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Items: 1 to 50 of 138

1.

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes.

Ringe RP, Pugach P, Cottrell CA, LaBranche CC, Seabright GE, Ketas TJ, Ozorowski G, Kumar S, Schorcht A, van Gils MJ, Crispin M, Montefiori DC, Wilson IA, Ward AB, Sanders RW, Klasse PJ, Moore JP.

J Virol. 2018 Nov 28. pii: JVI.01656-18. doi: 10.1128/JVI.01656-18. [Epub ahead of print]

PMID:
30487280
2.

HIV-1 vaccine design through minimizing envelope metastability.

He L, Kumar S, Allen JD, Huang D, Lin X, Mann CJ, Saye-Francisco KL, Copps J, Sarkar A, Blizard GS, Ozorowski G, Sok D, Crispin M, Ward AB, Nemazee D, Burton DR, Wilson IA, Zhu J.

Sci Adv. 2018 Nov 21;4(11):eaau6769. doi: 10.1126/sciadv.aau6769. eCollection 2018 Nov.

3.

Trends in genetic screening referral in breast cancer patients under the age of forty: 2001-2016.

Crispin M, Udovicich C, Chan S, Wong S, Pitcher M.

Breast J. 2018 Nov;24(6):1109-1111. doi: 10.1111/tbj.13130. Epub 2018 Sep 24. No abstract available.

PMID:
30251447
4.

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers.

Aldon Y, McKay PF, Allen J, Ozorowski G, Felfödiné Lévai R, Tolazzi M, Rogers P, He L, de Val N, Fábián K, Scarlatti G, Zhu J, Ward AB, Crispin M, Shattock RJ.

Cell Rep. 2018 Sep 18;24(12):3324-3338.e5. doi: 10.1016/j.celrep.2018.08.051.

5.

Self-reported Patient Motivations for Seeking Cosmetic Procedures.

Maisel A, Waldman A, Furlan K, Weil A, Sacotte K, Lazaroff JM, Lin K, Aranzazu D, Avram MM, Bell A, Cartee TV, Cazzaniga A, Chapas A, Crispin MK, Croix JA, DiGiorgio CM, Dover JS, Goldberg DJ, Goldman MP, Green JB, Griffin CL, Haimovic AD, Hausauer AK, Hernandez SL, Hsu S, Ibrahim O, Jones DH, Kaufman J, Kilmer SL, Lee NY, McDaniel DH, Schlessinger J, Tanzi E, Weiss ET, Weiss RA, Wu D, Poon E, Alam M.

JAMA Dermatol. 2018 Oct 1;154(10):1167-1174. doi: 10.1001/jamadermatol.2018.2357.

PMID:
30140900
6.

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.

Struwe WB, Chertova E, Allen JD, Seabright GE, Watanabe Y, Harvey DJ, Medina-Ramirez M, Roser JD, Smith R, Westcott D, Keele BF, Bess JW Jr, Sanders RW, Lifson JD, Moore JP, Crispin M.

Cell Rep. 2018 Aug 21;24(8):1958-1966.e5. doi: 10.1016/j.celrep.2018.07.080.

7.

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage.

Yang L, Sharma SK, Cottrell C, Guenaga J, Tran K, Wilson R, Behrens AJ, Crispin M, de Val N, Wyatt RT.

Front Immunol. 2018 Jul 17;9:1631. doi: 10.3389/fimmu.2018.01631. eCollection 2018.

8.

Structure of the Lassa virus glycan shield provides a model for immunological resistance.

Watanabe Y, Raghwani J, Allen JD, Seabright GE, Li S, Moser F, Huiskonen JT, Strecker T, Bowden TA, Crispin M.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7320-7325. doi: 10.1073/pnas.1803990115. Epub 2018 Jun 25.

9.

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies.

Bale S, Martiné A, Wilson R, Behrens AJ, Le Fourn V, de Val N, Sharma SK, Tran K, Torres JL, Girod PA, Ward AB, Crispin M, Wyatt RT.

Front Immunol. 2018 May 24;9:1116. doi: 10.3389/fimmu.2018.01116. eCollection 2018.

10.

Through the barricades: overcoming the barriers to effective antibody-based cancer therapeutics.

Dalziel M, Beers SA, Cragg MS, Crispin M.

Glycobiology. 2018 Sep 1;28(9):697-712. doi: 10.1093/glycob/cwy043.

PMID:
29800150
11.

Harnessing post-translational modifications for next-generation HIV immunogens.

Allen JD, Sanders RW, Doores KJ, Crispin M.

Biochem Soc Trans. 2018 Jun 19;46(3):691-698. doi: 10.1042/BST20170394. Epub 2018 May 21. Review.

