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Items: 1 to 50 of 96

1.

Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption.

Liu J, Gao M, Nipper M, Deng J, Sharkey FE, Johnson RL, Crawford HC, Chen Y, Wang P.

PLoS Biol. 2019 Sep 12;17(9):e3000418. doi: 10.1371/journal.pbio.3000418. eCollection 2019 Sep.

2.

Hiding in plain sight.

Halbrook CJ, Crawford HC.

Science. 2019 Jun 21;364(6446):1132-1133. doi: 10.1126/science.aax9341. No abstract available.

3.

Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.

Wen HJ, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC.

Cell Mol Gastroenterol Hepatol. 2019;8(2):173-192. doi: 10.1016/j.jcmgh.2019.05.006. Epub 2019 May 21.

4.

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.

Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM.

Genes Dev. 2019 Jun 1;33(11-12):641-655. doi: 10.1101/gad.323303.118. Epub 2019 May 2.

PMID:
31048544
5.

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA.

Cell Metab. 2019 Jun 4;29(6):1390-1399.e6. doi: 10.1016/j.cmet.2019.02.001. Epub 2019 Feb 28.

PMID:
30827862
6.

Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis.

Crawford HC, Pasca di Magliano M, Banerjee S.

Gastroenterology. 2019 May;156(7):2073-2084. doi: 10.1053/j.gastro.2018.12.042. Epub 2019 Feb 1. Review.

7.

Epithelial-Stromal Interactions in Pancreatic Cancer.

Zhang Y, Crawford HC, Pasca di Magliano M.

Annu Rev Physiol. 2019 Feb 10;81:211-233. doi: 10.1146/annurev-physiol-020518-114515. Epub 2018 Nov 12.

PMID:
30418798
8.

STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis.

D'Amico S, Shi J, Martin BL, Crawford HC, Petrenko O, Reich NC.

Genes Dev. 2018 Sep 1;32(17-18):1175-1187. doi: 10.1101/gad.311852.118. Epub 2018 Aug 22.

9.

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.

Abel EV, Goto M, Magnuson B, Abraham S, Ramanathan N, Hotaling E, Alaniz AA, Kumar-Sinha C, Dziubinski ML, Urs S, Wang L, Shi J, Waghray M, Ljungman M, Crawford HC, Simeone DM.

Elife. 2018 Aug 3;7. pii: e33947. doi: 10.7554/eLife.33947.

10.

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC.

Nat Commun. 2017 Nov 23;8(1):1728. doi: 10.1038/s41467-017-01967-6.

11.

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice.

Zhang Y, Yan W, Mathew E, Kane KT, Brannon A 3rd, Adoumie M, Vinta A, Crawford HC, Pasca di Magliano M.

Elife. 2017 Oct 5;6. pii: e27388. doi: 10.7554/eLife.27388.

12.

Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis.

Halbrook CJ, Wen HJ, Ruggeri JM, Takeuchi KK, Zhang Y, di Magliano MP, Crawford HC.

Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):99-118. doi: 10.1016/j.jcmgh.2016.09.009.

13.

PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.

Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC.

Genes Dev. 2016 Dec 15;30(24):2669-2683. doi: 10.1101/gad.291021.116.

14.

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA.

Cell. 2016 Aug 11;166(4):963-976. doi: 10.1016/j.cell.2016.06.056. Epub 2016 Jul 28.

15.

Plectin-1 as a Biomarker of Malignant Progression in Intraductal Papillary Mucinous Neoplasms: A Multicenter Study.

Moris M, Dawson DW, Jiang J, Lewis J, Nassar A, Takeuchi KK, Lay AR, Zhai Q, Donahue TR, Kelly KA, Crawford HC, Wallace M.

Pancreas. 2016 Oct;45(9):1353-8. doi: 10.1097/MPA.0000000000000652.

16.

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.

Liou GY, Döppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P.

Cell Rep. 2016 Mar 15;14(10):2325-36. doi: 10.1016/j.celrep.2016.02.029. Epub 2016 Mar 3.

17.

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.

Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3078-83. doi: 10.1073/pnas.1512603113. Epub 2016 Feb 29.

18.

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.

Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK.

Nat Med. 2015 Nov;21(11):1364-71. doi: 10.1038/nm.3973. Epub 2015 Oct 26.

