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PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.

Madera-Salcedo IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, Rodríguez-Rodríguez N, Trejo-Zambrano MI, García-González HB, Hernández-Molina G, Mutchinick OM, Alcocer-Varela J, Rosetti F, Crispín JC.

JCI Insight. 2019 Jul 23;5. pii: 126457. doi: 10.1172/jci.insight.126457.


The helminth-derived peptide GK-1 induces an anti-tumoral CD8 T cell response associated with downregulation of the PD-1/PD-L1 pathway.

Rodríguez-Rodríguez N, Madera-Salcedo IK, Bugarin-Estrada E, Sánchez-Miranda E, Torres-García D, Cervantes-Torres J, Fragoso G, Rosetti F, Crispín JC, Sciutto E.

Clin Immunol. 2019 Jul 9. pii: S1521-6616(19)30163-9. doi: 10.1016/j.clim.2019.07.006. [Epub ahead of print]


Gene-function studies in systemic lupus erythematosus.

Rosetti F, de la Cruz A, Crispín JC.

Curr Opin Rheumatol. 2019 Mar;31(2):185-192. doi: 10.1097/BOR.0000000000000572.


Gene-function studies in SLE.

Rosetti F, de la Cruz A, Crispín JC.

Curr Opin Rheumatol. 2018 Dec 11. doi: 10.1097/BOR.0000000000000572. [Epub ahead of print]


Intrathecal formation of anticardiolipin antibodies in a patient with SLE-related relapsing longitudinal myelitis: a possible pathogenic connection.

Aguirre-Villarreal D, Whittall LP, Fragoso-Loyo H, Cantú-Brito C, Crispín JC, Valdés-Ferrer SI.

Lupus. 2018 Dec;27(14):2292-2295. doi: 10.1177/0961203318810430. Epub 2018 Nov 4.


Mechanisms of Tissue Injury in Lupus Nephritis.

Flores-Mendoza G, Sansón SP, Rodríguez-Castro S, Crispín JC, Rosetti F.

Trends Mol Med. 2018 Apr;24(4):364-378. doi: 10.1016/j.molmed.2018.02.003. Epub 2018 Mar 8. Review.


SLE-Associated Defects Promote Altered T Cell Function.

Crispin JC, Hedrich CM, Suárez-Fueyo A, Comte D, Tsokos GC.

Crit Rev Immunol. 2017;37(1):39-58. doi: 10.1615/CritRevImmunol.2018025213. Review.


Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients.

Arrieta O, Montes-Servín E, Hernandez-Martinez JM, Cardona AF, Casas-Ruiz E, Crispín JC, Motola D, Flores-Estrada D, Barrera L.

Oncotarget. 2017 Oct 24;8(60):101994-102005. doi: 10.18632/oncotarget.22025. eCollection 2017 Nov 24.


Intrathecal anti-suprabasin antibodies in SLE, a cause of local concern?

Rosetti F, Crispín JC.

Clin Immunol. 2018 Aug;193:131-132. doi: 10.1016/j.clim.2017.11.013. Epub 2017 Nov 29. No abstract available.


Add-on Pyridostigmine Enhances CD4+ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study.

Valdés-Ferrer SI, Crispín JC, Belaunzarán-Zamudio PF, Rodríguez-Osorio CA, Cacho-Díaz B, Alcocer-Varela J, Cantú-Brito C, Sierra-Madero J.

Front Immunol. 2017 Oct 18;8:1301. doi: 10.3389/fimmu.2017.01301. eCollection 2017.


CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients.

Barrera L, Montes-Servín E, Hernandez-Martinez JM, García-Vicente MLÁ, Montes-Servín E, Herrera-Martínez M, Crispín JC, Borbolla-Escoboza JR, Arrieta O.

Br J Cancer. 2017 Jul 25;117(3):385-397. doi: 10.1038/bjc.2017.173. Epub 2017 Jun 20.


ICER is requisite for Th17 differentiation.

Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, Crispín JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC.

Nat Commun. 2016 Sep 29;7:12993. doi: 10.1038/ncomms12993.


Pro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells.

Rodríguez-Rodríguez N, Apostolidis SA, Fitzgerald L, Meehan BS, Corbett AJ, Martín-Villa JM, McCluskey J, Tsokos GC, Crispín JC.

Eur J Immunol. 2016 Jun;46(6):1383-91. doi: 10.1002/eji.201546056. Epub 2016 Apr 26.


Phosphatase PP2A is requisite for the function of regulatory T cells.

Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC.

Nat Immunol. 2016 May;17(5):556-64. doi: 10.1038/ni.3390. Epub 2016 Mar 14.


Complement receptor of the immunoglobulin superfamily reduces murine lupus nephritis and cutaneous disease.

Lieberman LA, Mizui M, Nalbandian A, Bossé R, Crispín JC, Tsokos GC.

Clin Immunol. 2015 Oct;160(2):286-91. doi: 10.1016/j.clim.2015.05.006. Epub 2015 May 16.


Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells.

Rodríguez-Rodríguez N, Apostolidis SA, Penaloza-MacMaster P, Martín Villa JM, Barouch DH, Tsokos GC, Crispín JC.

J Immunol. 2015 May 1;194(9):4207-14. doi: 10.4049/jimmunol.1402775. Epub 2015 Mar 30.


Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling.

Hedrich CM, Rauen T, Apostolidis SA, Grammatikos AP, Rodriguez Rodriguez N, Ioannidis C, Kyttaris VC, Crispin JC, Tsokos GC.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13457-62. doi: 10.1073/pnas.1408023111. Epub 2014 Sep 3.


KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.

Koga T, Mizui M, Yoshida N, Otomo K, Lieberman LA, Crispín JC, Tsokos GC.

Autoimmunity. 2014 Nov;47(7):445-50. doi: 10.3109/08916934.2014.915954. Epub 2014 May 15.


Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells.

Hedrich CM, Crispin JC, Tsokos GC.

Autoimmunity. 2014 Jun;47(4):234-41. doi: 10.3109/08916934.2013.801462. Epub 2014 Apr 24. Review.


CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.

Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC.

J Clin Invest. 2014 May;124(5):2234-45. doi: 10.1172/JCI73411. Epub 2014 Mar 25.


cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.

Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC.

J Biol Chem. 2014 Jan 24;289(4):2361-70. doi: 10.1074/jbc.M113.523605. Epub 2013 Dec 2.


cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.

Hedrich CM, Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M, Kyttaris VC, Tsokos GC.

J Biol Chem. 2013 Nov 1;288(44):31880-7. doi: 10.1074/jbc.M113.508655. Epub 2013 Sep 18.


Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.

Apostolidis SA, Rauen T, Hedrich CM, Tsokos GC, Crispín JC.

J Biol Chem. 2013 Sep 13;288(37):26775-84. doi: 10.1074/jbc.M113.483743. Epub 2013 Aug 5.


Gene-function studies in systemic lupus erythematosus.

Crispín JC, Hedrich CM, Tsokos GC.

Nat Rev Rheumatol. 2013 Aug;9(8):476-84. doi: 10.1038/nrrheum.2013.78. Epub 2013 Jun 4. Review.


Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.

Ichinose K, Zhang Z, Koga T, Juang YT, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, Tsokos GC.

Arthritis Rheum. 2013 Mar;65(3):764-9. doi: 10.1002/art.37790.


A TWEAK in lupus nephritis.

Crispín JC.

Clin Immunol. 2012 Nov;145(2):139-40. doi: 10.1016/j.clim.2012.09.002. Epub 2012 Sep 13. No abstract available.


cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.

Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16606-11. doi: 10.1073/pnas.1210129109. Epub 2012 Sep 26.


De Novo Donor-Specific HLA Antibody Development and Peripheral CD4(+)CD25(high) Cells in Kidney Transplant Recipients: A Place for Interaction?

Alberu J, Vargas-Rojas MI, Morales-Buenrostro LE, Crispin JC, Rodríguez-Romo R, Uribe-Uribe NO, Carrasco G, Gómez-Martín D, Alcocer-Varela J.

J Transplant. 2012;2012:302539. doi: 10.1155/2012/302539. Epub 2012 Aug 23.


Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.

Koga T, Ichinose K, Mizui M, Crispín JC, Tsokos GC.

J Immunol. 2012 Oct 1;189(7):3490-6. Epub 2012 Aug 31.


Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism.

Crispín JC, Apostolidis SA, Rosetti F, Keszei M, Wang N, Terhorst C, Mayadas TN, Tsokos GC.

J Immunol. 2012 Apr 15;188(8):3567-71. doi: 10.4049/jimmunol.1200143. Epub 2012 Mar 14.


CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.

Lippe R, Ohl K, Varga G, Rauen T, Crispin JC, Juang YT, Kuerten S, Tacke F, Wolf M, Roebrock K, Vogl T, Verjans E, Honke N, Ehrchen J, Foell D, Skryabin B, Wagner N, Tsokos GC, Roth J, Tenbrock K.

J Mol Cell Biol. 2012 Apr;4(2):121-3. doi: 10.1093/jmcb/mjs004. Epub 2012 Feb 20. No abstract available.


Phenotype and function of dendritic cells of patients with systemic lupus erythematosus.

Crispín JC, Vargas-Rojas MI, Monsiváis-Urenda A, Alcocer-Varela J.

Clin Immunol. 2012 Apr;143(1):45-50. doi: 10.1016/j.clim.2011.12.004. Epub 2011 Dec 22.


Human neurocysticercosis: in vivo expansion of peripheral regulatory T cells and their recruitment in the central nervous system.

Adalid-Peralta L, Fleury A, García-Ibarra TM, Hernández M, Parkhouse M, Crispín JC, Voltaire-Proaño J, Cárdenas G, Fragoso G, Sciutto E.

