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Items: 1 to 50 of 58

1.

Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene.

Chapadense F, Machado RLD, Ventura AMRDS, Áreas A, Machado RB, Viana GR, Zalis MG, Castro AM, Cravo P.

Rev Soc Bras Med Trop. 2019 Feb 21;52:e20180225. doi: 10.1590/0037-8682-0225-2018.

2.

Is there still room to explore cyclodextrin glycosyltransferase-producers in Brazilian biodiversity?

Gomes ACSM, Santos SRD, Ribeiro MC, Cravo PVL, Vieira JDG, Souza KMC, Amaral AC.

An Acad Bras Cienc. 2018 Apr-Jun;90(2):1473-1480. doi: 10.1590/0001-3765201820170670.

3.

QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities.

Lima MNN, Melo-Filho CC, Cassiano GC, Neves BJ, Alves VM, Braga RC, Cravo PVL, Muratov EN, Calit J, Bargieri DY, Costa FTM, Andrade CH.

Front Pharmacol. 2018 Mar 6;9:146. doi: 10.3389/fphar.2018.00146. eCollection 2018.

4.

In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases.

Andrade CH, Neves BJ, Melo-Filho CC, Rodrigues J, Silva DC, Braga RC, Cravo PVL.

Curr Med Chem. 2018 Mar 8. doi: 10.2174/0929867325666180309114824. [Epub ahead of print]

PMID:
29521204
5.

In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate.

Cravo P, Machado RB, Leite JA, Leda T, Suwanarusk R, Bittencourt N, Albrecht L, Judice C, Lopes SCP, Lacerda MVG, Ferreira MU, Soares IS, Goh YS, Bargieri DY, Nosten F, Russell B, Rénia L, Costa FTM.

Malar J. 2018 Jan 10;17(1):20. doi: 10.1186/s12936-017-2144-x.

6.

Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: a molecular epidemiological investigation.

Brasil P, Zalis MG, de Pina-Costa A, Siqueira AM, Júnior CB, Silva S, Areas ALL, Pelajo-Machado M, de Alvarenga DAM, da Silva Santelli ACF, Albuquerque HG, Cravo P, Santos de Abreu FV, Peterka CL, Zanini GM, Suárez Mutis MC, Pissinatti A, Lourenço-de-Oliveira R, de Brito CFA, de Fátima Ferreira-da-Cruz M, Culleton R, Daniel-Ribeiro CT.

Lancet Glob Health. 2017 Oct;5(10):e1038-e1046. doi: 10.1016/S2214-109X(17)30333-9. Epub 2017 Aug 31.

7.

Chalcone Derivatives: Promising Starting Points for Drug Design.

Gomes MN, Muratov EN, Pereira M, Peixoto JC, Rosseto LP, Cravo PVL, Andrade CH, Neves BJ.

Molecules. 2017 Jul 25;22(8). pii: E1210. doi: 10.3390/molecules22081210. Review.

8.

Human lagochilascariasis-A rare helminthic disease.

Campos DMB, Barbosa AP, Oliveira JA, Tavares GG, Cravo PVL, Ostermayer AL.

PLoS Negl Trop Dis. 2017 Jun 22;11(6):e0005510. doi: 10.1371/journal.pntd.0005510. eCollection 2017 Jun. Review.

9.

Conformation analysis of a novel fluorinated chalcone.

Carvalho PS Jr, Custodio JM, Vaz WF, Cirilo CC, Cidade AF, Aquino GL, Campos DM, Cravo P, Coelho CJ, Oliveira SS, Camargo AJ, Napolitano HB.

J Mol Model. 2017 Mar;23(3):97. doi: 10.1007/s00894-017-3245-8. Epub 2017 Mar 1.

PMID:
28251413
10.

Modern approaches to accelerate discovery of new antischistosomal drugs.

Neves BJ, Muratov E, Machado RB, Andrade CH, Cravo PV.

Expert Opin Drug Discov. 2016 Jun;11(6):557-67. doi: 10.1080/17460441.2016.1178230. Epub 2016 May 3. Review.

PMID:
27073973
11.

