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Items: 1 to 50 of 81

1.

An Ssd1 Homolog Impacts Trehalose and Chitin Biosynthesis and Contributes to Virulence in Aspergillus fumigatus.

Thammahong A, Dhingra S, Bultman KM, Kerkaert JD, Cramer RA.

mSphere. 2019 May 8;4(3). pii: e00244-19. doi: 10.1128/mSphere.00244-19.

2.

Natamycin and voriconazole exhibit synergistic interactions with non-antifungal ophthalmic agents against Fusarium species ocular isolates.

Rees CA, Bao R, Zegans ME, Cramer RA.

Antimicrob Agents Chemother. 2019 Apr 22. pii: AAC.02505-18. doi: 10.1128/AAC.02505-18. [Epub ahead of print]

PMID:
31010869
3.

Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus.

Mead ME, Knowles SL, Raja HA, Beattie SR, Kowalski CH, Steenwyk JL, Silva LP, Chiaratto J, Ries LNA, Goldman GH, Cramer RA, Oberlies NH, Rokas A.

mSphere. 2019 Feb 20;4(1). pii: e00018-19. doi: 10.1128/mSphere.00018-19.

4.

Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus.

de Assis LJ, Manfiolli A, Mattos E, Fabri JHTM, Malavazi I, Jacobsen ID, Brock M, Cramer RA, Thammahong A, Hagiwara D, Ries LNA, Goldman GH.

MBio. 2018 Dec 11;9(6). pii: e01952-18. doi: 10.1128/mBio.01952-18.

5.

Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung.

Alexander MP, Fiering SN, Ostroff GR, Cramer RA, Mullins DW.

Cancer Immunol Immunother. 2018 Nov;67(11):1731-1742. doi: 10.1007/s00262-018-2234-9. Epub 2018 Aug 23.

PMID:
30167860
6.

Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".

Shlezinger N, Irmer H, Dhingra S, Beattie SR, Cramer RA, Braus GH, Sharon A, Hohl TM.

Science. 2018 Jun 22;360(6395). pii: eaas9457. doi: 10.1126/science.aas9457.

PMID:
29930111
7.

Host-Derived Leukotriene B4 Is Critical for Resistance against Invasive Pulmonary Aspergillosis.

Caffrey-Carr AK, Hilmer KM, Kowalski CH, Shepardson KM, Temple RM, Cramer RA, Obar JJ.

Front Immunol. 2018 Jan 11;8:1984. doi: 10.3389/fimmu.2017.01984. eCollection 2017.

8.

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses.

Boutens L, Hooiveld GJ, Dhingra S, Cramer RA, Netea MG, Stienstra R.

Diabetologia. 2018 Apr;61(4):942-953. doi: 10.1007/s00125-017-4526-6. Epub 2018 Jan 14.

9.

Hyperbaric Oxygen Reduces Aspergillus fumigatus Proliferation In Vitro and Influences In Vivo Disease Outcomes.

Dhingra S, Buckey JC, Cramer RA.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01953-17. doi: 10.1128/AAC.01953-17. Print 2018 Mar.

10.

Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis.

Kale SD, Ayubi T, Chung D, Tubau-Juni N, Leber A, Dang HX, Karyala S, Hontecillas R, Lawrence CB, Cramer RA, Bassaganya-Riera J.

Sci Rep. 2017 Dec 6;7(1):17096. doi: 10.1038/s41598-017-17000-1.

11.

Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.

Ries LNA, Beattie S, Cramer RA, Goldman GH.

Mol Microbiol. 2018 Feb;107(3):277-297. doi: 10.1111/mmi.13887. Epub 2017 Dec 29. Review.

12.

Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates.

Caffrey-Carr AK, Kowalski CH, Beattie SR, Blaseg NA, Upshaw CR, Thammahong A, Lust HE, Tang YW, Hohl TM, Cramer RA, Obar JJ.

