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Items: 47


Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets.

Zhao W, Fitzgibbon M, Bergan L, Clegg N, Crispin D, Mills GB, McIntosh M.

Cancer J. 2017 Mar/Apr;23(2):108-114. doi: 10.1097/PPO.0000000000000258. Review.


Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival.

Miller NJ, Church CD, Dong L, Crispin D, Fitzgibbon MP, Lachance K, Jing L, Shinohara M, Gavvovidis I, Willimsky G, McIntosh M, Blankenstein T, Koelle DM, Nghiem P.

Cancer Immunol Res. 2017 Feb;5(2):137-147. doi: 10.1158/2326-6066.CIR-16-0210. Epub 2017 Jan 16.


Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

Pritchard LK, Spencer DI, Royle L, Bonomelli C, Seabright GE, Behrens AJ, Kulp DW, Menis S, Krumm SA, Dunlop DC, Crispin DJ, Bowden TA, Scanlan CN, Ward AB, Schief WR, Doores KJ, Crispin M.

Nat Commun. 2015 Jun 24;6:7479. doi: 10.1038/ncomms8479.


Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.

Karunadharma PP, Basisty N, Dai DF, Chiao YA, Quarles EK, Hsieh EJ, Crispin D, Bielas JH, Ericson NG, Beyer RP, MacKay VL, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2015 Aug;14(4):547-57. doi: 10.1111/acel.12317. Epub 2015 Mar 23.


Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer.

Chen R, Pan S, Lai K, Lai LA, Crispin DA, Bronner MP, Brentnall TA.

World J Gastroenterol. 2014 Dec 7;20(45):17037-48. doi: 10.3748/wjg.v20.i45.17037.


Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma.

Chen R, Dawson DW, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, May DH, Crispin DA, Lai LA, Lay AR, Waghray M, Wang S, McIntosh MW, Simeone DM, Maitra A, Brentnall TA.

Lab Invest. 2015 Jan;95(1):43-55. doi: 10.1038/labinvest.2014.128. Epub 2014 Oct 27.


Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate.

Collins PW, Solomon C, Sutor K, Crispin D, Hochleitner G, Rizoli S, Schöchl H, Schreiber M, Ranucci M.

Br J Anaesth. 2014 Oct;113(4):585-95. doi: 10.1093/bja/aeu086. Epub 2014 Jul 26.


Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.

Dai DF, Karunadharma PP, Chiao YA, Basisty N, Crispin D, Hsieh EJ, Chen T, Gu H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2014 Jun;13(3):529-39. doi: 10.1111/acel.12203. Epub 2014 Feb 25.


Quantitative glycoproteomics analysis reveals changes in N-glycosylation level associated with pancreatic ductal adenocarcinoma.

Pan S, Chen R, Tamura Y, Crispin DA, Lai LA, May DH, McIntosh MW, Goodlett DR, Brentnall TA.

J Proteome Res. 2014 Mar 7;13(3):1293-306. doi: 10.1021/pr4010184. Epub 2014 Jan 28.


Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.

Salk JJ, Bansal A, Lai LA, Crispin DA, Ussakli CH, Horwitz MS, Bronner MP, Brentnall TA, Loeb LA, Rabinovitch PS, Risques RA.

Inflamm Bowel Dis. 2013 Nov;19(12):2593-602. doi: 10.1097/MIB.0b013e3182a87640.


Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides.

Dai DF, Hsieh EJ, Chen T, Menendez LG, Basisty NB, Tsai L, Beyer RP, Crispin DA, Shulman NJ, Szeto HH, Tian R, MacCoss MJ, Rabinovitch PS.

Circ Heart Fail. 2013 Sep 1;6(5):1067-76. doi: 10.1161/CIRCHEARTFAILURE.113.000406. Epub 2013 Aug 9.


Private acute providers warned of slowing growth in NHS work.

Crispin D.

Health Serv J. 2012 Jan 26;122(6291):10-1. No abstract available.


Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer.

Lai LA, Risques RA, Bronner MP, Rabinovitch PS, Crispin D, Chen R, Brentnall TA.

Cancer Lett. 2012 Jul 28;320(2):180-8. doi: 10.1016/j.canlet.2012.02.031. Epub 2012 Mar 2.


FTs step closer to diluting national pay deal.

Crispin D.

Health Serv J. 2011 Sep 15;121(6274):4-5. No abstract available.


Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling.