Phenotypic and genotypic profile of pyrethroid resistance in populations of the mosquito Aedes aegypti from Goiânia, Central West Brazil.

Chapadense FG, Fernandes EK, Lima JB, Martins AJ, Silva LC, Rocha WT, Santos AH, Cravo P.

Rev Soc Bras Med Trop. 2015 Sep-Oct;48(5):607-9. doi: 10.1590/0037-8682-0046-2015.

12.

In silico search of energy metabolism inhibitors for alternative leishmaniasis treatments.

Silva LA, Vinaud MC, Castro AM, Cravo PV, Bezerra JC.

Biomed Res Int. 2015;2015:965725. doi: 10.1155/2015/965725. Epub 2015 Mar 30.

13.

How genomics is contributing to the fight against artemisinin-resistant malaria parasites.

Cravo P, Napolitano H, Culleton R.

Acta Trop. 2015 Aug;148:1-7. doi: 10.1016/j.actatropica.2015.04.007. Epub 2015 Apr 21. Review.

PMID:
25910626
14.

Natural products as leads in schistosome drug discovery.

Neves BJ, Andrade CH, Cravo PV.

Molecules. 2015 Jan 23;20(2):1872-903. doi: 10.3390/molecules20021872.

15.

In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni.

Neves BJ, Braga RC, Bezerra JC, Cravo PV, Andrade CH.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3435. doi: 10.1371/journal.pntd.0003435. eCollection 2015 Jan. Erratum in: PLoS Negl Trop Dis. 2015 Feb;9(2):e0003554.

16.

Emerging Plasmodium vivax resistance to chloroquine in South America: an overview.

Gonçalves LA, Cravo P, Ferreira MU.

Mem Inst Oswaldo Cruz. 2014 Aug;109(5):534-9. Review.

17.

Amazonian plant natural products: perspectives for discovery of new antimalarial drug leads.

Pohlit AM, Lima RB, Frausin G, Silva LF, Lopes SC, Moraes CB, Cravo P, Lacerda MV, Siqueira AM, Freitas-Junior LH, Costa FT.

Molecules. 2013 Aug 2;18(8):9219-40. doi: 10.3390/molecules18089219. Review.

18.

Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking.

Henriques G, Martinelli A, Rodrigues L, Modrzynska K, Fawcett R, Houston DR, Borges ST, d'Alessandro U, Tinto H, Karema C, Hunt P, Cravo P.

Malar J. 2013 Apr 5;12:118. doi: 10.1186/1475-2875-12-118.

19.

A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast.

Bispo NA, Culleton R, Silva LA, Cravo P.

PLoS One. 2013;8(3):e59288. doi: 10.1371/journal.pone.0059288. Epub 2013 Mar 26. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/0bbd3579-5212-4dcf-a5ef-dd3d8e26f287.

20.

MDR1-associated resistance to artesunate+mefloquine does not impair blood-stage parasite fitness in a rodent malaria model.

Rodrigues L, Henriques G, Cravo P.

Infect Genet Evol. 2013 Mar;14:340-6. doi: 10.1016/j.meegid.2012.12.011. Epub 2013 Jan 11.

21.

Characterization of the Plasmodium falciparum sarcoplasmic/endoplasmic reticulum Ca2+-ATPase gene in samples from Equatorial Guinea before implementation of artemisinin-based combination therapy.

Fernández-Martínez A, Mula P, Cravo P, Charle P, Amor A, Ncogo P, Benito A, Berzosa P.

Am J Trop Med Hyg. 2013 Jan;88(1):43-47. doi: 10.4269/ajtmh.2012.12-0364. Epub 2012 Nov 26.

22.

Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria.

Kinga Modrzynska K, Creasey A, Loewe L, Cezard T, Trindade Borges S, Martinelli A, Rodrigues L, Cravo P, Blaxter M, Carter R, Hunt P.

BMC Genomics. 2012 Mar 21;13:106. doi: 10.1186/1471-2164-13-106.

23.

The origins of African Plasmodium vivax; insights from mitochondrial genome sequencing.