Infect Immun. 2017 Nov 17;85(12). pii: e00661-17. doi: 10.1128/IAI.00661-17. Print 2017 Dec.

13.

Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death.

Shlezinger N, Irmer H, Dhingra S, Beattie SR, Cramer RA, Braus GH, Sharon A, Hohl TM.

Science. 2017 Sep 8;357(6355):1037-1041. doi: 10.1126/science.aan0365.

14.

Sniffing out the hypoxia volatile metabolic signature of Aspergillus fumigatus.

Rees CA, Stefanuto PH, Beattie SR, Bultman KM, Cramer RA, Hill JE.

J Breath Res. 2017 Aug 21;11(3):036003. doi: 10.1088/1752-7163/aa7b3e.

15.

Aspergillus fumigatus Trehalose-Regulatory Subunit Homolog Moonlights To Mediate Cell Wall Homeostasis through Modulation of Chitin Synthase Activity.

Thammahong A, Caffrey-Card AK, Dhingra S, Obar JJ, Cramer RA.

MBio. 2017 Apr 25;8(2). pii: e00056-17. doi: 10.1128/mBio.00056-17.

16.

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression.

Beattie SR, Mark KMK, Thammahong A, Ries LNA, Dhingra S, Caffrey-Carr AK, Cheng C, Black CC, Bowyer P, Bromley MJ, Obar JJ, Goldman GH, Cramer RA.

PLoS Pathog. 2017 Apr 19;13(4):e1006340. doi: 10.1371/journal.ppat.1006340. eCollection 2017 Apr.

17.

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.

Thammahong A, Puttikamonkul S, Perfect JR, Brennan RG, Cramer RA.

Microbiol Mol Biol Rev. 2017 Mar 15;81(2). pii: e00053-16. doi: 10.1128/MMBR.00053-16. Print 2017 Jun. Review.

18.

Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development.

Dhingra S, Cramer RA.

Front Microbiol. 2017 Feb 1;8:92. doi: 10.3389/fmicb.2017.00092. eCollection 2017. Review.

19.

7th Advances Against Aspergillosis: Basic, diagnostic, clinical and therapeutic studies.

Cramer RA, Sheppard DC, Clemons KV.

Med Mycol. 2017 Jan 1;55(1):1-3. No abstract available.

PMID:
27994098
20.

Functional and Genomic Architecture of Borrelia burgdorferi-Induced Cytokine Responses in Humans.

Oosting M, Kerstholt M, Ter Horst R, Li Y, Deelen P, Smeekens S, Jaeger M, Lachmandas E, Vrijmoeth H, Lupse M, Flonta M, Cramer RA, Kullberg BJ, Kumar V, Xavier R, Wijmenga C, Netea MG, Joosten LA.

Cell Host Microbe. 2016 Dec 14;20(6):822-833. doi: 10.1016/j.chom.2016.10.006. Epub 2016 Nov 3.

21.

Aspergillus fumigatus virulence through the lens of transcription factors.

Bultman KM, Kowalski CH, Cramer RA.

Med Mycol. 2017 Jan 1;55(1):24-38. Epub 2016 Nov 5. Review.

22.

Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence.

Kowalski CH, Beattie SR, Fuller KK, McGurk EA, Tang YW, Hohl TM, Obar JJ, Cramer RA Jr.

MBio. 2016 Sep 20;7(5). pii: e01515-16. doi: 10.1128/mBio.01515-16.

23.

Aspergillus fumigatus Photobiology Illuminates the Marked Heterogeneity between Isolates.

Fuller KK, Cramer RA, Zegans ME, Dunlap JC, Loros JJ.

MBio. 2016 Sep 20;7(5). pii: e01517-16. doi: 10.1128/mBio.01517-16.

24.

RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus.

Dhingra S, Kowlaski CH, Thammahong A, Beattie SR, Bultman KM, Cramer RA.

mSphere. 2016 Mar 2;1(2). pii: e00035-16. doi: 10.1128/mSphere.00035-16. eCollection 2016 Mar-Apr.