J Parasitol. 2012 Feb;98(1):142-8. doi: 10.1645/GE-2839.1. Epub 2011 Sep 28.


The dysregulation of cytokine networks in systemic lupus erythematosus.

Apostolidis SA, Lieberman LA, Kis-Toth K, Crispín JC, Tsokos GC.

J Interferon Cytokine Res. 2011 Oct;31(10):769-79. doi: 10.1089/jir.2011.0029. Epub 2011 Aug 30. Review.


Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus.

Crispín JC, Apostolidis SA, Finnell MI, Tsokos GC.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12443-8. doi: 10.1073/pnas.1103915108. Epub 2011 Jul 11.


Neurocysticercosis: local and systemic immune-inflammatory features related to severity.

Sáenz B, Fleury A, Chavarría A, Hernández M, Crispin JC, Vargas-Rojas MI, Fragoso G, Sciutto E.

Med Microbiol Immunol. 2012 Feb;201(1):73-80. doi: 10.1007/s00430-011-0207-0. Epub 2011 Jun 23.


Regulatory T cells as modulators of B cell antibody production.

Crispín JC.

Clin Immunol. 2011 Sep;140(3):216-7. doi: 10.1016/j.clim.2011.05.006. Epub 2011 May 24. No abstract available.


IL-17-producing T cells in lupus nephritis.

Apostolidis SA, Crispín JC, Tsokos GC.

Lupus. 2011 Feb;20(2):120-4. doi: 10.1177/0961203310389100. Review.


Quantitative and functional profiles of CD4+ lymphocyte subsets in systemic lupus erythematosus patients with lymphopenia.

Gómez-Martín D, Díaz-Zamudio M, Vanoye G, Crispín JC, Alcocer-Varela J.

Clin Exp Immunol. 2011 Apr;164(1):17-25. doi: 10.1111/j.1365-2249.2010.04309.x. Epub 2011 Jan 14.


Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV.

Ichinose K, Juang YT, Crispín JC, Kis-Toth K, Tsokos GC.

Arthritis Rheum. 2011 Feb;63(2):523-9. doi: 10.1002/art.30085.


Interleukin-17-producing T cells in lupus.

Crispín JC, Tsokos GC.

Curr Opin Rheumatol. 2010 Sep;22(5):499-503. doi: 10.1097/BOR.0b013e32833c62b0. Review.


T cells as therapeutic targets in SLE.

Crispín JC, Kyttaris VC, Terhorst C, Tsokos GC.

Nat Rev Rheumatol. 2010 Jun;6(6):317-25. doi: 10.1038/nrrheum.2010.60. Epub 2010 May 11. Review.


IL-17 in systemic lupus erythematosus.

Crispín JC, Tsokos GC.

J Biomed Biotechnol. 2010;2010:943254. doi: 10.1155/2010/943254. Epub 2010 Apr 6. Review.


Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity.

Crispín JC, Keenan BT, Finnell MD, Bermas BL, Schur P, Massarotti E, Karlson EW, Fitzgerald LM, Ergin S, Kyttaris VC, Tsokos GC, Costenbader KH.

Arthritis Rheum. 2010 May;62(5):1431-7. doi: 10.1002/art.27385.


Pathogenesis of human systemic lupus erythematosus: recent advances.

Crispín JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC.

Trends Mol Med. 2010 Feb;16(2):47-57. doi: 10.1016/j.molmed.2009.12.005. Epub 2010 Feb 4. Review.


Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype.

Crispín JC, Tsokos GC.

J Immunol. 2009 Oct 1;183(7):4675-81. doi: 10.4049/jimmunol.0901533. Epub 2009 Sep 4.


A novel inhibitor of the alternative pathway of complement attenuates intestinal ischemia/reperfusion-induced injury.

Chen J, Crispín JC, Dalle Lucca J, Tsokos GC.

J Surg Res. 2011 May 15;167(2):e131-6. doi: 10.1016/j.jss.2009.05.041. Epub 2009 Jun 25.


Acetylcholine-esterase inhibitor pyridostigmine decreases T cell overactivation in patients infected by HIV.

Valdés-Ferrer SI, Crispín JC, Belaunzarán PF, Cantú-Brito CG, Sierra-Madero J, Alcocer-Varela J.

AIDS Res Hum Retroviruses. 2009 Aug;25(8):749-55. doi: 10.1089/aid.2008.0257.


Interleukin-17 and systemic lupus erythematosus: current concepts.

Nalbandian A, Crispín JC, Tsokos GC.

Clin Exp Immunol. 2009 Aug;157(2):209-15. doi: 10.1111/j.1365-2249.2009.03944.x. Review.


B cells contribute to ischemia/reperfusion-mediated tissue injury.

Chen J, Crispín JC, Tedder TF, Dalle Lucca J, Tsokos GC.

J Autoimmun. 2009 May-Jun;32(3-4):195-200. doi: 10.1016/j.jaut.2009.02.021. Epub 2009 Apr 1.

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