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Items: 1 to 50 of 60

1.

Circular RNAs in the cardiovascular system.

Gomes CPC, Salgado-Somoza A, Creemers EE, Dieterich C, Lustrek M, Devaux Y; Cardiolinc™ network.

Noncoding RNA Res. 2018 Feb 25;3(1):1-11. doi: 10.1016/j.ncrna.2018.02.002. eCollection 2018 Mar. Review.

2.

AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart.

van den Hoogenhof MMG, van der Made I, de Groot NE, Damanafshan A, van Amersfoorth SCM, Zentilin L, Giacca M, Pinto YM, Creemers EE.

Sci Rep. 2018 Aug 3;8(1):11696. doi: 10.1038/s41598-018-29552-x.

3.

Study Design and qPCR Data Analysis Guidelines for Reliable Circulating miRNA Biomarker Experiments: A Review.

de Ronde MWJ, Ruijter JM, Moerland PD, Creemers EE, Pinto-Sietsma SJ.

Clin Chem. 2018 Sep;64(9):1308-1318. doi: 10.1373/clinchem.2017.285288. Epub 2018 Jun 14. Review.

PMID:
29903876
4.

Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis.

Medzikovic L, van Roomen C, Baartscheer A, van Loenen PB, de Vos J, Bakker ENTP, Koenis DS, Damanafshan A, Creemers EE, Arkenbout EK, de Vries CJM, de Waard V.

Cardiovasc Res. 2018 Oct 1;114(12):1617-1628. doi: 10.1093/cvr/cvy125.

PMID:
29850786
5.

A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.

Rivaud MR, Jansen JA, Postema PG, Nannenberg EA, Mizusawa Y, van der Nagel R, Wolswinkel R, van der Made I, Marchal GA, Rajamani S, Belardinelli L, van Tintelen JP, Tanck MWT, van der Wal AC, de Bakker JMT, van Rijen HV, Creemers EE, Wilde AAM, van den Berg MP, van Veen TAB, Bezzina CR, Remme CA.

Eur Heart J. 2018 Aug 14;39(31):2898-2907. doi: 10.1093/eurheartj/ehy247.

PMID:
29718149
6.

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling.

van den Hoogenhof MMG, Beqqali A, Amin AS, van der Made I, Aufiero S, Khan MAF, Schumacher CA, Jansweijer JA, van Spaendonck-Zwarts KY, Remme CA, Backs J, Verkerk AO, Baartscheer A, Pinto YM, Creemers EE.

Circulation. 2018 Apr 12. pii: CIRCULATIONAHA.117.031947. doi: 10.1161/CIRCULATIONAHA.117.031947. [Epub ahead of print]

PMID:
29650543
7.

Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons.

Aufiero S, van den Hoogenhof MMG, Reckman YJ, Beqqali A, van der Made I, Kluin J, Khan MAF, Pinto YM, Creemers EE.

RNA. 2018 Jun;24(6):815-827. doi: 10.1261/rna.064394.117. Epub 2018 Mar 22.

PMID:
29567830
8.

Circulating Circles Predict Postoperative Atrial Fibrillation.

Reckman YJ, Creemers EE.

J Am Heart Assoc. 2018 Jan 22;7(2). pii: e008261. doi: 10.1161/JAHA.117.008261. No abstract available.

9.

Small sample sizes in high-throughput miRNA screens: A common pitfall for the identification of miRNA biomarkers.

Kok MGM, de Ronde MWJ, Moerland PD, Ruijter JM, Creemers EE, Pinto-Sietsma SJ.

Biomol Detect Quantif. 2017 Dec 18;15:1-5. doi: 10.1016/j.bdq.2017.11.002. eCollection 2018 May.

10.

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart.

van Eldik W, den Adel B, Monshouwer-Kloots J, Salvatori D, Maas S, van der Made I, Creemers EE, Frank D, Frey N, Boontje N, van der Velden J, Steendijk P, Mummery C, Passier R, Beqqali A.

PLoS One. 2017 Dec 5;12(12):e0189139. doi: 10.1371/journal.pone.0189139. eCollection 2017.

11.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N.

Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z.

12.

The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice.

van den Hoogenhof MMG, van der Made I, Beqqali A, de Groot NE, Damanafshan A, van Oort RJ, Pinto YM, Creemers EE.

PLoS One. 2017 Aug 29;12(8):e0184093. doi: 10.1371/journal.pone.0184093. eCollection 2017.