19.

Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.

Qiu W, Tang SM, Lee S, Turk AT, Sireci AN, Qiu A, Rose C, Xie C, Kitajewski J, Wen HJ, Crawford HC, Sims PA, Hruban RH, Remotti HE, Su GH.

Gastroenterology. 2016 Jan;150(1):218-228.e12. doi: 10.1053/j.gastro.2015.09.013. Epub 2015 Sep 25.

20.

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17.

Palazuelos J, Klingener M, Raines EW, Crawford HC, Aguirre A.

J Neurosci. 2015 Sep 2;35(35):12241-7. doi: 10.1523/JNEUROSCI.3937-14.2015.

21.

Somatostatin receptor subtype 2 as pancreatic tumorigenesis suppressor: identification of a new targetable signaling node.

Crawford HC.

Gastroenterology. 2015 Jun;148(7):1279-81. doi: 10.1053/j.gastro.2015.04.025. Epub 2015 Apr 25. No abstract available.

PMID:
25921374
22.

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.

Li X, Maretzky T, Weskamp G, Monette S, Qing X, Issuree PD, Crawford HC, McIlwain DR, Mak TW, Salmon JE, Blobel CP.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6080-5. doi: 10.1073/pnas.1505649112. Epub 2015 Apr 27.

23.

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P.

Nat Commun. 2015 Feb 20;6:6200. doi: 10.1038/ncomms7200.

24.

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity.

Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Hebrok M, Neesse A, Koenig A, Ellenrieder V.

EMBO J. 2015 Feb 12;34(4):517-30. doi: 10.15252/embj.201489574. Epub 2015 Jan 13.

25.

The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.

Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

J Immunol. 2015 Jan 15;194(2):542-52. doi: 10.4049/jimmunol.1402070. Epub 2014 Dec 10.

26.

PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.

Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC.

Gastroenterology. 2014 Dec;147(6):1405-16.e7. doi: 10.1053/j.gastro.2014.08.032. Epub 2014 Aug 27.

27.

SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling.

Sheshadri N, Catanzaro JM, Bott AJ, Sun Y, Ullman E, Chen EI, Pan JA, Wu S, Crawford HC, Zhang J, Zong WX.

Cancer Res. 2014 Nov 1;74(21):6318-29. doi: 10.1158/0008-5472.CAN-14-0798. Epub 2014 Sep 11.

28.

TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination.

Palazuelos J, Crawford HC, Klingener M, Sun B, Karelis J, Raines EW, Aguirre A.

J Neurosci. 2014 Sep 3;34(36):11884-96. doi: 10.1523/JNEUROSCI.1220-14.2014.

29.

ADAM10 regulates Notch function in intestinal stem cells of mice.

Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ.

Gastroenterology. 2014 Oct;147(4):822-834.e13. doi: 10.1053/j.gastro.2014.07.003. Epub 2014 Jul 16.

30.

The conspiracy of autophagy, stress and inflammation in acute pancreatitis.

Hall JC, Crawford HC.

Curr Opin Gastroenterol. 2014 Sep;30(5):495-9. doi: 10.1097/MOG.0000000000000097. Review.

31.

Use of a preclinical model of pancreas cancer to identify potential candidates for rapalogue therapy.

Takeuchi KK, Crawford HC.

Gut. 2014 Sep;63(9):1379-80. doi: 10.1136/gutjnl-2014-307317. Epub 2014 Jun 25. No abstract available.

PMID:
24966285
32.

Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.

Mehner C, Miller E, Khauv D, Nassar A, Oberg AL, Bamlet WR, Zhang L, Waldmann J, Radisky ES, Crawford HC, Radisky DC.

Mol Cancer Res. 2014 Oct;12(10):1430-9. doi: 10.1158/1541-7786.MCR-13-0557-T. Epub 2014 May 21.

33.

Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4.

Catanzaro JM, Sheshadri N, Pan JA, Sun Y, Shi C, Li J, Powers RS, Crawford HC, Zong WX.

Nat Commun. 2014 Apr 23;5:3729. doi: 10.1038/ncomms4729.

34.

Persistent salmonellosis causes pancreatitis in a murine model of infection.

