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Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP2) Affinity and Signaling Sensitivities in Smooth Muscle Cells.

Brueggemann LI, Cribbs LL, Byron KL.

Mol Pharmacol. 2020 Mar;97(3):145-158. doi: 10.1124/mol.119.117192. Epub 2019 Dec 23.


Mechanisms of PKA-Dependent Potentiation of Kv7.5 Channel Activity in Human Airway Smooth Muscle Cells.

Brueggemann LI, Cribbs LL, Schwartz J, Wang M, Kouta A, Byron KL.

Int J Mol Sci. 2018 Jul 30;19(8). pii: E2223. doi: 10.3390/ijms19082223.


PKC-dependent regulation of Kv7.5 channels by the bronchoconstrictor histamine in human airway smooth muscle cells.

Haick JM, Brueggemann LI, Cribbs LL, Denning MF, Schwartz J, Byron KL.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L822-L834. doi: 10.1152/ajplung.00567.2016. Epub 2017 Mar 10.


Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents.

Mani BK, Robakowski C, Brueggemann LI, Cribbs LL, Tripathi A, Majetschak M, Byron KL.

Mol Pharmacol. 2016 Mar;89(3):323-34. doi: 10.1124/mol.115.101758. Epub 2015 Dec 23.


Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.

Brueggemann LI, Haick JM, Cribbs LL, Byron KL.

Mol Pharmacol. 2014 Sep;86(3):330-41. doi: 10.1124/mol.114.093799. Epub 2014 Jun 18.


KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.

Brueggemann LI, Haick JM, Neuburg S, Tate S, Randhawa D, Cribbs LL, Byron KL.

Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L476-86. doi: 10.1152/ajplung.00253.2013. Epub 2014 Jan 17.


Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.

Brueggemann LI, Mackie AR, Cribbs LL, Freda J, Tripathi A, Majetschak M, Byron KL.

J Biol Chem. 2014 Jan 24;289(4):2099-111. doi: 10.1074/jbc.M113.527820. Epub 2013 Dec 2.


Elimination of the actin-binding domain in kelch-like 1 protein induces T-type calcium channel modulation only in the presence of action potential waveforms.

Aromolaran KA, Benzow KA, Cribbs LL, Koob MD, Piedras-Rentería ES.

J Signal Transduct. 2012;2012:505346. doi: 10.1155/2012/505346. Epub 2012 Jul 11.


Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy.

Brueggemann LI, Kakad PP, Love RB, Solway J, Dowell ML, Cribbs LL, Byron KL.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L120-32. doi: 10.1152/ajplung.00194.2011. Epub 2011 Sep 30.


Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.

Hansen PB, Poulsen CB, Walter S, Marcussen N, Cribbs LL, Skøtt O, Jensen BL.

Hypertension. 2011 Sep;58(3):464-70. doi: 10.1161/HYPERTENSIONAHA.111.170845. Epub 2011 Jul 25.


Activation of vascular KCNQ (Kv7) potassium channels reverses spasmogen-induced constrictor responses in rat basilar artery.

Mani BK, Brueggemann LI, Cribbs LL, Byron KL.

Br J Pharmacol. 2011 Sep;164(2):237-49. doi: 10.1111/j.1476-5381.2011.01273.x.


Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells.

Pluteanu F, Cribbs LL.

Am J Physiol Cell Physiol. 2011 Mar;300(3):C517-25. doi: 10.1152/ajpcell.00107.2010. Epub 2010 Dec 9.


Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.

Markandeya YS, Fahey JM, Pluteanu F, Cribbs LL, Balijepalli RC.

J Biol Chem. 2011 Jan 28;286(4):2433-44. doi: 10.1074/jbc.M110.182550. Epub 2010 Nov 17.


T-type voltage-gated calcium channels regulate the tone of mouse efferent arterioles.

Poulsen CB, Al-Mashhadi RH, Cribbs LL, Skøtt O, Hansen PB.

Kidney Int. 2011 Feb;79(4):443-51. doi: 10.1038/ki.2010.429. Epub 2010 Nov 10.


Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits.

Brueggemann LI, Mackie AR, Martin JL, Cribbs LL, Byron KL.

Mol Pharmacol. 2011 Jan;79(1):10-23. doi: 10.1124/mol.110.067496. Epub 2010 Sep 28.


