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Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection.

Yang J, Schleicher TR, Dong Y, Park HB, Lan J, Cresswell P, Crawford J, Dimopoulos G, Fikrig E.

J Exp Med. 2020 Jan 6;217(1). pii: e20190682. doi: 10.1084/jem.20190682.


Intrinsic expression of viperin regulates thermogenesis in adipose tissues.

Eom J, Kim JJ, Yoon SG, Jeong H, Son S, Lee JB, Yoo J, Seo HJ, Cho Y, Kim KS, Choi KM, Kim IY, Lee HY, Nam KT, Cresswell P, Seong JK, Seo JY.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17419-17428. doi: 10.1073/pnas.1904480116. Epub 2019 Jul 24.


Proteasomal degradation within endocytic organelles mediates antigen cross-presentation.

Sengupta D, Graham M, Liu X, Cresswell P.

EMBO J. 2019 Aug 15;38(16):e99266. doi: 10.15252/embj.201899266. Epub 2019 Jul 4.


A personal retrospective on the mechanisms of antigen processing.

Cresswell P.

Immunogenetics. 2019 Mar;71(3):141-160. doi: 10.1007/s00251-018-01098-2. Epub 2019 Jan 29. Review.


miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC.

Jeon YJ, Kim T, Park D, Nuovo GJ, Rhee S, Joshi P, Lee BK, Jeong J, Suh SS, Grotzke JE, Kim SH, Song J, Sim H, Kim Y, Peng Y, Jeong Y, Garofalo M, Zanesi N, Kim J, Liang G, Nakano I, Cresswell P, Nana-Sinkam P, Cui R, Croce CM.

Nat Commun. 2018 Nov 30;9(1):5110. doi: 10.1038/s41467-018-07561-8.


Cytosolic Processing Governs TAP-Independent Presentation of a Critical Melanoma Antigen.

Vigneron N, Ferrari V, Van den Eynde BJ, Cresswell P, Leonhardt RM.

J Immunol. 2018 Oct 1;201(7):1875-1888. doi: 10.4049/jimmunol.1701479. Epub 2018 Aug 22.


A novel probe to assess cytosolic entry of exogenous proteins.

Lu Q, Grotzke JE, Cresswell P.

Nat Commun. 2018 Aug 6;9(1):3104. doi: 10.1038/s41467-018-05556-z.


A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission.

Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E.

Nat Commun. 2018 Jul 25;9(1):2908. doi: 10.1038/s41467-018-05374-3.


Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I.

Arshad N, Cresswell P.

J Biol Chem. 2018 Jun 22;293(25):9555-9569. doi: 10.1074/jbc.RA118.002836. Epub 2018 May 16.


Editing peptide presentation to T cells.

Cresswell P.

Science. 2017 Nov 24;358(6366):992-993. doi: 10.1126/science.aaq1398. No abstract available.


Editorial Overview: Antigen Processing and Presentation; many fingers in many pies.

Cresswell P, Roche PA.

Curr Opin Immunol. 2017 Jun;46:v-vii. doi: 10.1016/j.coi.2017.07.002. Epub 2017 Jul 14. No abstract available.


Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export.

Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5910-E5919. doi: 10.1073/pnas.1705242114. Epub 2017 Jul 5.


Structural studies of viperin, an antiviral radical SAM enzyme.

Fenwick MK, Li Y, Cresswell P, Modis Y, Ealick SE.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6806-6811. doi: 10.1073/pnas.1705402114. Epub 2017 Jun 12.


The ongoing saga of the mechanism(s) of MHC class I-restricted cross-presentation.

Grotzke JE, Sengupta D, Lu Q, Cresswell P.

Curr Opin Immunol. 2017 Jun;46:89-96. doi: 10.1016/j.coi.2017.03.015. Epub 2017 May 18. Review.


Viperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages.

Hee JS, Cresswell P.

PLoS One. 2017 Feb 16;12(2):e0172236. doi: 10.1371/journal.pone.0172236. eCollection 2017.


Access to diabetes drugs in New Zealand is inadequate.

Krebs J, Coppell KJ, Cresswell P, Downie M, Drury P, Gregory A, Kenealy T, McNamara C, Miller SC, Smallman K.

N Z Med J. 2016 Jun 10;129(1436):6-9. No abstract available.