25.

The effect of reducing agents on challenge of rainbow trout with Aeromonas salmonicida.

Supattapone SY, Supattapone S, Cramer RA.

J Fish Dis. 2017 Mar;40(3):437-441. doi: 10.1111/jfd.12511. Epub 2016 Jun 13. No abstract available.

PMID:
27291986
26.

New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches.

Obar JJ, Hohl TM, Cramer RA.

Cytokine. 2016 Aug;84:63-73. doi: 10.1016/j.cyto.2016.05.015. Epub 2016 May 30. Review.

27.

Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans.

Ries LN, Beattie SR, Espeso EA, Cramer RA, Goldman GH.

Genetics. 2016 May;203(1):335-52. doi: 10.1534/genetics.116.187872. Epub 2016 Mar 26.

28.

Role of Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Regulating Neutrophil Antifungal Activity and the Oxidative Burst During Respiratory Fungal Challenge.

Kasahara S, Jhingran A, Dhingra S, Salem A, Cramer RA, Hohl TM.

J Infect Dis. 2016 Apr 15;213(8):1289-98. doi: 10.1093/infdis/jiw054. Epub 2016 Feb 9.

29.

In vivo veritas: Aspergillus fumigatus proliferation and pathogenesis--conditionally speaking.

Cramer RA.

Virulence. 2016;7(1):7-10. doi: 10.1080/21505594.2015.1134074. No abstract available.

30.

Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus.

Lima Pde S, Chung D, Bailão AM, Cramer RA, Soares CM.

PLoS Negl Trop Dis. 2015 Dec 10;9(12):e0004282. doi: 10.1371/journal.pntd.0004282. eCollection 2015 Dec.

31.

IL-1α signaling is critical for leukocyte recruitment after pulmonary Aspergillus fumigatus challenge.

Caffrey AK, Lehmann MM, Zickovich JM, Espinosa V, Shepardson KM, Watschke CP, Hilmer KM, Thammahong A, Barker BM, Rivera A, Cramer RA, Obar JJ.

PLoS Pathog. 2015 Jan 28;11(1):e1004625. doi: 10.1371/journal.ppat.1004625. eCollection 2015 Jan.

32.

Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection.

Jhingran A, Kasahara S, Shepardson KM, Junecko BA, Heung LJ, Kumasaka DK, Knoblaugh SE, Lin X, Kazmierczak BI, Reinhart TA, Cramer RA, Hohl TM.

PLoS Pathog. 2015 Jan 26;11(1):e1004589. doi: 10.1371/journal.ppat.1004589. eCollection 2015 Jan.

33.

Biofilms: five-star accommodations for the aerobically challenged.

Cramer RA.

Curr Biol. 2014 Oct 20;24(20):R1002-4. doi: 10.1016/j.cub.2014.09.030. Epub 2014 Oct 21. No abstract available.

34.

ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.

Chung D, Barker BM, Carey CC, Merriman B, Werner ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas H, Mitchell AP, Cramer RA.

PLoS Pathog. 2014 Nov 6;10(11):e1004487. doi: 10.1371/journal.ppat.1004487. eCollection 2014 Nov. Erratum in: PLoS Pathog. 2014 Nov;10(11):e1004576.

35.

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG.

Science. 2014 Sep 26;345(6204):1250684. doi: 10.1126/science.1250684. Erratum in: Science. 2014 Nov 7;346(6210):aaa1503. van der Meer, Brian M J W [corrected to van der Veer, Brian M J W].

36.

Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection.

Shepardson KM, Jhingran A, Caffrey A, Obar JJ, Suratt BT, Berwin BL, Hohl TM, Cramer RA.

PLoS Pathog. 2014 Sep 25;10(9):e1004378. doi: 10.1371/journal.ppat.1004378. eCollection 2014 Sep.

37.

Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus.

Blosser SJ, Merriman B, Grahl N, Chung D, Cramer RA.

