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The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review.

Cree IA, Uttley L, Buckley Woods H, Kikuchi H, Reiman A, Harnan S, Whiteman BL, Philips ST, Messenger M, Cox A, Teare D, Sheils O, Shaw J; UK Early Cancer Detection Consortium.

BMC Cancer. 2017 Oct 23;17(1):697. doi: 10.1186/s12885-017-3693-7. Review.


Validation of an NGS mutation detection panel for melanoma.

Reiman A, Kikuchi H, Scocchia D, Smith P, Tsang YW, Snead D, Cree IA.

BMC Cancer. 2017 Feb 22;17(1):150. doi: 10.1186/s12885-017-3149-0.


Molecular chess? Hallmarks of anti-cancer drug resistance.

Cree IA, Charlton P.

BMC Cancer. 2017 Jan 5;17(1):10. doi: 10.1186/s12885-016-2999-1. Review.


Simultaneous automatic scoring and co-registration of hormone receptors in tumor areas in whole slide images of breast cancer tissue slides.

Trahearn N, Tsang YW, Cree IA, Snead D, Epstein D, Rajpoot N.

Cytometry A. 2017 Jun;91(6):585-594. doi: 10.1002/cyto.a.23035. Epub 2016 Dec 23.


Progress and potential of RAS mutation detection for diagnostics and companion diagnostics.

Cree IA.

Expert Rev Mol Diagn. 2016 Oct;16(10):1067-1072. Epub 2016 Aug 17. Review.


Chronic tarsal conjunctivitis.

Cook N, Mushtaq F, Leitner C, Ilchyshyn A, Smith GT, Cree IA.

BMC Ophthalmol. 2016 Jul 29;16:130. doi: 10.1186/s12886-016-0294-1.


Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review.

Uttley L, Whiteman BL, Woods HB, Harnan S, Philips ST, Cree IA; Early Cancer Detection Consortium.

EBioMedicine. 2016 Aug;10:164-73. doi: 10.1016/j.ebiom.2016.07.004. Epub 2016 Jul 6. Review.


Diagnostic RAS mutation analysis by polymerase chain reaction (PCR).

Cree IA.

Biomol Detect Quantif. 2016 Jun 6;8:29-32. doi: 10.1016/j.bdq.2016.05.001. eCollection 2016 Jun.


PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation.

Cree IA, Booton R, Cane P, Gosney J, Ibrahim M, Kerr K, Lal R, Lewanski C, Navani N, Nicholson AG, Nicolson M, Summers Y.

Histopathology. 2016 Aug;69(2):177-86. doi: 10.1111/his.12996. Epub 2016 Jun 30. Review. Erratum in: Histopathology. 2017 Jan;70(2):318.


Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images.

Sirinukunwattana K, Ahmed Raza SE, Yee-Wah Tsang, Snead DR, Cree IA, Rajpoot NM.

IEEE Trans Med Imaging. 2016 May;35(5):1196-1206. doi: 10.1109/TMI.2016.2525803. Epub 2016 Feb 4.


Molecular testing for familial hypercholesterolaemia-associated mutations in a UK-based cohort: development of an NGS-based method and comparison with multiplex polymerase chain reaction and oligonucleotide arrays.

Reiman A, Pandey S, Lloyd KL, Dyer N, Khan M, Crockard M, Latten MJ, Watson TL, Cree IA, Grammatopoulos DK.

Ann Clin Biochem. 2016 Nov;53(6):654-662. doi: 10.1177/0004563216629170. Epub 2016 Sep 28.


Validation of digital pathology imaging for primary histopathological diagnosis.

Snead DR, Tsang YW, Meskiri A, Kimani PK, Crossman R, Rajpoot NM, Blessing E, Chen K, Gopalakrishnan K, Matthews P, Momtahan N, Read-Jones S, Sah S, Simmons E, Sinha B, Suortamo S, Yeo Y, El Daly H, Cree IA.

Histopathology. 2016 Jun;68(7):1063-72. doi: 10.1111/his.12879. Epub 2015 Dec 6.


A multicentre validation of Metasin: a molecular assay for the intraoperative assessment of sentinel lymph nodes from breast cancer patients.

