti FJ, Bate N, Spence L, Mazzeo D, Pritchard CA, Monkley SJ, Critchley DR.

Biochem Biophys Res Commun. 2012 Sep 21;426(2):190-5. doi: 10.1016/j.bbrc.2012.08.061. Epub 2012 Aug 17.


Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.

Bate N, Gingras AR, Bachir A, Horwitz R, Ye F, Patel B, Goult BT, Critchley DR.

PLoS One. 2012;7(4):e34461. doi: 10.1371/journal.pone.0034461. Epub 2012 Apr 4.


Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.

Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg MH, Fässler R, Ley K.

Blood. 2012 May 3;119(18):4275-82. doi: 10.1182/blood-2011-08-373118. Epub 2012 Mar 19.


Subcellular localization of talin is regulated by inter-domain interactions.

Banno A, Goult BT, Lee H, Bate N, Critchley DR, Ginsberg MH.

J Biol Chem. 2012 Apr 20;287(17):13799-812. doi: 10.1074/jbc.M112.341214. Epub 2012 Feb 18.


New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.

Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ.

Eur J Cell Biol. 2012 Mar;91(3):180-91. doi: 10.1016/j.ejcb.2011.12.003. Epub 2012 Feb 3.


A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.

Bouaouina M, Goult BT, Huet-Calderwood C, Bate N, Brahme NN, Barsukov IL, Critchley DR, Calderwood DA.

J Biol Chem. 2012 Mar 2;287(10):6979-90. doi: 10.1074/jbc.M111.330845. Epub 2012 Jan 10.


Contact-dependent T cell activation and T cell stopping require talin1.

Wernimont SA, Wiemer AJ, Bennin DA, Monkley SJ, Ludwig T, Critchley DR, Huttenlocher A.

J Immunol. 2011 Dec 15;187(12):6256-67. doi: 10.4049/jimmunol.1102028. Epub 2011 Nov 9.


Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake.

Truttmann MC, Misselwitz B, Huser S, Hardt WD, Critchley DR, Dehio C.

J Cell Sci. 2011 Nov 1;124(Pt 21):3591-602. doi: 10.1242/jcs.084459. Epub 2011 Nov 1.


Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.

Liu J, He X, Qi Y, Tian X, Monkley SJ, Critchley DR, Corbett SA, Lowry SF, Graham AM, Li S.

Mol Cell Biol. 2011 Aug;31(16):3366-77. doi: 10.1128/MCB.01403-10. Epub 2011 Jun 13.


Tetraspanin CD9 in cell migration.

Powner D, Kopp PM, Monkley SJ, Critchley DR, Berditchevski F.

Biochem Soc Trans. 2011 Apr;39(2):563-7. doi: 10.1042/BST0390563. Review.


Structural diversity in integrin/talin interactions.

Anthis NJ, Wegener KL, Critchley DR, Campbell ID.

Structure. 2010 Dec 8;18(12):1654-66. doi: 10.1016/j.str.2010.09.018.


Endothelial cell talin1 is essential for embryonic angiogenesis.

Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA, Critchley DR.

Dev Biol. 2011 Jan 15;349(2):494-502. doi: 10.1016/j.ydbio.2010.11.010. Epub 2010 Nov 26.


Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

Haling JR, Monkley SJ, Critchley DR, Petrich BG.

Blood. 2011 Feb 3;117(5):1719-22. doi: 10.1182/blood-2010-09-305433. Epub 2010 Oct 22.


The Structure of the talin head reveals a novel extended conformation of the FERM domain.

Elliott PR, Goult BT, Kopp PM, Bate N, Grossmann JG, Roberts GC, Critchley DR, Barsukov IL.

Structure. 2010 Oct 13;18(10):1289-99. doi: 10.1016/j.str.2010.07.011.


Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.

Manevich-Mendelson E, Grabovsky V, Feigelson SW, Cinamon G, Gore Y, Goverse G, Monkley SJ, Margalit R, Melamed D, Mebius RE, Critchley DR, Shachar I, Alon R.

Blood. 2010 Dec 23;116(26):5907-18. doi: 10.1182/blood-2010-06-293506. Epub 2010 Oct 5.


Rap1 controls activation of the α(M)β(2) integrin in a talin-dependent manner.

Lim J, Dupuy AG, Critchley DR, Caron E.

J Cell Biochem. 2010 Nov 1;111(4):999-1009. doi: 10.1002/jcb.22788.


Central region of talin has a unique fold that binds vinculin and actin.

Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR.

J Biol Chem. 2010 Sep 17;285(38):29577-87. doi: 10.1074/jbc.M109.095455. Epub 2010 Jul 7.


Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

Kopp PM, Bate N, Hansen TM, Brindle NP, Praekelt U, Debrand E, Coleman S, Mazzeo D, Goult BT, Gingras AR, Pritchard CA, Critchley DR, Monkley SJ.