13.

High miR-124-3p expression identifies smoking individuals susceptible to atherosclerosis.

de Ronde MWJ, Kok MGM, Moerland PD, Van den Bossche J, Neele AE, Halliani A, van der Made I, de Winther MPJ, Meijers JCM, Creemers EE, Pinto-Sietsma SJ.

Atherosclerosis. 2017 Aug;263:377-384. doi: 10.1016/j.atherosclerosis.2017.03.045. Epub 2017 Apr 5.

14.

Circular RNAs in heart failure.

Devaux Y, Creemers EE, Boon RA, Werfel S, Thum T, Engelhardt S, Dimmeler S, Squire I; Cardiolinc network.

Eur J Heart Fail. 2017 Jun;19(6):701-709. doi: 10.1002/ejhf.801. Epub 2017 Mar 27. Review.

15.

Practical data handling pipeline improves performance of qPCR-based circulating miRNA measurements.

de Ronde MWJ, Ruijter JM, Lanfear D, Bayes-Genis A, Kok MGM, Creemers EE, Pinto YM, Pinto-Sietsma SJ.

RNA. 2017 May;23(5):811-821. doi: 10.1261/rna.059063.116. Epub 2017 Feb 15.

16.

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.

Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.

J Am Heart Assoc. 2017 Feb 10;6(2). pii: e003601. doi: 10.1161/JAHA.116.003601.

17.

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.

McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM.

PLoS One. 2017 Feb 3;12(2):e0170458. doi: 10.1371/journal.pone.0170458. eCollection 2017.

18.

RBM20 Regulates Circular RNA Production From the Titin Gene.

Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM.

Circ Res. 2016 Oct 14;119(9):996-1003. Epub 2016 Aug 16.

PMID:
27531932
19.

A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism.

Beqqali A, Bollen IA, Rasmussen TB, van den Hoogenhof MM, van Deutekom HW, Schafer S, Haas J, Meder B, Sørensen KE, van Oort RJ, Mogensen J, Hubner N, Creemers EE, van der Velden J, Pinto YM.

Cardiovasc Res. 2016 Oct;112(1):452-63. doi: 10.1093/cvr/cvw192. Epub 2016 Aug 5.

PMID:
27496873
20.

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress.

Sergeeva IA, Hooijkaas IB, Ruijter JM, van der Made I, de Groot NE, van de Werken HJ, Creemers EE, Christoffels VM.

Development. 2016 Jun 15;143(12):2135-46. doi: 10.1242/dev.132019. Epub 2016 Apr 5.

21.

RNA Splicing: Regulation and Dysregulation in the Heart.

van den Hoogenhof MM, Pinto YM, Creemers EE.

Circ Res. 2016 Feb 5;118(3):454-68. doi: 10.1161/CIRCRESAHA.115.307872. Review.

PMID:
26846640
22.

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Creemers EE, Bawazeer A, Ugalde AP, van Deutekom HW, van der Made I, de Groot NE, Adriaens ME, Cook SA, Bezzina CR, Hubner N, van der Velden J, Elkon R, Agami R, Pinto YM.

Circ Res. 2016 Feb 5;118(3):433-8. doi: 10.1161/CIRCRESAHA.115.307082. Epub 2015 Dec 15. Erratum in: Circ Res. 2016 Oct 14;119(9):e139.

PMID:
26671978
23.

Function and Therapeutic Potential of Noncoding RNAs in Cardiac Fibrosis.

Creemers EE, van Rooij E.

Circ Res. 2016 Jan 8;118(1):108-18. doi: 10.1161/CIRCRESAHA.115.305242. Epub 2015 Nov 4. Review.

PMID:
26538569
24.

Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity.

Kok MG, Mandolini C, Moerland PD, de Ronde MW, Sondermeijer BM, Halliani A, Nieuwland R, Cipollone F, Creemers EE, Meijers JC, Pinto-Sietsma SJ.

Int J Cardiol. 2016 Jan 15;203:262-3. doi: 10.1016/j.ijcard.2015.10.098. Epub 2015 Oct 23. No abstract available.

PMID:
26519680
25.

Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling.

Medzikovic L, Schumacher CA, Verkerk AO, van Deel ED, Wolswinkel R, van der Made I, Bleeker N, Cakici D, van den Hoogenhof MM, Meggouh F, Creemers EE, Remme CA, Baartscheer A, de Winter RJ, de Vries CJ, Arkenbout EK, de Waard V.