Sai-Giridhar P, Al-Ramadhani S, George D, Gopinath P, Andrews W, Jader S, Brown S, Findlay A, Arkoumani E, Al-Sam S, McKenzie JG, Bradpiece H, Jenkins S, Aylwin A, Holt S, Sharaiha Y, Yiangou C, Agrawal A, McDowell A, Gabriel FG, Jeffrey M, Agrawal N, Cree IA, Mansel RE, Keshtgar M, McDermott N, El Sheikh S, Wellsted D, Collard J, Chaplin H, Landt O, Bustin S, Sundaresan M, Sundaresan V.

Histopathology. 2016 May;68(6):875-87. doi: 10.1111/his.12863. Epub 2016 Jan 4.


Prediction of resistance to chemotherapy in ovarian cancer: a systematic review.

Lloyd KL, Cree IA, Savage RS.

BMC Cancer. 2015 Mar 11;15:117. doi: 10.1186/s12885-015-1101-8. Review.


Genomics driven-oncology: challenges and perspectives.

Normanno N, Cree IA.

BMC Cancer. 2015 Mar 23;15:141. doi: 10.1186/s12885-015-1147-7. Review.


The interplay of the gut microbiome, bile acids, and volatile organic compounds.

Sagar NM, Cree IA, Covington JA, Arasaradnam RP.

Gastroenterol Res Pract. 2015;2015:398585. doi: 10.1155/2015/398585. Epub 2015 Mar 3. Review.


Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium.

Tops BB, Normanno N, Kurth H, Amato E, Mafficini A, Rieber N, Le Corre D, Rachiglio AM, Reiman A, Sheils O, Noppen C, Lacroix L, Cree IA, Scarpa A, Ligtenberg MJ, Laurent-Puig P.

BMC Cancer. 2015 Jan 31;15:26. doi: 10.1186/s12885-015-1015-5.


KRAS mutation analysis by PCR: a comparison of two methods.

Bolton L, Reiman A, Lucas K, Timms J, Cree IA.

PLoS One. 2015 Jan 8;10(1):e0115672. doi: 10.1371/journal.pone.0115672. eCollection 2015.


Guidance for laboratories performing molecular pathology for cancer patients.

Cree IA, Deans Z, Ligtenberg MJ, Normanno N, Edsjö A, Rouleau E, Solé F, Thunnissen E, Timens W, Schuuring E, Dequeker E, Murray S, Dietel M, Groenen P, Van Krieken JH; European Society of Pathology Task Force on Quality Assurance in Molecular Pathology; Royal College of Pathologists.

J Clin Pathol. 2014 Nov;67(11):923-31. doi: 10.1136/jclinpath-2014-202404. Epub 2014 Jul 10. Review.


Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line model.

Glaysher S, Bolton LM, Johnson P, Torrance C, Cree IA.

BMC Res Notes. 2014 Jun 25;7:397. doi: 10.1186/1756-0500-7-397.


A comparison of methods for EGFR mutation testing in non-small cell lung cancer.

Young EC, Owens MM, Adebiyi I, Bedenham T, Butler R, Callaway J, Cranston T, Crosby C, Cree IA, Dutton L, Faulkes C, Faulkner C, Howard E, Knight J, Huang Y, Lavender L, Lazarou LP, Liu H, Mair D, Milano A, Sandell S, Skinner A, Wallace A, Williams M, Spivey V, Goodall J, Frampton J, Ellard S; Clinical Molecular Genetics Society (CMGS) Scientific Subcommittee.

Diagn Mol Pathol. 2013 Dec;22(4):190-5. doi: 10.1097/PDM.0b013e318294936c.


Targeting EGFR and PI3K pathways in ovarian cancer.

Glaysher S, Bolton LM, Johnson P, Atkey N, Dyson M, Torrance C, Cree IA.

Br J Cancer. 2013 Oct 1;109(7):1786-94. doi: 10.1038/bjc.2013.529. Epub 2013 Sep 10.


In vivo confocal microscopy and histopathology of the conjunctiva in trachomatous scarring and normal tissue: a systematic comparison.

Hu VH, Holland MJ, Cree IA, Pullin J, Weiss HA, Massae P, Makupa W, Mabey DC, Bailey RL, Burton MJ, Luthert P.

