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A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species.

Muok AR, Deng Y, Gumerov VM, Chong JE, DeRosa JR, Kurniyati K, Coleman RE, Lancaster KM, Li C, Zhulin IB, Crane BR.

Proc Natl Acad Sci U S A. 2019 Jul 3. pii: 201904234. doi: 10.1073/pnas.1904234116. [Epub ahead of print]


A nitric oxide synthase-like protein from Synechococcus produces NO/NO3 - from l-arginine and NAPDH in a tetrahydrobiopterin- and Ca2+-dependent manner.

Picciano AL, Crane BR.

J Biol Chem. 2019 Jul 5;294(27):10708-10719. doi: 10.1074/jbc.RA119.008399. Epub 2019 May 20.


Physical methods for studying flavoprotein photoreceptors.

Yee EF, Chandrasekaran S, Lin C, Crane BR.

Methods Enzymol. 2019;620:509-544. doi: 10.1016/bs.mie.2019.03.023. Epub 2019 Apr 4.


Nucleotide Spin Labeling for ESR Spectroscopy of ATP-Binding Proteins.

Muok AR, Chua TK, Le H, Crane BR.

Appl Magn Reson. 2018 Dec;49(12):1385-1395. doi: 10.1007/s00723-018-1070-6. Epub 2018 Nov 14.


Design, Validation, and Application of an Enzyme-Coupled Hydrogen Sulfide Detection Assay.

Lynch MJ, Crane BR.

Biochemistry. 2019 Feb 12;58(6):474-483. doi: 10.1021/acs.biochem.8b01083. Epub 2018 Dec 27.


Site-Specific Incorporation of a Cu2+ Spin Label into Proteins for Measuring Distances by Pulsed Dipolar Electron Spin Resonance Spectroscopy.

Merz GE, Borbat PP, Muok AR, Srivastava M, Bunck DN, Freed JH, Crane BR.

J Phys Chem B. 2018 Oct 18;122(41):9443-9451. doi: 10.1021/acs.jpcb.8b05619. Epub 2018 Oct 3.


Patching a leak in an R1 university gateway STEM course.

Lee S, Crane BR, Ruttledge T, Guelce D, Yee EF, Lenetsky M, Caffrey M, Johnsen WA, Lin A, Lu S, Rodriguez MA, Wague A, Wu K.

PLoS One. 2018 Sep 6;13(9):e0202041. doi: 10.1371/journal.pone.0202041. eCollection 2018.



Greer-Phillips SE, Sukomon N, Chua TK, Johnson MS, Crane BR, Watts KJ.

Mol Microbiol. 2018 May 2. doi: 10.1111/mmi.13978. [Epub ahead of print]


CK1/Doubletime activity delays transcription activation in the circadian clock.

Top D, O'Neil JL, Merz GE, Dusad K, Crane BR, Young MW.

Elife. 2018 Apr 3;7. pii: e32679. doi: 10.7554/eLife.32679.


Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction.

Lin C, Top D, Manahan CC, Young MW, Crane BR.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3822-3827. doi: 10.1073/pnas.1719376115. Epub 2018 Mar 26.


Production, characterization, and assessment of a stable analog of the response regulator CheY-phosphate from Thermotoga maritima.

Beyersdorf MS, Sircar R, Lookadoo DB, Bottone CJ, Lynch MJ, Crane BR, Halkides CJ.

Protein Sci. 2017 Aug;26(8):1547-1554. doi: 10.1002/pro.3180. Epub 2017 May 14.


Stability and Conformation of a Chemoreceptor HAMP Domain Chimera Correlates with Signaling Properties.

Sukomon N, Widom J, Borbat PP, Freed JH, Crane BR.

Biophys J. 2017 Apr 11;112(7):1383-1395. doi: 10.1016/j.bpj.2017.02.037.


Architecture of the Flagellar Switch Complex of Escherichia coli: Conformational Plasticity of FliG and Implications for Adaptive Remodeling.

Kim EA, Panushka J, Meyer T, Carlisle R, Baker S, Ide N, Lynch M, Crane BR, Blair DF.

J Mol Biol. 2017 May 5;429(9):1305-1320. doi: 10.1016/j.jmb.2017.02.014. Epub 2017 Mar 1.


Glutamine Amide Flip Elicits Long Distance Allosteric Responses in the LOV Protein Vivid.

Ganguly A, Thiel W, Crane BR.

J Am Chem Soc. 2017 Mar 1;139(8):2972-2980. doi: 10.1021/jacs.6b10701. Epub 2017 Feb 13.


Co-Folding of a FliF-FliG Split Domain Forms the Basis of the MS:C Ring Interface within the Bacterial Flagellar Motor.

Lynch MJ, Levenson R, Kim EA, Sircar R, Blair DF, Dahlquist FW, Crane BR.

Structure. 2017 Feb 7;25(2):317-328. doi: 10.1016/j.str.2016.12.006. Epub 2017 Jan 12.