Sci Rep. 2015 Oct 21;5:15404. doi: 10.1038/srep15404.

26.

Normalization panels for the reliable quantification of circulating microRNAs by RT-qPCR.

Kok MG, Halliani A, Moerland PD, Meijers JC, Creemers EE, Pinto-Sietsma SJ.

FASEB J. 2015 Sep;29(9):3853-62. doi: 10.1096/fj.15-271312. Epub 2015 May 28.

PMID:
26023181
27.

Long noncoding RNAs in cardiac development and ageing.

Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW 2nd, Thum T, Heymans S; Cardiolinc network.

Nat Rev Cardiol. 2015 Jul;12(7):415-25. doi: 10.1038/nrcardio.2015.55. Epub 2015 Apr 7. Review.

PMID:
25855606
28.

Insights into alternative splicing of sarcomeric genes in the heart.

Weeland CJ, van den Hoogenhof MM, Beqqali A, Creemers EE.

J Mol Cell Cardiol. 2015 Apr;81:107-13. doi: 10.1016/j.yjmcc.2015.02.008. Epub 2015 Feb 12. Review.

PMID:
25683494
29.

The microRNA-15 family inhibits the TGFβ-pathway in the heart.

Tijsen AJ, van der Made I, van den Hoogenhof MM, Wijnen WJ, van Deel ED, de Groot NE, Alekseev S, Fluiter K, Schroen B, Goumans MJ, van der Velden J, Duncker DJ, Pinto YM, Creemers EE.

Cardiovasc Res. 2014 Oct 1;104(1):61-71. doi: 10.1093/cvr/cvu184. Epub 2014 Aug 7.

PMID:
25103110
30.

Individual with subclinical atherosclerosis have impaired proliferation of blood outgrowth endothelial cells, which can be restored by statin therapy.

Martin-Ramirez J, Kok MG, Hofman M, Bierings R, Creemers EE, Meijers JC, Voorberg J, Pinto-Sietsma SJ.

PLoS One. 2014 Jun 23;9(6):e99890. doi: 10.1371/journal.pone.0099890. eCollection 2014.

31.

Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy.

Wijnen WJ, van der Made I, van den Oever S, Hiller M, de Boer BA, Picavet DI, Chatzispyrou IA, Houtkooper RH, Tijsen AJ, Hagoort J, van Veen H, Everts V, Ruijter JM, Pinto YM, Creemers EE.

PLoS One. 2014 May 2;9(5):e96290. doi: 10.1371/journal.pone.0096290. eCollection 2014.

32.

Matrix as an interstitial transport system.

Fan D, Creemers EE, Kassiri Z.

Circ Res. 2014 Feb 28;114(5):889-902. doi: 10.1161/CIRCRESAHA.114.302335. Review.

PMID:
24577968
33.

A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease.

Sergeeva IA, Hooijkaas IB, Van Der Made I, Jong WM, Creemers EE, Christoffels VM.

Cardiovasc Res. 2014 Jan 1;101(1):78-86. doi: 10.1093/cvr/cvt228. Epub 2013 Oct 8.

PMID:
24104878
34.

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stöger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schürmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, de Windt LJ, Lutgens E, Wouters K, de Winther MP, Zacchigna S, Giacca M, van Bilsen M, Papageorgiou AP, Schroen B.

Circulation. 2013 Sep 24;128(13):1420-32. doi: 10.1161/CIRCULATIONAHA.112.001357. Epub 2013 Aug 16.

PMID:
23956210
35.

The therapeutic potential of miRNAs in cardiac fibrosis: where do we stand?

Wijnen WJ, Pinto YM, Creemers EE.

J Cardiovasc Transl Res. 2013 Dec;6(6):899-908. doi: 10.1007/s12265-013-9483-y. Epub 2013 Jul 3. Review.

PMID:
23821466
36.

Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases.

Tijsen AJ, Pinto YM, Creemers EE.

Am J Physiol Heart Circ Physiol. 2012 Nov 1;303(9):H1085-95. doi: 10.1152/ajpheart.00191.2012. Epub 2012 Aug 31. Review.

37.

Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.

Leenders JJ, Wijnen WJ, van der Made I, Hiller M, Swinnen M, Vandendriessche T, Chuah M, Pinto YM, Creemers EE.