Microbiology. 2014 Nov;160(Pt 11):2492-506. doi: 10.1099/mic.0.080440-0. Epub 2014 Aug 8.

38.

The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess.

Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Mühlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H.

EMBO J. 2014 Oct 1;33(19):2261-76. doi: 10.15252/embj.201489468. Epub 2014 Aug 4.

39.

Large-scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA.

Losada L, Barker BM, Pakala S, Pakala S, Joardar V, Zafar N, Mounaud S, Fedorova N, Nierman WC, Cramer RA.

Mycopathologia. 2014 Dec;178(5-6):331-9. doi: 10.1007/s11046-014-9779-8. Epub 2014 Jul 5.

40.

Endoplasmic reticulum localized PerA is required for cell wall integrity, azole drug resistance, and virulence in Aspergillus fumigatus.

Chung D, Thammahong A, Shepardson KM, Blosser SJ, Cramer RA.

Mol Microbiol. 2014 Jun;92(6):1279-98. doi: 10.1111/mmi.12626. Epub 2014 May 9.

41.

Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1.

Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, Maccallum DM, Wheeler R, Munro CA, Gow NA, Cramer RA, Brown AJ, Brown GD.

PLoS Pathog. 2013;9(4):e1003315. doi: 10.1371/journal.ppat.1003315. Epub 2013 Apr 18.

42.

Fungal cell wall dynamics and infection site microenvironments: signal integration and infection outcome.

Shepardson KM, Cramer RA.

Curr Opin Microbiol. 2013 Aug;16(4):385-90. doi: 10.1016/j.mib.2013.03.003. Epub 2013 Apr 15.

43.

Some fungi in the air. Interview by Sophia Häfner.

Cramer RA, Hohl TM.

Microbes Infect. 2013 Apr;15(4):255-8. doi: 10.1016/j.micinf.2013.01.002. Epub 2013 Jan 29. No abstract available.

44.

Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.

Shepardson KM, Ngo LY, Aimanianda V, Latgé JP, Barker BM, Blosser SJ, Iwakura Y, Hohl TM, Cramer RA.

Microbes Infect. 2013 Apr;15(4):259-69. doi: 10.1016/j.micinf.2012.11.010. Epub 2012 Dec 4.

45.

Candida albicans induces arginine biosynthetic genes in response to host-derived reactive oxygen species.

Jiménez-López C, Collette JR, Brothers KM, Shepardson KM, Cramer RA, Wheeler RT, Lorenz MC.

Eukaryot Cell. 2013 Jan;12(1):91-100. doi: 10.1128/EC.00290-12. Epub 2012 Nov 9.

46.

Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi.

Chung D, Haas H, Cramer RA.

Front Microbiol. 2012 Nov 6;3:381. doi: 10.3389/fmicb.2012.00381. eCollection 2012.

47.

Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus.

Willger SD, Cornish EJ, Chung D, Fleming BA, Lehmann MM, Puttikamonkul S, Cramer RA.

Eukaryot Cell. 2012 Dec;11(12):1557-67. doi: 10.1128/EC.00252-12. Epub 2012 Oct 26.

48.

Hypoxia and fungal pathogenesis: to air or not to air?

Grahl N, Shepardson KM, Chung D, Cramer RA.

Eukaryot Cell. 2012 May;11(5):560-70. doi: 10.1128/EC.00031-12. Epub 2012 Mar 23. Review.

49.

Aspergillus fumigatus mitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis.

Grahl N, Dinamarco TM, Willger SD, Goldman GH, Cramer RA.

Mol Microbiol. 2012 Apr;84(2):383-99. doi: 10.1111/j.1365-2958.2012.08034.x. Epub 2012 Mar 23.

50.

Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter.

Barker BM, Kroll K, Vödisch M, Mazurie A, Kniemeyer O, Cramer RA.

BMC Genomics. 2012 Feb 6;13:62. doi: 10.1186/1471-2164-13-62.

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