PMID:
29784645
12.

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.

Sarkar A, Bale S, Behrens AJ, Kumar S, Sharma SK, de Val N, Pallesen J, Irimia A, Diwanji DC, Stanfield RL, Ward AB, Crispin M, Wyatt RT, Wilson IA.

Nat Commun. 2018 May 16;9(1):1956. doi: 10.1038/s41467-018-04272-y.

13.

Signature of Antibody Domain Exchange by Native Mass Spectrometry and Collision-Induced Unfolding.

Watanabe Y, Vasiljevic S, Allen JD, Seabright GE, Duyvesteyn HME, Doores KJ, Crispin M, Struwe WB.

Anal Chem. 2018 Jun 19;90(12):7325-7331. doi: 10.1021/acs.analchem.8b00573. Epub 2018 May 25.

PMID:
29757629
14.

Quantitative mass imaging of single biological macromolecules.

Young G, Hundt N, Cole D, Fineberg A, Andrecka J, Tyler A, Olerinyova A, Ansari A, Marklund EG, Collier MP, Chandler SA, Tkachenko O, Allen J, Crispin M, Billington N, Takagi Y, Sellers JR, Eichmann C, Selenko P, Frey L, Riek R, Galpin MR, Struwe WB, Benesch JLP, Kukura P.

Science. 2018 Apr 27;360(6387):423-427. doi: 10.1126/science.aar5839.

PMID:
29700264
15.

Collision Cross Sections and Ion Mobility Separation of Fragment Ions from Complex N-Glycans.

Harvey DJ, Watanabe Y, Allen JD, Rudd P, Pagel K, Crispin M, Struwe WB.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1250-1261. doi: 10.1007/s13361-018-1930-1. Epub 2018 Apr 19.

PMID:
29675741
16.

Structural analysis of glycoproteins: building N-linked glycans with Coot.

Emsley P, Crispin M.

Acta Crystallogr D Struct Biol. 2018 Apr 1;74(Pt 4):256-263. doi: 10.1107/S2059798318005119. Epub 2018 Apr 6.

17.

Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses.

Maurer MA, Meyer L, Bianchi M, Turner HL, Le NPL, Steck M, Wyrzucki A, Orlowski V, Ward AB, Crispin M, Hangartner L.

Cell Rep. 2018 Apr 3;23(1):90-99. doi: 10.1016/j.celrep.2018.03.027.

18.

Structure and Immune Recognition of the HIV Glycan Shield.

Crispin M, Ward AB, Wilson IA.

Annu Rev Biophys. 2018 Mar 29. doi: 10.1146/annurev-biophys-060414-034156. [Epub ahead of print]

PMID:
29595997
19.

Isomer Information from Ion Mobility Separation of High-Mannose Glycan Fragments.

Harvey DJ, Seabright GE, Vasiljevic S, Crispin M, Struwe WB.

J Am Soc Mass Spectrom. 2018 May;29(5):972-988. doi: 10.1007/s13361-018-1890-5. Epub 2018 Mar 5.

20.

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages.

Behrens AJ, Kumar A, Medina-Ramirez M, Cupo A, Marshall K, Cruz Portillo VM, Harvey DJ, Ozorowski G, Zitzmann N, Wilson IA, Ward AB, Struwe WB, Moore JP, Sanders RW, Crispin M.

J Proteome Res. 2018 Mar 2;17(3):987-999. doi: 10.1021/acs.jproteome.7b00639. Epub 2018 Feb 8.

PMID:
29420040
21.

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.

Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, Burton DR.

Cell Rep. 2018 Jan 23;22(4):1103. doi: 10.1016/j.celrep.2017.10.089. Epub 2018 Jan 28. No abstract available.

22.

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate.

Dey AK, Cupo A, Ozorowski G, Sharma VK, Behrens AJ, Go EP, Ketas TJ, Yasmeen A, Klasse PJ, Sayeed E, Desaire H, Crispin M, Wilson IA, Sanders RW, Hassell T, Ward AB, Moore JP.

Biotechnol Bioeng. 2018 Apr;115(4):885-899. doi: 10.1002/bit.26498. Epub 2017 Dec 11.

23.

Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN.

Mitchell DA, Zhang Q, Voorhaar L, Haddleton DM, Herath S, Gleinich AS, Randeva HS, Crispin M, Lehnert H, Wallis R, Patterson S, Becer CR.

Chem Sci. 2017 Oct 1;8(10):6974-6980. doi: 10.1039/c7sc01515a. Epub 2017 Aug 16.

24.

