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Items: 35

1.

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition.

Latif-Hernandez A, Shah D, Craessaerts K, Saido T, Saito T, De Strooper B, Van der Linden A, D'Hooge R.

Behav Brain Res. 2019 May 17;364:431-441. doi: 10.1016/j.bbr.2017.11.017. Epub 2017 Nov 20.

PMID:
29158112
2.

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency.

Vos M, Geens A, Böhm C, Deaulmerie L, Swerts J, Rossi M, Craessaerts K, Leites EP, Seibler P, Rakovic A, Lohnau T, De Strooper B, Fendt SM, Morais VA, Klein C, Verstreken P.

J Cell Biol. 2017 Mar 6;216(3):695-708. doi: 10.1083/jcb.201511044. Epub 2017 Jan 30.

3.

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.

Hammad H, Vanderkerken M, Pouliot P, Deswarte K, Toussaint W, Vergote K, Vandersarren L, Janssens S, Ramou I, Savvides SN, Haigh JJ, Hendriks R, Kopf M, Craessaerts K, de Strooper B, Kearney JF, Conrad DH, Lambrecht BN.

Nat Immunol. 2017 Mar;18(3):313-320. doi: 10.1038/ni.3657. Epub 2017 Jan 9.

PMID:
28068307
4.

In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues.

Aerts L, Craessaerts K, De Strooper B, Morais VA.

PLoS One. 2016 Jan 19;11(1):e0146083. doi: 10.1371/journal.pone.0146083. eCollection 2016.

5.

PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402.

Aerts L, Craessaerts K, De Strooper B, Morais VA.

J Biol Chem. 2015 Jan 30;290(5):2798-811. doi: 10.1074/jbc.M114.620906. Epub 2014 Dec 19.

6.

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B.

Science. 2014 Apr 11;344(6180):203-7. doi: 10.1126/science.1249161. Epub 2014 Mar 20.

7.

Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy.

Haddad DM, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM, Craessaerts K, Leyssen M, Nascimento RM, Vianna-Morgante AM, De Strooper B, Van Esch H, Morais VA, Verstreken P.

Mol Cell. 2013 Jun 27;50(6):831-43. doi: 10.1016/j.molcel.2013.04.012. Epub 2013 May 16.

8.

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.

Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, Saftig P.

J Neurosci. 2010 Apr 7;30(14):4833-44. doi: 10.1523/JNEUROSCI.5221-09.2010.

9.

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains.

Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B.

Nat Cell Biol. 2009 Nov;11(11):1340-6. doi: 10.1038/ncb1978. Epub 2009 Oct 18.

PMID:
19838174
10.

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B.

Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19.

11.

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.

Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B.

Cell. 2006 Jul 14;126(1):163-75.

12.

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.

Hébert SS, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov MA, Müller U, De Strooper B.

EMBO Rep. 2006 Jul;7(7):739-45. Epub 2006 May 19.

13.

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.

Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B.

J Biol Chem. 2005 Sep 2;280(35):30797-806. Epub 2005 Jun 29.

14.

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.

Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1719-24. Epub 2005 Jan 21.

15.

Neuronal membrane cholesterol loss enhances amyloid peptide generation.

Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, Dotti CG.

J Cell Biol. 2004 Dec 6;167(5):953-60.

16.

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, Saftig P, Craessaerts K, De Strooper B, Hartmann D.

Hum Mol Genet. 2004 Jul 1;13(13):1321-31. Epub 2004 May 5.

PMID:
15128703
17.

CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior.

Frints SG, Marynen P, Hartmann D, Fryns JP, Steyaert J, Schachner M, Rolf B, Craessaerts K, Snellinx A, Hollanders K, D'Hooge R, De Deyn PP, Froyen G.

Hum Mol Genet. 2003 Jul 1;12(13):1463-74.

PMID:
12812975
18.

Gene profiling of hippocampal neuronal culture.

Dabrowski M, Aerts S, Van Hummelen P, Craessaerts K, De Moor B, Annaert W, Moreau Y, De Strooper B.

J Neurochem. 2003 Jun;85(5):1279-88.

19.

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.

Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B.

J Cell Sci. 2003 Mar 15;116(Pt 6):1127-36.

20.

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P.

Hum Mol Genet. 2002 Oct 1;11(21):2615-24.

PMID:
12354787
21.

No endogenous A beta production in presenilin-deficient fibroblasts.

Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B.

Nat Cell Biol. 2002 Jul;4(7):E164; author reply E165-6. No abstract available.

PMID:
12105423
22.

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.

Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B.

Neuron. 2001 Nov 20;32(4):579-89.

24.

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.

Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.

J Cell Biol. 2001 Aug 20;154(4):731-40. Epub 2001 Aug 13.

25.

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B.

Hum Mol Genet. 2001 Aug 1;10(16):1665-71.

PMID:
11487570
26.

Processing of beta-secretase by furin and other members of the proprotein convertase family.

Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B.

J Biol Chem. 2001 Feb 9;276(6):4211-7. Epub 2000 Nov 8.

27.

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.

Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B.

J Cell Biol. 1999 Oct 18;147(2):277-94.

28.

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.

Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B.

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7.

29.

Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.

Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE.

Mol Med. 1999 Aug;5(8):542-54.

30.

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R.

Nature. 1999 Apr 8;398(6727):518-22.

PMID:
10206645
31.

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F.

Nature. 1998 Jan 22;391(6665):387-90.

PMID:
9450754
32.

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F.

J Biol Chem. 1997 Feb 7;272(6):3590-8.

33.

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B.

J Biol Chem. 1996 Nov 1;271(44):27241-4.

35.

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