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Items: 40

1.

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy.

Witkin JM, Smith JL, Ping X, Gleason SD, Poe MM, Li G, Jin X, Hobbs J, Schkeryantz JM, McDermott JS, Alatorre AI, Siemian JN, Cramer JW, Airey DC, Methuku KR, Tiruveedhula VVNPB, Jones TM, Crawford J, Krambis MJ, Fisher JL, Cook JM, Cerne R.

Neuropharmacology. 2018 Jul 15;137:332-343. doi: 10.1016/j.neuropharm.2018.05.006. Epub 2018 May 3.

PMID:
29778948
2.

Clinical and Echocardiographic Prevalence and Detection of Congenital and Acquired Cardiac Abnormalities in Girls and Women with the Turner Syndrome.

Yetman AT, Starr L, Sanmann J, Wilde M, Murray M, Cramer JW.

Am J Cardiol. 2018 Jul 15;122(2):327-330. doi: 10.1016/j.amjcard.2018.03.357. Epub 2018 Apr 17.

PMID:
29731120
3.

Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.

Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish T.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1758-1764. doi: 10.1016/j.bmcl.2018.04.028. Epub 2018 Apr 13.

4.

Authors' Reply.

Cramer JW, Kutty S, Patel SG, Frommelt MA, Frommelt PC.

J Am Soc Echocardiogr. 2018 Jan;31(1):114. doi: 10.1016/j.echo.2017.10.006. Epub 2017 Nov 23. No abstract available.

PMID:
29174338
5.

Echocardiographic Diagnosis, Surgical Treatment, and Outcomes of Anomalous Left Coronary Artery from the Pulmonary Artery.

Patel SG, Frommelt MA, Frommelt PC, Kutty S, Cramer JW.

J Am Soc Echocardiogr. 2017 Sep;30(9):896-903. doi: 10.1016/j.echo.2017.05.005. Epub 2017 Jun 23.

PMID:
28651802
6.

Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.

Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, Cook JM, Schkeryantz JM.

J Med Chem. 2016 Dec 8;59(23):10800-10806. Epub 2016 Nov 28.

7.

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.

Svensson KA, Heinz BA, Schaus JM, Beck JP, Hao J, Krushinski JH, Reinhard MR, Cohen MP, Hellman SL, Getman BG, Wang X, Menezes MM, Maren DL, Falcone JF, Anderson WH, Wright RA, Morin SM, Knopp KL, Adams BL, Rogovoy B, Okun I, Suter TM, Statnick MA, Gehlert DR, Nelson DL, Lucaites VL, Emkey R, DeLapp NW, Wiernicki TR, Cramer JW, Yang CR, Bruns RF.

J Pharmacol Exp Ther. 2017 Jan;360(1):117-128. Epub 2016 Nov 3.

8.

Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats.

Zhou X, Rougée LR, Bedwell DW, Cramer JW, Mohutsky MA, Calvert NA, Moulton RD, Cassidy KC, Yumibe NP, Adams LA, Ruterbories KJ.

Drug Metab Dispos. 2016 Aug;44(8):1184-92. doi: 10.1124/dmd.116.070623. Epub 2016 May 23.

PMID:
27217490
9.

Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo.

Moraski GC, Cheng Y, Cho S, Cramer JW, Godfrey A, Masquelin T, Franzblau SG, Miller MJ, Schorey J.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):5018-22. doi: 10.1128/AAC.00618-16. Print 2016 Aug.

10.

Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity.

Chandrasekera NS, Alling T, Bailey MA, Files M, Early JV, Ollinger J, Ovechkina Y, Masquelin T, Desai PV, Cramer JW, Hipskind PA, Odingo JO, Parish T.

J Med Chem. 2015 Sep 24;58(18):7273-85. doi: 10.1021/acs.jmedchem.5b00546. Epub 2015 Sep 2.

PMID:
26295286
11.

Takeuchi repair of anomalous left coronary artery from the pulmonary artery.

Cramer JW, Cinquegrani M, Cohen SB.

J Cardiovasc Comput Tomogr. 2015 Sep-Oct;9(5):457-8. doi: 10.1016/j.jcct.2015.02.002. Epub 2015 Feb 17.

PMID:
25843240
12.

Tricuspid repair at pulmonary valve replacement does not alter outcomes in tetralogy of Fallot.

