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Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry.

Canonica GW, Colombo GL, Bruno GM, Di Matteo S, Martinotti C, Blasi F, Bucca C, Crimi N, Paggiaro P, Pelaia G, Passalaqua G, Senna G, Heffler E; SANI Network.

World Allergy Organ J. 2019 Jan 26;12(1):100007. doi: 10.1016/j.waojou.2018.12.001. eCollection 2019.


Vitamin D and disease severity in bronchiectasis.

Ferri S, Crimi C, Heffler E, Campisi R, Noto A, Crimi N.

Respir Med. 2019 Mar;148:1-5. doi: 10.1016/j.rmed.2019.01.009. Epub 2019 Jan 24.


Early management of COPD: where are we now and where do we go from here? A Delphi consensus project.

Di Marco F, Balbo P, de Blasio F, Cardaci V, Crimi N, Girbino G, Pelaia G, Pirina P, Roversi P, Santus P, Scichilone N, Vatrella A, Pasqualetti P, Carone M.

Int J Chron Obstruct Pulmon Dis. 2019 Feb 4;14:353-360. doi: 10.2147/COPD.S176662. eCollection 2019.


Bronchiectasis and asthma: a dangerous liaison?

Crimi C, Ferri S, Crimi N.

Curr Opin Allergy Clin Immunol. 2019 Feb;19(1):46-52. doi: 10.1097/ACI.0000000000000492.


Predictors of response to omalizumab and relapse in chronic spontaneous urticaria: a study of 470 patients.

Marzano AV, Genovese G, Casazza G, Fierro MT, Dapavo P, Crimi N, Ferrucci S, Pepe P, Liberati S, Pigatto PD, Offidani A, Martina E, Girolomoni G, Rovaris M, Foti C, Stingeni L, Cristaudo A, Canonica GW, Nettis E, Asero R.

J Eur Acad Dermatol Venereol. 2019 May;33(5):918-924. doi: 10.1111/jdv.15350. Epub 2018 Dec 7.


Mediterranean Diet and Particulate Matter Exposure Are Associated With LINE-1 Methylation: Results From a Cross-Sectional Study in Women.

Barchitta M, Maugeri A, Quattrocchi A, Barone G, Mazzoleni P, Catalfo A, De Guidi G, Iemmolo MG, Crimi N, Agodi A.

Front Genet. 2018 Oct 30;9:514. doi: 10.3389/fgene.2018.00514. eCollection 2018.


Utility of ultrasound assessment of diaphragmatic function before and after pulmonary rehabilitation in COPD patients.

Crimi C, Heffler E, Augelletti T, Campisi R, Noto A, Vancheri C, Crimi N.

Int J Chron Obstruct Pulmon Dis. 2018 Oct 8;13:3131-3139. doi: 10.2147/COPD.S171134. eCollection 2018.


Misdiagnosis of asthma and COPD and underuse of spirometry in primary care unselected patients.

Heffler E, Crimi C, Mancuso S, Campisi R, Puggioni F, Brussino L, Crimi N.

Respir Med. 2018 Sep;142:48-52. doi: 10.1016/j.rmed.2018.07.015. Epub 2018 Jul 24.


The accuracy of the HemoCue WBC DIFF in assessing blood eosinophils depends on the clinical setting and medical condition.

Heffler E, Crimi C, Crimi N.

Acta Paediatr. 2017 Oct;106(10):1706. doi: 10.1111/apa.13979. Epub 2017 Jul 26. No abstract available.


Point-of-care blood eosinophil count in a severe asthma clinic setting.

Heffler E, Terranova G, Chessari C, Frazzetto V, Crimi C, Fichera S, Picardi G, Nicolosi G, Porto M, Intravaia R, Crimi N.

Ann Allergy Asthma Immunol. 2017 Jul;119(1):16-20. doi: 10.1016/j.anai.2017.05.016.


Integrated approach of nutritional and molecular epidemiology, mineralogical and chemical pollutant characterisation: the protocol of a cross-sectional study in women.

Barchitta M, Quattrocchi A, Maugeri A, Barone G, Mazzoleni P, Catalfo A, De Guidi G, Iemmolo M, Crimi N, Agodi A.

