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Items: 1 to 50 of 165

1.

Significant correlation of species longevity with DNA double strand break recognition but not with telomere length.

Lorenzini A, Johnson FB, Oliver A, Tresini M, Smith JS, Hdeib M, Sell C, Cristofalo VJ, Stamato TD.

Mech Ageing Dev. 2009 Nov-Dec;130(11-12):784-92. doi: 10.1016/j.mad.2009.10.004.

2.

Modulation of replicative senescence of diploid human cells by nuclear ERK signaling.

Tresini M, Lorenzini A, Torres C, Cristofalo VJ.

J Biol Chem. 2007 Feb 9;282(6):4136-51. Epub 2006 Dec 4.

3.

Proteasome inhibitors shorten replicative life span and induce a senescent-like phenotype of human fibroblasts.

Torres C, Lewis L, Cristofalo VJ.

J Cell Physiol. 2006 Jun;207(3):845-53.

PMID:
16523493
4.

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF.

EMBO Rep. 2005 Nov;6(11):1006-8. No abstract available.

5.

SA beta Gal staining: biomarker or delusion.

Cristofalo VJ.

Exp Gerontol. 2005 Oct;40(10):836-8. Epub 2005 Sep 21. No abstract available.

PMID:
16181758
6.

Cellular replicative capacity correlates primarily with species body mass not longevity.

Lorenzini A, Tresini M, Austad SN, Cristofalo VJ.

Mech Ageing Dev. 2005 Oct;126(10):1130-3.

PMID:
15993927
7.

Replicative senescence: a critical review.

Cristofalo VJ, Lorenzini A, Allen RG, Torres C, Tresini M.

Mech Ageing Dev. 2004 Oct-Nov;125(10-11):827-48. Review.

PMID:
15541776
8.

The aging factor in health and disease: the promise of basic research on aging.

Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL, West MD, Wilmoth JR, Wright WE.

Aging Clin Exp Res. 2004 Apr;16(2):104-11; discussion 111-2. Review. No abstract available.

PMID:
15195984
9.

Loss of EPC-1/PEDF expression during skin aging in vivo.

Francis MK, Appel S, Meyer C, Balin SJ, Balin AK, Cristofalo VJ.

J Invest Dermatol. 2004 May;122(5):1096-105.

10.

Immortalization in a normal foreskin fibroblast culture following transduction of cyclin A2 or cdk1 genes in retroviral vectors.

Luo P, Tresini M, Cristofalo V, Chen X, Saulewicz A, Gray MD, Banker DE, Klingelhutz AL, Ohtsubo M, Takihara Y, Norwood TH.

Exp Cell Res. 2004 Apr 1;294(2):406-19.

PMID:
15023530
11.

Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts.

Torres C, Francis MK, Lorenzini A, Tresini M, Cristofalo VJ.

Exp Cell Res. 2003 Nov 1;290(2):195-206.

PMID:
14567979
12.

Cell senescence: an evaluation of replicative senescence in culture as a model for cell aging in situ.

Cristofalo VJ, Beck J, Allen RG.

J Gerontol A Biol Sci Med Sci. 2003 Sep;58(9):B776-9; discussion 779-81. No abstract available.

PMID:
14528030
13.
14.

Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts.

Pignolo RJ, Francis MK, Rotenberg MO, Cristofalo VJ.

J Cell Physiol. 2003 Apr;195(1):12-20.

PMID:
12599204
15.

Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence.

Lorenzini A, Tresini M, Mawal-Dewan M, Frisoni L, Zhang H, Allen RG, Sell C, Cristofalo VJ.

Exp Gerontol. 2002 Oct-Nov;37(10-11):1149-56.

PMID:
12470826
16.

"I no longer believe that cell death is programmed. ..", an interview with Vincent Cristofalo.

Cristofalo V.

Biogerontology. 2001;2(4):283-90. No abstract available.

PMID:
11868903
17.

Regulation of collagenase expression during replicative senescence in human fibroblasts by Akt-forkhead signaling.

Mawal-Dewan M, Lorenzini A, Frisoni L, Zhang H, Cristofalo VJ, Sell C.