Pan S, Chen R, Crispin DA, May D, Stevens T, McIntosh MW, Bronner MP, Ziogas A, Anton-Culver H, Brentnall TA.

J Proteome Res. 2011 May 6;10(5):2359-76. doi: 10.1021/pr101148r. Epub 2011 Mar 28.


Investigating neoplastic progression of ulcerative colitis with label-free comparative proteomics.

May D, Pan S, Crispin DA, Lai K, Bronner MP, Hogan J, Hockenbery DM, McIntosh M, Brentnall TA, Chen R.

J Proteome Res. 2011 Jan 7;10(1):200-9. doi: 10.1021/pr100574p. Epub 2010 Oct 20.


Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non-dysplastic biopsies distinguish progressors from non-progressors.

Bronner MP, Skacel M, Crispin DA, Hoff PD, Emond MJ, Lai LA, Tubbs RR, O'Sullivan JN, Rabinovitch PS, Brentnall TA.

Mod Pathol. 2010 Dec;23(12):1624-33. doi: 10.1038/modpathol.2010.161. Epub 2010 Aug 27.


Pilot study of blood biomarker candidates for detection of pancreatic cancer.

Chen R, Crispin DA, Pan S, Hawley S, McIntosh MW, May D, Anton-Culver H, Ziogas A, Bronner MP, Brentnall TA.

Pancreas. 2010 Oct;39(7):981-8. doi: 10.1097/MPA.0b013e3181dac920.


Proteins That Underlie Neoplastic Progression of Ulcerative Colitis.

Brentnall TA, Pan S, Bronner MP, Crispin DA, Mirzaei H, Cooke K, Tamura Y, Nikolskaya T, Jebailey L, Goodlett DR, McIntosh M, Aebersold R, Rabinovitch PS, Chen R.

Proteomics Clin Appl. 2009 Sep 14;3(11):1326.


Clonal expansions in ulcerative colitis identify patients with neoplasia.

Salk JJ, Salipante SJ, Risques RA, Crispin DA, Li L, Bronner MP, Brentnall TA, Rabinovitch PS, Horwitz MS, Loeb LA.

Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20871-6. doi: 10.1073/pnas.0909428106. Epub 2009 Nov 19.


Quantitative proteomics investigation of pancreatic intraepithelial neoplasia.

Pan S, Chen R, Reimel BA, Crispin DA, Mirzaei H, Cooke K, Coleman JF, Lane Z, Bronner MP, Goodlett DR, McIntosh MW, Traverso W, Aebersold R, Brentnall TA.

Electrophoresis. 2009 Apr;30(7):1132-44. doi: 10.1002/elps.200800752.


Genomic biomarkers to improve ulcerative colitis neoplasia surveillance.

Bronner MP, O'Sullivan JN, Rabinovitch PS, Crispin DA, Chen L, Emond MJ, Rubin CE, Brentnall TA.

Am J Pathol. 2008 Dec;173(6):1853-60. doi: 10.2353/ajpath.2008.080250. Epub 2008 Nov 6.


Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer.

Chen R, Brentnall TA, Pan S, Cooke K, Moyes KW, Lane Z, Crispin DA, Goodlett DR, Aebersold R, Bronner MP.

Mol Cell Proteomics. 2007 Aug;6(8):1331-42. Epub 2007 May 12.


Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.

Pogue-Geile KL, Chen R, Bronner MP, Crnogorac-Jurcevic T, Moyes KW, Dowen S, Otey CA, Crispin DA, George RD, Whitcomb DC, Brentnall TA.

PLoS Med. 2006 Dec;3(12):e516.


Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape.

Chen R, Yi EC, Donohoe S, Pan S, Eng J, Cooke K, Crispin DA, Lane Z, Goodlett DR, Bronner MP, Aebersold R, Brentnall TA.

Gastroenterology. 2005 Oct;129(4):1187-97.


Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regions.

Chen R, Bronner MP, Crispin DA, Rabinovitch PS, Brentnall TA.

Cancer Genet Cytogenet. 2005 Oct 15;162(2):99-106.


The initiation of colon cancer in a chronic inflammatory setting.

Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Bronner MP, Brentnall TA.

Carcinogenesis. 2005 Sep;26(9):1513-9. Epub 2005 Apr 28.


DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free.

Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Koprowicz KM, Bronner MP, Brentnall TA.

Am J Pathol. 2003 Feb;162(2):665-72.


Chromosomal instability in ulcerative colitis is related to telomere shortening.

