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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides.

Becker S, Feldmann J, Wiedemann S, Okamura H, Schneider C, Iwan K, Crisp A, Rossa M, Amatov T, Carell T.

Science. 2019 Oct 4;366(6461):76-82. doi: 10.1126/science.aax2747.


Proto-Urea-RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides.

Okamura H, Crisp A, Hübner S, Becker S, Rovó P, Carell T.

Angew Chem Int Ed Engl. 2019 Oct 1. doi: 10.1002/anie.201911746. [Epub ahead of print] Review.


Influence of Energy Balance on the Rate of Weight Loss Throughout One Year of Roux-en-Y Gastric Bypass: a Doubly Labeled Water Study.

Novaes Ravelli M, Schoeller DA, Crisp AH, Shriver T, Ferriolli E, Ducatti C, Marques de Oliveira MR.

Obes Surg. 2019 Oct;29(10):3299-3308. doi: 10.1007/s11695-019-03989-z.


Acute Effects of the New Method Sarcoplasma Stimulating Training Versus Traditional Resistance Training on Total Training Volume, Lactate and Muscle Thickness.

de Almeida FN, Lopes CR, da Conceição RM, Oenning L, Crisp AH, de Sousa NMF, Trindade TB, Willardson JM, Prestes J.

Front Physiol. 2019 May 15;10:579. doi: 10.3389/fphys.2019.00579. eCollection 2019.


Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.

Walker JA, Clark PA, Crisp A, Barlow JL, Szeto A, Ferreira ACF, Rana BMJ, Jolin HE, Rodriguez-Rodriguez N, Sivasubramaniam M, Pannell R, Cruickshank J, Daly M, Haim-Vilmovsky L, Teichmann SA, McKenzie ANJ.

Immunity. 2019 Jul 16;51(1):104-118.e7. doi: 10.1016/j.immuni.2019.05.002. Epub 2019 May 22.


Publisher Correction: Non-canonical nucleosides and chemistry of the emergence of life.

Becker S, Schneider C, Crisp A, Carell T.

Nat Commun. 2019 Jan 15;10(1):325. doi: 10.1038/s41467-019-08340-9.


The changing landscape of data monitoring committees-Perspectives from regulators, members, and sponsors.

Bhattacharyya A, Gallo P, Crisp A, LaVange L, Molenberghs G, Pétavy F, Seltzer J.

Biom J. 2019 Sep;61(5):1232-1241. doi: 10.1002/bimj.201700307. Epub 2018 Dec 27. Review.


Non-canonical nucleosides and chemistry of the emergence of life.

Becker S, Schneider C, Crisp A, Carell T.

Nat Commun. 2018 Dec 12;9(1):5174. doi: 10.1038/s41467-018-07222-w. Erratum in: Nat Commun. 2019 Jan 15;10(1):325.


R-loop formation during S phase is restricted by PrimPol-mediated repriming.

Šviković S, Crisp A, Tan-Wong SM, Guilliam TA, Doherty AJ, Proudfoot NJ, Guilbaud G, Sale JE.

EMBO J. 2019 Feb 1;38(3). pii: e99793. doi: 10.15252/embj.201899793. Epub 2018 Nov 26.


Accuracy of total energy expenditure predictive equations after a massive weight loss induced by bariatric surgery.

Ravelli MN, Schoeller DA, Crisp AH, Racine NM, Pfrimer K, Rasera Junior I, Oliveira MRM.

Clin Nutr ESPEN. 2018 Aug;26:57-65. doi: 10.1016/j.clnesp.2018.04.013. Epub 2018 May 3.


Rethinking the tools of the RNA world.

Crisp A, Carell T.

Elife. 2018 Jun 15;7. pii: e38297. doi: 10.7554/eLife.38297.


Comparative genomics of bdelloid rotifers: Insights from desiccating and nondesiccating species.

