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A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma.

Koay EJ, Lee Y, Cristini V, Lowengrub JS, Kang Y, Lucas FAS, Hobbs BP, Ye R, Elganainy D, Almahariq M, Amer AM, Chatterjee D, Yan H, Park PC, Rios Perez MV, Li D, Garg N, Reiss KA, Yu S, Chauhan A, Zaid M, Nikzad N, Wolff RA, Javle M, Varadhachary GR, Shroff RT, Das P, Lee JE, Ferrari M, Maitra A, Taniguchi CM, Kim MP, Crane CH, Katz MH, Wang H, Bhosale P, Tamm EP, Fleming JB.

Clin Cancer Res. 2018 Aug 6. doi: 10.1158/1078-0432.CCR-17-3668. [Epub ahead of print]


Understanding the Connection between Nanoparticle Uptake and Cancer Treatment Efficacy using Mathematical Modeling.

Brocato TA, Coker EN, Durfee PN, Lin YS, Townson J, Wyckoff EF, Cristini V, Brinker CJ, Wang Z.

Sci Rep. 2018 May 24;8(1):7538. doi: 10.1038/s41598-018-25878-8.


Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ.

Butner JD, Cristini V, Zhihui Wang.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:86-89. doi: 10.1109/EMBC.2017.8036769.


Development of a three dimensional, lattice-free multiscale model of the mammary terminal end bud.

Butner JD, Cristini V, Zhihui Wang.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:6134-6137. doi: 10.1109/EMBC.2016.7592128.


A hybrid agent-based model of the developing mammary terminal end bud.

Butner JD, Chuang YL, Simbawa E, Al-Fhaid AS, Mahmoud SR, Cristini V, Wang Z.

J Theor Biol. 2016 Oct 21;407:259-270. doi: 10.1016/j.jtbi.2016.07.040. Epub 2016 Jul 28.


Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill.

Wang Z, Kerketta R, Chuang YL, Dogra P, Butner JD, Brocato TA, Day A, Xu R, Shen H, Simbawa E, Al-Fhaid AS, Mahmoud SR, Curley SA, Ferrari M, Koay EJ, Cristini V.

PLoS Comput Biol. 2016 Jun 10;12(6):e1004969. doi: 10.1371/journal.pcbi.1004969. eCollection 2016 Jun.


A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud.

Paine I, Chauviere A, Landua J, Sreekumar A, Cristini V, Rosen J, Lewis MT.

PLoS Comput Biol. 2016 Apr 26;12(4):e1004839. doi: 10.1371/journal.pcbi.1004839. eCollection 2016 Apr.


Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

Hosoya H, Dobroff AS, Driessen WH, Cristini V, Brinker LM, Staquicini FI, Cardó-Vila M, D'Angelo S, Ferrara F, Proneth B, Lin YS, Dunphy DR, Dogra P, Melancon MP, Stafford RJ, Miyazono K, Gelovani JG, Kataoka K, Brinker CJ, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1877-82. doi: 10.1073/pnas.1525796113. Epub 2016 Feb 2.


A modeling approach to study the normal mammary gland growth process.

Butner JD, Cristini V, Zhihui Wang.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:1444-7. doi: 10.1109/EMBC.2015.7318641.


Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma.

Frieboes HB, Smith BR, Wang Z, Kotsuma M, Ito K, Day A, Cahill B, Flinders C, Mumenthaler SM, Mallick P, Simbawa E, Al-Fhaid AS, Mahmoud SR, Gambhir SS, Cristini V.

PLoS One. 2015 Jun 10;10(6):e0129433. doi: 10.1371/journal.pone.0129433. eCollection 2015.


Integrated PK-PD and agent-based modeling in oncology.

Wang Z, Butner JD, Cristini V, Deisboeck TS.

J Pharmacokinet Pharmacodyn. 2015 Apr;42(2):179-89. doi: 10.1007/s10928-015-9403-7. Epub 2015 Jan 15. Review.