Immunoglobulin G Fc glycans are not essential for antibody-mediated immune suppression to murine erythrocytes.

Marjoram D, Cruz-Leal Y, Bernardo L, Le NPL, Crispin M, Yu X, Uchikawa M, Lazarus AH.

Blood. 2017 Dec 28;130(26):2902-2905. doi: 10.1182/blood-2017-06-793729. Epub 2017 Nov 6. No abstract available.

PMID:
29109102
25.

Lasers and Energy-Based Devices in Men.

Crispin MK, Hruza GJ, Kilmer SL.

Dermatol Surg. 2017 Nov;43 Suppl 2:S176-S184. doi: 10.1097/DSS.0000000000001274. Review.

PMID:
29064982
26.

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.

Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, Burton DR.

Cell Rep. 2017 Oct 3;21(1):222-235. doi: 10.1016/j.celrep.2017.09.024. Erratum in: Cell Rep. 2018 Jan 23;22(4):1103.

27.

Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1.

Behrens AJ, Struwe WB, Crispin M.

Expert Rev Proteomics. 2017 Oct;14(10):881-890. doi: 10.1080/14789450.2017.1376658. Epub 2017 Sep 14. Review.

28.

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, Cupo A, van der Woude P, Golabek M, Sliepen K, Blane T, Kootstra N, van Breemen MJ, Pritchard LK, Stanfield RL, Crispin M, Ward AB, Stamatatos L, Klasse PJ, Moore JP, Nemazee D, Nussenzweig MC, Wilson IA, Sanders RW.

J Exp Med. 2017 Sep 4;214(9):2573-2590. doi: 10.1084/jem.20161160. Epub 2017 Aug 28.

29.

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.

Torrents de la Peña A, Julien JP, de Taeye SW, Garces F, Guttman M, Ozorowski G, Pritchard LK, Behrens AJ, Go EP, Burger JA, Schermer EE, Sliepen K, Ketas TJ, Pugach P, Yasmeen A, Cottrell CA, Torres JL, Vavourakis CD, van Gils MJ, LaBranche C, Montefiori DC, Desaire H, Crispin M, Klasse PJ, Lee KK, Moore JP, Ward AB, Wilson IA, Sanders RW.

Cell Rep. 2017 Aug 22;20(8):1805-1817. doi: 10.1016/j.celrep.2017.07.077.

30.

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.

Zeltina A, Krumm SA, Sahin M, Struwe WB, Harlos K, Nunberg JH, Crispin M, Pinschewer DD, Doores KJ, Bowden TA.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7031-7036. doi: 10.1073/pnas.1702127114. Epub 2017 Jun 19.

31.

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers.

Ringe RP, Ozorowski G, Rantalainen K, Struwe WB, Matthews K, Torres JL, Yasmeen A, Cottrell CA, Ketas TJ, LaBranche CC, Montefiori DC, Cupo A, Crispin M, Wilson IA, Ward AB, Sanders RW, Klasse PJ, Moore JP.

J Virol. 2017 Jul 12;91(15). pii: e00677-17. doi: 10.1128/JVI.00677-17. Print 2017 Aug 1.

32.

Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy.

Järnum S, Runström A, Bockermann R, Winstedt L, Crispin M, Kjellman C.

Mol Cancer Ther. 2017 Sep;16(9):1887-1897. doi: 10.1158/1535-7163.MCT-17-0108. Epub 2017 May 22.

33.

Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering.

Yu X, Marshall MJE, Cragg MS, Crispin M.

BioDrugs. 2017 Jun;31(3):151-166. doi: 10.1007/s40259-017-0223-8. Review.

PMID:
28466278
34.

The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans.

Hopper JTS, Ambrose S, Grant OC, Krumm SA, Allison TM, Degiacomi MT, Tully MD, Pritchard LK, Ozorowski G, Ward AB, Crispin M, Doores KJ, Woods RJ, Benesch JLP, Robinson CV, Struwe WB.

Structure. 2017 May 2;25(5):773-782.e5. doi: 10.1016/j.str.2017.03.015. Epub 2017 Apr 20.

35.

Structural principles controlling HIV envelope glycosylation.

Behrens AJ, Crispin M.

Curr Opin Struct Biol. 2017 Jun;44:125-133. doi: 10.1016/j.sbi.2017.03.008. Epub 2017 Mar 29. Review.

36.

Appendiceal schwannoma: an incidental finding after Crohn's bowel resection.

Crispin MD.

ANZ J Surg. 2017 Mar 20. doi: 10.1111/ans.13966. [Epub ahead of print] No abstract available.

PMID:
28320054
37.

