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Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.

Nicklisch SC, Rees SD, McGrath AP, Gökirmak T, Bonito LT, Vermeer LM, Cregger C, Loewen G, Sandin S, Chang G, Hamdoun A.

Sci Adv. 2016 Apr 15;2(4):e1600001. doi: 10.1126/sciadv.1600001. eCollection 2016 Apr.


Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.

Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, Swartz DJ, Falson PG, Urbatsch IL, Govaerts C, Steyaert J, Chang G.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13386-91. doi: 10.1073/pnas.1309275110. Epub 2013 Jul 30.

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