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Items: 1 to 50 of 325

1.

Behavioral Evaluation of Angelman Syndrome Mice at Older Ages.

Dutta R, Crawley JN.

Neuroscience. 2019 Nov 12. pii: S0306-4522(19)30719-5. doi: 10.1016/j.neuroscience.2019.10.027. [Epub ahead of print]

2.

Behavioral analyses of animal models of intellectual and developmental disabilities.

Crawley JN, Fagiolini M, Harrison FE, Samaco R, Wozniak DF, Robinson MB.

Neurobiol Learn Mem. 2019 Nov;165:107087. doi: 10.1016/j.nlm.2019.107087. Epub 2019 Sep 6.

PMID:
31499164
3.

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size.

Le Duc D, Giulivi C, Hiatt SM, Napoli E, Panoutsopoulos A, Harlan De Crescenzo A, Kotzaeridou U, Syrbe S, Anagnostou E, Azage M, Bend R, Begtrup A, Brown NJ, Büttner B, Cho MT, Cooper GM, Doering JH, Dubourg C, Everman DB, Hildebrand MS, Santos FJR, Kellam B, Keller-Ramey J, Lemke JR, Liu S, Niyazov D, Payne K, Person R, Quélin C, Schnur RE, Smith BT, Strober J, Walker S, Wallis M, Walsh L, Yang S, Yuen RKC, Ziegler A, Sticht H, Pride MC, Orosco L, Martínez-Cerdeño V, Silverman JL, Crawley JN, Scherer SW, Zarbalis KS, Jamra R.

Brain. 2019 Sep 1;142(9):2617-2630. doi: 10.1093/brain/awz198. Erratum in: Brain. 2019 Nov 1;142(11):e63.

PMID:
31327001
4.

Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities.

Lauterborn JC, Schultz MN, Le AA, Amani M, Friedman AE, Leach PT, Gall CM, Lynch GS, Crawley JN.

Transl Psychiatry. 2019 Jun 10;9(1):166. doi: 10.1038/s41398-019-0495-5.

5.

Rigor in science and science reporting: updated guidelines for submissions to Molecular Autism.

Buxbaum JD, Baron-Cohen S, Anagnostou E, Ashwin C, Betancur C, Chakrabarti B, Crawley JN, Hoekstra RA, Hof PR, Lai MC, Lombardo MV, Schumann CM.

Mol Autism. 2019 Feb 4;10:6. doi: 10.1186/s13229-018-0249-x. eCollection 2019. No abstract available.

6.

Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.

Rhine MA, Parrott JM, Schultz MN, Kazdoba TM, Crawley JN.

Autism Res. 2019 Mar;12(3):401-421. doi: 10.1002/aur.2066. Epub 2019 Jan 17.

7.

MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome.

Vogel Ciernia A, Yasui DH, Pride MC, Durbin-Johnson B, Noronha AB, Chang A, Knotts TA, Rutkowsky JR, Ramsey JJ, Crawley JN, LaSalle JM.

Hum Mol Genet. 2018 Dec 1;27(23):4077-4093. doi: 10.1093/hmg/ddy301.

8.

Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models.

Deurloo MHS, Turlova E, Chen WL, Lin YW, Tam E, Tassew NG, Wu M, Huang YC, Crawley JN, Monnier PP, Groffen AJA, Sun HS, Osborne LR, Feng ZP.

Mol Neurobiol. 2019 May;56(5):3313-3325. doi: 10.1007/s12035-018-1290-7. Epub 2018 Aug 17.

9.

Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism.

Jones KL, Pride MC, Edmiston E, Yang M, Silverman JL, Crawley JN, Van de Water J.

Mol Psychiatry. 2018 Jun 28. doi: 10.1038/s41380-018-0126-1. [Epub ahead of print]

10.

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.

Matt L, Kirk LM, Chenaux G, Speca DJ, Puhger KR, Pride MC, Qneibi M, Haham T, Plambeck KE, Stern-Bach Y, Silverman JL, Crawley JN, Hell JW, Díaz E.

Cell Rep. 2018 Feb 27;22(9):2246-2253. doi: 10.1016/j.celrep.2018.02.026.

