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Fetal origin confers radioresistance on liver macrophages via p21cip1/WAF1.

Soysa R, Lampert S, Yuen S, Douglass AN, Li W, Pfeffer K, Crispe IN.

J Hepatol. 2019 Sep;71(3):553-562. doi: 10.1016/j.jhep.2019.04.015. Epub 2019 May 9.


Mobilization of CD8+ T Cells via CXCR4 Blockade Facilitates PD-1 Checkpoint Therapy in Human Pancreatic Cancer.

Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG.

Clin Cancer Res. 2019 Jul 1;25(13):3934-3945. doi: 10.1158/1078-0432.CCR-19-0081. Epub 2019 Apr 2.


Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.

Song H, Tan G, Yang Y, Cui A, Li H, Li T, Wu Z, Yang M, Lv G, Chi X, Niu J, Zhu K, Crispe IN, Su L, Tu Z.

J Immunol. 2019 Apr 15;202(8):2266-2275. doi: 10.4049/jimmunol.1800848. Epub 2019 Mar 6.


Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner.

Li T, Yang Y, Song H, Li H, Cui A, Liu Y, Su L, Crispe IN, Tu Z.

J Leukoc Biol. 2019 Apr;105(4):695-704. doi: 10.1002/JLB.2A0118-031RR. Epub 2019 Feb 12.


Precision-cut human liver slice cultures as an immunological platform.

Wu X, Roberto JB, Knupp A, Kenerson HL, Truong CD, Yuen SY, Brempelis KJ, Tuefferd M, Chen A, Horton H, Yeung RS, Crispe IN.

J Immunol Methods. 2018 Apr;455:71-79. doi: 10.1016/j.jim.2018.01.012. Epub 2018 Feb 1.


HCV immune evasion and regulatory T cell activation: cause or consequence?

Li H, Li T, Crispe IN, Tu Z.

Cell Mol Immunol. 2018 May;15(5):536-538. doi: 10.1038/cmi.2017.131. Epub 2017 Nov 27. No abstract available.


Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection.

Li H, Zhai N, Wang Z, Song H, Yang Y, Cui A, Li T, Wang G, Niu J, Crispe IN, Su L, Tu Z.

Gut. 2018 Nov;67(11):2035-2044. doi: 10.1136/gutjnl-2017-314098. Epub 2017 Sep 12.


Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment.

Jiang X, Seo YD, Chang JH, Coveler A, Nigjeh EN, Pan S, Jalikis F, Yeung RS, Crispe IN, Pillarisetty VG.

Oncoimmunology. 2017 May 25;6(7):e1333210. doi: 10.1080/2162402X.2017.1333210. eCollection 2017.


Dendritic cells in hepatitis and liver transplantation.

Soysa R, Wu X, Crispe IN.

Liver Transpl. 2017 Nov;23(11):1433-1439. doi: 10.1002/lt.24833. Epub 2017 Oct 9.


BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.

Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, Jaspan HB.

JCI Insight. 2017 Apr 6;2(7):e91963. doi: 10.1172/jci.insight.91963.


Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury.

Brempelis KJ, Yuen SY, Schwarz N, Mohar I, Crispe IN.

Hepatology. 2017 Apr;65(4):1336-1351. doi: 10.1002/hep.29078. Epub 2017 Mar 3.


Hepatitis C Virus Induces MDSCs-Like Monocytes through TLR2/PI3K/AKT/STAT3 Signaling.

Zhai N, Li H, Song H, Yang Y, Cui A, Li T, Niu J, Crispe IN, Su L, Tu Z.

PLoS One. 2017 Jan 23;12(1):e0170516. doi: 10.1371/journal.pone.0170516. eCollection 2017.


Infiltrating monocytes in liver injury and repair.

Brempelis KJ, Crispe IN.

Clin Transl Immunology. 2016 Nov 4;5(11):e113. eCollection 2016 Nov. Review.


Subcapsular Hepatic Dendritic Cells: Hiding in Plain Sight.

Soysa DR, Crispe IN.

Gastroenterology. 2016 Dec;151(6):1065-1067. doi: 10.1053/j.gastro.2016.10.030. Epub 2016 Oct 27. No abstract available.


HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway.

Zhang Q, Wang Y, Zhai N, Song H, Li H, Yang Y, Li T, Guo X, Chi B, Niu J, Crispe IN, Su L, Tu Z.

Sci Rep. 2016 Oct 27;6:36160. doi: 10.1038/srep36160.