J Biol Chem. 2002 Mar 8;277(10):7857-64. Epub 2001 Dec 19.

18.

Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease.

Spranger J, Osterhoff M, Reimann M, Möhlig M, Ristow M, Francis MK, Cristofalo V, Hammes HP, Smith G, Boulton M, Pfeiffer AF.

Diabetes. 2001 Dec;50(12):2641-5.

19.

Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors.

Gerhard GS, Benko FA, Allen RG, Tresini M, Kalbach A, Cristofalo VJ, Gocke CD.

Mech Ageing Dev. 2002 Jan;123(2-3):155-66.

PMID:
11718809
20.

Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.

Tresini M, Lorenzini A, Frisoni L, Allen RG, Cristofalo VJ.

Exp Cell Res. 2001 Oct 1;269(2):287-300.

PMID:
11570821
21.

Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence.

Wang W, Yang X, Cristofalo VJ, Holbrook NJ, Gorospe M.

Mol Cell Biol. 2001 Sep;21(17):5889-98.

22.

Is increased arachidonic acid release a cause or a consequence of replicative senescence?

Lorenzini A, Hrelia S, Bordoni A, Biagi P, Frisoni L, Marinucci T, Cristofalo VJ.

Exp Gerontol. 2001 Jan;36(1):65-78.

PMID:
11162912
23.

Regulation of EPC-1/PEDF in normal human fibroblasts is posttranscriptional.

Coljee VW, Rotenberg MO, Tresini M, Francis MK, Cristofalo VJ, Sell C.

J Cell Biochem. 2000 Sep 7;79(3):442-52.

PMID:
10972981
24.

Mitogen-independent phosphorylation of S6K1 and decreased ribosomal S6 phosphorylation in senescent human fibroblasts.

Zhang H, Hoff H, Marinucci T, Cristofalo VJ, Sell C.

Exp Cell Res. 2000 Aug 25;259(1):284-92.

PMID:
10942600
25.

Is beta-galactosidase staining a marker of senescence in vitro and in vivo?

Severino J, Allen RG, Balin S, Balin A, Cristofalo VJ.

Exp Cell Res. 2000 May 25;257(1):162-71.

PMID:
10854064
26.

A DNA chip off the aging block.

Cristofalo VJ.

Nat Med. 2000 May;6(5):507. No abstract available.

PMID:
10802702
27.

Extension of cell life-span and telomere length in animals cloned from senescent somatic cells.

Lanza RP, Cibelli JB, Blackwell C, Cristofalo VJ, Francis MK, Baerlocher GM, Mak J, Schertzer M, Chavez EA, Sawyer N, Lansdorp PM, West MD.

Science. 2000 Apr 28;288(5466):665-9.

28.

Use of the fibroblast model in the study of cellular senescence.

Cristofalo VJ, Volker C, Allen RG.

Methods Mol Med. 2000;38:23-52. doi: 10.1385/1-59259-070-5:23.

PMID:
22351263
29.

Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38).

Allen RG, Tresini M, Keogh BP, Doggett DL, Cristofalo VJ.

J Cell Physiol. 1999 Jul;180(1):114-22.

PMID:
10362024
30.

Cell culture aging: insights for cell aging in vivo?

Cristofalo VJ.

Aging (Milano). 1999 Feb;11(1):1-3. Review. No abstract available.

PMID:
10337435
31.

Effects of donor age on the expression of a marker of replicative senescence (EPC-1) in human dermal fibroblasts.

Tresini M, Pignolo RJ, Allen RG, Cristofalo VJ.

J Cell Physiol. 1999 Apr;179(1):11-7.

PMID:
10082127
33.

Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation.

Cristofalo VJ, Allen RG, Pignolo RJ, Martin BG, Beck JC.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10614-9.

34.

Antioxidants stimulate transcriptional activation of the c-fos gene by multiple pathways in human fetal lung fibroblasts (WI-38).

Keogh B, Allen RG, Tresini M, Furth JJ, Cristofalo VJ.

