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Items: 1 to 50 of 122


Early-Career Scientists Shaping the World.

Cristea IM, Dorrestein PC, Eisen JA, Gilbert JA, Huber JA, Jansson JK, Knight R, Pollard KS, Raes J, Silver PA, Webster NS, Xu J.

mSystems. 2019 May 7;4(3). pii: e00196-19. doi: 10.1128/mSystems.00196-19. No abstract available.


Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships.

Hernández Durán A, Greco TM, Vollmer B, Cristea IM, Grünewald K, Topf M.

PLoS Biol. 2019 Jun 14;17(6):e3000316. doi: 10.1371/journal.pbio.3000316. eCollection 2019 Jun.


Hdac4 interactions in Huntington's Disease viewed through the prism of multiomics.

Federspiel JD, Greco TM, Lum KK, Cristea IM.

Mol Cell Proteomics. 2019 Apr 30. pii: mcp.RA118.001253. doi: 10.1074/mcp.RA118.001253. [Epub ahead of print]


Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis.

Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, Zheng H, Cheung C, Magnani JL, Lin SH, Cristea IM, Sackstein R, Kang Y.

Nat Cell Biol. 2019 May;21(5):627-639. doi: 10.1038/s41556-019-0309-2. Epub 2019 Apr 15.


Considerations for Identifying Endogenous Protein Complexes from Tissue via Immunoaffinity Purification and Quantitative Mass Spectrometry.

Federspiel JD, Cristea IM.

Methods Mol Biol. 2019;1977:115-143. doi: 10.1007/978-1-4939-9232-4_9.


Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions.

Betsinger CN, Cristea IM.

J Proteome Res. 2019 May 3;18(5):1929-1938. doi: 10.1021/acs.jproteome.9b00086. Epub 2019 Apr 8.


Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos.

Hashimoto Y, Kinoshita N, Greco TM, Federspiel JD, Jean Beltran PM, Ueno N, Cristea IM.

Cell Syst. 2019 Mar 27;8(3):226-241.e7. doi: 10.1016/j.cels.2019.01.006. Epub 2019 Mar 6.


YfmK is an Nε-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in Bacillus subtilis.

Carabetta VJ, Greco TM, Cristea IM, Dubnau D.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3752-3757. doi: 10.1073/pnas.1815511116. Epub 2019 Feb 11.


Editorial overview: Untangling proteome organization in space and time.

Cristea IM, Lilley KS.

Curr Opin Chem Biol. 2019 Feb;48:A1-A4. doi: 10.1016/j.cbpa.2019.02.001. No abstract available.


Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.

Lum KK, Song B, Federspiel JD, Diner BA, Howard T, Cristea IM.

Cell Syst. 2018 Dec 26;7(6):627-642.e6. doi: 10.1016/j.cels.2018.10.010. Epub 2018 Nov 21.


Orchestration of protein acetylation as a toggle for cellular defense and virus replication.

Murray LA, Sheng X, Cristea IM.

Nat Commun. 2018 Nov 23;9(1):4967. doi: 10.1038/s41467-018-07179-w.


Location is everything: protein translocations as a viral infection strategy.

Cook KC, Cristea IM.

Curr Opin Chem Biol. 2019 Feb;48:34-43. doi: 10.1016/j.cbpa.2018.09.021. Epub 2018 Oct 16. Review.


Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription.

Gilbertson S, Federspiel JD, Hartenian E, Cristea IM, Glaunsinger B.

Elife. 2018 Oct 3;7. pii: e37663. doi: 10.7554/eLife.37663.


Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication.

Jean Beltran PM, Cook KC, Hashimoto Y, Galitzine C, Murray LA, Vitek O, Cristea IM.

Cell Host Microbe. 2018 Oct 10;24(4):526-541.e7. doi: 10.1016/j.chom.2018.09.002. Epub 2018 Sep 27.


Principles of Systems Biology, No. 31.

Cho H, Berger B, Peng J, Galitzine C, Vitek O, Beltran PMJ, Cristea IM, Görtler F, Solbrig S, Wettig T, Oefner PJ, Spang R, Altenbuchinger M, Basso RS, Hochbaum D, Vandin F, Silverbush D, Cristea S, Yanovich G, Geiger T, Beerenwinkel N, Sharan R, Zhou Z, Luhmann N, Alikhan NF, Achtman M.

Cell Syst. 2018 Aug 22;7(2):133-135. doi: 10.1016/j.cels.2018.08.005.


Initiating Events in Direct Cardiomyocyte Reprogramming.