TLR4-Dependent Secretion by Hepatic Stellate Cells of the Neutrophil-Chemoattractant CXCL1 Mediates Liver Response to Gut Microbiota.

Bigorgne AE, John B, Ebrahimkhani MR, Shimizu-Albergine M, Campbell JS, Crispe IN.

PLoS One. 2016 Mar 22;11(3):e0151063. doi: 10.1371/journal.pone.0151063. eCollection 2016.


Presentation of hepatocellular antigens.

Grakoui A, Crispe IN.

Cell Mol Immunol. 2016 May;13(3):293-300. doi: 10.1038/cmi.2015.109. Epub 2016 Feb 29. Review.


Hepatocytes as Immunological Agents.

Crispe IN.

J Immunol. 2016 Jan 1;196(1):17-21. doi: 10.4049/jimmunol.1501668. Review.


Isolation of Non-parenchymal Cells from the Mouse Liver.

Mohar I, Brempelis KJ, Murray SA, Ebrahimkhani MR, Crispe IN.

Methods Mol Biol. 2015;1325:3-17. doi: 10.1007/978-1-4939-2815-6_1.


CD40 is required for protective immunity against liver stage Plasmodium infection.

Murray SA, Mohar I, Miller JL, Brempelis KJ, Vaughan AM, Kappe SH, Crispe IN.

J Immunol. 2015 Mar 1;194(5):2268-79. doi: 10.4049/jimmunol.1401724. Epub 2015 Feb 2.


Hepatitis C virus core protein triggers expansion and activation of CD4(+)CD25(+) regulatory T cells in chronic hepatitis C patients.

Zhai N, Chi X, Li T, Song H, Li H, Jin X, Crispe IN, Su L, Niu J, Tu Z.

Cell Mol Immunol. 2015 Nov;12(6):743-9. doi: 10.1038/cmi.2014.119. Epub 2014 Dec 22.


APC licensing and CD4+T cell help in liver-stage malaria.

Crispe IN.

Front Microbiol. 2014 Nov 11;5:617. doi: 10.3389/fmicb.2014.00617. eCollection 2014. Review.


Identification of pre-erythrocytic malaria antigens that target hepatocytes for killing in vivo and contribute to protection elicited by whole-parasite vaccination.

Chen L, Keitany GJ, Peng X, Gibson C, Mohar I, Vignali M, Crispe IN, Huang F, Wang R.

PLoS One. 2014 Jul 15;9(7):e102225. doi: 10.1371/journal.pone.0102225. eCollection 2014.


Immune tolerance in liver disease.

Crispe IN.

Hepatology. 2014 Dec;60(6):2109-17. doi: 10.1002/hep.27254. Epub 2014 Sep 26.


Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes.

Brownell J, Wagoner J, Lovelace ES, Thirstrup D, Mohar I, Smith W, Giugliano S, Li K, Crispe IN, Rosen HR, Polyak SJ.

J Hepatol. 2013 Oct;59(4):701-8. doi: 10.1016/j.jhep.2013.06.001. Epub 2013 Jun 12.


Killer T cells find meaningful encounters through iMATEs.

Crispe IN, Pierce RH.

Nat Immunol. 2013 Jun;14(6):533-4. doi: 10.1038/ni.2620. No abstract available.


Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii.

Miller JL, Murray S, Vaughan AM, Harupa A, Sack B, Baldwin M, Crispe IN, Kappe SH.

PLoS One. 2013 Apr 11;8(4):e60820. doi: 10.1371/journal.pone.0060820. Print 2013.


Migration of lymphocytes into hepatic sinusoids.

Crispe IN.

J Hepatol. 2012 Jul;57(1):218-20. doi: 10.1016/j.jhep.2011.12.035. Epub 2012 Mar 23. No abstract available.


HCV core and NS3 proteins manipulate human blood-derived dendritic cell development and promote Th 17 differentiation.

Tu Z, Hamalainen-Laanaya HK, Nishitani C, Kuroki Y, Crispe IN, Orloff MS.

Int Immunol. 2012 Feb;24(2):97-106. doi: 10.1093/intimm/dxr104. Epub 2011 Dec 20.


IL-17 in liver injury: an inflammatory issue?

Crispe IN.

Immunol Cell Biol. 2012 Apr;90(4):369-70. doi: 10.1038/icb.2011.82. Epub 2011 Sep 27. No abstract available.


Ineffective CD8(+) T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis.