J Cell Physiol. 1998 Sep;176(3):624-33.

PMID:
9699515
35.

Age-dependent modifications of gene expression in human fibroblasts.

Cristofalo VJ, Volker C, Francis MK, Tresini M.

Crit Rev Eukaryot Gene Expr. 1998;8(1):43-80. Review.

PMID:
9673450
36.

Defects in signal transduction during replicative senescence of diploid human fibroblasts in vitro.

Cristofalo VJ, Tresini M.

Aging (Milano). 1998 Apr;10(2):151-2. No abstract available.

PMID:
9666204
37.

Senescent WI-38 fibroblasts overexpress LPC-1, a putative transmembrane shock protein.

Pignolo RJ, Rotenberg MO, Horton JH, Cristofalo VJ.

Exp Cell Res. 1998 May 1;240(2):305-11.

PMID:
9597003
38.

Cell culture as a model for gerontological research.

Cristofalo VJ.

Aging (Milano). 1997 Dec;9(6):441-2. Review. No abstract available.

PMID:
9553632
39.

The pathway of cell senescence: WI-38 cells arrest in late G1 and are unable to traverse the cell cycle from a true G0 state.

Pignolo RJ, Martin BG, Horton JH, Kalbach AN, Cristofalo VJ.

Exp Gerontol. 1998 Jan-Mar;33(1-2):67-80.

PMID:
9467718
40.

A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts.

Tresini M, Mawal-Dewan M, Cristofalo VJ, Sell C.

Cancer Res. 1998 Jan 1;58(1):1-4.

41.

A reproducible procedure for primary culture and subsequent maintenance of multiple lines of human skin fibroblasts.

Gibson GE, Tofel-Grehl B, Scheffold K, Cristofalo VJ, Blass JP.

Age (Omaha). 1998 Jan;21(1):7-14. doi: 10.1007/s11357-998-0002-z.

42.

Development and age-associated differences in electron transport potential and consequences for oxidant generation.

Allen RG, Keogh BP, Tresini M, Gerhard GS, Volker C, Pignolo RJ, Horton J, Cristofalo VJ.

J Biol Chem. 1997 Oct 3;272(40):24805-12.

43.

Abundance of alpha 1(I) and alpha 1(III) procollagen and p21 mRNAs in fibroblasts cultured from fetal and postnatal dermis.

Furth JJ, Allen RG, Tresini M, Keogh B, Cristofalo VJ.

Mech Ageing Dev. 1997 Aug;97(2):131-42.

PMID:
9226632
44.

Cloning of the human twist gene: its expression is retained in adult mesodermally-derived tissues.

Wang SM, Coljee VW, Pignolo RJ, Rotenberg MO, Cristofalo VJ, Sierra F.

Gene. 1997 Mar 10;187(1):83-92.

PMID:
9073070
45.
46.

Expression of p21 is not required for senescence of human fibroblasts.

Medcalf AS, Klein-Szanto AJ, Cristofalo VJ.

Cancer Res. 1996 Oct 15;56(20):4582-5.

47.

Altered expression of the twist gene in young versus senescent human diploid fibroblasts.

Wang SM, Phillips PD, Sierra F, Cristofalo VJ.

Exp Cell Res. 1996 Oct 10;228(1):138-45.

PMID:
8892981
48.

Late induction of CREB/ATF binding and a concomitant increase in cAMP levels in T and B lymphocytes stimulated via the antigen receptor.

Feuerstein N, Firestein R, Aiyar N, He X, Murasko D, Cristofalo V.

J Immunol. 1996 Jun 15;156(12):4582-93.

PMID:
8648100
49.

Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages.

Keogh BP, Allen RG, Pignolo R, Horton J, Tresini M, Cristofalo VJ.

J Cell Physiol. 1996 Jun;167(3):512-22.

PMID:
8655605
50.

Effects of cellular aging on the induction of c-fos by antioxidant treatments.

Keogh BP, Tresini M, Cristofalo VJ, Allen RG.

Mech Ageing Dev. 1996 Mar 29;86(3):151-60.

PMID:
8733110

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