Antigen Processing and Presentation Mechanisms in Myeloid Cells.

Roche PA, Cresswell P.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0008-2015. Review.


A randomised trial of the feasibility of a low carbohydrate diet vs standard carbohydrate counting in adults with type 1 diabetes taking body weight into account.

Krebs JD, Parry Strong A, Cresswell P, Reynolds AN, Hanna A, Haeusler S.

Asia Pac J Clin Nutr. 2016;25(1):78-84. doi: 10.6133/apjcn.2016.25.1.11.


From 'pleasure to chemistry': the experience of carbohydrate counting with and without carbohydrate restriction for people with Type 1 diabetes.

Cresswell P, Krebs J, Gilmour J, Hanna A, Parry-Strong A.

J Prim Health Care. 2015 Dec 1;7(4):291-8.


The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways.

Samie M, Cresswell P.

Nat Immunol. 2015 Jul;16(7):729-36. doi: 10.1038/ni.3196. Epub 2015 Jun 1.


Are ERAD components involved in cross-presentation?

Grotzke JE, Cresswell P.

Mol Immunol. 2015 Dec;68(2 Pt A):112-5. doi: 10.1016/j.molimm.2015.05.002. Epub 2015 May 23. Review.


A congenital disorder of deglycosylation: Biochemical characterization of N-glycanase 1 deficiency in patient fibroblasts.

He P, Grotzke JE, Ng BG, Gunel M, Jafar-Nejad H, Cresswell P, Enns GM, Freeze HH.

Glycobiology. 2015 Aug;25(8):836-44. doi: 10.1093/glycob/cwv024. Epub 2015 Apr 21.


The informed consent process in randomised controlled trials: a nurse-led process.

Cresswell P, Gilmour J.

Nurs Prax N Z. 2014 Mar;30(1):17-28.


Invariant chain-MHC class II complexes: always odd and never invariant.

Cresswell P, Roche PA.

Immunol Cell Biol. 2014 Jul;92(6):471-2. doi: 10.1038/icb.2014.36. Epub 2014 Apr 29. No abstract available.


Three tapasin docking sites in TAP cooperate to facilitate transporter stabilization and heterodimerization.

Leonhardt RM, Abrahimi P, Mitchell SM, Cresswell P.

J Immunol. 2014 Mar 1;192(5):2480-94. doi: 10.4049/jimmunol.1302637. Epub 2014 Feb 5.


Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Salio M, Ghadbane H, Dushek O, Shepherd D, Cypen J, Gileadi U, Aichinger MC, Napolitani G, Qi X, van der Merwe PA, Wojno J, Veerapen N, Cox LR, Besra GS, Yuan W, Cresswell P, Cerundolo V.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4753-61. doi: 10.1073/pnas.1310050110. Epub 2013 Nov 18.


Intracellular regulation of cross-presentation during dendritic cell maturation.

Wagner CS, Grotzke J, Cresswell P.

PLoS One. 2013 Oct 3;8(10):e76801. doi: 10.1371/journal.pone.0076801. eCollection 2013.


Viperin regulates cellular lipid metabolism during human cytomegalovirus infection.

Seo JY, Cresswell P.

PLoS Pathog. 2013;9(8):e1003497. doi: 10.1371/journal.ppat.1003497. Epub 2013 Aug 1.


Endoplasmic reticulum glycoprotein quality control regulates CD1d assembly and CD1d-mediated antigen presentation.

Kunte A, Zhang W, Paduraru C, Veerapen N, Cox LR, Besra GS, Cresswell P.

J Biol Chem. 2013 Jun 7;288(23):16391-402. doi: 10.1074/jbc.M113.474221. Epub 2013 Apr 24.


Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.

Paduraru C, Bezbradica JS, Kunte A, Kelly R, Shayman JA, Veerapen N, Cox LR, Besra GS, Cresswell P.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5097-102. doi: 10.1073/pnas.1302923110. Epub 2013 Mar 14.


Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation.

Grotzke JE, Lu Q, Cresswell P.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3393-8. doi: 10.1073/pnas.1300328110. Epub 2013 Feb 11.


Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils.

Leonhardt RM, Vigneron N, Hee JS, Graham M, Cresswell P.

Mol Biol Cell. 2013 Apr;24(7):964-81. doi: 10.1091/mbc.E12-10-0742. Epub 2013 Feb 6.


Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells.

Wen X, Rao P, Carreño LJ, Kim S, Lawrenczyk A, Porcelli SA, Cresswell P, Yuan W.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2963-8. doi: 10.1073/pnas.1300200110. Epub 2013 Feb 4.


In vitro reconstitution of the MHC class I peptide-loading complex.

Wearsch PA, Cresswell P.

Methods Mol Biol. 2013;960:67-79. doi: 10.1007/978-1-62703-218-6_6.


MHC class II-restricted presentation of the major house dust mite allergen Der p 1 Is GILT-dependent: implications for allergic asthma.

West LC, Grotzke JE, Cresswell P.

PLoS One. 2013;8(1):e51343. doi: 10.1371/journal.pone.0051343. Epub 2013 Jan 11.


Pathways of antigen processing.

Blum JS, Wearsch PA, Cresswell P.

Annu Rev Immunol. 2013;31:443-73. doi: 10.1146/annurev-immunol-032712-095910. Epub 2013 Jan 3. Review.


Sibling rivalry: competition between MHC class II family members inhibits immunity.

Denzin LK, Cresswell P.

Nat Struct Mol Biol. 2013 Jan;20(1):7-10. doi: 10.1038/nsmb.2484.


Expanding roles for GILT in immunity.

West LC, Cresswell P.

Curr Opin Immunol. 2013 Feb;25(1):103-8. doi: 10.1016/j.coi.2012.11.006. Epub 2012 Dec 12. Review.


Dynamics of major histocompatibility complex class I association with the human peptide-loading complex.

Panter MS, Jain A, Leonhardt RM, Ha T, Cresswell P.

J Biol Chem. 2012 Sep 7;287(37):31172-84. doi: 10.1074/jbc.M112.387704. Epub 2012 Jul 24.


Inefficient exogenous loading of a tapasin-dependent peptide onto HLA-B*44:02 can be improved by acid treatment or fixation of target cells.

Stroobant V, Demotte N, Luiten RM, Leonhardt RM, Cresswell P, Bonehill A, Michaux A, Ma W, Mulder A, Van den Eynde BJ, van der Bruggen P, Vigneron N.

Eur J Immunol. 2012 Jun;42(6):1417-28. doi: 10.1002/eji.201141954.


Intracellular events regulating cross-presentation.

Wagner CS, Grotzke JE, Cresswell P.

Front Immunol. 2012 Jun 4;3:138. doi: 10.3389/fimmu.2012.00138. eCollection 2012.


Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.

Metcalfe C, Cresswell P, Barclay AN.

Open Biol. 2012 Jan;2(1):110036. doi: 10.1098/rsob.110036.


Labile disulfide bonds are common at the leucocyte cell surface.

Metcalfe C, Cresswell P, Ciaccia L, Thomas B, Barclay AN.

Open Biol. 2011 Nov;1(3):110010. doi: 10.1098/rsob.110010.


A switch in pathogenic mechanism in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in IFN-γ-inducible lysosomal thiol reductase-free mice.

Bergman CM, Marta CB, Maric M, Pfeiffer SE, Cresswell P, Ruddle NH.

J Immunol. 2012 Jun 15;188(12):6001-9. doi: 10.4049/jimmunol.1101898. Epub 2012 May 14.


GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.

Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD.

Science. 2012 Apr 27;336(6080):481-5. doi: 10.1126/science.1217141. Epub 2012 Mar 29.


Viperin: a multifunctional, interferon-inducible protein that regulates virus replication.

Seo JY, Yaneva R, Cresswell P.

Cell Host Microbe. 2011 Dec 15;10(6):534-9. doi: 10.1016/j.chom.2011.11.004. Review.


TLR and nucleotide-binding oligomerization domain-like receptor signals differentially regulate exogenous antigen presentation.

Wagner CS, Cresswell P.

J Immunol. 2012 Jan 15;188(2):686-93. doi: 10.4049/jimmunol.1102214. Epub 2011 Dec 9.


The interferon-inducible gene viperin restricts West Nile virus pathogenesis.

Szretter KJ, Brien JD, Thackray LB, Virgin HW, Cresswell P, Diamond MS.

J Virol. 2011 Nov;85(22):11557-66. doi: 10.1128/JVI.05519-11. Epub 2011 Aug 31.

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