BMJ Open. 2017 Apr 4;7(4):e014756. doi: 10.1136/bmjopen-2016-014756.


Anaphylaxis due to progesterone hypersensitivity successfully treated with omalizumab.

Heffler E, Fichera S, Nicolosi G, Crimi N.

J Allergy Clin Immunol Pract. 2017 May - Jun;5(3):852-854. doi: 10.1016/j.jaip.2017.01.003. Epub 2017 Mar 1. No abstract available.


Exhaled breath condensate pH and cysteinyl leukotriens in patients with chronic cough secondary to acid gastroesophageal reflux.

Heffler E, Crimi C, Brussino L, Nicola S, Sichili S, Dughera L, Rolla G, Crimi N.

J Breath Res. 2016 Dec 22;11(1):016002. doi: 10.1088/1752-7163/11/1/016002.


Higher serum levels of periostin and the risk of exacerbations in moderate asthmatics.

Scichilone N, Crimi C, Benfante A, Battaglia S, Iemmolo M, Spatafora M, Crimi N.

Asthma Res Pract. 2016 Jan 4;2:1. doi: 10.1186/s40733-015-0019-x. eCollection 2016.


Omalizumab for the treatment of chronic spontaneous urticaria in clinical practice.

Bongiorno MR, Crimi N, Corrao S, Allotta A, Arena A, Brusca I, Heffler E, Malara G, Milioto M, Pistone G, Porto M, Raia E, Valenti G.

Ann Allergy Asthma Immunol. 2016 Dec;117(6):703-707. doi: 10.1016/j.anai.2016.08.006. Epub 2016 Oct 6. Review. No abstract available.


The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma.

Scichilone N, Caponetto C, Fagone E, Benfante A, Paternò A, Heffler E, Crimi N, Vancheri C.

J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1251-1252. doi: 10.1016/j.jaip.2016.06.014. Epub 2016 Jul 13. No abstract available.


Asthma control and bronchodilator response.

Heffler E, Crimi N.

Respir Med. 2016 Jul;116:109. doi: 10.1016/j.rmed.2016.05.013. Epub 2016 May 15. No abstract available.


The management of asthma in the phenotype and biomarker era: The proposal of a new diagnostic-therapeutic model.

Blasi F, Bettoncelli G, Canonica GW, Centanni S, Crimi N, DiMaria G, Gasparini S, Gentili G, Girbino G, Mereu C, Minghetti P, Nardini S, Paggiaro P, Papi A, Pistolesi M, Rossi A.

J Asthma. 2016 Sep;53(7):665-7. doi: 10.3109/02770903.2016.1140774. Epub 2016 Apr 6.


Depression, body mass index, and chronic obstructive pulmonary disease - a holistic approach.

Catalfo G, Crea L, Lo Castro T, Magnano San Lio F, Minutolo G, Siscaro G, Vaccino N, Crimi N, Aguglia E.

Int J Chron Obstruct Pulmon Dis. 2016 Feb 4;11:239-49. doi: 10.2147/COPD.S84347. eCollection 2016.


Bronchodilator response as a marker of poor asthma control.

Heffler E, Crimi C, Campisi R, Sichili S, Nicolosi G, Porto M, Intravaia R, Sberna ME, Liuzzo MT, Crimi N.

Respir Med. 2016 Mar;112:45-50. doi: 10.1016/j.rmed.2016.01.012. Epub 2016 Jan 22.


High prevalence of Anisakis simplex hypersensitivity and allergy in Sicily, Italy.

Heffler E, Sberna ME, Sichili S, Intravaia R, Nicolosi G, Porto M, Liuzzo MT, Picardi G, Fichera S, Crimi N.

Ann Allergy Asthma Immunol. 2016 Feb;116(2):146-50. doi: 10.1016/j.anai.2015.12.014.


Omalizumab Treatment of Vernal Keratoconjunctivitis.

Heffler E, Picardi G, Liuzzo MT, Pistorio MP, Crimi N.

JAMA Ophthalmol. 2016 Apr;134(4):461-3. doi: 10.1001/jamaophthalmol.2015.5679. No abstract available.


A Bloody Mess: An Unusual Case of Diffuse Alveolar Hemorrhage Because of Warfarin Overdose.