Nowell RW, Almeida P, Wilson CG, Smith TP, Fontaneto D, Crisp A, Micklem G, Tunnacliffe A, Boschetti C, Barraclough TG.

PLoS Biol. 2018 Apr 24;16(4):e2004830. doi: 10.1371/journal.pbio.2004830. eCollection 2018 Apr.


Practical experiences of adopting assurance as a quantitative framework to support decision making in drug development.

Crisp A, Miller S, Thompson D, Best N.

Pharm Stat. 2018 Jul;17(4):317-328. doi: 10.1002/pst.1856. Epub 2018 Apr 10.


Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations.

Schneider C, Becker S, Okamura H, Crisp A, Amatov T, Stadlmeier M, Carell T.

Angew Chem Int Ed Engl. 2018 May 14;57(20):5943-5946. doi: 10.1002/anie.201801919. Epub 2018 Apr 17.


From NHS to devolved independent regional health services.

Crisp A.

J R Soc Med. 2018 Jan;111(1):4. doi: 10.1177/0141076817737963. No abstract available.


Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis.

Becker S, Schneider C, Okamura H, Crisp A, Amatov T, Dejmek M, Carell T.

Nat Commun. 2018 Jan 11;9(1):163. doi: 10.1038/s41467-017-02639-1.


Changes in Physical Activities and Body Composition after Roux-Y Gastric Bypass Surgery.

Crisp AH, Verlengia R, Ravelli MN, Junior IR, de Oliveira MRM.

Obes Surg. 2018 Jun;28(6):1665-1671. doi: 10.1007/s11695-017-3074-y.


Association of 5-HT2C (rs3813929) and UCP3 (rs1800849) gene polymorphisms with type 2 diabetes in obese women candidates for bariatric surgery.

Schnor NPP, Verlengia R, Novais PFS, Crisp AH, Leite CVS, Rasera-Junior I, Oliveira MRM.

Arch Endocrinol Metab. 2017 Jul-Aug;61(4):326-331. doi: 10.1590/2359-3997000000260.


The Effect of Different Resistance Training Load Schemes on Strength and Body Composition in Trained Men.

Lopes CR, Aoki MS, Crisp AH, de Mattos RS, Lins MA, da Mota GR, Schoenfeld BJ, Marchetti PH.

J Hum Kinet. 2017 Aug 1;58:177-186. doi: 10.1515/hukin-2017-0081. eCollection 2017 Sep.


Greater muscle damage in athletes with ACTN3 R577X (RS1815739) gene polymorphism after an ultra-endurance race: a pilot study.

Belli T, Crisp AH, Verlengia R.

Biol Sport. 2017 Jun;34(2):105-110. doi: 10.5114/biolsport.2017.64583. Epub 2017 Jan 1.


Micronutrient supplementation in gastric bypass surgery: prospective study on inflammation and iron metabolism in premenopausal women.

Marin FA, Verlengia R, Crisp AH, Sousa Novais PF, Rasera-Junior I, De Oliveira MRM.

Nutr Hosp. 2017 Mar 30;34(2):369-375. doi: 10.20960/nh.1162.


Culturally Relevant Human Subjects Protection Training: A Case Study in Community-Engaged Research in the United States.

Kue J, Szalacha LA, Happ MB, Crisp AL, Menon U.

J Immigr Minor Health. 2018 Feb;20(1):107-114. doi: 10.1007/s10903-017-0548-x.


Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.

Yi B, Sahn JJ, Ardestani PM, Evans AK, Scott LL, Chan JZ, Iyer S, Crisp A, Zuniga G, Pierce JT, Martin SF, Shamloo M.

J Neurochem. 2017 Feb;140(4):561-575. doi: 10.1111/jnc.13917.


Neuromuscular and Blood Lactate Response After a Motocross Training Session in Amateur Riders.

Simões VR, Crisp AH, Verlengia R, Pellegrinotti IL.

