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Items: 1 to 50 of 52

1.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28.

PMID:
29953201
2.

Preparation of α-Synuclein Amyloid Assemblies for Toxicity Experiments.

Chen SW, Cremades N.

Methods Mol Biol. 2018;1779:45-60. doi: 10.1007/978-1-4939-7816-8_4.

PMID:
29886526
3.

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.

Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VMY, Martinez TN, Dave KD.

J Parkinsons Dis. 2018;8(2):303-322. doi: 10.3233/JPD-171248.

4.

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.

Fusco G, Chen SW, Williamson PTF, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM, De Simone A.

Science. 2017 Dec 15;358(6369):1440-1443. doi: 10.1126/science.aan6160.

5.

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.

Cremades N, Dobson CM.

Neurobiol Dis. 2018 Jan;109(Pt B):178-190. doi: 10.1016/j.nbd.2017.07.009. Epub 2017 Jul 12. Review.

6.

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N.

Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23.

PMID:
28230968
7.

Structural Characteristics of α-Synuclein Oligomers.

Cremades N, Chen SW, Dobson CM.

Int Rev Cell Mol Biol. 2017;329:79-143. doi: 10.1016/bs.ircmb.2016.08.010. Epub 2016 Oct 31. Review.

PMID:
28109332
8.

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2543. Limboker, Ryan [corrected to Limbocker, Ryan].

9.

Ca2+ is a key factor in α-synuclein-induced neurotoxicity.

Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY.

J Cell Sci. 2016 May 1;129(9):1792-801. doi: 10.1242/jcs.180737. Epub 2016 Mar 17.

10.

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.

Pedersen JT, Chen SW, Borg CB, Ness S, Bahl JM, Heegaard NH, Dobson CM, Hemmingsen L, Cremades N, Teilum K.

J Am Chem Soc. 2016 Mar 30;138(12):3966-9. doi: 10.1021/jacs.5b13577. Epub 2016 Mar 21.

11.

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.

Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1206-15. doi: 10.1073/pnas.1524128113. Epub 2016 Feb 16.

12.

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.

Horrocks MH, Lee SF, Gandhi S, Magdalinou NK, Chen SW, Devine MJ, Tosatto L, Kjaergaard M, Beckwith JS, Zetterberg H, Iljina M, Cremades N, Dobson CM, Wood NW, Klenerman D.

ACS Chem Neurosci. 2016 Mar 16;7(3):399-406. doi: 10.1021/acschemneuro.5b00324. Epub 2016 Feb 4.

13.

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.

Tosatto L, Horrocks MH, Dear AJ, Knowles TP, Dalla Serra M, Cremades N, Dobson CM, Klenerman D.

Sci Rep. 2015 Nov 19;5:16696. doi: 10.1038/srep16696.

14.

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

Deas E, Cremades N, Angelova PR, Ludtmann MH, Yao Z, Chen S, Horrocks MH, Banushi B, Little D, Devine MJ, Gissen P, Klenerman D, Dobson CM, Wood NW, Gandhi S, Abramov AY.

Antioxid Redox Signal. 2016 Mar 1;24(7):376-91. doi: 10.1089/ars.2015.6343. Epub 2016 Feb 1.

15.

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.

Horrocks MH, Tosatto L, Dear AJ, Garcia GA, Iljina M, Cremades N, Dalla Serra M, Knowles TP, Dobson CM, Klenerman D.

Anal Chem. 2015 Sep 1;87(17):8818-26. doi: 10.1021/acs.analchem.5b01811. Epub 2015 Aug 14.

PMID:
26258431
16.

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis.

Nimmervoll B, Chtcheglova LA, Juhasz K, Cremades N, Aprile FA, Sonnleitner A, Hinterdorfer P, Vigh L, Preiner J, Balogi Z.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2747-53. doi: 10.1016/j.febslet.2015.07.037. Epub 2015 Aug 6.

17.

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM, Dobson CM, Cremades N.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112. Epub 2015 Apr 8.

18.

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.

Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, Callaway K, Anderson JP, Jobling MF, Buell AK, Yednock TA, Knowles TP, Vendruscolo M, Christodoulou J, Dobson CM, Schenk D, McConlogue L.

PLoS One. 2014 Feb 14;9(2):e87133. doi: 10.1371/journal.pone.0087133. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e99274.