Heffler E, Campisi R, Ferri S, Crimi N.

Am J Ther. 2016 Sep-Oct;23(5):e1280-3. doi: 10.1097/MJT.0000000000000397.


Choosing wisely in Allergology: a Slow Medicine approach to the discipline promoted by the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC).

Heffler E, Landi M, Quadrino S, Incorvaia C, Pizzimenti S, Vernero S, Crimi N, Rolla G, Canonica GW.

Clin Mol Allergy. 2015 Nov 20;13:28. doi: 10.1186/s12948-015-0034-8. eCollection 2015.


In vitro antiproliferative effect of trastuzumab (Herceptin(®)) combined with cetuximab (Erbitux(®)) in a model of human non-small cell lung cancer expressing EGFR and HER2.

Privitera G, Luca T, Musso N, Vancheri C, Crimi N, Barresi V, Condorelli D, Castorina S.

Clin Exp Med. 2016 May;16(2):161-8. doi: 10.1007/s10238-015-0343-8. Epub 2015 Feb 26.


PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition.

Conte E, Gili E, Fruciano M, Korfei M, Fagone E, Iemmolo M, Lo Furno D, Giuffrida R, Crimi N, Guenther A, Vancheri C.

Lab Invest. 2013 May;93(5):566-76. doi: 10.1038/labinvest.2013.6. Epub 2013 Feb 25.


Thymosin β4 protects C57BL/6 mice from bleomycin-induced damage in the lung.

Conte E, Genovese T, Gili E, Esposito E, Iemmolo M, Fruciano M, Fagone E, Pistorio MP, Crimi N, Cuzzocrea S, Vancheri C.

Eur J Clin Invest. 2013 Mar;43(3):309-15. doi: 10.1111/eci.12048. Epub 2013 Jan 16.


Protective effects of thymosin β4 in a mouse model of lung fibrosis.

Conte E, Genovese T, Gili E, Esposito E, Iemmolo M, Fruciano M, Fagone E, Pistorio MP, Crimi N, Cuzzocrea S, Vancheri C.

Ann N Y Acad Sci. 2012 Oct;1269:69-73. doi: 10.1111/j.1749-6632.2012.06694.x.


Step-down from high dose fixed combination therapy in asthma patients: a randomized controlled trial.

Papi A, Nicolini G, Crimi N, Fabbri L, Olivieri D, Rossi A, Paggiaro P.

Respir Res. 2012 Jun 25;13:54. doi: 10.1186/1465-9921-13-54.


Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms.

Conte E, Fruciano M, Fagone E, Gili E, Caraci F, Iemmolo M, Crimi N, Vancheri C.

PLoS One. 2011;6(10):e24663. doi: 10.1371/journal.pone.0024663. Epub 2011 Oct 3.


Resveratrol inhibits transforming growth factor-β-induced proliferation and differentiation of ex vivo human lung fibroblasts into myofibroblasts through ERK/Akt inhibition and PTEN restoration.

Fagone E, Conte E, Gili E, Fruciano M, Pistorio MP, Lo Furno D, Giuffrida R, Crimi N, Vancheri C.

Exp Lung Res. 2011 Apr;37(3):162-74. doi: 10.3109/01902148.2010.524722. Epub 2011 Jan 26.


Acute additive effect of montelukast and beclomethasone on AMP induced bronchoconstriction.

Mastruzzo C, Contrafatto MR, Crimi C, Palermo F, Vancheri C, Crimi N.

Respir Med. 2010 Oct;104(10):1417-24. doi: 10.1016/j.rmed.2010.04.014. Epub 2010 May 14.


Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology.

Vancheri C, Failla M, Crimi N, Raghu G.

Eur Respir J. 2010 Mar;35(3):496-504. doi: 10.1183/09031936.00077309.


16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis.

Failla M, Genovese T, Mazzon E, Fruciano M, Fagone E, Gili E, Barera A, La Rosa C, Conte E, Crimi N, Cuzzocrea S, Vancheri C.

Am J Respir Cell Mol Biol. 2009 Jul;41(1):50-8. doi: 10.1165/rcmb.2007-0438OC. Epub 2008 Dec 4.