Br J Ophthalmol. 2013 Oct;97(10):1333-7. doi: 10.1136/bjophthalmol-2013-303126. Epub 2013 Aug 6.


Designing personalised cancer treatments.

Cree IA.

J Control Release. 2013 Dec 10;172(2):405-9. doi: 10.1016/j.jconrel.2013.07.007. Epub 2013 Jul 16.


Guideline on the requirements of external quality assessment programs in molecular pathology.

van Krieken JH, Normanno N, Blackhall F, Boone E, Botti G, Carneiro F, Celik I, Ciardiello F, Cree IA, Deans ZC, Edsjö A, Groenen PJ, Kamarainen O, Kreipe HH, Ligtenberg MJ, Marchetti A, Murray S, Opdam FJ, Patterson SD, Patton S, Pinto C, Rouleau E, Schuuring E, Sterck S, Taron M, Tejpar S, Timens W, Thunnissen E, van de Ven PM, Siebers AG, Dequeker E.

Virchows Arch. 2013 Jan;462(1):27-37. doi: 10.1007/s00428-012-1354-4. Epub 2012 Dec 19.


Improved blood tests for cancer screening: general or specific?

Cree IA.

BMC Cancer. 2011 Nov 30;11:499. doi: 10.1186/1471-2407-11-499.


Identification of markers of prostate cancer progression using candidate gene expression.

Larkin SE, Holmes S, Cree IA, Walker T, Basketter V, Bickers B, Harris S, Garbis SD, Townsend PA, Aukim-Hastie C.

Br J Cancer. 2012 Jan 3;106(1):157-65. doi: 10.1038/bjc.2011.490. Epub 2011 Nov 10.


The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures.

Parker KA, Glaysher S, Hurren J, Knight LA, McCormick D, Suovouri A, Amberger-Murphy V, Pilkington GJ, Cree IA.

Anticancer Drugs. 2012 Jan;23(1):65-9. doi: 10.1097/CAD.0b013e32834b1894.


Circulating tumour markers can define patients with normal colons, benign polyps, and cancers.

Mead R, Duku M, Bhandari P, Cree IA.

Br J Cancer. 2011 Jul 12;105(2):239-45. doi: 10.1038/bjc.2011.230. Epub 2011 Jun 28.


The biology of micrometastases from uveal melanoma.

Borthwick NJ, Thombs J, Polak M, Gabriel FG, Hungerford JL, Damato B, Rennie IG, Jager MJ, Cree IA.

J Clin Pathol. 2011 Aug;64(8):666-71. doi: 10.1136/jcp.2010.087999. Epub 2011 May 18.


Measuring gene expression from cell cultures by quantitative reverse-transcriptase polymerase chain reaction.

Glaysher S, Gabriel FG, Cree IA.

Methods Mol Biol. 2011;731:381-93. doi: 10.1007/978-1-61779-080-5_31.


Cell sensitivity assays: the ATP-based tumor chemosensitivity assay.

Glaysher S, Cree IA.

Methods Mol Biol. 2011;731:247-57. doi: 10.1007/978-1-61779-080-5_21.


Isolation and culture of colon cancer cells and cell lines.

Glaysher S, Cree IA.

Methods Mol Biol. 2011;731:135-40. doi: 10.1007/978-1-61779-080-5_12.


Quality assurance and good laboratory practice.

Knight LA, Cree IA.

Methods Mol Biol. 2011;731:115-24. doi: 10.1007/978-1-61779-080-5_10.


Principles of cancer cell culture.

Cree IA.

Methods Mol Biol. 2011;731:13-26. doi: 10.1007/978-1-61779-080-5_2.


Cancer biology.

Cree IA.

Methods Mol Biol. 2011;731:1-11. doi: 10.1007/978-1-61779-080-5_1. Review.


In vivo confocal microscopy of trachoma in relation to normal tarsal conjunctiva.

Hu VH, Massae P, Weiss HA, Cree IA, Courtright P, Mabey DC, Bailey RL, Burton MJ.

Ophthalmology. 2011 Apr;118(4):747-54. doi: 10.1016/j.ophtha.2010.08.029. Epub 2010 Nov 5.


The molecular basis of the chemosensitivity of metastatic cutaneous melanoma to chemotherapy.