O'Sullivan JN, Bronner MP, Brentnall TA, Finley JC, Shen WT, Emerson S, Emond MJ, Gollahon KA, Moskovitz AH, Crispin DA, Potter JD, Rabinovitch PS.

Nat Genet. 2002 Oct;32(2):280-4. Epub 2002 Sep 23.


Targetting out of the workforce nurses: a promising local recruitment strategy.

Williams A, Brown A, Crispin D, Gibson D.

Collegian. 2002 Jan;9(1):8-11.


A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34.

Eberle MA, Pfützer R, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, Duerr RH, Kruglyak L, Whitcomb DC, Brentnall TA.

Am J Hum Genet. 2002 Apr;70(4):1044-8. Epub 2002 Feb 27.


Familial fibrocystic pancreatic atrophy with endocrine cell hyperplasia and pancreatic carcinoma.

Meckler KA, Brentnall TA, Haggitt RC, Crispin D, Byrd DR, Kimmey MB, Bronner MP.

Am J Surg Pathol. 2001 Aug;25(8):1047-53.


Neoplasms of the ampulla of vater with concurrent pancreatic intraductal neoplasia: a histological and molecular study.

Agoff SN, Crispin DA, Bronner MP, Dail DH, Hawes SE, Haggitt RC.

Mod Pathol. 2001 Mar;14(3):139-46.


Patients with intractable epilepsy have low melatonin, which increases following seizures.

Bazil CW, Short D, Crispin D, Zheng W.

Neurology. 2000 Dec 12;55(11):1746-8.


The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia.

Agoff SN, Brentnall TA, Crispin DA, Taylor SL, Raaka S, Haggitt RC, Reed MW, Afonina IA, Rabinovitch PS, Stevens AC, Feng Z, Bronner MP.

Am J Pathol. 2000 Sep;157(3):737-45.


Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis.

Rabinovitch PS, Dziadon S, Brentnall TA, Emond MJ, Crispin DA, Haggitt RC, Bronner MP.

Cancer Res. 1999 Oct 15;59(20):5148-53.


EEG checkerboard pattern of bruxism.

Hirsch LJ, Crispin D.

Neurology. 1999 Sep 11;53(4):669. No abstract available.


Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis.

Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland CR.

Cancer Res. 1996 Mar 15;56(6):1237-40.


Risk and natural history of colonic neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis.

Brentnall TA, Haggitt RC, Rabinovitch PS, Kimmey MB, Bronner MP, Levine DS, Kowdley KV, Stevens AC, Crispin DA, Emond M, Rubin CE.

Gastroenterology. 1996 Feb;110(2):331-8.


A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis.

Brentnall TA, Rubin CE, Crispin DA, Stevens A, Batchelor RH, Haggitt RC, Bronner MP, Evans JP, McCahill LE, Bilir N, et al.

Gastroenterology. 1995 Jul;109(1):151-5.


[Kinship lexical organization and psychosis].

Martins F, Crispin D, Percílio D.

Acta Psiquiatr Psicol Am Lat. 1995 May;41(2):130-40. Spanish.


Familial pancreatic adenocarcinoma: association with diabetes and early molecular diagnosis.

Evans JP, Burke W, Chen R, Bennett RL, Schmidt RA, Dellinger EP, Kimmey M, Crispin D, Brentnall TA, Byrd DR.

J Med Genet. 1995 May;32(5):330-5.


Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

Brentnall TA, Crispin DA, Rabinovitch PS, Haggitt RC, Rubin CE, Stevens AC, Burmer GC.

Gastroenterology. 1994 Aug;107(2):369-78.


Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele.

Burmer GC, Rabinovitch PS, Haggitt RC, Crispin DA, Brentnall TA, Kolli VR, Stevens AC, Rubin CE.

Gastroenterology. 1992 Nov;103(5):1602-10.


Evolution of the salmonid mitochondrial control region.

Shedlock AM, Parker JD, Crispin DA, Pietsch TW, Burmer GC.

Mol Phylogenet Evol. 1992 Sep;1(3):179-92.


Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis.

Burmer GC, Crispin DA, Kolli VR, Haggitt RC, Kulander BG, Rubin CE, Rabinovitch PS.

Cancer Commun. 1991 Jun;3(6):167-72.


Experiments in steroid synthesis: oestrone.

Crispin DJ, Vanstone AE, Whithurst JS.

J Chem Soc Perkin 1. 1970;1:10-8. No abstract available.


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