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Items: 1 to 50 of 65

1.

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Gutu AD, Hertzog P, Purcell T, Shen HH, Moskowitz SM, Velkov T, Li J.

mSystems. 2019 Jan 8;4(1). pii: e00149-18. doi: 10.1128/mSystems.00149-18. eCollection 2019 Jan-Feb.

2.

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa.

Hussein M, Han ML, Zhu Y, Schneider-Futschik EK, Hu X, Zhou QT, Lin YW, Anderson D, Creek DJ, Hoyer D, Li J, Velkov T.

Comput Struct Biotechnol J. 2018 Nov 10;16:587-599. doi: 10.1016/j.csbj.2018.11.001. eCollection 2018.

3.

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii.

Han ML, Liu X, Velkov T, Lin YW, Zhu Y, Li M, Yu HH, Zhou Z, Creek DJ, Zhang J, Li J.

Front Microbiol. 2018 Nov 16;9:2776. doi: 10.3389/fmicb.2018.02776. eCollection 2018.

4.

Discovery and Validation of Clinical Biomarkers of Cancer: A Review Combining Metabolomics and Proteomics.

Srivastava A, Creek DJ.

Proteomics. 2018 Oct 24:e1700448. doi: 10.1002/pmic.201700448. [Epub ahead of print] Review.

PMID:
30353665
5.

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP.

PLoS Negl Trop Dis. 2018 May 14;12(5):e0006450. doi: 10.1371/journal.pntd.0006450. eCollection 2018 May.

6.

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study.

Tran TB, Bergen PJ, Creek DJ, Velkov T, Li J.

Front Pharmacol. 2018 Apr 16;9:359. doi: 10.3389/fphar.2018.00359. eCollection 2018.

7.

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline).

Wang M, Gustafsson OJR, Siddiqui G, Javed I, Kelly HG, Blin T, Yin H, Kent SJ, Creek DJ, Kempe K, Ke PC, Davis TP.

Nanoscale. 2018 Jun 14;10(23):10863-10875. doi: 10.1039/c8nr00835c.

PMID:
29658020
8.

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Anderson D, Shen HH, Tsuji B, Gutu AD, Moskowitz SM, Velkov T, Li J.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02656-17. doi: 10.1128/AAC.02656-17. Print 2018 Jun.

9.

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.

Tjhin ET, Spry C, Sewell AL, Hoegl A, Barnard L, Sexton AE, Siddiqui G, Howieson VM, Maier AG, Creek DJ, Strauss E, Marquez R, Auclair K, Saliba KJ.

PLoS Pathog. 2018 Apr 3;14(4):e1006918. doi: 10.1371/journal.ppat.1006918. eCollection 2018 Apr.

10.

A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages.

Chou ES, Abidi SZ, Teye M, Leliwa-Sytek A, Rask TS, Cobbold SA, Tonkin-Hill GQ, Subramaniam KS, Sexton AE, Creek DJ, Daily JP, Duffy MF, Day KP.

FEBS J. 2018 Mar;285(5):848-870. doi: 10.1111/febs.14370. Epub 2018 Jan 11.

PMID:
29281179
11.

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.

Giannangelo C, Stingelin L, Yang T, Tilley L, Charman SA, Creek DJ.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01566-17. doi: 10.1128/AAC.01566-17. Print 2018 Mar.

12.

Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles.

Wang M, Siddiqui G, Gustafsson OJR, Käkinen A, Javed I, Voelcker NH, Creek DJ, Ke PC, Davis TP.

Small. 2017 Sep;13(36). doi: 10.1002/smll.201701528. Epub 2017 Aug 7.

PMID:
28783260
13.

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

Mwenechanya R, Kovářová J, Dickens NJ, Mudaliar M, Herzyk P, Vincent IM, Weidt SK, Burgess KE, Burchmore RJS, Pountain AW, Smith TK, Creek DJ, Kim DH, Lepesheva GI, Barrett MP.

PLoS Negl Trop Dis. 2017 Jun 16;11(6):e0005649. doi: 10.1371/journal.pntd.0005649. eCollection 2017 Jun.

14.

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.

Alzahrani KJH, Ali JAM, Eze AA, Looi WL, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP.

Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):206-226. doi: 10.1016/j.ijpddr.2017.04.003. Epub 2017 Apr 20.

15.

Global Gene Expression Profile of Acinetobacter baumannii During Bacteremia.

Murray GL, Tsyganov K, Kostoulias XP, Bulach DM, Powell D, Creek DJ, Boyce JD, Paulsen IT, Peleg AY.

J Infect Dis. 2017 Feb 15;215(suppl_1):S52-S57. doi: 10.1093/infdis/jiw529.

PMID:
28375520
16.

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum.

Siddiqui G, Srivastava A, Russell AS, Creek DJ.

J Infect Dis. 2017 May 1;215(9):1435-1444. doi: 10.1093/infdis/jix156.

PMID:
28368494
17.

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii.

Maifiah MH, Creek DJ, Nation RL, Forrest A, Tsuji BT, Velkov T, Li J.

