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Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase.

Hickman AB, Voth AR, Ewis H, Li X, Craig NL, Dyda F.

Nucleic Acids Res. 2018 Nov 2;46(19):10286-10301. doi: 10.1093/nar/gky838.


Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase.

Morellet N, Li X, Wieninger SA, Taylor JL, Bischerour J, Moriau S, Lescop E, Bardiaux B, Mathy N, Assrir N, B├ętermier M, Nilges M, Hickman AB, Dyda F, Craig NL, Guittet E.

Nucleic Acids Res. 2018 Mar 16;46(5):2660-2677. doi: 10.1093/nar/gky044.


Avoiding the ends: internal epitope tagging of proteins using transposon Tn7.

Zordan RE, Beliveau BJ, Trow JA, Craig NL, Cormack BP.

Genetics. 2015 May;200(1):47-58. doi: 10.1534/genetics.114.169482. Epub 2015 Mar 5.


Mobile genetic elements and genome evolution 2014.

Singh PK, Bourque G, Craig NL, Dubnau JT, Feschotte C, Flasch DA, Gunderson KL, Malik HS, Moran JV, Peters JE, Slotkin RK, Levin HL.

Mob DNA. 2014 Nov 18;5:26. doi: 10.1186/1759-8753-5-26. eCollection 2014.


Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss AL, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F.

Cell. 2014 Jul 17;158(2):353-367. doi: 10.1016/j.cell.2014.05.037.


The Tn7 transposition regulator TnsC interacts with the transposase subunit TnsB and target selector TnsD.

Choi KY, Spencer JM, Craig NL.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2858-65. doi: 10.1073/pnas.1409869111. Epub 2014 Jun 30.


Integration profiling of gene function with dense maps of transposon integration.

Guo Y, Park JM, Cui B, Humes E, Gangadharan S, Hung S, FitzGerald PC, Hoe KL, Grewal SI, Craig NL, Levin HL.

Genetics. 2013 Oct;195(2):599-609. doi: 10.1534/genetics.113.152744. Epub 2013 Jul 26.


IPB7 transposase behavior in Drosophila melanogaster and Aedes aegypti.

Wright JA, Smith RC, Li X, Craig NL, Atkinson PW.

Insect Biochem Mol Biol. 2013 Oct;43(10):899-906. doi: 10.1016/j.ibmb.2013.06.009. Epub 2013 Jul 5.


piggyBac transposase tools for genome engineering.

Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB Jr, Bushman FD, Sinn PL, Craig NL.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2279-87. doi: 10.1073/pnas.1305987110. Epub 2013 May 30.


Direct interaction between the TnsA and TnsB subunits controls the heteromeric Tn7 transposase.

Choi KY, Li Y, Sarnovsky R, Craig NL.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2038-45. doi: 10.1073/pnas.1305716110. Epub 2013 May 14.


A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon.

Burnight ER, Staber JM, Korsakov P, Li X, Brett BT, Scheetz TE, Craig NL, McCray PB Jr.

Mol Ther Nucleic Acids. 2012 Oct 16;1:e50. doi: 10.1038/mtna.2012.12.


Functional characterization of piggyBat from the bat Myotis lucifugus unveils an active mammalian DNA transposon.

Mitra R, Li X, Kapusta A, Mayhew D, Mitra RD, Feschotte C, Craig NL.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):234-9. doi: 10.1073/pnas.1217548110. Epub 2012 Dec 17.


Comparative analysis of the recently discovered hAT transposon TcBuster in human cells.

Woodard LE, Li X, Malani N, Kaja A, Hice RH, Atkinson PW, Bushman FD, Craig NL, Wilson MH.

PLoS One. 2012;7(11):e42666. doi: 10.1371/journal.pone.0042666. Epub 2012 Nov 15.


A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture.