Subsegmental pulmonary embolism: value of thoracic ultrasound for diagnosis and follow-up.

Mastruzzo C, Perracchio G, Poidomani G, Romano M, Crimi N, Vancheri C.

Intern Med. 2008;47(15):1415-7. Epub 2008 Aug 1.


TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.

Caraci F, Gili E, Calafiore M, Failla M, La Rosa C, Crimi N, Sortino MA, Nicoletti F, Copani A, Vancheri C.

Pharmacol Res. 2008 Apr;57(4):274-82. doi: 10.1016/j.phrs.2008.02.001. Epub 2008 Feb 9.


A case of pulmonary Langerhans cell histiocytosis in a young woman with coeliac disease.

Mastruzzo C, Vancheri C, Li Mura D, Poletti V, Failla M, Crimi N.

Swiss Med Wkly. 2007 Jun 2;137(21-22):326-7.


Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma.

Papi A, Canonica GW, Maestrelli P, Paggiaro P, Olivieri D, Pozzi E, Crimi N, Vignola AM, Morelli P, Nicolini G, Fabbri LM; BEST Study Group.

N Engl J Med. 2007 May 17;356(20):2040-52.


Protective effect of orally administered carnosine on bleomycin-induced lung injury.

Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C.

Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1095-104. Epub 2007 Jan 12.


Exhaled bronchial cysteinyl leukotrienes in allergic patients.

Failla M, Crimi N, Vancheri C.

Curr Opin Allergy Clin Immunol. 2007 Feb;7(1):25-31. Review.


Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy: the Sublingual Immunotherapy Pollen Allergy Italy (SPAI) study.

Berto P, Passalacqua G, Crimi N, Frati F, Ortolani C, Senna G, Canonica GW; Italian SPAI Study Group.

Ann Allergy Asthma Immunol. 2006 Nov;97(5):615-21.


Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.

Failla M, Genovese T, Mazzon E, Gili E, Muià C, Sortino M, Crimi N, Caputi AP, Cuzzocrea S, Vancheri C.

Respir Res. 2006 Nov 21;7:137.


Effects of TGF-beta and glucocorticoids on map kinase phosphorylation, IL-6/IL-11 secretion and cell proliferation in primary cultures of human lung fibroblasts.

Pelaia G, Gallelli L, D'Agostino B, Vatrella A, Cuda G, Fratto D, Renda T, Galderisi U, Piegari E, Crimi N, Rossi F, Caputi M, Costanzo FS, Vancheri C, Maselli R, Marsico SA.

J Cell Physiol. 2007 Feb;210(2):489-97.


Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis.

Trovato-Salinaro A, Trovato-Salinaro E, Failla M, Mastruzzo C, Tomaselli V, Gili E, Crimi N, Condorelli DF, Vancheri C.

Respir Res. 2006 Sep 27;7:122.


Intranasal steroid reduces exhaled bronchial cysteinyl leukotrienes in allergic patients.

Failla M, Biondi G, Provvidenza Pistorio M, Gili E, Mastruzzo C, Vancheri C, Crimi N.

Clin Exp Allergy. 2006 Mar;36(3):325-30.


Cellular and molecular effects of protons: apoptosis induction and potential implications for cancer therapy.

Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M.

Apoptosis. 2006 Jan;11(1):57-66.


Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor.

Vancheri C, Gili E, Failla M, Mastruzzo C, Salinaro ET, Lofurno D, Pistorio MP, La Rosa C, Caruso M, Crimi N.

J Allergy Clin Immunol. 2005 Dec;116(6):1242-8. Epub 2005 Nov 8.


Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma.

Prosperini G, Arcidiacono G, Ciamarra I, Crimi N, Polosa R.

Respir Med. 2006 Jun;100(6):1006-12. Epub 2005 Nov 15.


The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils.

Vancheri C, Mastruzzo C, Tomaselli V, Bellistrì G, Pistorio MP, Greco LR, Salinaro ET, Failla M, Contrafatto MR, Crimi N.

Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.


Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells.

Vancheri C, Mastruzzo C, Trovato-Salinaro E, Gili E, Lo Furno D, Pistorio MP, Caruso M, La Rosa C, Crimi C, Failla M, Crimi N.

Respir Res. 2005 Sep 13;6:103.

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