Parker KA, Glaysher S, Polak M, Gabriel FG, Johnson P, Knight LA, Poole M, Narayanan A, Hurren J, Cree IA.

J Clin Pathol. 2010 Nov;63(11):1012-20. doi: 10.1136/jcp.2010.080119. Epub 2010 Oct 5.


Long-term follow-up after submandibular gland transplantation in severe dry eyes secondary to cicatrizing conjunctivitis.

Borrelli M, Schröder C, Dart JK, Collin JR, Sieg P, Cree IA, Matheson MA, Tiffany JM, Proctor G, van Best J, Hyde N, Geerling G.

Am J Ophthalmol. 2010 Dec;150(6):894-904. doi: 10.1016/j.ajo.2010.05.010.


Patterns of expression of DNA repair genes and relapse from melanoma.

Jewell R, Conway C, Mitra A, Randerson-Moor J, Lobo S, Nsengimana J, Harland M, Marples M, Edward S, Cook M, Powell B, Boon A, de Kort F, Parker KA, Cree IA, Barrett JH, Knowles MA, Bishop DT, Newton-Bishop J.

Clin Cancer Res. 2010 Nov 1;16(21):5211-21. doi: 10.1158/1078-0432.CCR-10-1521. Epub 2010 Aug 12.


Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy.

Glaysher S, Gabriel FG, Johnson P, Polak M, Knight LA, Parker K, Poole M, Narayanan A, Cree IA; NHS Collaborative Research Programme for Predictive Oncology.

Br J Cancer. 2010 Aug 24;103(5):656-62. doi: 10.1038/sj.bjc.6605817. Epub 2010 Aug 10.


High-throughput screening of natural products for cancer therapy.

Harvey AL, Cree IA.

Planta Med. 2010 Aug;76(11):1080-6. doi: 10.1055/s-0030-1250162. Epub 2010 Jul 15. Review.


An exploratory investigation of the influence of publication on translational medicine research.

Douet LJ, Preedy D, Thomas V, Cree IA.

J Transl Med. 2010 Jun 23;8:62. doi: 10.1186/1479-5876-8-62.


Efficacy of anti-cancer agents in cell lines versus human primary tumour tissue.

Cree IA, Glaysher S, Harvey AL.

Curr Opin Pharmacol. 2010 Aug;10(4):375-9. doi: 10.1016/j.coph.2010.05.001. Review.


Observational and cost analysis of the implementation of breast cancer sentinel node intraoperative molecular diagnosis.

Cutress RI, McDowell A, Gabriel FG, Gill J, Jeffrey MJ, Agrawal A, Wise M, Raftery J, Cree IA, Yiangou C.

J Clin Pathol. 2010 Jun;63(6):522-9. doi: 10.1136/jcp.2009.072942. Epub 2010 May 3.


The effect of pentamidine on melanoma ex vivo.

Smith J, Stewart BJ, Glaysher S, Peregrin K, Knight LA, Weber DJ, Cree IA.

Anticancer Drugs. 2010 Feb;21(2):181-5. doi: 10.1097/CAD.0b013e3283340cee.


Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC).

Glaysher S, Yiannakis D, Gabriel FG, Johnson P, Polak ME, Knight LA, Goldthorpe Z, Peregrin K, Gyi M, Modi P, Rahamim J, Smith ME, Amer K, Addis B, Poole M, Narayanan A, Gulliford TJ, Andreotti PE, Cree IA.

BMC Cancer. 2009 Aug 27;9:300. doi: 10.1186/1471-2407-9-300.


Recurrence of treated ciliary body melanoma following trabeculectomy.

Tay E, Cree IA, Hungerford J, Franks W.

Clin Exp Ophthalmol. 2009 Jul;37(5):503-5. doi: 10.1111/j.1442-9071.2009.02069.x.


Epidemiological characteristics, predisposing factors and microbiological profiles of infectious corneal ulcers: the Portsmouth corneal ulcer study.

Ibrahim YW, Boase DL, Cree IA.

Br J Ophthalmol. 2009 Oct;93(10):1319-24. doi: 10.1136/bjo.2008.151167. Epub 2009 Jun 4.


Melanoma vaccines: The problems of local immunosuppression.

Polak ME, Borthwick NJ, Jager MJ, Cree IA.

Hum Immunol. 2009 May;70(5):331-9.


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