Li X, Ewis H, Hice RH, Malani N, Parker N, Zhou L, Feschotte C, Bushman FD, Atkinson PW, Craig NL.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E478-87. doi: 10.1073/pnas.1121543109. Epub 2012 Oct 22.


Functional characterization of an active Rag-like transposase.

Hencken CG, Li X, Craig NL.

Nat Struct Mol Biol. 2012 Aug;19(8):834-6. doi: 10.1038/nsmb.2338. Epub 2012 Jul 8.


Insertion site preference of Mu, Tn5, and Tn7 transposons.

Green B, Bouchier C, Fairhead C, Craig NL, Cormack BP.

Mob DNA. 2012 Feb 7;3(1):3. doi: 10.1186/1759-8753-3-3.


The mosquito Aedes aegypti has a large genome size and high transposable element load but contains a low proportion of transposon-specific piRNAs.

Arensburger P, Hice RH, Wright JA, Craig NL, Atkinson PW.

BMC Genomics. 2011 Dec 15;12:606. doi: 10.1186/1471-2164-12-606.


Hyperactive piggyBac gene transfer in human cells and in vivo.

Doherty JE, Huye LE, Yusa K, Zhou L, Craig NL, Wilson MH.

Hum Gene Ther. 2012 Mar;23(3):311-20. doi: 10.1089/hum.2011.138. Epub 2011 Dec 14.


Mobilization of giant piggyBac transposons in the mouse genome.

Li MA, Turner DJ, Ning Z, Yusa K, Liang Q, Eckert S, Rad L, Fitzgerald TW, Craig NL, Bradley A.

Nucleic Acids Res. 2011 Dec;39(22):e148. doi: 10.1093/nar/gkr764. Epub 2011 Sep 24.


Phylogenetic and functional characterization of the hAT transposon superfamily.

Arensburger P, Hice RH, Zhou L, Smith RC, Tom AC, Wright JA, Knapp J, O'Brochta DA, Craig NL, Atkinson PW.

Genetics. 2011 May;188(1):45-57. doi: 10.1534/genetics.111.126813. Epub 2011 Mar 2.


A hyperactive piggyBac transposase for mammalian applications.

Yusa K, Zhou L, Li MA, Bradley A, Craig NL.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1531-6. doi: 10.1073/pnas.1008322108. Epub 2011 Jan 4.


DNA transposon Hermes inserts into DNA in nucleosome-free regions in vivo.

Gangadharan S, Mularoni L, Fain-Thornton J, Wheelan SJ, Craig NL.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):21966-72. doi: 10.1073/pnas.1016382107. Epub 2010 Dec 3.


Characterization of the TnsD-attTn7 complex that promotes site-specific insertion of Tn7.

Mitra R, McKenzie GJ, Yi L, Lee CA, Craig NL.

Mob DNA. 2010 Jul 23;1(1):18. doi: 10.1186/1759-8753-1-18.


Architecture of the Tn7 posttransposition complex: an elaborate nucleoprotein structure.

Holder JW, Craig NL.

J Mol Biol. 2010 Aug 13;401(2):167-81. doi: 10.1016/j.jmb.2010.06.003. Epub 2010 Jun 9.


Welcome to mobile DNA.

Craig NL, Eickbush TH, Voytas DF.

Mob DNA. 2010 Jan 25;1(1):1. doi: 10.1186/1759-8753-1-1. No abstract available.


piggyBac can bypass DNA synthesis during cut and paste transposition.

Mitra R, Fain-Thornton J, Craig NL.

EMBO J. 2008 Apr 9;27(7):1097-109. doi: 10.1038/emboj.2008.41. Epub 2008 Mar 20.


Multiple waves of recent DNA transposon activity in the bat, Myotis lucifugus.

Ray DA, Feschotte C, Pagan HJ, Smith JD, Pritham EJ, Arensburger P, Atkinson PW, Craig NL.

Genome Res. 2008 May;18(5):717-28. doi: 10.1101/gr.071886.107. Epub 2008 Mar 13.


