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Items: 1 to 50 of 51

1.

The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin.

McDowell MA, Byrne AM, Mylona E, Johnson R, Sagfors A, Crepin VF, Lea S, Frankel G.

Life Sci Alliance. 2019 May 29;2(3). pii: e201800272. doi: 10.26508/lsa.201800272. Print 2019 Jun.

2.

Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Connolly JPR, Slater SL, O'Boyle N, Goldstone RJ, Crepin VF, Ruano-Gallego D, Herzyk P, Smith DGE, Douce GR, Frankel G, Roe AJ.

Nat Commun. 2018 Nov 29;9(1):5148. doi: 10.1038/s41467-018-07612-0.

3.

The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses.

Berger CN, Crepin VF, Roumeliotis TI, Wright JC, Serafini N, Pevsner-Fischer M, Yu L, Elinav E, Di Santo JP, Choudhary JS, Frankel G.

PLoS Pathog. 2018 Oct 26;14(10):e1007406. doi: 10.1371/journal.ppat.1007406. eCollection 2018 Oct.

4.

Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Connolly JPR, Slater SL, O'Boyle N, Goldstone RJ, Crepin VF, Ruano-Gallego D, Herzyk P, Smith DGE, Douce GR, Frankel G, Roe AJ.

Nat Commun. 2018 Oct 10;9(1):4187. doi: 10.1038/s41467-018-06701-4. Erratum in: Nat Commun. 2018 Nov 29;9(1):5148.

5.

Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa.

Mullineaux-Sanders C, Collins JW, Ruano-Gallego D, Levy M, Pevsner-Fischer M, Glegola-Madejska IT, Sågfors AM, Wong JLC, Elinav E, Crepin VF, Frankel G.

Cell Rep. 2017 Dec 19;21(12):3381-3389. doi: 10.1016/j.celrep.2017.11.086.

6.

Hierarchical protein targeting and secretion is controlled by an affinity switch in the type III secretion system of enteropathogenic Escherichia coli.

Portaliou AG, Tsolis KC, Loos MS, Balabanidou V, Rayo J, Tsirigotaki A, Crepin VF, Frankel G, Kalodimos CG, Karamanou S, Economou A.

EMBO J. 2017 Dec 1;36(23):3517-3531. doi: 10.15252/embj.201797515. Epub 2017 Nov 6.

7.

Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.

Berger CN, Crepin VF, Roumeliotis TI, Wright JC, Carson D, Pevsner-Fischer M, Furniss RCD, Dougan G, Dori-Bachash M, Yu L, Clements A, Collins JW, Elinav E, Larrouy-Maumus GJ, Choudhary JS, Frankel G.

Cell Metab. 2017 Nov 7;26(5):738-752.e6. doi: 10.1016/j.cmet.2017.09.003. Epub 2017 Oct 5.

8.

The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner.

Sandu P, Crepin VF, Drechsler H, McAinsh AD, Frankel G, Berger CN.

Infect Immun. 2017 Aug 18;85(9). pii: e00244-17. doi: 10.1128/IAI.00244-17. Print 2017 Sep.

9.

Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Feb 13;2:17024. doi: 10.1038/nmicrobiol.2017.24. No abstract available.

10.

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Jan 13;2:16258. doi: 10.1038/nmicrobiol.2016.258. Erratum in: Nat Microbiol. 2017 Feb 13;2:17024.

11.

The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

Johnson R, Byrne A, Berger CN, Klemm E, Crepin VF, Dougan G, Frankel G.

J Bacteriol. 2017 Jan 30;199(4). pii: e00647-16. doi: 10.1128/JB.00647-16. Print 2017 Feb 15.

12.

Model of Host-Pathogen Interaction Dynamics Links In Vivo Optical Imaging and Immune Responses.

Ale A, Crepin VF, Collins JW, Constantinou N, Habibzay M, Babtie AC, Frankel G, Stumpf MPH.

Infect Immun. 2016 Dec 29;85(1). pii: e00606-16. doi: 10.1128/IAI.00606-16. Print 2017 Jan.

13.

Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells.

Pallett MA, Crepin VF, Serafini N, Habibzay M, Kotik O, Sanchez-Garrido J, Di Santo JP, Shenoy AR, Berger CN, Frankel G.

Mucosal Immunol. 2017 May;10(3):602-612. doi: 10.1038/mi.2016.77. Epub 2016 Sep 14.

14.

Citrobacter rodentium mouse model of bacterial infection.

Crepin VF, Collins JW, Habibzay M, Frankel G.

Nat Protoc. 2016 Oct;11(10):1851-76. doi: 10.1038/nprot.2016.100. Epub 2016 Sep 8.

PMID:
27606775
15.

Tir Triggers Expression of CXCL1 in Enterocytes and Neutrophil Recruitment during Citrobacter rodentium Infection.

Crepin VF, Habibzay M, Glegola-Madejska I, Guenot M, Collins JW, Frankel G.