Development of a diffusion-based mathematical model for predicting chemotherapy effects.

Wang Z, Kerketta R, Chuang YL, Cristini V.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:2480-3. doi: 10.1109/EMBC.2014.6944125.


Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer.

Koay EJ, Baio FE, Ondari A, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Zhang J, Court L, Bhosale PR, Tamm EP, Qayyum A, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Maitra A, Ferrari M, Varadhachary GR, Fleming JB.

Phys Biol. 2014 Nov 26;11(6):065002. doi: 10.1088/1478-3975/11/6/065002.


Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models.

Wang Z, Deisboeck TS, Cristini V.

IET Syst Biol. 2014 Oct;8(5):191-7. doi: 10.1049/iet-syb.2013.0026.


Understanding Drug Resistance in Breast Cancer with Mathematical Oncology.

Brocato T, Dogra P, Koay EJ, Day A, Chuang YL, Wang Z, Cristini V.

Curr Breast Cancer Rep. 2014 Jun 1;6(2):110-120.


Simulating cancer growth with multiscale agent-based modeling.

Wang Z, Butner JD, Kerketta R, Cristini V, Deisboeck TS.

Semin Cancer Biol. 2015 Feb;30:70-8. doi: 10.1016/j.semcancer.2014.04.001. Epub 2014 May 2. Review.


The effect of interstitial pressure on therapeutic agent transport: coupling with the tumor blood and lymphatic vascular systems.

Wu M, Frieboes HB, Chaplain MA, McDougall SR, Cristini V, Lowengrub JS.

J Theor Biol. 2014 Aug 21;355:194-207. doi: 10.1016/j.jtbi.2014.04.012. Epub 2014 Apr 19.


Transport properties of pancreatic cancer describe gemcitabine delivery and response.

Koay EJ, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Bhosale PR, Tamm EP, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Varadhachary GR, Ferrari M, Fleming JB.

J Clin Invest. 2014 Apr;124(4):1525-36. doi: 10.1172/JCI73455. Epub 2014 Mar 10.


Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation.

Tang L, van de Ven AL, Guo D, Andasari V, Cristini V, Li KC, Zhou X.

PLoS One. 2014 Jan 3;9(1):e83962. doi: 10.1371/journal.pone.0083962. eCollection 2014.


Tumor vascular permeabilization using localized mild hyperthermia to improve macromolecule transport.

Kirui DK, Koay EJ, Guo X, Cristini V, Shen H, Ferrari M.

Nanomedicine. 2014 Oct;10(7):1487-96. doi: 10.1016/j.nano.2013.11.001. Epub 2013 Nov 18.


Mechanistic modeling identifies drug-uptake history as predictor of tumor drug resistance and nano-carrier-mediated response.

Pascal J, Ashley CE, Wang Z, Brocato TA, Butner JD, Carnes EC, Koay EJ, Brinker CJ, Cristini V.

ACS Nano. 2013 Dec 23;7(12):11174-11182. doi: 10.1021/nn4048974. Epub 2013 Nov 11.


Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements.

Pascal J, Bearer EL, Wang Z, Koay EJ, Curley SA, Cristini V.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14266-71. doi: 10.1073/pnas.1300619110. Epub 2013 Aug 12.


Impact of diffusion barriers to small cytotoxic molecules on the efficacy of immunotherapy in breast cancer.

Das H, Wang Z, Niazi MK, Aggarwal R, Lu J, Kanji S, Das M, Joseph M, Gurcan M, Cristini V.

PLoS One. 2013 Apr 19;8(4):e61398. doi: 10.1371/journal.pone.0061398. Print 2013. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/94eab1ba-657a-445d-abf2-a709fc6a9806.


An integrated computational/experimental model of lymphoma growth.

Frieboes HB, Smith BR, Chuang YL, Ito K, Roettgers AM, Gambhir SS, Cristini V.