Eur J Cell Biol. 2010 Sep;89(9):661-73. doi: 10.1016/j.ejcb.2010.05.003.


The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.

Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC.

FEBS Lett. 2010 Jun 3;584(11):2237-41. doi: 10.1016/j.febslet.2010.04.028. Epub 2010 Apr 20.


Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.

Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL.

EMBO J. 2010 Mar 17;29(6):1069-80. doi: 10.1038/emboj.2010.4. Epub 2010 Feb 11.


Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.

Clark K, Howe JD, Pullar CE, Green JA, Artym VV, Yamada KM, Critchley DR.

J Cell Biochem. 2010 Mar 1;109(4):808-17. doi: 10.1002/jcb.22460.


The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.

Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR.

J Mol Biol. 2009 Dec 18;394(5):944-56. doi: 10.1016/j.jmb.2009.09.061. Epub 2009 Oct 3.


The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID.

EMBO J. 2009 Nov 18;28(22):3623-32. doi: 10.1038/emboj.2009.287. Epub 2009 Oct 1.


Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.

Conti FJ, Monkley SJ, Wood MR, Critchley DR, Müller U.

Development. 2009 Nov;136(21):3597-606. doi: 10.1242/dev.035857. Epub 2009 Sep 30.


Structural and biophysical properties of the integrin-associated cytoskeletal protein talin.

Roberts GC, Critchley DR.

Biophys Rev. 2009 Jul;1(2):61-69. Epub 2009 Jun 4.


NMR assignment of the C-terminal actin-binding domain of talin.

Goult BT, Gingras AR, Bate N, Roberts GC, Critchley DR, Barsukov IL.

Biomol NMR Assign. 2008 Jun;2(1):17-9. doi: 10.1007/s12104-007-9073-5. Epub 2007 Dec 22.


Structural and biophysical properties of the integrin-associated cytoskeletal protein talin.

Roberts GCK, Critchley DR.

Biophys Rev. 2009 Jul;1(2):61-69. doi: 10.1007/s12551-009-0009-4. Epub 2009 Jun 4. Review.


Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.

Critchley DR.

Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. Review.


Smurf1 zaps the talin head.

Critchley DR.

Nat Cell Biol. 2009 May;11(5):538-40. doi: 10.1038/ncb0509-538.


The structure of an interdomain complex that regulates talin activity.

Goult BT, Bate N, Anthis NJ, Wegener KL, Gingras AR, Patel B, Barsukov IL, Campbell ID, Roberts GC, Critchley DR.

J Biol Chem. 2009 May 29;284(22):15097-106. doi: 10.1074/jbc.M900078200. Epub 2009 Mar 18.


Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms.

Debrand E, El Jai Y, Spence L, Bate N, Praekelt U, Pritchard CA, Monkley SJ, Critchley DR.

FEBS J. 2009 Mar;276(6):1610-28. doi: 10.1111/j.1742-4658.2009.06893.x. Epub 2009 Feb 7.


Structural determinants of integrin binding to the talin rod.

Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg MH, Critchley DR.

J Biol Chem. 2009 Mar 27;284(13):8866-76. doi: 10.1074/jbc.M805937200. Epub 2009 Jan 27.


Talin depletion reveals independence of initial cell spreading from integrin activation and traction.

Zhang X, Jiang G, Cai Y, Monkley SJ, Critchley DR, Sheetz MP.

Nat Cell Biol. 2008 Sep;10(9):1062-8. doi: 10.1038/ncb1765.


Quantifying cell-matrix adhesion dynamics in living cells using interference reflection microscopy.

Holt MR, Calle Y, Sutton DH, Critchley DR, Jones GE, Dunn GA.

J Microsc. 2008 Oct;232(1):73-81. doi: 10.1111/j.1365-2818.2008.02069.x.


Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.

Srivastava J, Barreiro G, Groscurth S, Gingras AR, Goult BT, Critchley DR, Kelly MJ, Jacobson MP, Barber DL.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14436-41. doi: 10.1073/pnas.0805163105. Epub 2008 Sep 9.


Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

Wegener KL, Basran J, Bagshaw CR, Campbell ID, Roberts GC, Critchley DR, Barsukov IL.

J Mol Biol. 2008 Sep 26;382(1):112-26. doi: 10.1016/j.jmb.2008.06.087. Epub 2008 Jul 7.


Rapid leukocyte migration by integrin-independent flowing and squeezing.

Lämmermann T, Bader BL, Monkley SJ, Worbs T, Wedlich-Söldner R, Hirsch K, Keller M, Förster R, Critchley DR, Fässler R, Sixt M.

Nature. 2008 May 1;453(7191):51-5. doi: 10.1038/nature06887.


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