Infect Immun. 2015 Sep;83(9):3342-54. doi: 10.1128/IAI.00291-15. Epub 2015 Jun 15.

16.

Citrobacter rodentium: infection, inflammation and the microbiota.

Collins JW, Keeney KM, Crepin VF, Rathinam VA, Fitzgerald KA, Finlay BB, Frankel G.

Nat Rev Microbiol. 2014 Sep;12(9):612-23. doi: 10.1038/nrmicro3315. Epub 2014 Aug 4. Review.

PMID:
25088150
17.

Fermented dairy products modulate Citrobacter rodentium-induced colonic hyperplasia.

Collins JW, Chervaux C, Raymond B, Derrien M, Brazeilles R, Kosta A, Chambaud I, Crepin VF, Frankel G.

J Infect Dis. 2014 Oct 1;210(7):1029-41. doi: 10.1093/infdis/jiu205. Epub 2014 Apr 4.

18.

A type III effector antagonizes death receptor signalling during bacterial gut infection.

Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, Mühlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL.

Nature. 2013 Sep 12;501(7466):247-51. doi: 10.1038/nature12524.

19.

EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation.

Berger CN, Crepin VF, Baruch K, Mousnier A, Rosenshine I, Frankel G.

MBio. 2012 Oct 2;3(5). pii: e00317-12. doi: 10.1128/mBio.00317-12. Print 2012.

20.

The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP).

Wong AR, Raymond B, Collins JW, Crepin VF, Frankel G.

Cell Microbiol. 2012 Jul;14(7):1051-70. doi: 10.1111/j.1462-5822.2012.01778.x. Epub 2012 Mar 16.

21.

The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.

Wong AR, Clements A, Raymond B, Crepin VF, Frankel G.

MBio. 2012 Jan 17;3(1). pii: e00250-11. doi: 10.1128/mBio.00250-11. Print 2012.

22.

The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner.

Raymond B, Crepin VF, Collins JW, Frankel G.

Cell Microbiol. 2011 Dec;13(12):1881-93. doi: 10.1111/j.1462-5822.2011.01666.x. Epub 2011 Sep 14.

23.

Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.

Martinez E, Schroeder GN, Berger CN, Lee SF, Robinson KS, Badea L, Simpson N, Hall RA, Hartland EL, Crepin VF, Frankel G.

Cell Microbiol. 2010 Dec;12(12):1718-31. doi: 10.1111/j.1462-5822.2010.01503.x.

24.

N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins.

Munera D, Crepin VF, Marches O, Frankel G.

J Bacteriol. 2010 Jul;192(13):3534-9. doi: 10.1128/JB.00046-10. Epub 2010 Apr 16.

25.

Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.

Bulgin R, Raymond B, Garnett JA, Frankel G, Crepin VF, Berger CN, Arbeloa A.

Infect Immun. 2010 Apr;78(4):1417-25. doi: 10.1128/IAI.01250-09. Epub 2010 Feb 1. Review.

26.

The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals.

Bulgin R, Arbeloa A, Goulding D, Dougan G, Crepin VF, Raymond B, Frankel G.

PLoS Pathog. 2009 Dec;5(12):e1000683. doi: 10.1371/journal.ppat.1000683. Epub 2009 Dec 11.

27.

The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.

Petty NK, Bulgin R, Crepin VF, Cerdeño-Tárraga AM, Schroeder GN, Quail MA, Lennard N, Corton C, Barron A, Clark L, Toribio AL, Parkhill J, Dougan G, Frankel G, Thomson NR.

J Bacteriol. 2010 Jan;192(2):525-38. doi: 10.1128/JB.01144-09. Epub 2009 Nov 6.

28.

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo.

Crepin VF, Girard F, Schüller S, Phillips AD, Mousnier A, Frankel G.

Mol Microbiol. 2010 Jan;75(2):308-23. doi: 10.1111/j.1365-2958.2009.06938.x. Epub 2009 Nov 2.

29.

Modelling of infection by enteropathogenic Escherichia coli strains in lineages 2 and 4 ex vivo and in vivo by using Citrobacter rodentium expressing TccP.

Girard F, Crepin VF, Frankel G.

Infect Immun. 2009 Apr;77(4):1304-14. doi: 10.1128/IAI.01351-08. Epub 2009 Feb 2.

30.

The mechanisms used by enteropathogenic Escherichia coli to control filopodia dynamics.

Berger CN, Crepin VF, Jepson MA, Arbeloa A, Frankel G.

Cell Microbiol. 2009 Feb;11(2):309-22. doi: 10.1111/j.1462-5822.2008.01254.x. Epub 2008 Nov 28.

31.

Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.

Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD, Berger CN, Mousnier A, Crepin VF, Kruidenier L, Woodward MJ, Stevens MP, La Ragione RM, MacDonald TT, Frankel G.