The hermes transposon of Musca domestica is an efficient tool for the mutagenesis of Schizosaccharomyces pombe.

Evertts AG, Plymire C, Craig NL, Levin HL.

Genetics. 2007 Dec;177(4):2519-23. Epub 2007 Oct 18.


Purification, crystallization and preliminary crystallographic analysis of the Hermes transposase.

Perez ZN, Musingarimi P, Craig NL, Dyda F, Hickman AB.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt 6):587-90. Epub 2005 Jun 1.


New wrinkles and folds in site-specific recombination.

Segall AM, Craig NL.

Mol Cell. 2005 Aug 19;19(4):433-5. Review.


Molecular architecture of a eukaryotic DNA transposase.

Hickman AB, Perez ZN, Zhou L, Musingarimi P, Ghirlando R, Hinshaw JE, Craig NL, Dyda F.

Nat Struct Mol Biol. 2005 Aug;12(8):715-21. Epub 2005 Jul 24.


An open letter to Elias Zerhouni.

Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N.

Science. 2005 Mar 4;307(5714):1409-10. No abstract available.


Site-specific Tn7 transposition into the human genome.

Kuduvalli PN, Mitra R, Craig NL.

Nucleic Acids Res. 2005 Feb 8;33(3):857-63. Print 2005.


Transposition of hAT elements links transposable elements and V(D)J recombination.

Zhou L, Mitra R, Atkinson PW, Hickman AB, Dyda F, Craig NL.

Nature. 2004 Dec 23;432(7020):995-1001.


Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae.

Ferguson SB, Anderson ES, Harshaw RB, Thate T, Craig NL, Nelson HC.

Genetics. 2005 Mar;169(3):1203-14. Epub 2004 Nov 15.


Large-scale mutagenesis of the yeast genome using a Tn7-derived multipurpose transposon.

Kumar A, Seringhaus M, Biery MC, Sarnovsky RJ, Umansky L, Piccirillo S, Heidtman M, Cheung KH, Dobry CJ, Gerstein MB, Craig NL, Snyder M.

Genome Res. 2004 Oct;14(10A):1975-86.


The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA.

Ronning DR, Li Y, Perez ZN, Ross PD, Hickman AB, Craig NL, Dyda F.

EMBO J. 2004 Aug 4;23(15):2972-81. Epub 2004 Jul 15.


Tn7-based genome-wide random insertional mutagenesis of Candida glabrata.

Castano I, Kaur R, Pan S, Cregg R, Penas Ade L, Guo N, Biery MC, Craig NL, Cormack BP.

Genome Res. 2003 May;13(5):905-15. Epub 2003 Apr 14.


Definition of the Escherichia coli MC4100 genome by use of a DNA array.

Peters JE, Thate TE, Craig NL.

J Bacteriol. 2003 Mar;185(6):2017-21.


Tn7-mediated mutagenesis of Saccharomyces cerevisiae genomic DNA in vitro.

Bachman N, Biery MC, Boeke JD, Craig NL.

Methods Enzymol. 2002;350:230-47. No abstract available.


Tn7: smarter than we thought.

Peters JE, Craig NL.

Nat Rev Mol Cell Biol. 2001 Nov;2(11):806-14. Review.


Target DNA structure plays a critical role in Tn7 transposition.

Kuduvalli PN, Rao JE, Craig NL.

EMBO J. 2001 Feb 15;20(4):924-32.


Analysis of gain-of-function mutants of an ATP-dependent regulator of Tn7 transposition.

Stellwagen AE, Craig NL.

J Mol Biol. 2001 Jan 19;305(3):633-42.


Unexpected structural diversity in DNA recombination: the restriction endonuclease connection.

Hickman AB, Li Y, Mathew SV, May EW, Craig NL, Dyda F.

Mol Cell. 2000 Jun;5(6):1025-34.

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