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Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.

Hughey CC, Crawford PA.

Cell Metab. 2019 Jun 4;29(6):1236-1238. doi: 10.1016/j.cmet.2019.05.013.


Application of Stable Isotope Labels for Metabolomics in Studies in Fatty Liver Disease.

Puchalska P, Crawford PA.

Methods Mol Biol. 2019;1996:259-272. doi: 10.1007/978-1-4939-9488-5_20.


The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.

Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP.

JCI Insight. 2019 Feb 21;4(4). pii: 124079. doi: 10.1172/jci.insight.124079. eCollection 2019 Feb 21.


Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells.

Niu X, Chen YJ, Crawford PA, Patti GJ.

Cancer Metab. 2018 Dec 12;6:19. doi: 10.1186/s40170-018-0192-5. eCollection 2018.


Refueling the Failing Heart: A Case for Sodium-Glucose Cotransporter 2 Inhibition in Cardiac Energy Homeostasis.

Crawford PA.

JACC Basic Transl Sci. 2018 Aug 26;3(5):588-590. doi: 10.1016/j.jacbts.2018.08.002. eCollection 2018 Oct. No abstract available.


Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.

Puchalska P, Martin SE, Huang X, Lengfeld JE, Daniel B, Graham MJ, Han X, Nagy L, Patti GJ, Crawford PA.

Cell Metab. 2019 Feb 5;29(2):383-398.e7. doi: 10.1016/j.cmet.2018.10.015. Epub 2018 Nov 15.


Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments.

Puchalska P, Huang X, Martin SE, Han X, Patti GJ, Crawford PA.

iScience. 2018 Nov 30;9:298-313. doi: 10.1016/j.isci.2018.10.029. Epub 2018 Nov 2.


Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure.

Wang C, Liu F, Frisch-Daiello JL, Martin S, Patterson TA, Gu Q, Liu S, Paule MG, Hanig JP, Slikker W Jr, Crawford PA, Wang C, Han X.

Anal Chim Acta. 2018 Dec 11;1037:87-96. doi: 10.1016/j.aca.2017.11.052. Epub 2017 Nov 30.


Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome.

d'Avignon DA, Puchalska P, Ercal B, Chang Y, Martin SE, Graham MJ, Patti GJ, Han X, Crawford PA.

JCI Insight. 2018 Jun 21;3(12). pii: 99762. doi: 10.1172/jci.insight.99762. eCollection 2018 Jun 21.


Ketone bodies as epigenetic modifiers.

Ruan HB, Crawford PA.

Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):260-266. doi: 10.1097/MCO.0000000000000475. Review.


Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.

Polidori D, Iijima H, Goda M, Maruyama N, Inagaki N, Crawford PA.

Diabetes Obes Metab. 2018 May;20(5):1321-1326. doi: 10.1111/dom.13224. Epub 2018 Feb 14.


Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond.

Ruiz M, Labarthe F, Fortier A, Bouchard B, Thompson Legault J, Bolduc V, Rigal O, Chen J, Ducharme A, Crawford PA, Tardif JC, Des Rosiers C.

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H768-H781. doi: 10.1152/ajpheart.00820.2016. Epub 2017 Jul 14.


Comprehensive and Quantitative Analysis of Polyphosphoinositide Species by Shotgun Lipidomics Revealed Their Alterations in db/db Mouse Brain.

Wang C, Palavicini JP, Wang M, Chen L, Yang K, Crawford PA, Han X.

Anal Chem. 2016 Dec 20;88(24):12137-12144. doi: 10.1021/acs.analchem.6b02947. Epub 2016 Dec 1.


Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.

Puchalska P, Crawford PA.

Cell Metab. 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022. Review.


Lactate metabolism is associated with mammalian mitochondria.

Chen YJ, Mahieu NG, Huang X, Singh M, Crawford PA, Johnson SL, Gross RW, Schaefer J, Patti GJ.

Nat Chem Biol. 2016 Nov;12(11):937-943. doi: 10.1038/nchembio.2172. Epub 2016 Sep 12.


The Failing Heart Relies on Ketone Bodies as a Fuel.

Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27. Erratum in: Circulation. 2018 Oct 9;138(15):e422.


The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.

Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD.

Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.


Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.

Schugar RC, Moll AR, André d'Avignon D, Weinheimer CJ, Kovacs A, Crawford PA.

Mol Metab. 2014 Aug 13;3(7):754-69. doi: 10.1016/j.molmet.2014.07.010. eCollection 2014 Oct.


Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia.

Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA.

J Clin Invest. 2014 Dec;124(12):5175-90. doi: 10.1172/JCI76388. Epub 2014 Oct 27.


Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice.

Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA.

Am J Physiol Endocrinol Metab. 2014 Jul 15;307(2):E176-85. doi: 10.1152/ajpendo.00087.2014. Epub 2014 May 27.


X13CMS: global tracking of isotopic labels in untargeted metabolomics.

Huang X, Chen YJ, Cho K, Nikolskiy I, Crawford PA, Patti GJ.

Anal Chem. 2014 Feb 4;86(3):1632-9. doi: 10.1021/ac403384n. Epub 2014 Jan 24.


PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, Finck BN.

Mol Metab. 2013 May 9;2(3):194-204. doi: 10.1016/j.molmet.2013.05.001. eCollection 2013.


Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet.

Schugar RC, Huang X, Moll AR, Brunt EM, Crawford PA.

PLoS One. 2013 Aug 29;8(8):e74806. doi: 10.1371/journal.pone.0074806. eCollection 2013.


Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.

Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA.

J Biol Chem. 2013 Jul 5;288(27):19739-49. doi: 10.1074/jbc.M113.454868. Epub 2013 May 20.


Ketone body metabolism and cardiovascular disease.

Cotter DG, Schugar RC, Crawford PA.

Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1060-76. doi: 10.1152/ajpheart.00646.2012. Epub 2013 Feb 8. Review.


Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.

Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP, Finck BN.

PLoS One. 2012;7(12):e52645. doi: 10.1371/journal.pone.0052645. Epub 2012 Dec 28.


Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation.

Cotter DG, Schugar RC, Wentz AE, d'Avignon DA, Crawford PA.

Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E363-74. doi: 10.1152/ajpendo.00547.2012. Epub 2012 Dec 11.


Metabolic stress in the myocardium: adaptations of gene expression.

Crawford PA, Schaffer JE.

J Mol Cell Cardiol. 2013 Feb;55:130-8. doi: 10.1016/j.yjmcc.2012.06.008. Epub 2012 Jun 21. Review.


Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease.

Schugar RC, Crawford PA.

Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):374-80. doi: 10.1097/MCO.0b013e3283547157. Review.


Altered systemic ketone body metabolism in advanced heart failure.

Janardhan A, Chen J, Crawford PA.

Tex Heart Inst J. 2011;38(5):533-8.


Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet.

Garbow JR, Doherty JM, Schugar RC, Travers S, Weber ML, Wentz AE, Ezenwajiaku N, Cotter DG, Brunt EM, Crawford PA.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G956-67. doi: 10.1152/ajpgi.00539.2010. Epub 2011 Mar 31.


Obligate role for ketone body oxidation in neonatal metabolic homeostasis.

Cotter DG, d'Avignon DA, Wentz AE, Weber ML, Crawford PA.

J Biol Chem. 2011 Mar 4;286(9):6902-10. doi: 10.1074/jbc.M110.192369. Epub 2011 Jan 5.


Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.

Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ.

J Mol Cell Cardiol. 2010 Dec;49(6):931-40. doi: 10.1016/j.yjmcc.2010.08.011. Epub 2010 Aug 20.


Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment.

Wentz AE, d'Avignon DA, Weber ML, Cotter DG, Doherty JM, Kerns R, Nagarajan R, Reddy N, Sambandam N, Crawford PA.

J Biol Chem. 2010 Aug 6;285(32):24447-56. doi: 10.1074/jbc.M110.100651. Epub 2010 Jun 7.


Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody.

Ivanenkov VV, Crawford PA, Toyama A, Sévigny J, Kirley TL.

Protein Eng Des Sel. 2010 Jul;23(7):579-88. doi: 10.1093/protein/gzq027. Epub 2010 May 27.


Coordinated regulation of the metabolome and lipidome at the host-microbial interface.

Bäckhed F, Crawford PA.

Biochim Biophys Acta. 2010 Mar;1801(3):240-5. doi: 10.1016/j.bbalip.2009.09.009. Epub 2009 Sep 24. Review.


Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation.

Crawford PA, Crowley JR, Sambandam N, Muegge BD, Costello EK, Hamady M, Knight R, Gordon JI.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11276-81. doi: 10.1073/pnas.0902366106. Epub 2009 Jun 22.


DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function.

Mouillet JF, Yan X, Ou Q, Jin L, Muglia LJ, Crawford PA, Sadovsky Y.

Endocrinology. 2008 May;149(5):2168-75. doi: 10.1210/en.2007-1237. Epub 2008 Feb 7.


Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor.

Bäckhed F, Crawford PA, O'Donnell D, Gordon JI.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):606-11. Epub 2007 Jan 3.


Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors.

Belcher SM, Zsarnovszky A, Crawford PA, Hemani H, Spurling L, Kirley TL.

Neuroscience. 2006;137(4):1331-46. Epub 2005 Dec 7.


Microbial regulation of intestinal radiosensitivity.

Crawford PA, Gordon JI.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13254-9. Epub 2005 Aug 29.


Spectroscopic studies on cobalt(II)-substituted metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.

Crawford PA, Yang KW, Sharma N, Bennett B, Crowder MW.

Biochemistry. 2005 Apr 5;44(13):5168-76.


Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase.

Murphy-Piedmonte DM, Crawford PA, Kirley TL.

Biochim Biophys Acta. 2005 Mar 14;1747(2):251-9. Epub 2005 Jan 11.


Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.

Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW.

Protein Expr Purif. 2004 Aug;36(2):272-9.


Explaining the inhibition of glyoxalase II by 9-fluorenylmethoxycarbonyl-protected glutathione derivatives.

Yang KW, Sobieski DN, Carenbauer AL, Crawford PA, Makaroff CA, Crowder MW.

Arch Biochem Biophys. 2003 Jun 15;414(2):271-8.


RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.

Enomoto H, Crawford PA, Gorodinsky A, Heuckeroth RO, Johnson EM Jr, Milbrandt J.

Development. 2001 Oct;128(20):3963-74.


Steroidogenic factor 1 is a monomeric orphan, but does not work alone.

Ou Q, Mouillet JF, Yan X, Dorn C, Crawford PA, Sadovsky Y.

Endocr Res. 2000 Nov;26(4):1003-4. No abstract available.


The DEAD box protein DP103 is a regulator of steroidogenic factor-1.

Ou Q, Mouillet JF, Yan X, Dorn C, Crawford PA, Sadovsky Y.

Mol Endocrinol. 2001 Jan;15(1):69-79.


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