Sauls K, Greco TM, Wang L, Zou M, Villasmil M, Qian L, Cristea IM, Conlon FL.

Cell Rep. 2018 Feb 13;22(7):1913-1922. doi: 10.1016/j.celrep.2018.01.047.


Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease.

Rowland EA, Snowden CK, Cristea IM.

Curr Opin Chem Biol. 2018 Feb;42:76-85. doi: 10.1016/j.cbpa.2017.11.003. Epub 2017 Nov 21. Review.


Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.

Mirzaei M, Gupta VB, Chick JM, Greco TM, Wu Y, Chitranshi N, Wall RV, Hone E, Deng L, Dheer Y, Abbasi M, Rezaeian M, Braidy N, You Y, Salekdeh GH, Haynes PA, Molloy MP, Martins R, Cristea IM, Gygi SP, Graham SL, Gupta VK.

Sci Rep. 2017 Oct 4;7(1):12685. doi: 10.1038/s41598-017-12858-7.


Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.

Kennedy L, Kaltenbrun E, Greco TM, Temple B, Herring LE, Cristea IM, Conlon FL.

PLoS Genet. 2017 Sep 25;13(9):e1007011. doi: 10.1371/journal.pgen.1007011. eCollection 2017 Sep.


Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes.

Rowland EA, Greco TM, Snowden CK, McCabe AL, Silhavy TJ, Cristea IM.

MBio. 2017 Sep 12;8(5). pii: e01096-17. doi: 10.1128/mBio.01096-17.


Exploring and Exploiting Proteome Organization during Viral Infection.

Jean Beltran PM, Cook KC, Cristea IM.

J Virol. 2017 Aug 24;91(18). pii: e00268-17. doi: 10.1128/JVI.00268-17. Print 2017 Sep 15. Review.


Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor.

Santos JM, Josling G, Ross P, Joshi P, Orchard L, Campbell T, Schieler A, Cristea IM, Llinás M.

Cell Host Microbe. 2017 Jun 14;21(6):731-741.e10. doi: 10.1016/j.chom.2017.05.006.


Regulation, Function, and Detection of Protein Acetylation in Bacteria.

Carabetta VJ, Cristea IM.

J Bacteriol. 2017 Jul 25;199(16). pii: e00107-17. doi: 10.1128/JB.00107-17. Print 2017 Aug 15. Review.


Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from Latency.

Alfonso-Dunn R, Turner AW, Jean Beltran PM, Arbuckle JH, Budayeva HG, Cristea IM, Kristie TM.

Cell Host Microbe. 2017 Apr 12;21(4):507-517.e5. doi: 10.1016/j.chom.2017.03.007.


Proteomics and integrative omic approaches for understanding host-pathogen interactions and infectious diseases.

Jean Beltran PM, Federspiel JD, Sheng X, Cristea IM.

Mol Syst Biol. 2017 Mar 27;13(3):922. doi: 10.15252/msb.20167062. Review.


The Host-Pathogen Ecosystem Viewed Through the Prism of Proteomics.

Cristea IM.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S1-S4. doi: 10.1074/mcp.E117.068270. Epub 2017 Mar 10. No abstract available.


Proteomics Tracing the Footsteps of Infectious Disease.

Greco TM, Cristea IM.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S5-S14. doi: 10.1074/mcp.O116.066001. Epub 2017 Feb 5. Review.


Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

Crow MS, Cristea IM.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S200-S214. doi: 10.1074/mcp.M116.064741. Epub 2017 Jan 11.


A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection.

Jean Beltran PM, Mathias RA, Cristea IM.

Cell Syst. 2016 Oct 26;3(4):361-373.e6. doi: 10.1016/j.cels.2016.08.012. Epub 2016 Sep 15.


Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.

Crow MS, Lum KK, Sheng X, Song B, Cristea IM.

Crit Rev Biochem Mol Biol. 2016 Nov/Dec;51(6):452-481. doi: 10.1080/10409238.2016.1226250. Epub 2016 Sep 21. Review.


Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

McDonald KR, Guise AJ, Pourbozorgi-Langroudi P, Cristea IM, Zakian VA, Capra JA, Sabouri N.

PLoS Genet. 2016 Sep 9;12(9):e1006238. doi: 10.1371/journal.pgen.1006238. eCollection 2016 Sep.


Identification of RNA Binding Proteins Associated with Dengue Virus RNA in Infected Cells Reveals Temporally Distinct Host Factor Requirements.

Viktorovskaya OV, Greco TM, Cristea IM, Thompson SR.