Culleton R, Coban C, Zeyrek FY, Cravo P, Kaneko A, Randrianarivelojosia M, Andrianaranjaka V, Kano S, Farnert A, Arez AP, Sharp PM, Carter R, Tanabe K.

PLoS One. 2011;6(12):e29137. doi: 10.1371/journal.pone.0029137. Epub 2011 Dec 14.

24.

Genomewide scan reveals amplification of mdr1 as a common denominator of resistance to mefloquine, lumefantrine, and artemisinin in Plasmodium chabaudi malaria parasites.

Borges S, Cravo P, Creasey A, Fawcett R, Modrzynska K, Rodrigues L, Martinelli A, Hunt P.

Antimicrob Agents Chemother. 2011 Oct;55(10):4858-65. doi: 10.1128/AAC.01748-10. Epub 2011 Jun 27.

25.

Whole genome re-sequencing identifies a mutation in an ABC transporter (mdr2) in a Plasmodium chabaudi clone with altered susceptibility to antifolate drugs.

Martinelli A, Henriques G, Cravo P, Hunt P.

Int J Parasitol. 2011 Feb;41(2):165-71. doi: 10.1016/j.ijpara.2010.08.008. Epub 2010 Sep 19.

26.

Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.

Hunt P, Martinelli A, Modrzynska K, Borges S, Creasey A, Rodrigues L, Beraldi D, Loewe L, Fawcett R, Kumar S, Thomson M, Trivedi U, Otto TD, Pain A, Blaxter M, Cravo P.

BMC Genomics. 2010 Sep 16;11:499. doi: 10.1186/1471-2164-11-499.

27.

Experimental evolution of resistance to artemisinin combination therapy results in amplification of the mdr1 gene in a rodent malaria parasite.

Rodrigues LA, Henriques G, Borges ST, Hunt P, Sanchez CP, Martinelli A, Cravo P.

PLoS One. 2010 Jul 15;5(7):e11593. doi: 10.1371/journal.pone.0011593.

28.

Tracing the origins and signatures of selection of antifolate resistance in island populations of Plasmodium falciparum.

Salgueiro P, Vicente JL, Ferreira C, Teófilo V, Galvão A, do Rosário VE, Cravo P, Pinto J.

BMC Infect Dis. 2010 Jun 9;10:163. doi: 10.1186/1471-2334-10-163.

29.

Plasmodium vivax in the Democratic Republic of East Timor: Parasite prevalence and antifolate resistance-associated mutations.

de Almeida A, Rosário VE, Henriques G, Arez AP, Cravo P.

Acta Trop. 2010 Sep;115(3):288-92. doi: 10.1016/j.actatropica.2010.04.008. Epub 2010 Apr 20.

PMID:
20412783
30.

Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity.

Jambou R, Martinelli A, Pinto J, Gribaldo S, Legrand E, Niang M, Kim N, Pharath L, Volnay B, Ekala MT, Bouchier C, Fandeur T, Berzosa P, Benito A, Ferreira ID, Ferreira C, Vieira PP, Alecrim Md, Mercereau-Puijalon O, Cravo P.

PLoS One. 2010 Feb 25;5(2):e9424. doi: 10.1371/journal.pone.0009424.

31.

Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor.

de Almeida A, Arez AP, Cravo PV, do Rosário VE.

Malar J. 2009 Apr 9;8:59. doi: 10.1186/1475-2875-8-59.

32.

Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing.

Culleton RL, Mita T, Ndounga M, Unger H, Cravo PV, Paganotti GM, Takahashi N, Kaneko A, Eto H, Tinto H, Karema C, D'Alessandro U, do Rosário V, Kobayakawa T, Ntoumi F, Carter R, Tanabe K.

Malar J. 2008 Sep 11;7:174. doi: 10.1186/1475-2875-7-174.

33.

Antiplasmodial activity of lignans and extracts from Pycnanthus angolensis.

Abrantes M, Mil-Homens T, Duarte N, Lopes D, Cravo P, Madureira Md, Ferreira MJ.

