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Items: 13

1.

Engineering allosteric regulation in protein kinases.

Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA.

Sci Signal. 2018 Nov 6;11(555). pii: eaar3250. doi: 10.1126/scisignal.aar3250.

PMID:
30401787
2.

Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.

Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB.

Cell Syst. 2018 Oct 24;7(4):371-383.e4. doi: 10.1016/j.cels.2018.08.008. Epub 2018 Sep 19.

3.

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution.

Zhao B, Sedlak JC, Srinivas R, Creixell P, Pritchard JR, Tidor B, Lauffenburger DA, Hemann MT.

Cell. 2016 Mar 24;165(1):234-246. doi: 10.1016/j.cell.2016.01.045. Epub 2016 Feb 25.

4.

Unmasking determinants of specificity in the human kinome.

Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):187-201. doi: 10.1016/j.cell.2015.08.057. Epub 2015 Sep 17.

5.

Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):202-17. doi: 10.1016/j.cell.2015.08.056. Epub 2015 Sep 17.

6.

Pathway and network analysis of cancer genomes.

Creixell P, Reimand J, Haider S, Wu G, Shibata T, Vazquez M, Mustonen V, Gonzalez-Perez A, Pearson J, Sander C, Raphael BJ, Marks DS, Ouellette BFF, Valencia A, Bader GD, Boutros PC, Stuart JM, Linding R, Lopez-Bigas N, Stein LD; Mutation Consequences and Pathway Analysis Working Group of the International Cancer Genome Consortium.

Nat Methods. 2015 Jul;12(7):615-621. doi: 10.1038/nmeth.3440.

7.

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.

PMID:
25852190
8.

CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.

Pasculescu A, Schoof EM, Creixell P, Zheng Y, Olhovsky M, Tian R, So J, Vanderlaan RD, Pawson T, Linding R, Colwill K.

J Proteomics. 2014 Apr 4;100:167-73. doi: 10.1016/j.jprot.2014.01.023. Epub 2014 Feb 3.

PMID:
24503186
9.

Personalized network-based treatments in oncology.

Robin X, Creixell P, Radetskaya O, Santini CC, Longden J, Linding R.

Clin Pharmacol Ther. 2013 Dec;94(6):646-50. doi: 10.1038/clpt.2013.171. Epub 2013 Aug 29. Review.

PMID:
23995267
10.

Computational approaches to identify functional genetic variants in cancer genomes.

Gonzalez-Perez A, Mustonen V, Reva B, Ritchie GR, Creixell P, Karchin R, Vazquez M, Fink JL, Kassahn KS, Pearson JV, Bader GD, Boutros PC, Muthuswamy L, Ouellette BF, Reimand J, Linding R, Shibata T, Valencia A, Butler A, Dronov S, Flicek P, Shannon NB, Carter H, Ding L, Sander C, Stuart JM, Stein LD, Lopez-Bigas N; International Cancer Genome Consortium Mutation Pathways and Consequences Subgroup of the Bioinformatics Analyses Working Group.

Nat Methods. 2013 Aug;10(8):723-9. doi: 10.1038/nmeth.2562.

11.

Navigating cancer network attractors for tumor-specific therapy.

Creixell P, Schoof EM, Erler JT, Linding R.

Nat Biotechnol. 2012 Sep;30(9):842-8. doi: 10.1038/nbt.2345.

PMID:
22965061
12.

Mutational properties of amino acid residues: implications for evolvability of phosphorylatable residues.

Creixell P, Schoof EM, Tan CS, Linding R.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2584-93. doi: 10.1098/rstb.2012.0076. Erratum in: Philos Trans R Soc Lond B Biol Sci. 2012 Nov 5;367(1602):3058.

13.

Cells, shared memory and breaking the PTM code.

Creixell P, Linding R.

Mol Syst Biol. 2012;8:598. doi: 10.1038/msb.2012.33. No abstract available.

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