Bacterial Energy Sensor Aer Modulates the Activity of the Chemotaxis Kinase CheA Based on the Redox State of the Flavin Cofactor.

Samanta D, Widom J, Borbat PP, Freed JH, Crane BR.

J Biol Chem. 2016 Dec 9;291(50):25809-25814. Epub 2016 Nov 1.


Spirochaete flagella hook proteins self-catalyse a lysinoalanine covalent crosslink for motility.

Miller MR, Miller KA, Bian J, James ME, Zhang S, Lynch MJ, Callery PS, Hettick JM, Cockburn A, Liu J, Li C, Crane BR, Charon NW.

Nat Microbiol. 2016 Aug 8;1(10):16134. doi: 10.1038/nmicrobiol.2016.134.


Changes in active site histidine hydrogen bonding trigger cryptochrome activation.

Ganguly A, Manahan CC, Top D, Yee EF, Lin C, Young MW, Thiel W, Crane BR.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10073-8. doi: 10.1073/pnas.1606610113. Epub 2016 Aug 22.


Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c.

Payne TM, Yee EF, Dzikovski B, Crane BR.

Biochemistry. 2016 Aug 30;55(34):4807-22. doi: 10.1021/acs.biochem.6b00262. Epub 2016 Aug 17.


Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock.

Conrad KS, Hurley JM, Widom J, Ringelberg CS, Loros JJ, Dunlap JC, Crane BR.

EMBO J. 2016 Aug 1;35(15):1707-19. doi: 10.15252/embj.201694327. Epub 2016 Jun 23.


Signal transduction in light-oxygen-voltage receptors lacking the adduct-forming cysteine residue.

Yee EF, Diensthuber RP, Vaidya AT, Borbat PP, Engelhard C, Freed JH, Bittl R, Möglich A, Crane BR.

Nat Commun. 2015 Dec 9;6:10079. doi: 10.1038/ncomms10079.


Conformational Transitions that Enable Histidine Kinase Autophosphorylation and Receptor Array Integration.

Greenswag AR, Muok A, Li X, Crane BR.

J Mol Biol. 2015 Dec 4;427(24):3890-907. doi: 10.1016/j.jmb.2015.10.015. Epub 2015 Oct 30.


Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation.

Greenswag AR, Li X, Borbat PP, Samanta D, Watts KJ, Freed JH, Crane BR.

Biochemistry. 2015 Jun 9;54(22):3454-68. doi: 10.1021/bi501570n. Epub 2015 May 28.


Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distances.

Samanta D, Borbat PP, Dzikovski B, Freed JH, Crane BR.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2455-60. doi: 10.1073/pnas.1414155112. Epub 2015 Feb 9.


Assembly states of FliM and FliG within the flagellar switch complex.

Sircar R, Borbat PP, Lynch MJ, Bhatnagar J, Beyersdorf MS, Halkides CJ, Freed JH, Crane BR.

J Mol Biol. 2015 Feb 27;427(4):867-886. doi: 10.1016/j.jmb.2014.12.009. Epub 2014 Dec 20.


Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes.

Pratt AJ, Shin DS, Merz GE, Rambo RP, Lancaster WA, Dyer KN, Borbat PP, Poole FL 2nd, Adams MW, Freed JH, Crane BR, Tainer JA, Getzoff ED.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4568-76. doi: 10.1073/pnas.1308531111. Epub 2014 Oct 14.


Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states.

Merz GE, Borbat PP, Pratt AJ, Getzoff ED, Freed JH, Crane BR.

Biophys J. 2014 Oct 7;107(7):1669-74. doi: 10.1016/j.bpj.2014.07.068.


Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus.

Davydov R, Labby KJ, Chobot SE, Lukoyanov DA, Crane BR, Silverman RB, Hoffman BM.

Biochemistry. 2014 Oct 21;53(41):6511-9. doi: 10.1021/bi500485z. Epub 2014 Oct 8.


Photochemistry of flavoprotein light sensors.

Conrad KS, Manahan CC, Crane BR.

Nat Chem Biol. 2014 Oct;10(10):801-9. doi: 10.1038/nchembio.1633. Review.


Interactive features of proteins composing eukaryotic circadian clocks.

Crane BR, Young MW.

Annu Rev Biochem. 2014;83:191-219. doi: 10.1146/annurev-biochem-060713-035644. Review.


Flavin reduction activates Drosophila cryptochrome.

Vaidya AT, Top D, Manahan CC, Tokuda JM, Zhang S, Pollack L, Young MW, Crane BR.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20455-60. doi: 10.1073/pnas.1313336110. Epub 2013 Dec 2.


Distance-independent charge recombination kinetics in cytochrome c-cytochrome c peroxidase complexes: compensating changes in the electronic coupling and reorganization energies.

Jiang N, Kuznetsov A, Nocek JM, Hoffman BM, Crane BR, Hu X, Beratan DN.