Identification of Lewis and Blood Group Carbohydrate Epitopes by Ion Mobility-Tandem-Mass Spectrometry Fingerprinting.

Hofmann J, Stuckmann A, Crispin M, Harvey DJ, Pagel K, Struwe WB.

Anal Chem. 2017 Feb 21;89(4):2318-2325. doi: 10.1021/acs.analchem.6b03853. Epub 2017 Feb 1.

PMID:
28192913
38.

Global N-Glycan Site Occupancy of HIV-1 gp120 by Metabolic Engineering and High-Resolution Intact Mass Spectrometry.

Struwe WB, Stuckmann A, Behrens AJ, Pagel K, Crispin M.

ACS Chem Biol. 2017 Feb 17;12(2):357-361. doi: 10.1021/acschembio.6b00854. Epub 2017 Jan 9.

39.

A Hyperpigmented Reticular Rash in a Patient on Peritoneal Dialysis.

South AM, Crispin MK, Marqueling AL, Sutherland SM.

Perit Dial Int. 2016 11-12;36(6):699-700.

40.

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.

van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW.

Nat Microbiol. 2016 Nov 14;2:16199. doi: 10.1038/nmicrobiol.2016.199.

41.

Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer.

Behrens AJ, Harvey DJ, Milne E, Cupo A, Kumar A, Zitzmann N, Struwe WB, Moore JP, Crispin M.

J Virol. 2017 Jan 3;91(2). pii: e01894-16. doi: 10.1128/JVI.01894-16. Print 2017 Jan 15.

42.

Travelling-wave ion mobility mass spectrometry and negative ion fragmentation of hybrid and complex N-glycans.

Harvey DJ, Scarff CA, Edgeworth M, Pagel K, Thalassinos K, Struwe WB, Crispin M, Scrivens JH.

J Mass Spectrom. 2016 Nov;51(11):1064-1079. doi: 10.1002/jms.3828.

43.

HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual.

Coss KP, Vasiljevic S, Pritchard LK, Krumm SA, Glaze M, Madzorera S, Moore PL, Crispin M, Doores KJ.

J Virol. 2016 Nov 28;90(24):11132-11144. Print 2016 Dec 15.

44.

Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity.

Calow J, Behrens AJ, Mader S, Bockau U, Struwe WB, Harvey DJ, Cormann KU, Nowaczyk MM, Loser K, Schinor D, Hartmann MW, Crispin M.

MAbs. 2016 Nov/Dec;8(8):1498-1511. Epub 2016 Sep 3.

45.

Integrating metabolomics and transcriptomics data to discover a biocatalyst that can generate the amine precursors for alkamide biosynthesis.

Rizhsky L, Jin H, Shepard MR, Scott HW, Teitgen AM, Perera MA, Mhaske V, Jose A, Zheng X, Crispin M, Wurtele ES, Jones D, Hur M, Góngora-Castillo E, Buell CR, Minto RE, Nikolau BJ.

Plant J. 2016 Dec;88(5):775-793. doi: 10.1111/tpj.13295. Epub 2016 Sep 27.

46.

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.

Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7154-9. doi: 10.1073/pnas.1603827113. Epub 2016 Jun 20.

47.

Esophageal Apoplexy.

Crispin MD, Chan KJ, Winter N, Hii M.

J Gastrointest Surg. 2016 Aug;20(8):1535-6. doi: 10.1007/s11605-016-3184-1. Epub 2016 Jun 6.

PMID:
27271541
48.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.

Stewart-Jones GB, Soto C, Lemmin T, Chuang GY, Druz A, Kong R, Thomas PV, Wagh K, Zhou T, Behrens AJ, Bylund T, Choi CW, Davison JR, Georgiev IS, Joyce MG, Kwon YD, Pancera M, Taft J, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CC, Wu CY, Bewley CA, Burton DR, Koff WC, Connors M, Crispin M, Baxa U, Korber BT, Wong CH, Mascola JR, Kwong PD.

Cell. 2016 May 5;165(4):813-26. doi: 10.1016/j.cell.2016.04.010. Epub 2016 Apr 21.

49.

Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies.

Le NP, Bowden TA, Struwe WB, Crispin M.

Biochim Biophys Acta. 2016 Aug;1860(8):1655-68. doi: 10.1016/j.bbagen.2016.04.016. Epub 2016 Apr 20. Review.

50.

Native functionality and therapeutic targeting of arenaviral glycoproteins.

Crispin M, Zeltina A, Zitzmann N, Bowden TA.

Curr Opin Virol. 2016 Jun;18:70-5. doi: 10.1016/j.coviro.2016.04.001. Epub 2016 Apr 19. Review.

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