PLoS Negl Trop Dis. 2016 Aug 24;10(8):e0004921. doi: 10.1371/journal.pntd.0004921. eCollection 2016 Aug.


Stimulatory effects of advanced glycation endproducts (AGEs) on fibronectin matrix assembly.

Pastino AK, Greco TM, Mathias RA, Cristea IM, Schwarzbauer JE.

Matrix Biol. 2017 May;59:39-53. doi: 10.1016/j.matbio.2016.07.003. Epub 2016 Jul 15.


HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1.

Ashford P, Hernandez A, Greco TM, Buch A, Sodeik B, Cristea IM, Grünewald K, Shepherd A, Topf M.

Mol Cell Proteomics. 2016 Sep;15(9):2939-53. doi: 10.1074/mcp.M116.058552. Epub 2016 Jul 6.


Temporal Regulation of the Bacillus subtilis Acetylome and Evidence for a Role of MreB Acetylation in Cell Wall Growth.

Carabetta VJ, Greco TM, Tanner AW, Cristea IM, Dubnau D.

mSystems. 2016 May;1(3). pii: e00005-16. Epub 2016 May 31.


HIV-host interactome revealed directly from infected cells.

Luo Y, Jacobs EY, Greco TM, Mohammed KD, Tong T, Keegan S, Binley JM, Cristea IM, Fenyö D, Rout MP, Chait BT, Muesing MA.

Nat Microbiol. 2016 Jul;1(7):16068. Epub 2016 May 23.


Identification of Sirtuin4 (SIRT4) Protein Interactions: Uncovering Candidate Acyl-Modified Mitochondrial Substrates and Enzymatic Regulators.

Mathias RA, Greco TM, Cristea IM.

Methods Mol Biol. 2016;1436:213-39. doi: 10.1007/978-1-4939-3667-0_15.


Approaches for Studying the Subcellular Localization, Interactions, and Regulation of Histone Deacetylase 5 (HDAC5).

Guise AJ, Cristea IM.

Methods Mol Biol. 2016;1436:47-84. doi: 10.1007/978-1-4939-3667-0_5.


Determining the Composition and Stability of Protein Complexes Using an Integrated Label-Free and Stable Isotope Labeling Strategy.

Greco TM, Guise AJ, Cristea IM.

Methods Mol Biol. 2016;1410:39-63. doi: 10.1007/978-1-4939-3524-6_3.


The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.

Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, Temple B, Yang XH, Wilczewski CM, Davis IJ, Cristea IM, Moskowitz IP, Conlon FL.

Dev Cell. 2016 Feb 8;36(3):262-75. doi: 10.1016/j.devcel.2016.01.009.


Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion.

Song R, Koyuncu OO, Greco TM, Diner BA, Cristea IM, Enquist LW.

MBio. 2016 Feb 2;7(1):e02145-15. doi: 10.1128/mBio.02145-15.


Proteomic approaches to uncovering virus-host protein interactions during the progression of viral infection.

Lum KK, Cristea IM.

Expert Rev Proteomics. 2016;13(3):325-40. doi: 10.1586/14789450.2016.1147353. Review.


The Biochemical Evolution of Protein Complexes.

Greco TM, Cristea IM.

Trends Biochem Sci. 2016 Jan;41(1):4-6. doi: 10.1016/j.tibs.2015.11.007. Epub 2015 Dec 9.


The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression.

Giguère SS, Guise AJ, Jean Beltran PM, Joshi PM, Greco TM, Quach OL, Kong J, Cristea IM.

Mol Cell Proteomics. 2016 Mar;15(3):791-809. doi: 10.1074/mcp.M115.054619. Epub 2015 Dec 9.


Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens.

Budayeva HG, Rowland EA, Cristea IM.

J Virol. 2015 Oct 21;90(1):5-8. doi: 10.1128/JVI.03220-14. Print 2016 Jan 1. Review.


Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length.

Lin KW, McDonald KR, Guise AJ, Chan A, Cristea IM, Zakian VA.

Nat Commun. 2015 Sep 14;6:8290. doi: 10.1038/ncomms9290.


Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing.

Diner BA, Cristea IM.

Cell Host Microbe. 2015 Sep 9;18(3):270-2. doi: 10.1016/j.chom.2015.08.012.


The emerging role of nuclear viral DNA sensors.

Diner BA, Lum KK, Cristea IM.

J Biol Chem. 2015 Oct 30;290(44):26412-21. doi: 10.1074/jbc.R115.652289. Epub 2015 Sep 9. Review.

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