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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1994 3
1995 9
1996 23
1997 40
1998 50
1999 71
2000 82
2001 98
2002 85
2003 70
2004 94
2005 98
2006 51
2007 51
2008 57
2009 65
2010 75
2011 88
2012 102
2013 100
2014 113
2015 111
2016 126
2017 104
2018 115
2019 119
2020 146
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2022 130
2023 136
2024 39

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2,327 results

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CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
Huang YH, Cai K, Xu PP, Wang L, Huang CX, Fang Y, Cheng S, Sun XJ, Liu F, Huang JY, Ji MM, Zhao WL. Huang YH, et al. Signal Transduct Target Ther. 2021 Jan 11;6(1):10. doi: 10.1038/s41392-020-00437-8. Signal Transduct Target Ther. 2021. PMID: 33431788 Free PMC article.
Among them, CREBBP/EP300 mutations were significantly associated with decreased peripheral blood absolute lymphocyte-to-monocyte ratios, as well as inferior progression-free and overall survival. ...In B-lymphoma murine models, xenografted tumors bearing CREBBP/EP30 …
Among them, CREBBP/EP300 mutations were significantly associated with decreased peripheral blood absolute lymphocyte-to-monocyte rati …
The Role of CREBBP/EP300 and Its Therapeutic Implications in Hematological Malignancies.
Zhu Y, Wang Z, Li Y, Peng H, Liu J, Zhang J, Xiao X. Zhu Y, et al. Cancers (Basel). 2023 Feb 14;15(4):1219. doi: 10.3390/cancers15041219. Cancers (Basel). 2023. PMID: 36831561 Free PMC article. Review.
CREBBP/EP300 dysregulation and CREBBP/EP300-containing complexes are critical for the initiation, progression, and chemoresistance of hematological malignancies. ...In this review, we summarize the role of CREBBP/EP300 in normal hematopoiesis and highlight th …
CREBBP/EP300 dysregulation and CREBBP/EP300-containing complexes are critical for the initiation, progression, and chemoresist …
Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.
Yi F, Cai C, Ruan B, Hao M, Yeo SK, Haas M, Yang F, Zhang X, Guan JL. Yi F, et al. Autophagy. 2023 Jun;19(6):1662-1677. doi: 10.1080/15548627.2022.2148432. Epub 2022 Nov 27. Autophagy. 2023. PMID: 36394358 Free PMC article.
Here, we report acetylation of several lysine residues of RB1CC1 by acetyltransferase CREBBP (CREB binding protein), with K276 as the major CREBBP acetylation site. ...Our findings demonstrate regulation of RB1CC1 by a new post-translational mechanism and suggest po …
Here, we report acetylation of several lysine residues of RB1CC1 by acetyltransferase CREBBP (CREB binding protein), with K276 as the …
CREBBP and p300 lysine acetyl transferases in the DNA damage response.
Dutto I, Scalera C, Prosperi E. Dutto I, et al. Cell Mol Life Sci. 2018 Apr;75(8):1325-1338. doi: 10.1007/s00018-017-2717-4. Epub 2017 Nov 23. Cell Mol Life Sci. 2018. PMID: 29170789 Review.
The CREB-binding protein (CREBBP, or in short CBP) and p300 are lysine (K) acetyl transferases (KAT) belonging to the KAT3 family of proteins known to modify histones, as well as non-histone proteins, thereby regulating chromatin accessibility and transcription. ...
The CREB-binding protein (CREBBP, or in short CBP) and p300 are lysine (K) acetyl transferases (KAT) belonging to the KAT3 family of …
KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.
Vlasevska S, Garcia-Ibanez L, Duval R, Holmes AB, Jahan R, Cai B, Kim A, Mo T, Basso K, Soni RK, Bhagat G, Dalla-Favera R, Pasqualucci L. Vlasevska S, et al. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218330120. doi: 10.1073/pnas.2218330120. Epub 2023 Mar 9. Proc Natl Acad Sci U S A. 2023. PMID: 36893259 Free PMC article.
Here, we show that combined germinal center (GC)-specific haploinsufficiency of Crebbp and Kmt2d synergizes in vivo to promote the expansion of abnormally polarized GCs, a common preneoplastic event. These enzymes form a biochemical complex on select enhancers/superenhance …
Here, we show that combined germinal center (GC)-specific haploinsufficiency of Crebbp and Kmt2d synergizes in vivo to promote the ex …
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. ACS Chem Biol. 2023 Oct 20;18(10):2249-2258. doi: 10.1021/acschembio.3c00293. Epub 2023 Sep 22. ACS Chem Biol. 2023. PMID: 37737090
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. ...Overall, our study demonstrates how knowledge of the relative inhibitor potency can guide the study of EP300/CRE …
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicate …
Rubinstein-Taybi Syndrome: A Model of Epigenetic Disorder.
Van Gils J, Magdinier F, Fergelot P, Lacombe D. Van Gils J, et al. Genes (Basel). 2021 Jun 24;12(7):968. doi: 10.3390/genes12070968. Genes (Basel). 2021. PMID: 34202860 Free PMC article. Review.
It occurs at between 1/100,000 and 1/125,000 births. Two genes are currently known to cause RSTS, CREBBP and EP300, mutated in around 55% and 8% of clinically diagnosed cases, respectively. To date, 500 pathogenic variants have been reported for the CREBBP gene and …
It occurs at between 1/100,000 and 1/125,000 births. Two genes are currently known to cause RSTS, CREBBP and EP300, mutated in around …
Circ-CREBBP promotes cell tumorigenesis and glutamine catabolism in glioma by regulating miR-375/glutaminase axis.
Zhang L, Ye L, Xu Z, Jin Y, Song D. Zhang L, et al. Brain Res. 2022 Jan 15;1775:147730. doi: 10.1016/j.brainres.2021.147730. Epub 2021 Nov 20. Brain Res. 2022. PMID: 34813772
Murine xenograft model was established to investigate the role of circ-CREBBP in vivo. The binding interactions between miR-375 and circ-CREBBP or GLS were confirmed by the dual-luciferase reporter assay. Circ-CREBBP was highly expressed in glioma tissues and …
Murine xenograft model was established to investigate the role of circ-CREBBP in vivo. The binding interactions between miR-375 and c …
Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.
Ding N, Zhang Y, Huang M, Liu J, Wang C, Zhang C, Cao J, Zhang Q, Jiang L. Ding N, et al. Commun Biol. 2022 Dec 7;5(1):1339. doi: 10.1038/s42003-022-04263-2. Commun Biol. 2022. PMID: 36476986 Free PMC article.
In addition, miR-10384 and miR-143-3p can regulate the expression of MCL1, CREB1 and CREBBP. Furthermore, we demonstrated that MCL1 interacted directly with BAX and that CREBBP interacted with CREB1 in sperm. We showed that inhibition of circ-CREBBP can reduc …
In addition, miR-10384 and miR-143-3p can regulate the expression of MCL1, CREB1 and CREBBP. Furthermore, we demonstrated that MCL1 i …
2,327 results