Planta Med. 2008 Sep;74(11):1408-12. doi: 10.1055/s-2008-1081317. Epub 2008 Jul 31.

PMID:
18671202
34.

Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites.

Franke-Fayard B, Djokovic D, Dooren MW, Ramesar J, Waters AP, Falade MO, Kranendonk M, Martinelli A, Cravo P, Janse CJ.

Int J Parasitol. 2008 Dec;38(14):1651-62. doi: 10.1016/j.ijpara.2008.05.012. Epub 2008 Jun 12.

PMID:
18590736
35.

Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.

Restrepo-Pineda E, Arango E, Maestre A, Do Rosário VE, Cravo P.

Parasitology. 2008 Apr;135(5):547-53. doi: 10.1017/S0031182008004307.

PMID:
18426617
36.

A primer-introduced restriction analysis-polymerase chain reaction method to detect knockdown resistance mutations in Anopheles gambiae.

Janeira F, Vicente JL, Kanganje Y, Moreno M, Do Rosário VE, Cravo P, Pinto J.

J Med Entomol. 2008 Mar;45(2):237-41.

PMID:
18402139
37.

Plasmodium chabaudi: efficacy of artemisinin + curcumin combination treatment on a clone selected for artemisinin resistance in mice.

Martinelli A, Rodrigues LA, Cravo P.

Exp Parasitol. 2008 Jun;119(2):304-7. doi: 10.1016/j.exppara.2008.02.011. Epub 2008 Mar 7.

PMID:
18397786
38.

Plasmodium falciparum from Pará state (Brazil) shows satisfactory in vitro response to artemisinin derivatives and absence of the S769N mutation in the SERCA-type PfATPase6.

Ferreira ID, Martinelli A, Rodrigues LA, do Carmo EL, do Rosário VE, Póvoa MM, Cravo P.

Trop Med Int Health. 2008 Feb;13(2):199-207. doi: 10.1111/j.1365-3156.2007.01991.x.

39.

[Sulfadoxine-pyrimethamine resistance in Maputo, Mozambique: presence of mutations in the dhfr and dhps genes of Plasmodium falciparum].

Fernandes NE, Cravo P, do Rosário VE.

Rev Soc Bras Med Trop. 2007 Jul-Aug;40(4):447-50. Portuguese.

40.

Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.

Hunt P, Afonso A, Creasey A, Culleton R, Sidhu AB, Logan J, Valderramos SG, McNae I, Cheesman S, do Rosario V, Carter R, Fidock DA, Cravo P.

Mol Microbiol. 2007 Jul;65(1):27-40.

42.
43.

Validation of Pyrosequencing for accurate and high throughput estimation of allele frequencies in malaria parasites.

Cheesman S, Creasey A, Degnan K, Kooij T, Afonso A, Cravo P, Carter R, Hunt P.

Mol Biochem Parasitol. 2007 Apr;152(2):213-9. Epub 2006 Dec 21. No abstract available.

PMID:
17239454
44.
45.
47.

An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi.

Martinelli A, Hunt P, Fawcett R, Cravo PV, Walliker D, Carter R.

Malar J. 2005 Feb 11;4:11.

48.

Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites?

Ferreira ID, Nogueira F, Borges ST, do Rosário VE, Cravo P.

Mol Biochem Parasitol. 2004 Jul;136(1):43-50.

PMID:
15138066
49.

High frequency of the genetic polymorphisms associated with sulfadoxine-pyrimethamine resistance, among Plasmodium falciparum isolates from São Tomé and Príncipe, West Africa.

Cravo P, Figueiredo S, Nogueira F, Lopes D, Ferreira ID, Ferreira C, Gil JP, do Rosario VE.

Ann Trop Med Parasitol. 2004 Apr;98(3):293-6. No abstract available.

PMID:
15119975
50.

Chloroquine resistance in Plasmodium chabaudi: are chloroquine-resistance transporter (crt) and multi-drug resistance (mdr1) orthologues involved?

Hunt P, Cravo PV, Donleavy P, Carlton JM, Walliker D.

Mol Biochem Parasitol. 2004 Jan;133(1):27-35.

PMID:
14668009

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