Asian J Sports Med. 2016 Mar 12;7(2):e23805. doi: 10.5812/asjsm.23805. eCollection 2016 Jun.


Gene polymorphisms as a predictor of body weight loss after Roux-en-Y gastric bypass surgery among obese women.

Novais PF, Weber TK, Lemke N, Verlengia R, Crisp AH, Rasera-Junior I, de Oliveira MR.

Obes Res Clin Pract. 2016 Nov - Dec;10(6):724-727. doi: 10.1016/j.orcp.2016.07.002. Epub 2016 Aug 21.


Erratum to "Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency" [Eur J Heart Fail 2016;18:482-489].

Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Floch CL, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F.

Eur J Heart Fail. 2016 Jun;18(6):727. doi: 10.1002/ejhf.591. No abstract available.


A functional difference between native and horizontally acquired genes in bdelloid rotifers.

Barbosa EG, Crisp A, Broadbent SE, Carrillo M, Boschetti C, Tunnacliffe A.

Gene. 2016 Sep 15;590(1):186-91. doi: 10.1016/j.gene.2016.06.019. Epub 2016 Jun 13.


On the limitations of permuted blocked randomization.

Crisp A.

Stat Med. 2016 May 30;35(12):2109-10. doi: 10.1002/sim.6756. No abstract available.


Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency.

Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Le Floch C, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F.

Eur J Heart Fail. 2016 May;18(5):482-9. doi: 10.1002/ejhf.516. Epub 2016 Apr 12. Review. Erratum in: Eur J Heart Fail. 2016 Jun;18(6):727.


Effect of High Intensity Interval and Continuous Swimming Training on Body Mass Adiposity Level and Serum Parameters in High-Fat Diet Fed Rats.

da Rocha GL, Crisp AH, de Oliveira MR, da Silva CA, Silva JO, Duarte AC, Sene-Fiorese M, Verlengia R.

ScientificWorldJournal. 2016;2016:2194120. doi: 10.1155/2016/2194120. Epub 2016 Jan 19.


Horizontal gene transfer in bdelloid rotifers is ancient, ongoing and more frequent in species from desiccating habitats.

Eyres I, Boschetti C, Crisp A, Smith TP, Fontaneto D, Tunnacliffe A, Barraclough TG.

BMC Biol. 2015 Nov 4;13:90. doi: 10.1186/s12915-015-0202-9.


Blinding in pharmaceutical clinical trials: An overview of points to consider.

Crisp A.

Contemp Clin Trials. 2015 Jul;43:155-63. doi: 10.1016/j.cct.2015.06.002. Epub 2015 Jun 2.


Rationale and design of the LosmApimod To Inhibit p38 MAP kinase as a TherapeUtic target and moDify outcomes after an acute coronary syndromE trial.

O'Donoghue ML, Glaser R, Aylward PE, Cavender MA, Crisp A, Fox KA, Laws I, Lopez-Sendon JL, Steg PG, Theroux P, Sabatine MS, Morrow DA.

Am Heart J. 2015 May;169(5):622-630.e6. doi: 10.1016/j.ahj.2015.02.012. Epub 2015 Feb 23.


Multiple horizontally acquired genes from fungal and prokaryotic donors encode cellulolytic enzymes in the bdelloid rotifer Adineta ricciae.

Szydlowski L, Boschetti C, Crisp A, Barbosa EG, Tunnacliffe A.

Gene. 2015 Jul 25;566(2):125-37. doi: 10.1016/j.gene.2015.04.007. Epub 2015 Apr 8.


Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes.

Crisp A, Boschetti C, Perry M, Tunnacliffe A, Micklem G.

Genome Biol. 2015 Mar 13;16:50. doi: 10.1186/s13059-015-0607-3.


Acute effects of movement velocity on blood lactate and growth hormone responses after eccentric bench press exercise in resistance-trained men.

Calixto R, Verlengia R, Crisp A, Carvalho T, Crepaldi M, Pereira A, Yamada A, da Mota G, Lopes C.