DelGiorno KE, Tam JW, Hall JC, Thotakura G, Crawford HC, van der Velden AW.

PLoS One. 2014 Apr 9;9(4):e92807. doi: 10.1371/journal.pone.0092807. eCollection 2014.

35.

The secret origins and surprising fates of pancreas tumors.

Bailey JM, DelGiorno KE, Crawford HC.

Carcinogenesis. 2014 Jul;35(7):1436-40. doi: 10.1093/carcin/bgu056. Epub 2014 Feb 28. Review.

36.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC.

Gastroenterology. 2014 Jan;146(1):233-44.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30.

37.

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.

Liou GY, Döppler H, Necela B, Krishna M, Crawford HC, Raimondo M, Storz P.

J Cell Biol. 2013 Aug 5;202(3):563-77. doi: 10.1083/jcb.201301001.

38.

ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.

Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP.

Mol Cell Biol. 2013 Aug;33(16):3077-90. doi: 10.1128/MCB.00291-13. Epub 2013 Jun 3.

39.

Human hair follicle dermal sheath and papilla cells support keratinocyte growth in monolayer coculture.

Hill RP, Gardner A, Crawford HC, Richer R, Dodds A, Owens WA, Lawrence C, Rao S, Kara B, James SE, Jahoda CA.

Exp Dermatol. 2013 Mar;22(3):236-8. doi: 10.1111/exd.12107.

PMID:
23489431
40.

Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.

Ali WH, Chen Q, Delgiorno KE, Su W, Hall JC, Hongu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, Frohman MA.

PLoS One. 2013;8(1):e55325. doi: 10.1371/journal.pone.0055325. Epub 2013 Jan 28.

41.

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.

Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA.

Nat Immunol. 2013 Mar;14(3):262-70. doi: 10.1038/ni.2538. Epub 2013 Feb 3.

42.

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.

Ray KC, Moss ME, Franklin JL, Weaver CJ, Higginbotham J, Song Y, Revetta FL, Blaine SA, Bridges LR, Guess KE, Coffey RJ, Crawford HC, Washington MK, Means AL.

Oncogene. 2014 Feb 13;33(7):823-31. doi: 10.1038/onc.2013.3. Epub 2013 Feb 4.

43.

KRAS above and beyond - EGFR in pancreatic cancer.

Siveke JT, Crawford HC.

Oncotarget. 2012 Nov;3(11):1262-3. No abstract available.

44.

EGF receptor is required for KRAS-induced pancreatic tumorigenesis.

Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT.

Cancer Cell. 2012 Sep 11;22(3):304-17. doi: 10.1016/j.ccr.2012.07.024.

45.

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF.

Neurobiol Dis. 2013 Jan;49:137-47. doi: 10.1016/j.nbd.2012.08.011. Epub 2012 Aug 24.

46.

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia.

Scotti ML, Smith KE, Butler AM, Calcagno SR, Crawford HC, Leitges M, Fields AP, Murray NR.

PLoS One. 2012;7(2):e30509. doi: 10.1371/journal.pone.0030509. Epub 2012 Feb 16.

47.

DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity.

Guerriero JL, Ditsworth D, Catanzaro JM, Sabino G, Furie MB, Kew RR, Crawford HC, Zong WX.

J Immunol. 2011 Mar 15;186(6):3517-26. doi: 10.4049/jimmunol.1003267. Epub 2011 Feb 7.

48.

Pancreas-specific ablation of beta1 integrin induces tissue degeneration by disrupting acinar cell polarity.

Bombardelli L, Carpenter ES, Wu AP, Alston N, DelGiorno KE, Crawford HC.

Gastroenterology. 2010 Jun;138(7):2531-40, 2540.e1-4. doi: 10.1053/j.gastro.2010.02.043. Epub 2010 Feb 23.

49.

Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.

Song Y, Washington MK, Crawford HC.

Cancer Res. 2010 Mar 1;70(5):2115-25. doi: 10.1158/0008-5472.CAN-09-2979. Epub 2010 Feb 16.

50.

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.

Gibb DR, El Shikh M, Kang DJ, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG, Dempsey PJ, Crawford HC, Conrad DH.

J Exp Med. 2010 Mar 15;207(3):623-35. doi: 10.1084/jem.20091990. Epub 2010 Feb 15.

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