T-type current modulation by the actin-binding protein Kelch-like 1.

Aromolaran KA, Benzow KA, Cribbs LL, Koob MD, Piedras-Rentería ES.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1353-62. doi: 10.1152/ajpcell.00235.2009. Epub 2010 Feb 10.


Kelch-like 1 protein upregulates T-type currents by an actin-F dependent increase in α(1H) channels via the recycling endosome.

Aromolaran KA, Benzow KA, Cribbs LL, Koob MD, Piedras-Rentería ES.

Channels (Austin). 2009 Nov;3(6):402-12. Epub 2009 Nov 19.


T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes.

Pluteanu F, Cribbs LL.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1304-13. doi: 10.1152/ajpheart.00528.2009. Epub 2009 Aug 7.


Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles.

Brueggemann LI, Mackie AR, Mani BK, Cribbs LL, Byron KL.

Mol Pharmacol. 2009 Nov;76(5):1053-61. doi: 10.1124/mol.109.057844. Epub 2009 Jul 15.


Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells.

Mani BK, Brueggemann LI, Cribbs LL, Byron KL.

Cell Calcium. 2009 Apr;45(4):400-11. doi: 10.1016/j.ceca.2009.01.004. Epub 2009 Feb 25.


Non-L-type voltage-dependent calcium channels control vascular tone of the rat basilar artery.

Navarro-Gonzalez MF, Grayson TH, Meaney KR, Cribbs LL, Hill CE.

Clin Exp Pharmacol Physiol. 2009 Jan;36(1):55-66. doi: 10.1111/j.1440-1681.2008.05035.x. Epub 2008 Aug 26.


Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.

Mackie AR, Brueggemann LI, Henderson KK, Shiels AJ, Cribbs LL, Scrogin KE, Byron KL.

J Pharmacol Exp Ther. 2008 May;325(2):475-83. doi: 10.1124/jpet.107.135764. Epub 2008 Feb 13.


Protein kinase Cepsilon-dependent MARCKS phosphorylation in neonatal and adult rat ventricular myocytes.

Heidkamp MC, Iyengar R, Szotek EL, Cribbs LL, Samarel AM.

J Mol Cell Cardiol. 2007 Feb;42(2):422-31. Epub 2006 Dec 8.


Vasopressin stimulates action potential firing by protein kinase C-dependent inhibition of KCNQ5 in A7r5 rat aortic smooth muscle cells.

Brueggemann LI, Moran CJ, Barakat JA, Yeh JZ, Cribbs LL, Byron KL.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1352-63. Epub 2006 Oct 27.


T-type Ca2+ channels in vascular smooth muscle: multiple functions.

Cribbs LL.

Cell Calcium. 2006 Aug;40(2):221-30. Epub 2006 Jun 23. Review.


Pharmacological and electrophysiological characterization of store-operated currents and capacitative Ca(2+) entry in vascular smooth muscle cells.

Brueggemann LI, Markun DR, Henderson KK, Cribbs LL, Byron KL.

J Pharmacol Exp Ther. 2006 May;317(2):488-99. Epub 2006 Jan 13.


Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells.

Panner A, Cribbs LL, Zainelli GM, Origitano TC, Singh S, Wurster RD.

Cell Calcium. 2005 Feb;37(2):105-19.


Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking.

Brueggemann LI, Martin BL, Barakat J, Byron KL, Cribbs LL.

Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H923-35. Epub 2004 Oct 21.


Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels.

Chen CC, Lamping KG, Nuno DW, Barresi R, Prouty SJ, Lavoie JL, Cribbs LL, England SK, Sigmund CD, Weiss RM, Williamson RA, Hill JA, Campbell KP.

Science. 2003 Nov 21;302(5649):1416-8.


Single-channel pharmacology of mibefradil in human native T-type and recombinant Ca(v)3.2 calcium channels.

Michels G, Matthes J, Handrock R, Kuchinke U, Groner F, Cribbs LL, Pereverzev A, Schneider T, Perez-Reyes E, Herzig S.

Mol Pharmacol. 2002 Mar;61(3):682-94.


Vascular smooth muscle calcium channels: could "T" be a target?

Cribbs LL.

Circ Res. 2001 Sep 28;89(7):560-2. No abstract available.


Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.

Cribbs LL, Martin BL, Schroder EA, Keller BB, Delisle BP, Satin J.