Sci Rep. 2017 Mar 30;7:45527. doi: 10.1038/srep45527.

18.

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate.

Counihan NA, Chisholm SA, Bullen HE, Srivastava A, Sanders PR, Jonsdottir TK, Weiss GE, Ghosh S, Crabb BS, Creek DJ, Gilson PR, de Koning-Ward TF.

Elife. 2017 Mar 2;6. pii: e23217. doi: 10.7554/eLife.23217.

19.

Metabolomics-Based Elucidation of Active Metabolic Pathways in Erythrocytes and HSC-Derived Reticulocytes.

Srivastava A, Evans KJ, Sexton AE, Schofield L, Creek DJ.

J Proteome Res. 2017 Apr 7;16(4):1492-1505. doi: 10.1021/acs.jproteome.6b00902. Epub 2017 Mar 1.

PMID:
28166632
20.

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.

Srivastava A, Philip N, Hughes KR, Georgiou K, MacRae JI, Barrett MP, Creek DJ, McConville MJ, Waters AP.

PLoS Pathog. 2016 Dec 27;12(12):e1006094. doi: 10.1371/journal.ppat.1006094. eCollection 2016 Dec.

21.

Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics.

Srivastava A, Kowalski GM, Callahan DL, Meikle PJ, Creek DJ.

Metabolites. 2016 Oct 1;6(4). pii: E32.

22.

Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells.

Peterson AL, Walker AK, Sloan EK, Creek DJ.

Metabolites. 2016 Sep 22;6(4). pii: E30. doi: 10.3390/metabo6040030.

23.

An oncogenic role for sphingosine kinase 2.

Neubauer HA, Pham DH, Zebol JR, Moretti PA, Peterson AL, Leclercq TM, Chan H, Powell JA, Pitman MR, Samuel MS, Bonder CS, Creek DJ, Gliddon BL, Pitson SM.

Oncotarget. 2016 Oct 4;7(40):64886-64899. doi: 10.18632/oncotarget.11714.

24.

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.

Creek DJ, Chua HH, Cobbold SA, Nijagal B, MacRae JI, Dickerman BK, Gilson PR, Ralph SA, McConville MJ.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6650-6663. doi: 10.1128/AAC.01226-16. Print 2016 Nov.

25.

Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis.

Bhuiyan MS, Ellett F, Murray GL, Kostoulias X, Cerqueira GM, Schulze KE, Mahamad Maifiah MH, Li J, Creek DJ, Lieschke GJ, Peleg AY.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9599-604. doi: 10.1073/pnas.1523116113. Epub 2016 Aug 9.

26.

Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria.

Tchaparian E, Sambol NC, Arinaitwe E, McCormack SA, Bigira V, Wanzira H, Muhindo M, Creek DJ, Sukumar N, Blessborn D, Tappero JW, Kakuru A, Bergqvist Y, Aweeka FT, Parikh S.

J Infect Dis. 2016 Oct 15;214(8):1243-51. doi: 10.1093/infdis/jiw338. Epub 2016 Jul 28.

27.

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains.

Yang T, Xie SC, Cao P, Giannangelo C, McCaw J, Creek DJ, Charman SA, Klonis N, Tilley L.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4501-10. doi: 10.1128/AAC.00574-16. Print 2016 Aug.

28.

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii.

Maifiah MH, Cheah SE, Johnson MD, Han ML, Boyce JD, Thamlikitkul V, Forrest A, Kaye KS, Hertzog P, Purcell AW, Song J, Velkov T, Creek DJ, Li J.

Sci Rep. 2016 Feb 29;6:22287. doi: 10.1038/srep22287.

29.

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

Aurelio L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek DJ, Pitson SM, Flynn BL.

J Med Chem. 2016 Feb 11;59(3):965-84. doi: 10.1021/acs.jmedchem.5b01439. Epub 2016 Feb 3.

PMID:
26780304
30.

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii.

Tran TB, Cheah SE, Yu HH, Bergen PJ, Nation RL, Creek DJ, Purcell A, Forrest A, Doi Y, Song J, Velkov T, Li J.

J Antibiot (Tokyo). 2016 Jun;69(6):415-21. doi: 10.1038/ja.2015.127. Epub 2015 Dec 16.

31.

Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs.

Cobbold SA, Chua HH, Nijagal B, Creek DJ, Ralph SA, McConville MJ.

J Infect Dis. 2016 Jan 15;213(2):276-86. doi: 10.1093/infdis/jiv372. Epub 2015 Jul 6.

PMID:
26150544
32.

Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites.

Srivastava A, Creek DJ, Evans KJ, De Souza D, Schofield L, Müller S, Barrett MP, McConville MJ, Waters AP.

PLoS Pathog. 2015 Jun 4;11(6):e1004882. doi: 10.1371/journal.ppat.1004882. eCollection 2015 Jun.

33.

What role can metabolomics play in the discovery and development of new medicines for infectious diseases?

Kim DH, Creek DJ.

Bioanalysis. 2015;7(6):629-31. doi: 10.4155/bio.15.5. No abstract available.

PMID:
25871581
34.