Infect Immun. 2008 Nov;76(11):4804-13. doi: 10.1128/IAI.00742-08. Epub 2008 Aug 25.

32.

The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium.

Dennis A, Kudo T, Kruidenier L, Girard F, Crepin VF, MacDonald TT, Frankel G, Wiles S.

Infect Immun. 2008 Nov;76(11):4978-88. doi: 10.1128/IAI.00736-08. Epub 2008 Aug 11.

33.

Structural and functional properties of chimeric EspA-FliCi filaments of EPEC.

Crepin VF, Martinez E, Shaw RK, Frankel G, Daniell SJ.

J Mol Biol. 2008 Apr 18;378(1):243-50. doi: 10.1016/j.jmb.2008.02.042. Epub 2008 Mar 4.

PMID:
18353364
34.

Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens.

Arbeloa A, Bulgin RR, MacKenzie G, Shaw RK, Pallen MJ, Crepin VF, Berger CN, Frankel G.

Cell Microbiol. 2008 Jul;10(7):1429-41. doi: 10.1111/j.1462-5822.2008.01136.x. Epub 2008 Mar 5.

35.

Identification of amino acid residues within the N-terminal domain of EspA that play a role in EspA filament biogenesis and function.

Singh MP, Shaw RK, Knutton S, Pallen MJ, Crepin VF, Frankel G.

J Bacteriol. 2008 Mar;190(6):2221-6. doi: 10.1128/JB.01753-07. Epub 2008 Jan 4.

36.

Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents.

Wiles S, Crepin VF, Childs G, Frankel G, Kerton A.

Lab Anim. 2007 Jul;41(3):321-8.

PMID:
17640459
37.

Vaccination of calves with EspA, a key colonisation factor of Escherichia coli O157:H7, induces antigen-specific humoral responses but does not confer protection against intestinal colonisation.

Dziva F, Vlisidou I, Crepin VF, Wallis TS, Frankel G, Stevens MP.

Vet Microbiol. 2007 Jul 20;123(1-3):254-61. Epub 2007 Feb 23.

PMID:
17374460
38.

The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea.

Simpson N, Shaw R, Crepin VF, Mundy R, FitzGerald AJ, Cummings N, Straatman-Iwanowska A, Connerton I, Knutton S, Frankel G.

Mol Microbiol. 2006 Apr;60(2):349-63.

39.

Subversion of actin dynamics by EPEC and EHEC.

Caron E, Crepin VF, Simpson N, Knutton S, Garmendia J, Frankel G.

Curr Opin Microbiol. 2006 Feb;9(1):40-5. Epub 2006 Jan 6. Review.

PMID:
16406772
40.

Molecular basis of antigenic polymorphism of EspA filaments: development of a peptide display technology.

Crepin VF, Shaw R, Knutton S, Frankel G.

J Mol Biol. 2005 Jul 1;350(1):42-52.

PMID:
15921692
41.

Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation.

Garmendia J, Frankel G, Crepin VF.

Infect Immun. 2005 May;73(5):2573-85. Review. No abstract available.

42.

Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion.

Crepin VF, Shaw R, Abe CM, Knutton S, Frankel G.

J Bacteriol. 2005 Apr;187(8):2881-9.

43.

(1)H, (13)C, and (15)N resonance assignments of the EscJ protein, a structural component of the Type III secretion system of enteropathogenic E. coli (EPEC).

Prasannan S, Simpson P, Wilson RK, Crepin VF, Frankel G, Matthews S.

J Biomol NMR. 2004 Nov;30(3):387-8. No abstract available.

PMID:
15754065
44.

Structural and functional studies of the enteropathogenic Escherichia coli type III needle complex protein EscJ.

Crepin VF, Prasannan S, Shaw RK, Wilson RK, Creasey E, Abe CM, Knutton S, Frankel G, Matthews S.

Mol Microbiol. 2005 Mar;55(6):1658-70.

45.

Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes.

Dahan S, Knutton S, Shaw RK, Crepin VF, Dougan G, Frankel G.

Infect Immun. 2004 Sep;72(9):5452-9.

46.

The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity.

Garcia-Conesa MT, Crepin VF, Goldson AJ, Williamson G, Cummings NJ, Connerton IF, Faulds CB, Kroon PA.

J Biotechnol. 2004 Mar 18;108(3):227-41.

PMID:
15006424
47.

Functional classification of the microbial feruloyl esterases.

Crepin VF, Faulds CB, Connerton IF.

Appl Microbiol Biotechnol. 2004 Feb;63(6):647-52. Epub 2003 Dec 6. Review.

PMID:
14661116
48.

Identification of a type-D feruloyl esterase from Neurospora crassa.

Crepin VF, Faulds CB, Connerton IF.

Appl Microbiol Biotechnol. 2004 Feb;63(5):567-70. Epub 2003 Nov 1.

PMID:
14595525
49.
50.

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