PLoS Comput Biol. 2013;9(3):e1003008. doi: 10.1371/journal.pcbi.1003008. Epub 2013 Mar 28.


A computational model for predicting nanoparticle accumulation in tumor vasculature.

Frieboes HB, Wu M, Lowengrub J, Decuzzi P, Cristini V.

PLoS One. 2013;8(2):e56876. doi: 10.1371/journal.pone.0056876. Epub 2013 Feb 28.


The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems.

Wu M, Frieboes HB, McDougall SR, Chaplain MA, Cristini V, Lowengrub J.

J Theor Biol. 2013 Mar 7;320:131-51. doi: 10.1016/j.jtbi.2012.11.031. Epub 2012 Dec 7.


Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.

Seamster PE, Loewenberg M, Pascal J, Chauviere A, Gonzales A, Cristini V, Bearer EL.

Phys Biol. 2012 Oct;9(5):055005. doi: 10.1088/1478-3975/9/5/055005. Epub 2012 Sep 25.


Density-dependent quiescence in glioma invasion: instability in a simple reaction-diffusion model for the migration/proliferation dichotomy.

Pham K, Chauviere A, Hatzikirou H, Li X, Byrne HM, Cristini V, Lowengrub J.

J Biol Dyn. 2012;6 Suppl 1:54-71. doi: 10.1080/17513758.2011.590610. Epub 2011 Jun 27.


Dynamic density functional theory of solid tumor growth: Preliminary models.

Chauviere A, Hatzikirou H, Kevrekidis IG, Lowengrub JS, Cristini V.

AIP Adv. 2012 Mar;2(1):11210. Epub 2012 Mar 22.


Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors.

van de Ven AL, Wu M, Lowengrub J, McDougall SR, Chaplain MA, Cristini V, Ferrari M, Frieboes HB.

AIP Adv. 2012 Mar;2(1):11208. Epub 2012 Mar 22.


Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression.

Macklin P, Edgerton ME, Thompson AM, Cristini V.

J Theor Biol. 2012 May 21;301:122-40. doi: 10.1016/j.jtbi.2012.02.002. Epub 2012 Feb 9.


A novel, patient-specific mathematical pathology approach for assessment of surgical volume: application to ductal carcinoma in situ of the breast.

Edgerton ME, Chuang YL, Macklin P, Yang W, Bearer EL, Cristini V.

Anal Cell Pathol (Amst). 2011;34(5):247-63. doi: 10.3233/ACP-2011-0019.


Integrative physical oncology.

Hatzikirou H, Chauviere A, Bauer AL, Leier A, Lewis MT, Macklin P, Marquez-Lago TT, Bearer EL, Cristini V.

Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):1-14. doi: 10.1002/wsbm.158. Epub 2011 Aug 18. Review.


Multiscale cancer modeling.

Deisboeck TS, Wang Z, Macklin P, Cristini V.

Annu Rev Biomed Eng. 2011 Aug 15;13:127-55. doi: 10.1146/annurev-bioeng-071910-124729. Review.


Applications of a new In vivo tumor spheroid based shell-less chorioallantoic membrane 3-D model in bioengineering research.

De Magalhães N, Liaw LH, Berns M, Cristini V, Chen Z, Stupack D, Lowengrub J.

J Biomed Sci Eng. 2010 Jan 1;3(1):20-26.


Physical oncology: a bench-to-bedside quantitative and predictive approach.

Frieboes HB, Chaplain MA, Thompson AM, Bearer EL, Lowengrub JS, Cristini V.

Cancer Res. 2011 Jan 15;71(2):298-302. doi: 10.1158/0008-5472.CAN-10-2676. Epub 2011 Jan 11. Review. Erratum in: Cancer Res. 2011 Mar 1;71(5):2024.


Mathematical Oncology: How Are the Mathematical and Physical Sciences Contributing to the War on Breast Cancer?