11.

Rigor and reproducibility in rodent behavioral research.

Gulinello M, Mitchell HA, Chang Q, Timothy O'Brien W, Zhou Z, Abel T, Wang L, Corbin JG, Veeraragavan S, Samaco RC, Andrews NA, Fagiolini M, Cole TB, Burbacher TM, Crawley JN.

Neurobiol Learn Mem. 2019 Nov;165:106780. doi: 10.1016/j.nlm.2018.01.001. Epub 2018 Jan 4.

PMID:
29307548
12.

Touchscreen learning deficits in Ube3a, Ts65Dn and Mecp2 mouse models of neurodevelopmental disorders with intellectual disabilities.

Leach PT, Crawley JN.

Genes Brain Behav. 2018 Jul;17(6):e12452. doi: 10.1111/gbb.12452. Epub 2018 Feb 15.

13.

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome.

Berry-Kravis EM, Lindemann L, Jønch AE, Apostol G, Bear MF, Carpenter RL, Crawley JN, Curie A, Des Portes V, Hossain F, Gasparini F, Gomez-Mancilla B, Hessl D, Loth E, Scharf SH, Wang PP, Von Raison F, Hagerman R, Spooren W, Jacquemont S.

Nat Rev Drug Discov. 2018 Apr;17(4):280-299. doi: 10.1038/nrd.2017.221. Epub 2017 Dec 8. Review.

14.

R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice.

Stoppel LJ, Kazdoba TM, Schaffler MD, Preza AR, Heynen A, Crawley JN, Bear MF.

Neuropsychopharmacology. 2018 Feb;43(3):513-524. doi: 10.1038/npp.2017.236. Epub 2017 Oct 6.

15.

Germline Chd8 haploinsufficiency alters brain development in mouse.

Gompers AL, Su-Feher L, Ellegood J, Copping NA, Riyadh MA, Stradleigh TW, Pride MC, Schaffler MD, Wade AA, Catta-Preta R, Zdilar I, Louis S, Kaushik G, Mannion BJ, Plajzer-Frick I, Afzal V, Visel A, Pennacchio LA, Dickel DE, Lerch JP, Crawley JN, Zarbalis KS, Silverman JL, Nord AS.

Nat Neurosci. 2017 Aug;20(8):1062-1073. doi: 10.1038/nn.4592. Epub 2017 Jun 26.

16.

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism.

Dhamne SC, Silverman JL, Super CE, Lammers SHT, Hameed MQ, Modi ME, Copping NA, Pride MC, Smith DG, Rotenberg A, Crawley JN, Sahin M.

Mol Autism. 2017 Jun 15;8:26. doi: 10.1186/s13229-017-0142-z. eCollection 2017.

17.

Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.

Vogel Ciernia A, Pride MC, Durbin-Johnson B, Noronha A, Chang A, Yasui DH, Crawley JN, LaSalle JM.

Hum Mol Genet. 2017 May 15;26(10):1839-1854. doi: 10.1093/hmg/ddx087.

18.

Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.

Yan L, Shamir A, Skirzewski M, Leiva-Salcedo E, Kwon OB, Karavanova I, Paredes D, Malkesman O, Bailey KR, Vullhorst D, Crawley JN, Buonanno A.

Mol Psychiatry. 2018 May;23(5):1233-1243. doi: 10.1038/mp.2017.22. Epub 2017 Mar 21.

19.

Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders.

Sukoff Rizzo SJ, Crawley JN.

Annu Rev Anim Biosci. 2017 Feb 8;5:371-389. doi: 10.1146/annurev-animal-022516-022754. Review.

PMID:
28199172
20.

Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.

Kazdoba TM, Leach PT, Yang M, Silverman JL, Solomon M, Crawley JN.

Curr Top Behav Neurosci. 2016;28:1-52. doi: 10.1007/7854_2015_5003. Review.

21.

Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task.

Leach PT, Hayes J, Pride M, Silverman JL, Crawley JN.

eNeuro. 2016 Mar 15;3(1). pii: ENEURO.0143-15.2016. doi: 10.1523/ENEURO.0143-15.2016. eCollection 2016 Jan-Feb.