PLoS One. 2012;7(5):e36754. doi: 10.1371/journal.pone.0036754. Epub 2012 May 7.

38.

Monocyte gene expression signature of patients with early onset coronary artery disease.

Sivapalaratnam S, Basart H, Watkins NA, Maiwald S, Rendon A, Krishnan U, Sondermeijer BM, Creemers EE, Pinto-Sietsma SJ, Hovingh K, Ouwehand WH, Kastelein JJ, Goodall AH, Trip MD.

PLoS One. 2012;7(2):e32166. doi: 10.1371/journal.pone.0032166. Epub 2012 Feb 21.

39.

Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?

Creemers EE, Tijsen AJ, Pinto YM.

Circ Res. 2012 Feb 3;110(3):483-95. doi: 10.1161/CIRCRESAHA.111.247452. Review.

PMID:
22302755
40.

MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration.

Mokalled MH, Johnson AN, Creemers EE, Olson EN.

Genes Dev. 2012 Jan 15;26(2):190-202. doi: 10.1101/gad.179663.111.

41.

Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner.

Amin AS, Giudicessi JR, Tijsen AJ, Spanjaart AM, Reckman YJ, Klemens CA, Tanck MW, Kapplinger JD, Hofman N, Sinner MF, Müller M, Wijnen WJ, Tan HL, Bezzina CR, Creemers EE, Wilde AA, Ackerman MJ, Pinto YM.

Eur Heart J. 2012 Mar;33(6):714-23. doi: 10.1093/eurheartj/ehr473. Epub 2011 Dec 23.

42.

Non-cardiomyocyte microRNAs in heart failure.

Tijsen AJ, Pinto YM, Creemers EE.

Cardiovasc Res. 2012 Mar 15;93(4):573-82. doi: 10.1093/cvr/cvr344. Epub 2011 Dec 16. Review.

PMID:
22180601
43.

Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*.

Sondermeijer BM, Bakker A, Halliani A, de Ronde MW, Marquart AA, Tijsen AJ, Mulders TA, Kok MG, Battjes S, Maiwald S, Sivapalaratnam S, Trip MD, Moerland PD, Meijers JC, Creemers EE, Pinto-Sietsma SJ.

PLoS One. 2011;6(10):e25946. doi: 10.1371/journal.pone.0025946. Epub 2011 Oct 13.

44.

Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling.

Leenders JJ, Pinto YM, Creemers EE.

J Mol Cell Cardiol. 2011 Aug;51(2):156-67. doi: 10.1016/j.yjmcc.2011.04.017. Epub 2011 May 7. Review.

PMID:
21586293
45.

Heart failure: advances through genomics.

Creemers EE, Wilde AA, Pinto YM.

Nat Rev Genet. 2011 May;12(5):357-62. doi: 10.1038/nrg2983. Epub 2011 Mar 22. Review.

PMID:
21423240
46.

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart.

Creemers EE, Pinto YM.

Cardiovasc Res. 2011 Feb 1;89(2):265-72. doi: 10.1093/cvr/cvq308. Epub 2010 Sep 28. Review.

PMID:
20880837
47.

Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.

Leenders JJ, Wijnen WJ, Hiller M, van der Made I, Lentink V, van Leeuwen RE, Herias V, Pokharel S, Heymans S, de Windt LJ, Høydal MA, Pinto YM, Creemers EE.

J Biol Chem. 2010 Aug 27;285(35):27449-56. doi: 10.1074/jbc.M110.107292. Epub 2010 Jun 21.

48.

MiR423-5p as a circulating biomarker for heart failure.

Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE, Pinto YM.

Circ Res. 2010 Apr 2;106(6):1035-9. doi: 10.1161/CIRCRESAHA.110.218297. Epub 2010 Feb 25.

PMID:
20185794
49.

miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling.

Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, van der Made I, Herias V, van Leeuwen RE, Schellings MW, Barenbrug P, Maessen JG, Heymans S, Pinto YM, Creemers EE.

Circ Res. 2009 Jan 30;104(2):170-8, 6p following 178. doi: 10.1161/CIRCRESAHA.108.182535. Epub 2008 Dec 18.

PMID:
19096030
50.

Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function.

French WJ, Creemers EE, Tallquist MD.

Mol Cell Biol. 2008 Sep;28(18):5646-57. doi: 10.1128/MCB.00441-08. Epub 2008 Jul 7.

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