Circ Res. 2001 Mar 2;88(4):403-7.


Mibefradil block of cloned T-type calcium channels.

Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA.

J Pharmacol Exp Ther. 2000 Oct;295(1):302-8.


Identification of a T-type Ca(2+) channel isoform in murine atrial myocytes (AT-1 cells)

Satin J, Cribbs LL.

Circ Res. 2000 Mar 31;86(6):636-42.


Corrigendum to: molecular cloning and functional expression of ca(v)3.1c, a T-type calcium channel from human brain.

Cribbs LL, Gomora JC, Daud AN, Lee J, Perez-Reyes E.

FEBS Lett. 2000 Mar 31;470(3):378. No abstract available.


Molecular cloning and functional expression of Ca(v)3.1c, a T-type calcium channel from human brain.

Cribbs LL, Gomora JC, Daud AN, Lee JH, Perez-Reyes E.

FEBS Lett. 2000 Jan 21;466(1):54-8. Erratum in: FEBS Lett 2000 Mar 31;470(3):378.


Arachidonic acid modulation of alpha1H, a cloned human T-type calcium channel.

Zhang Y, Cribbs LL, Satin J.

Am J Physiol Heart Circ Physiol. 2000 Jan;278(1):H184-93.


Comparison of the Ca2 + currents induced by expression of three cloned alpha1 subunits, alpha1G, alpha1H and alpha1I, of low-voltage-activated T-type Ca2 + channels.

Klöckner U, Lee JH, Cribbs LL, Daud A, Hescheler J, Pereverzev A, Perez-Reyes E, Schneider T.

Eur J Neurosci. 1999 Dec;11(12):4171-8.


Distinct kinetics of cloned T-type Ca2 + channels lead to differential Ca2 + entry and frequency-dependence during mock action potentials.

Kozlov AS, McKenna F, Lee JH, Cribbs LL, Perez-Reyes E, Feltz A, Lambert RC.

Eur J Neurosci. 1999 Dec;11(12):4149-58.


Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H.

Lee JH, Gomora JC, Cribbs LL, Perez-Reyes E.

Biophys J. 1999 Dec;77(6):3034-42.


The effect of alpha2-delta and other accessory subunits on expression and properties of the calcium channel alpha1G.

Dolphin AC, Wyatt CN, Richards J, Beattie RE, Craig P, Lee JH, Cribbs LL, Volsen SG, Perez-Reyes E.

J Physiol. 1999 Aug 15;519 Pt 1:35-45.


Molecular characterization of two members of the T-type calcium channel family.

Perez-Reyes E, Lee JH, Cribbs LL.

Ann N Y Acad Sci. 1999 Apr 30;868:131-43.


Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels.

Lee JH, Cribbs LL, Perez-Reyes E.

FEBS Lett. 1999 Feb 26;445(2-3):231-6.


Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family.

Lee JH, Daud AN, Cribbs LL, Lacerda AE, Pereverzev A, Klöckner U, Schneider T, Perez-Reyes E.

J Neurosci. 1999 Mar 15;19(6):1912-21.


Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels.

Talley EM, Cribbs LL, Lee JH, Daud A, Perez-Reyes E, Bayliss DA.

J Neurosci. 1999 Mar 15;19(6):1895-911.


Low-voltage-activated Ca2+ currents are generated by members of the CavT subunit family (alpha1G/H) in rat primary sensory neurons.

Lambert RC, McKenna F, Maulet Y, Talley EM, Bayliss DA, Cribbs LL, Lee JH, Perez-Reyes E, Feltz A.

J Neurosci. 1998 Nov 1;18(21):8605-13.


Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.

Cribbs LL, Lee JH, Yang J, Satin J, Zhang Y, Daud A, Barclay J, Williamson MP, Fox M, Rees M, Perez-Reyes E.

Circ Res. 1998 Jul 13;83(1):103-9.


Molecular characterization of a neuronal low-voltage-activated T-type calcium channel.

Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH.

Nature. 1998 Feb 26;391(6670):896-900.


Full reversal of Pb++ block of L-type Ca++ channels requires treatment with heavy metal antidotes.

Bernal J, Lee JH, Cribbs LL, Perez-Reyes E.

J Pharmacol Exp Ther. 1997 Jul;282(1):172-80.


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