Cramer JW, Ginde S, Hill GD, Cohen SB, Bartz PJ, Tweddell JS, Earing MG.

Ann Thorac Surg. 2015 Mar;99(3):899-904. doi: 10.1016/j.athoracsur.2014.09.086. Epub 2015 Jan 14.

PMID:
25596869
13.

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.

Odingo J, O'Malley T, Kesicki EA, Alling T, Bailey MA, Early J, Ollinger J, Dalai S, Kumar N, Singh RV, Hipskind PA, Cramer JW, Ioerger T, Sacchettini J, Vickers R, Parish T.

Bioorg Med Chem. 2014 Dec 15;22(24):6965-79. doi: 10.1016/j.bmc.2014.10.007. Epub 2014 Oct 22.

14.

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders.

Rorick-Kehn LM, Witkin JM, Statnick MA, Eberle EL, McKinzie JH, Kahl SD, Forster BM, Wong CJ, Li X, Crile RS, Shaw DB, Sahr AE, Adams BL, Quimby SJ, Diaz N, Jimenez A, Pedregal C, Mitch CH, Knopp KL, Anderson WH, Cramer JW, McKinzie DL.

Neuropharmacology. 2014 Feb;77:131-44. doi: 10.1016/j.neuropharm.2013.09.021. Epub 2013 Sep 23.

PMID:
24071566
15.

The spectrum of congenital heart disease and outcomes after surgical repair among children with Turner syndrome: a single-center review.

Cramer JW, Bartz PJ, Simpson PM, Zangwill SD.

Pediatr Cardiol. 2014 Feb;35(2):253-60. doi: 10.1007/s00246-013-0766-5. Epub 2013 Aug 10.

PMID:
23933717
16.

Aortic aneurysms remain a significant source of morbidity and mortality after use of Dacron(®) patch aortoplasty to repair coarctation of the aorta: results from a single center.

Cramer JW, Ginde S, Bartz PJ, Tweddell JS, Litwin SB, Earing MG.

Pediatr Cardiol. 2013 Feb;34(2):296-301. doi: 10.1007/s00246-012-0442-1. Epub 2012 Jul 28.

PMID:
22843204
17.

Strategies for conducting ADME studies during lead generation in the drug discovery process.

Cramer JW, Mattioni BE, Savin KA.

IDrugs. 2010 Dec;13(12):857-61. Review.

PMID:
21154143
18.

Synthesis and SAR of novel histamine H3 receptor antagonists.

Jesudason CD, Beavers LS, Cramer JW, Dill J, Finley DR, Lindsley CW, Stevens FC, Gadski RA, Oldham SW, Pickard RT, Siedem CS, Sindelar DK, Singh A, Watson BM, Hipskind PA.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3415-8. Epub 2006 May 3.

PMID:
16677814
19.

Central H3R activation by thioperamide does not affect energy balance.

Sindelar DK, Shepperd ML, Pickard RT, Alexander-Chacko J, Dill MJ, Cramer JW, Smith DP, Gadski R.

Pharmacol Biochem Behav. 2004 Jun;78(2):275-83.

PMID:
15219768
20.

Preclinical characterization of 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic acid metabolism: in vitro species comparison and in vivo disposition in rats.

Perkins EJ, Cramer JW, Farid NA, Gadberry MG, Jackson DA, Mattiuz EL, O'Bannon DD, Weiss HJ, Wheeler WJ, Wood PG, Cassidy KC.

Drug Metab Dispos. 2003 Nov;31(11):1382-90.

PMID:
14570771
21.

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.

Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMattos RB, Holtzman DM.

J Neurosci. 2003 Oct 1;23(26):8844-53.

22.

Disposition of LY333531, a selective protein kinase C beta inhibitor, in the Fischer 344 rat and beagle dog.

Burkey JL, Campanale KM, O'Bannon DD, Cramer JW, Farid NA.

Xenobiotica. 2002 Nov;32(11):1045-52.

PMID:
12487733
23.

Barbiturate inhibition of growth and of synthesis of deoxyribonucleic acid, ribonucleic acid and protein in cultured mammalian cells.

Whyatt PL, Cramer JW.

Biochem Pharmacol. 1973 Jan 15;22(2):229-45. No abstract available.

PMID:
4202809
24.

5-iodo-2'-deoxyuridine and DNA synthesis in mammalian cells.