J Phys Chem B. 2013 Aug 8;117(31):9129-41. doi: 10.1021/jp401551t. Epub 2013 Jul 29.


The 3.2 Å resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.

Li X, Fleetwood AD, Bayas C, Bilwes AM, Ortega DR, Falke JJ, Zhulin IB, Crane BR.

Biochemistry. 2013 Jun 4;52(22):3852-65. doi: 10.1021/bi400383e. Epub 2013 May 23.


Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study.

Piasta KN, Ulliman CJ, Slivka PF, Crane BR, Falke JJ.

Biochemistry. 2013 Jun 4;52(22):3866-80. doi: 10.1021/bi400385c. Epub 2013 May 23.


Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family.

Sircar R, Greenswag AR, Bilwes AM, Gonzalez-Bonet G, Crane BR.

J Biol Chem. 2013 May 10;288(19):13493-502. doi: 10.1074/jbc.M112.445171. Epub 2013 Mar 26.


Updated structure of Drosophila cryptochrome.

Levy C, Zoltowski BD, Jones AR, Vaidya AT, Top D, Widom J, Young MW, Scrutton NS, Crane BR, Leys D.

Nature. 2013 Mar 21;495(7441):E3-4. doi: 10.1038/nature11995. No abstract available.


HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors.

Airola MV, Sukomon N, Samanta D, Borbat PP, Freed JH, Watts KJ, Crane BR.

PLoS Biol. 2013;11(2):e1001479. doi: 10.1371/journal.pbio.1001479. Epub 2013 Feb 12.


Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling.

Airola MV, Huh D, Sukomon N, Widom J, Sircar R, Borbat PP, Freed JH, Watts KJ, Crane BR.

J Mol Biol. 2013 Mar 11;425(5):886-901. doi: 10.1016/j.jmb.2012.12.011. Epub 2012 Dec 26.


Light-induced subunit dissociation by a light-oxygen-voltage domain photoreceptor from Rhodobacter sphaeroides.

Conrad KS, Bilwes AM, Crane BR.

Biochemistry. 2013 Jan 15;52(2):378-91. doi: 10.1021/bi3015373. Epub 2013 Jan 3.


Azurin as a protein scaffold for a low-coordinate nonheme iron site with a small-molecule binding pocket.

McLaughlin MP, Retegan M, Bill E, Payne TM, Shafaat HS, Peña S, Sudhamsu J, Ensign AA, Crane BR, Neese F, Holland PL.

J Am Chem Soc. 2012 Dec 5;134(48):19746-57. doi: 10.1021/ja308346b. Epub 2012 Nov 20.


Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis.

Barry SM, Kers JA, Johnson EG, Song L, Aston PR, Patel B, Krasnoff SB, Crane BR, Gibson DM, Loria R, Challis GL.

Nat Chem Biol. 2012 Oct;8(10):814-6.


Self-association of the histidine kinase CheA as studied by pulsed dipolar ESR spectroscopy.

Bhatnagar J, Sircar R, Borbat PP, Freed JH, Crane BR.

Biophys J. 2012 May 2;102(9):2192-201. doi: 10.1016/j.bpj.2012.03.038.


Biochemistry. Nature's intricate clockwork.

Crane BR.

Science. 2012 Jul 13;337(6091):165-6. doi: 10.1126/science.1224611. No abstract available.


Crystallization and preliminary X-ray crystallographic analysis of Thermotoga maritima CheA P3-P4-P5 domains in complex with CheW.

Park S, Kim KY, Kim S, Crane BR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):713-5. doi: 10.1107/S174430911201826X. Epub 2012 May 24.


Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins.

Briegel A, Li X, Bilwes AM, Hughes KT, Jensen GJ, Crane BR.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3766-71. doi: 10.1073/pnas.1115719109. Epub 2012 Feb 21.


Structure of full-length Drosophila cryptochrome.

Zoltowski BD, Vaidya AT, Top D, Widom J, Young MW, Crane BR.

Nature. 2011 Nov 13;480(7377):396-9. doi: 10.1038/nature10618. Erratum in: Nature. 2013 Apr 11;496(7444):252.


Structure of an enclosed dimer formed by the Drosophila period protein.

King HA, Hoelz A, Crane BR, Young MW.

J Mol Biol. 2011 Oct 28;413(3):561-72. doi: 10.1016/j.jmb.2011.08.048. Epub 2011 Sep 3.


Structure of a light-activated LOV protein dimer that regulates transcription.

Vaidya AT, Chen CH, Dunlap JC, Loros JJ, Crane BR.

Sci Signal. 2011 Aug 2;4(184):ra50. doi: 10.1126/scisignal.2001945.


Structural insight into the low affinity between Thermotoga maritima CheA and CheB compared to their Escherichia coli/Salmonella typhimurium counterparts.

Park S, Crane BR.

Int J Biol Macromol. 2011 Nov 1;49(4):794-800. doi: 10.1016/j.ijbiomac.2011.07.012. Epub 2011 Jul 23.

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