19.

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.

Aprile FA, Dhulesia A, Stengel F, Roodveldt C, Benesch JL, Tortora P, Robinson CV, Salvatella X, Dobson CM, Cremades N.

PLoS One. 2013 Jun 28;8(6):e67961. doi: 10.1371/journal.pone.0067961. Print 2013.

20.

Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.

Guilliams T, El-Turk F, Buell AK, O'Day EM, Aprile FA, Esbjörner EK, Vendruscolo M, Cremades N, Pardon E, Wyns L, Welland ME, Steyaert J, Christodoulou J, Dobson CM, De Genst E.

J Mol Biol. 2013 Jul 24;425(14):2397-411. doi: 10.1016/j.jmb.2013.01.040. Epub 2013 Apr 1.

21.

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Cremades N, Cohen SI, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TP, Dobson CM, Klenerman D.

Cell. 2012 May 25;149(5):1048-59. doi: 10.1016/j.cell.2012.03.037.

22.

Cryopreservation of human testicular diploid germ cell suspensions.

Sá R, Cremades N, Malheiro I, Sousa M.

Andrologia. 2012 Dec;44(6):366-72. doi: 10.1111/j.1439-0272.2012.01290.x. Epub 2012 Mar 15.

PMID:
22420610
23.

Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme.

Zambelli B, Cremades N, Neyroz P, Turano P, Uversky VN, Ciurli S.

Mol Biosyst. 2012 Jan;8(1):220-8. doi: 10.1039/c1mb05227f. Epub 2011 Sep 16.

PMID:
21922108
24.

Population of nonnative states of lysozyme variants drives amyloid fibril formation.

Buell AK, Dhulesia A, Mossuto MF, Cremades N, Kumita JR, Dumoulin M, Welland ME, Knowles TPJ, Salvatella X, Dobson CM.

J Am Chem Soc. 2011 May 25;133(20):7737-7743. doi: 10.1021/ja109620d. Epub 2011 Apr 29.

25.

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution.

Dhulesia A, Cremades N, Kumita JR, Hsu ST, Mossuto MF, Dumoulin M, Nietlispach D, Akke M, Salvatella X, Dobson CM.

J Am Chem Soc. 2010 Nov 10;132(44):15580-8. doi: 10.1021/ja103524m.

26.

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.

De Genst EJ, Guilliams T, Wellens J, O'Day EM, Waudby CA, Meehan S, Dumoulin M, Hsu ST, Cremades N, Verschueren KH, Pardon E, Wyns L, Steyaert J, Christodoulou J, Dobson CM.

J Mol Biol. 2010 Sep 17;402(2):326-43. doi: 10.1016/j.jmb.2010.07.001. Epub 2010 Jul 8.

27.

Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection.

Cremades N, Velázquez-Campoy A, Martínez-Júlvez M, Neira JL, Pérez-Dorado I, Hermoso J, Jiménez P, Lanas A, Hoffman PS, Sancho J.

ACS Chem Biol. 2009 Nov 20;4(11):928-38. doi: 10.1021/cb900166q.

PMID:
19725577
28.

On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.

Lendel C, Bertoncini CW, Cremades N, Waudby CA, Vendruscolo M, Dobson CM, Schenk D, Christodoulou J, Toth G.

Biochemistry. 2009 Sep 8;48(35):8322-34. doi: 10.1021/bi901285x.

PMID:
19645507
30.

Cytological and expression studies and quantitative analysis of the temporal and stage-specific effects of follicle-stimulating hormone and testosterone during cocultures of the normal human seminiferous epithelium.

Sá R, Neves R, Fernandes S, Alves C, Carvalho F, Silva J, Cremades N, Malheiro I, Barros A, Sousa M.

Biol Reprod. 2008 Nov;79(5):962-75. doi: 10.1095/biolreprod.107.067546. Epub 2008 Jul 30.

PMID:
18667755
31.

Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria.

Pey AL, Ying M, Cremades N, Velazquez-Campoy A, Scherer T, Thöny B, Sancho J, Martinez A.

J Clin Invest. 2008 Aug;118(8):2858-67. doi: 10.1172/JCI34355.

32.
33.

The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.

Cremades N, Velazquez-Campoy A, Freire E, Sancho J.