Morris NR, Cramer JW.

Exp Cell Res. 1968 Aug-Sep;51(2-3):555-63. No abstract available.

PMID:
4234098
25.

A simple method for concentration of cells in the DNA synthetic period of the mitotic cycle.

Morris NR, Cramer JW, Reno D.

Exp Cell Res. 1967 Oct;48(1):216-8. No abstract available.

PMID:
4964749
26.

Sulfate esters of 5-iododeoxyuridine and 5-iododeoxycytidine.

Chang PK, Sciarini LJ, Cramer JW.

J Med Chem. 1967 Jul;10(4):733-4. No abstract available.

PMID:
6037072
27.

Absence of DNA synthesis in one-half of a population of mammalian tumor cells inhibited in culture by 5-lodo-2-deoxyuridine.

Cramer JW, Morris NR.

Mol Pharmacol. 1966 Jul;2(4):563-7. No abstract available.

PMID:
5968077
28.

DNA synthesis by mammalian cells inhibited in culture by 5-lodo-2'-deoxyuridine.

Morris NR, Cramer JW.

Mol Pharmacol. 1966 Jan;2(1):1-9. No abstract available.

PMID:
5907356
29.

Studies on the biochemical pharmacology of 5-iodo-2'-deoxycytidine in vitro and in vivo.

CRAMER JW, PRUSOFF WH, WELCH AD, SARTORELLIAC, DELAMORE IW, VON ESSEN CF, CHANG PK.

Biochem Pharmacol. 1962 Aug;11:761-8. No abstract available.

PMID:
13881995
30.

5-Bromo-2'-deoxycytidine (BCDR). I. Studies on metabolism in vitro and in mice.

PRUSOFF WH, CRAMER JW, CHU MY, WELCH AD.

Biochem Pharmacol. 1961 Nov;8:324-6. No abstract available.

PMID:
14489045
31.

5-Bromo-2'-deoxycytidine (BCDR). II. Studies with murine neoplastic cells in culture and in vitro.

CRAMER JW, PRUSOFF WH, WELCH AD.

Biochem Pharmacol. 1961 Nov;8:331-5. No abstract available.

PMID:
13881996
32.

Vitamin D and urinary amino acid excretion in the rat.

ENGSTROM GW, DeLUCA HF, CRAMER JW, STEENBOCKH.

Proc Soc Exp Biol Med. 1961 Oct;108:105-8. No abstract available.

PMID:
13890298
33.

The N- and ringhydroxylation of 2-acetylaminofluorene during carcinogenesis in the rat.

MILLER JA, CRAMER JW, MILLER EC.

Cancer Res. 1960 Jul;20:950-62. No abstract available.

34.

N-Hydroxylation: A new metabolic reaction observed in the rat with the carcinogen 2-acetylaminofluorene.

CRAMER JW, MILLER JA, MILLER EC.

J Biol Chem. 1960 Mar;235:885-8. No abstract available.

35.
36.

Growth hormone and vitamin D in relation to growth and calcification on a calcium deficient diet.

CRAMER JW, PORRATA-DORIA EI, STEENBOCK H.

Endocrinology. 1957 Nov;61(5):590-3. No abstract available.

PMID:
13480271
37.

Calcium metabolism and growth in the rat on a low-phosphorus diet as affected by vitamin D and increases in calcium intake.

CRAMER JW, STEENBOCK H.

Arch Biochem Biophys. 1956 Jul;63(1):9-13. No abstract available.

PMID:
13341037
38.

A rachitogenic and growth-promoting effect of citrate.

CRAMER JW, PORRATA-DORIA EI, STEENBOCK H.

Arch Biochem Biophys. 1956 Jan;60(1):58-63. No abstract available.

PMID:
13283588
39.

Citrate in the prevention of rickets in rats.

PILEGGI VJ, DE LUCA HF, CRAMER JW, STEENBOCK H.

Arch Biochem Biophys. 1956 Jan;60(1):52-7. No abstract available.

PMID:
13283587
40.

The effect of vitamin D on urinary citrate in relation to calcium, phosphorus and urinary pH.

BELLIN SA, HERTING DC, CRAMER JW, PILEGGI VJ, STEENBOCK H.

Arch Biochem Biophys. 1954 May;50(1):16-24. No abstract available.

PMID:
13159296

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