Spahn J, Pierce RH, Crispe IN.

Am J Pathol. 2011 Nov;179(5):2370-81. doi: 10.1016/j.ajpath.2011.08.004. Epub 2011 Sep 15.


Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells.

Tu Z, Hamalainen-Laanaya HK, Crispe IN, Orloff MS.

Cell Immunol. 2011;271(2):286-91. doi: 10.1016/j.cellimm.2011.07.006. Epub 2011 Jul 20.


Cross-presentation of antigen by diverse subsets of murine liver cells.

Ebrahimkhani MR, Mohar I, Crispe IN.

Hepatology. 2011 Oct;54(4):1379-87. doi: 10.1002/hep.24508.


CD4+ T cell effects on CD8+ T cell location defined using bioluminescence.

Azadniv M, Bowers WJ, Topham DJ, Crispe IN.

PLoS One. 2011 Jan 20;6(1):e16222. doi: 10.1371/journal.pone.0016222.


Liver antigen-presenting cells.

Crispe IN.

J Hepatol. 2011 Feb;54(2):357-65. doi: 10.1016/j.jhep.2010.10.005. Epub 2010 Oct 16. Review.


TLRs in Hepatic Cellular Crosstalk.

Bigorgne AE, Crispe IN.

Gastroenterol Res Pract. 2010;2010. pii: 618260. doi: 10.1155/2010/618260. Epub 2010 Aug 30.


Direct, help-independent priming of CD8+ T cells by adeno-associated virus-transduced hepatocytes.

Wuensch SA, Spahn J, Crispe IN.

Hepatology. 2010 Sep;52(3):1068-77. doi: 10.1002/hep.23745.


Toll-like receptor signaling in liver diseases.

Szabo G, Billiar TR, Machida K, Crispe IN, Seki E.

Gastroenterol Res Pract. 2010;2010:971270. doi: 10.1155/2010/971270. Epub 2011 May 5. No abstract available.


Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells.

Tu Z, Pierce RH, Kurtis J, Kuroki Y, Crispe IN, Orloff MS.

Gastroenterology. 2010 Jan;138(1):305-14. doi: 10.1053/j.gastro.2009.09.009. Epub 2009 Sep 19.


Galactosylated LDL nanoparticles: a novel targeting delivery system to deliver antigen to macrophages and enhance antigen specific T cell responses.

Wu F, Wuensch SA, Azadniv M, Ebrahimkhani MR, Crispe IN.

Mol Pharm. 2009 Sep-Oct;6(5):1506-17. doi: 10.1021/mp900081y.


Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4.

Bancos S, Cao Q, Bowers WJ, Crispe IN.

Cell Immunol. 2009;257(1-2):44-54. doi: 10.1016/j.cellimm.2009.02.006.


The liver as a lymphoid organ.

Crispe IN.

Annu Rev Immunol. 2009;27:147-63. doi: 10.1146/annurev.immunol.021908.132629. Review.


Polyketal copolymers: a new acid-sensitive delivery vehicle for treating acute inflammatory diseases.

Yang SC, Bhide M, Crispe IN, Pierce RH, Murthy N.

Bioconjug Chem. 2008 Jun;19(6):1164-9. doi: 10.1021/bc700442g. Epub 2008 May 24.


Isolation of mouse intrahepatic lymphocytes.

Crispe IN.

Curr Protoc Immunol. 2001 May;Chapter 3:Unit 3.21. doi: 10.1002/0471142735.im0321s22.


TLR-dependent cross talk between human Kupffer cells and NK cells.

Tu Z, Bozorgzadeh A, Pierce RH, Kurtis J, Crispe IN, Orloff MS.

J Exp Med. 2008 Jan 21;205(1):233-44. doi: 10.1084/jem.20072195. Epub 2008 Jan 14.


Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter.

Azadniv M, Dugger K, Bowers WJ, Weaver C, Crispe IN.

Int Immunol. 2007 Oct;19(10):1165-73. Epub 2007 Aug 14.


Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages.

Klein I, Cornejo JC, Polakos NK, John B, Wuensch SA, Topham DJ, Pierce RH, Crispe IN.

Blood. 2007 Dec 1;110(12):4077-85. Epub 2007 Aug 9.


Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses.

Polakos NK, Klein I, Richter MV, Zaiss DM, Giannandrea M, Crispe IN, Topham DJ.

J Immunol. 2007 Jul 1;179(1):201-10.

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