Biol Sport. 2014 Dec;31(4):289-94. doi: 10.5604/20831862.1127287. Epub 2014 Oct 16.


Lack of Association Between ACE Indel Polymorphism and Cardiorespiratory Fitness in Physically Active and Sedentary Young Women.

Verlengia R, Rebelo AC, Crisp AH, Kunz VC, Dos Santos Carneiro Cordeiro MA, Hirata MH, Crespo Hirata RD, Silva E.

Asian J Sports Med. 2014 Sep;5(3):e22768. doi: 10.5812/asjsm.22768. Epub 2014 Aug 28.


Muscle damage of resistance-trained men after two bouts of eccentric bench press exercise.

Meneghel AJ, Verlengia R, Crisp AH, Aoki MS, Nosaka K, da Mota GR, Lopes CR.

J Strength Cond Res. 2014 Oct;28(10):2961-6. doi: 10.1519/JSC.0000000000000494.


Declining incidence of osteoporotic hip fracture in Australia.

Crisp A, Dixon T, Jones G, Cumming RG, Laslett LL, Bhatia K, Webster A, Ebeling PR.

Arch Osteoporos. 2012;7:179-85. doi: 10.1007/s11657-012-0095-y. Epub 2012 Aug 29.


Biochemical diversification through foreign gene expression in bdelloid rotifers.

Boschetti C, Carr A, Crisp A, Eyres I, Wang-Koh Y, Lubzens E, Barraclough TG, Micklem G, Tunnacliffe A.

PLoS Genet. 2012;8(11):e1003035. doi: 10.1371/journal.pgen.1003035. Epub 2012 Nov 15.


New explorations into the genetic diversity of breast cancer.

Crisp A.

Pharmacogenomics. 2012 Jul;13(10):1109-10. doi: 10.2217/pgs.12.106. No abstract available.


Oncogenic osteomalacia, raised FGF-23, and renal Fanconi syndrome.

Norden AG, Laing RJ, Rowe P, Unwin RJ, Wrong O, Crisp AJ.

QJM. 2014 Feb;107(2):139-41. doi: 10.1093/qjmed/hcr247. Epub 2011 Dec 16. No abstract available.


Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin.

Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17504-9. doi: 10.1073/pnas.1108673108. Epub 2011 Oct 3.


Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.

Crisp A, Yin H, Goyenvalle A, Betts C, Moulton HM, Seow Y, Babbs A, Merritt T, Saleh AF, Gait MJ, Stuckey DJ, Clarke K, Davies KE, Wood MJ.

Hum Mol Genet. 2011 Feb 1;20(3):413-21. doi: 10.1093/hmg/ddq477. Epub 2010 Nov 9.


The relevance framework for category-based induction: Evidence from garden-path arguments.

Feeney A, Coley JD, Crisp A.

J Exp Psychol Learn Mem Cogn. 2010 Jul;36(4):906-19. doi: 10.1037/a0019762.


Causal conjunction fallacies: the roles of causal strength and mental resources.

Crisp AK, Feeney A.

Q J Exp Psychol (Hove). 2009 Dec;62(12):2320-37. doi: 10.1080/17470210902783638. Epub 2009 Apr 17.


Reduction of four-and-a-half LIM-protein 2 expression occurs in human left ventricular failure and leads to altered localization and reduced activity of metabolic enzymes.

Bovill E, Westaby S, Crisp A, Jacobs S, Shaw T.

J Thorac Cardiovasc Surg. 2009 Apr;137(4):853-61. doi: 10.1016/j.jtcvs.2008.09.006.


Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program.

Bovill E, Westaby S, Reji S, Sayeed R, Crisp A, Shaw T.

J Thorac Cardiovasc Surg. 2008 Sep;136(3):709-16. doi: 10.1016/j.jtcvs.2008.02.020. Epub 2008 Jun 9.

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