Biochemistry. 2008 Jan 15;47(2):627-39. Epub 2007 Dec 21.

34.

Conformational stability of Helicobacter pylori flavodoxin: fit to function at pH 5.

Cremades N, Bueno M, Neira JL, Velázquez-Campoy A, Sancho J.

J Biol Chem. 2008 Feb 1;283(5):2883-95. Epub 2007 Nov 11.

35.

Common conformational changes in flavodoxins induced by FMN and anion binding: the structure of Helicobacter pylori apoflavodoxin.

Martínez-Júlvez M, Cremades N, Bueno M, Pérez-Dorado I, Maya C, Cuesta-López S, Prada D, Falo F, Hermoso JA, Sancho J.

Proteins. 2007 Nov 15;69(3):581-94.

PMID:
17623845
36.
37.

Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.

Hoffman PS, Sisson G, Croxen MA, Welch K, Harman WD, Cremades N, Morash MG.

Antimicrob Agents Chemother. 2007 Mar;51(3):868-76. Epub 2006 Dec 11.

38.

The native-state ensemble of proteins provides clues for folding, misfolding and function.

Cremades N, Sancho J, Freire E.

Trends Biochem Sci. 2006 Sep;31(9):494-6. Epub 2006 Jul 25.

PMID:
16870449
39.

Filling small, empty protein cavities: structural and energetic consequences.

Bueno M, Cremades N, Neira JL, Sancho J.

J Mol Biol. 2006 May 5;358(3):701-12. Epub 2006 Mar 10.

PMID:
16563433
40.

Towards a new therapeutic target: Helicobacter pylori flavodoxin.

Cremades N, Bueno M, Toja M, Sancho J.

Biophys Chem. 2005 Apr 1;115(2-3):267-76. Epub 2005 Jan 7.

PMID:
15752617
41.

Experimental vitrification of human compacted morulae and early blastocysts using fine diameter plastic micropipettes.

Cremades N, Sousa M, Silva J, Viana P, Sousa S, Oliveira C, Teixeira da Silva J, Barros A.

Hum Reprod. 2004 Feb;19(2):300-5.

PMID:
14747171
42.

Unique (Y;13) translocation in a male with oligozoospermia: cytogenetic and molecular studies.

Alves C, Carvalho F, Cremades N, Sousa M, Barros A.

Eur J Hum Genet. 2002 Aug;10(8):467-74.

43.

Predictive value of testicular histology in secretory azoospermic subgroups and clinical outcome after microinjection of fresh and frozen-thawed sperm and spermatids.

Sousa M, Cremades N, Silva J, Oliveira C, Ferraz L, Teixeira da Silva J, Viana P, Barros A.

Hum Reprod. 2002 Jul;17(7):1800-10.

PMID:
12093843
44.

Follicular fluid markers of oocyte developmental potential.

Mendoza C, Ruiz-Requena E, Ortega E, Cremades N, Martinez F, Bernabeu R, Greco E, Tesarik J.

Hum Reprod. 2002 Apr;17(4):1017-22.

PMID:
11925399
45.

Developmental potential of human spermatogenic cells co-cultured with Sertoli cells.

Sousa M, Cremades N, Alves C, Silva J, Barros A.

Hum Reprod. 2002 Jan;17(1):161-72.

PMID:
11756382
46.

[The history of medicine in Cordoba. Its teachers].

Cremades NA.

Rev Museo Fac Odontol B Aires. 1999;14(29):35-7. Spanish.

PMID:
11625825
47.
48.

In-vitro maturation of round spermatids using co-culture on Vero cells.

Cremades N, Bernabeu R, Barros A, Sousa M.

Hum Reprod. 1999 May;14(5):1287-93.

PMID:
10325279
49.

Relationship between fertilization results after intracytoplasmic sperm injection, and intrafollicular steroid, pituitary hormone and cytokine concentrations.

Mendoza C, Cremades N, Ruiz-Requena E, Martinez F, Ortega E, Bernabeu S, Tesarik J.

Hum Reprod. 1999 Mar;14(3):628-35.

PMID:
10221687
50.

Successful pregnancy after spermatid injection.

Bernabeu R, Cremades N, Takahashi K, Sousa M.

Hum Reprod. 1998 Jul;13(7):1898-900.

PMID:
9740445

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