22.

Curiosity as an approach to ethoexperimental analysis: Behavioral neuroscience as seen by students and colleagues of Bob Blanchard.

Pearson BL, Crawley JN, Eilam D, Pentkowski NS, Summers CH.

Neurosci Biobehav Rev. 2017 May;76(Pt B):415-422. doi: 10.1016/j.neubiorev.2016.03.012. Epub 2016 Mar 24. Review.

23.

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets.

Crawley JN, Heyer WD, LaSalle JM.

Trends Genet. 2016 Mar;32(3):139-146. doi: 10.1016/j.tig.2016.01.001. Epub 2016 Jan 29. Review.

24.

Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder.

Daimon CM, Jasien JM, Wood WH 3rd, Zhang Y, Becker KG, Silverman JL, Crawley JN, Martin B, Maudsley S.

Front Physiol. 2015 Nov 24;6:324. doi: 10.3389/fphys.2015.00324. eCollection 2015.

25.

16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks.

Yang M, Lewis FC, Sarvi MS, Foley GM, Crawley JN.

Learn Mem. 2015 Nov 16;22(12):622-32. doi: 10.1101/lm.039602.115. Print 2015 Dec.

26.

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.

Kazdoba TM, Hagerman RJ, Zolkowska D, Rogawski MA, Crawley JN.

Psychopharmacology (Berl). 2016 Jan;233(2):309-23. doi: 10.1007/s00213-015-4115-7. Epub 2015 Nov 3.

27.

Behavioral phenotypes of genetic mouse models of autism.

Kazdoba TM, Leach PT, Crawley JN.

Genes Brain Behav. 2016 Jan;15(1):7-26. doi: 10.1111/gbb.12256. Epub 2015 Oct 22. Review.

28.

Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior.

Genestine M, Lin L, Durens M, Yan Y, Jiang Y, Prem S, Bailoor K, Kelly B, Sonsalla PK, Matteson PG, Silverman J, Crawley JN, Millonig JH, DiCicco-Bloom E.

Hum Mol Genet. 2015 Oct 15;24(20):5805-27. doi: 10.1093/hmg/ddv301. Epub 2015 Jul 28.

29.
30.

Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism.

Ellegood J, Crawley JN.

Neurotherapeutics. 2015 Jul;12(3):521-33. doi: 10.1007/s13311-015-0360-z. Review.

31.

GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism.

Silverman JL, Pride MC, Hayes JE, Puhger KR, Butler-Struben HM, Baker S, Crawley JN.

Neuropsychopharmacology. 2015 Aug;40(9):2228-39. doi: 10.1038/npp.2015.66. Epub 2015 Mar 10.

32.

16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions.

Yang M, Mahrt EJ, Lewis F, Foley G, Portmann T, Dolmetsch RE, Portfors CV, Crawley JN.

Autism Res. 2015 Oct;8(5):507-21. doi: 10.1002/aur.1465. Epub 2015 Feb 7.

33.

3D visualization of the regional differences.

Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.

Mol Psychiatry. 2015 Feb;20(1):1. doi: 10.1038/mp.2014.168. No abstract available.

34.

Modeling fragile X syndrome in the Fmr1 knockout mouse.

Kazdoba TM, Leach PT, Silverman JL, Crawley JN.

Intractable Rare Dis Res. 2014 Nov;3(4):118-33. doi: 10.5582/irdr.2014.01024. Review.

35.

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine.

Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ.

Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45. doi: 10.1016/j.ntt.2014.10.008. Epub 2014 Nov 8.

36.

Long-term exposure to intranasal oxytocin in a mouse autism model.

Bales KL, Solomon M, Jacob S, Crawley JN, Silverman JL, Larke RH, Sahagun E, Puhger KR, Pride MC, Mendoza SP.

Transl Psychiatry. 2014 Nov 11;4:e480. doi: 10.1038/tp.2014.117.

37.

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.

Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.

Mol Psychiatry. 2015 Feb;20(1):118-25. doi: 10.1038/mp.2014.98. Epub 2014 Sep 9.