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.

Creek DJ, Mazet M, Achcar F, Anderson J, Kim DH, Kamour R, Morand P, Millerioux Y, Biran M, Kerkhoven EJ, Chokkathukalam A, Weidt SK, Burgess KE, Breitling R, Watson DG, Bringaud F, Barrett MP.

PLoS Pathog. 2015 Mar 16;11(3):e1004689. doi: 10.1371/journal.ppat.1004689. eCollection 2015 Mar.

35.

Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria.

Sambol NC, Yan L, Creek DJ, McCormack SA, Arinaitwe E, Bigira V, Wanzira H, Kakuru A, Tappero JW, Lindegardh N, Tarning J, Nosten F, Aweeka FT, Parikh S.

Clin Pharmacol Ther. 2015 Jul;98(1):87-95. doi: 10.1002/cpt.104. Epub 2015 May 2.

36.

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.

Trochine A, Creek DJ, Faral-Tello P, Barrett MP, Robello C.

Antimicrob Agents Chemother. 2015 May;59(5):2921-5. doi: 10.1128/AAC.05046-14. Epub 2015 Feb 23.

37.

An attenuated total reflection (ATR) and Raman spectroscopic investigation into the effects of chloroquine on Plasmodium falciparum-infected red blood cells.

Kozicki M, Creek DJ, Sexton A, Morahan BJ, Wesełucha-Birczyńska A, Wood BR.

Analyst. 2015 Apr 7;140(7):2236-46. doi: 10.1039/c4an01904k.

PMID:
25654140
38.

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.

Alkhaldi AA, Creek DJ, Ibrahim H, Kim DH, Quashie NB, Burgess KE, Changtam C, Barrett MP, Suksamrarn A, de Koning HP.

Mol Pharmacol. 2015;87(3):451-64. doi: 10.1124/mol.114.096016. Epub 2014 Dec 19.

39.

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F.

Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44. doi: 10.1093/nar/gku944. Epub 2014 Oct 9.

40.

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.

Oppenheim RD, Creek DJ, Macrae JI, Modrzynska KK, Pino P, Limenitakis J, Polonais V, Seeber F, Barrett MP, Billker O, McConville MJ, Soldati-Favre D.

PLoS Pathog. 2014 Jul 17;10(7):e1004263. doi: 10.1371/journal.ppat.1004263. eCollection 2014 Jul.

41.

Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.

Trochine A, Creek DJ, Faral-Tello P, Barrett MP, Robello C.

PLoS Negl Trop Dis. 2014 May 22;8(5):e2844. doi: 10.1371/journal.pntd.0002844. eCollection 2014 May.

42.

Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks.

Chokkathukalam A, Kim DH, Barrett MP, Breitling R, Creek DJ.

Bioanalysis. 2014 Feb;6(4):511-24. doi: 10.4155/bio.13.348. Review.

43.

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins.

Klonis N, Creek DJ, Tilley L.

Curr Opin Microbiol. 2013 Dec;16(6):722-7. doi: 10.1016/j.mib.2013.07.005. Epub 2013 Aug 7. Review.

PMID:
23932203
44.

Stable isotope labeled metabolomics improves identification of novel metabolites and pathways.

Creek DJ.

Bioanalysis. 2013 Aug;5(15):1807-10. doi: 10.4155/bio.13.131. No abstract available.

45.

Determination of antiprotozoal drug mechanisms by metabolomics approaches.

Creek DJ, Barrett MP.

Parasitology. 2014 Jan;141(1):83-92. doi: 10.1017/S0031182013000814. Epub 2013 Jun 5. Review.

46.

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.

Creek DJ, Nijagal B, Kim DH, Rojas F, Matthews KR, Barrett MP.

Antimicrob Agents Chemother. 2013 Jun;57(6):2768-79. doi: 10.1128/AAC.00044-13. Epub 2013 Apr 9.

47.

Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants.

Creek DJ, Bigira V, McCormack S, Arinaitwe E, Wanzira H, Kakuru A, Tappero JW, Sandison TG, Lindegardh N, Nosten F, Aweeka FT, Parikh S.

J Infect Dis. 2013 Jun 1;207(11):1646-54. doi: 10.1093/infdis/jit078. Epub 2013 Feb 27.

48.

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii.

Limenitakis J, Oppenheim RD, Creek DJ, Foth BJ, Barrett MP, Soldati-Favre D.

Mol Microbiol. 2013 Feb;87(4):894-908. doi: 10.1111/mmi.12139. Epub 2013 Jan 11.

49.

Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.

Ali JA, Creek DJ, Burgess K, Allison HC, Field MC, Mäser P, De Koning HP.

Mol Pharmacol. 2013 Feb;83(2):439-53. doi: 10.1124/mol.112.082321. Epub 2012 Nov 27.

50.

mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data.

Chokkathukalam A, Jankevics A, Creek DJ, Achcar F, Barrett MP, Breitling R.

Bioinformatics. 2013 Jan 15;29(2):281-3. doi: 10.1093/bioinformatics/bts674. Epub 2012 Nov 17.

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