Chauviere AH, Hatzikirou H, Lowengrub JS, Frieboes HB, Thompson AM, Cristini V.

Curr Breast Cancer Rep. 2010 Sep;2(3):121-129. Epub 2010 Jul 22.


An Adaptive Multigrid Algorithm for Simulating Solid Tumor Growth Using Mixture Models.

Wise SM, Lowengrub JS, Cristini V.

Math Comput Model. 2011 Jan 1;53(1-2):1-20.


Nonlinear modelling of cancer: bridging the gap between cells and tumours.

Lowengrub JS, Frieboes HB, Jin F, Chuang YL, Li X, Macklin P, Wise SM, Cristini V.

Nonlinearity. 2010;23(1):R1-R9.


Predictions of tumour morphological stability and evaluation against experimental observations.

Pham K, Frieboes HB, Cristini V, Lowengrub J.

J R Soc Interface. 2011 Jan 6;8(54):16-29. doi: 10.1098/rsif.2010.0194. Epub 2010 Jun 2.


Three-dimensional multispecies nonlinear tumor growth-II: Tumor invasion and angiogenesis.

Frieboes HB, Jin F, Chuang YL, Wise SM, Lowengrub JS, Cristini V.

J Theor Biol. 2010 Jun 21;264(4):1254-78. doi: 10.1016/j.jtbi.2010.02.036. Epub 2010 Mar 18.


Prediction of drug response in breast cancer using integrative experimental/computational modeling.

Frieboes HB, Edgerton ME, Fruehauf JP, Rose FR, Worrall LK, Gatenby RA, Ferrari M, Cristini V.

Cancer Res. 2009 May 15;69(10):4484-92. doi: 10.1158/0008-5472.CAN-08-3740. Epub 2009 Apr 14.


Multiparameter computational modeling of tumor invasion.

Bearer EL, Lowengrub JS, Frieboes HB, Chuang YL, Jin F, Wise SM, Ferrari M, Agus DB, Cristini V.

Cancer Res. 2009 May 15;69(10):4493-501. doi: 10.1158/0008-5472.CAN-08-3834. Epub 2009 Apr 14.


Nonlinear simulations of solid tumor growth using a mixture model: invasion and branching.

Cristini V, Li X, Lowengrub JS, Wise SM.

J Math Biol. 2009 Apr;58(4-5):723-63. doi: 10.1007/s00285-008-0215-x. Epub 2008 Sep 12.


Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation.

Sinek JP, Sanga S, Zheng X, Frieboes HB, Ferrari M, Cristini V.

J Math Biol. 2009 Apr;58(4-5):485-510. doi: 10.1007/s00285-008-0214-y. Epub 2008 Sep 10.


Multiscale modelling and nonlinear simulation of vascular tumour growth.

Macklin P, McDougall S, Anderson AR, Chaplain MA, Cristini V, Lowengrub J.

J Math Biol. 2009 Apr;58(4-5):765-98. doi: 10.1007/s00285-008-0216-9. Epub 2008 Sep 10.


Three-dimensional multispecies nonlinear tumor growth--I Model and numerical method.

Wise SM, Lowengrub JS, Frieboes HB, Cristini V.

J Theor Biol. 2008 Aug 7;253(3):524-43. doi: 10.1016/j.jtbi.2008.03.027. Epub 2008 Mar 28.


Prototyping virtual cancer therapist (VCT): a software engineering approach.

Liu S, Gaudiot JL, Cristini V.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:5424-7.


Brain mapping in stereotactic surgery: a brief overview from the probabilistic targeting to the patient-based anatomic mapping.

Lemaire JJ, Coste J, Ouchchane L, Caire F, Nuti C, Derost P, Cristini V, Gabrillargues J, Hemm S, Durif F, Chazal J.

Neuroimage. 2007;37 Suppl 1:S109-15. Epub 2007 Jun 14. Review.


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