38.

Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome.

Portmann T, Yang M, Mao R, Panagiotakos G, Ellegood J, Dolen G, Bader PL, Grueter BA, Goold C, Fisher E, Clifford K, Rengarajan P, Kalikhman D, Loureiro D, Saw NL, Zhengqui Z, Miller MA, Lerch JP, Henkelman M, Shamloo M, Malenka RC, Crawley JN, Dolmetsch RE.

Cell Rep. 2014 May 22;7(4):1077-1092. doi: 10.1016/j.celrep.2014.03.036. Epub 2014 May 1.

39.

Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed-2 knockout mice.

Brielmaier J, Senerth JM, Silverman JL, Matteson PG, Millonig JH, DiCicco-Bloom E, Crawley JN.

Genes Brain Behav. 2014 Mar;13(3):286-298.

40.

The promising trajectory of autism therapeutics discovery.

Silverman JL, Crawley JN.

Drug Discov Today. 2014 Jul;19(7):838-44. doi: 10.1016/j.drudis.2013.12.007. Epub 2013 Dec 18. Review.

PMID:
24362109
41.

Male mice emit distinct ultrasonic vocalizations when the female leaves the social interaction arena.

Yang M, Loureiro D, Kalikhman D, Crawley JN.

Front Behav Neurosci. 2013 Nov 19;7:159. doi: 10.3389/fnbeh.2013.00159. eCollection 2013.

42.

Cognitive abilities on transitive inference using a novel touchscreen technology for mice.

Silverman JL, Gastrell PT, Karras MN, Solomon M, Crawley JN.

Cereb Cortex. 2015 May;25(5):1133-42. doi: 10.1093/cercor/bht293. Epub 2013 Nov 28.

43.

Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice.

Kerr TM, Muller CL, Miah M, Jetter CS, Pfeiffer R, Shah C, Baganz N, Anderson GM, Crawley JN, Sutcliffe JS, Blakely RD, Veenstra-Vanderweele J.

Mol Autism. 2013 Oct 1;4(1):35. doi: 10.1186/2040-2392-4-35.

44.

Low home cage social behaviors in BTBR T+tf/J mice during juvenile development.

Babineau BA, Yang M, Berman RF, Crawley JN.

Physiol Behav. 2013 Apr 10;114-115:49-54. doi: 10.1016/j.physbeh.2013.03.006. Epub 2013 Mar 17.

45.

Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging.

Ellegood J, Babineau BA, Henkelman RM, Lerch JP, Crawley JN.

Neuroimage. 2013 Apr 15;70:288-300. doi: 10.1016/j.neuroimage.2012.12.029. Epub 2012 Dec 26.

46.

Translational animal models of autism and neurodevelopmental disorders.

Crawley JN.

Dialogues Clin Neurosci. 2012 Sep;14(3):293-305. Review.

47.

Preclinical research in Rett syndrome: setting the foundation for translational success.

Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, St Hillaire-Clarke C, Young JL, Zoghbi HY, Mamounas LA.

Dis Model Mech. 2012 Nov;5(6):733-45. doi: 10.1242/dmm.011007. Review.

48.

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

Ey E, Yang M, Katz AM, Woldeyohannes L, Silverman JL, Leblond CS, Faure P, Torquet N, Le Sourd AM, Bourgeron T, Crawley JN.

Genes Brain Behav. 2012 Nov;11(8):928-941. doi: 10.1111/j.1601-183X.2012.00849.x. Epub 2012 Oct 10.

49.

Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism.

Silverman JL, Babineau BA, Oliver CF, Karras MN, Crawley JN.

Neuropharmacology. 2013 May;68:210-22. doi: 10.1016/j.neuropharm.2012.07.042. Epub 2012 Aug 8.

50.

Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice.

Brielmaier J, Matteson PG, Silverman JL, Senerth JM, Kelly S, Genestine M, Millonig JH, DiCicco-Bloom E, Crawley JN.

PLoS One. 2012;7(7):e40914. doi: 10.1371/journal.pone.0040914. Epub 2012 Jul 19.

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