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Items: 25

1.

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus.

Antoniani C, Meneghini V, Lattanzi A, Felix T, Romano O, Magrin E, Weber L, Pavani G, El Hoss S, Kurita R, Nakamura Y, Cradick TJ, Lundberg AS, Porteus M, Amendola M, El Nemer W, Cavazzana M, Mavilio F, Miccio A.

Blood. 2018 Apr 26;131(17):1960-1973. doi: 10.1182/blood-2017-10-811505. Epub 2018 Mar 8.

2.

A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood.

Zhao J, Akinsanmi I, Arafat D, Cradick TJ, Lee CM, Banskota S, Marigorta UM, Bao G, Gibson G.

Am J Hum Genet. 2016 Feb 4;98(2):299-309. doi: 10.1016/j.ajhg.2015.12.023.

3.

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells.

Lee CM, Cradick TJ, Bao G.

Mol Ther. 2016 Mar;24(3):645-54. doi: 10.1038/mt.2016.8. Epub 2016 Jan 19.

4.

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing.

Lee CM, Cradick TJ, Fine EJ, Bao G.

Mol Ther. 2016 Mar;24(3):475-87. doi: 10.1038/mt.2016.1. Epub 2016 Jan 11. Review.

5.

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.

Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC.

Mol Ther Nucleic Acids. 2016 Jan 5;5:e273. doi: 10.1038/mtna.2015.43.

6.

Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome.

Müller M, Lee CM, Gasiunas G, Davis TH, Cradick TJ, Siksnys V, Bao G, Cathomen T, Mussolino C.

Mol Ther. 2016 Mar;24(3):636-44. doi: 10.1038/mt.2015.218. Epub 2015 Dec 14.

7.

Codon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector.

Abarrategui-Pontes C, Créneguy A, Thinard R, Fine EJ, Thepenier V, Fournier le RL, Cradick TJ, Bao G, Tesson L, Podevin G, Anegon I, Nguyen TH.

Curr Gene Ther. 2014;14(5):365-76.

PMID:
25687502
8.

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites.

Cradick TJ, Qiu P, Lee CM, Fine EJ, Bao G.

Mol Ther Nucleic Acids. 2014 Dec 2;3:e214. doi: 10.1038/mtna.2014.64.

9.

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection.

Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9591-6. doi: 10.1073/pnas.1407473111. Epub 2014 Jun 9.

10.

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences.

Lin Y, Cradick TJ, Brown MT, Deshmukh H, Ranjan P, Sarode N, Wile BM, Vertino PM, Stewart FJ, Bao G.

Nucleic Acids Res. 2014 Jun;42(11):7473-85. doi: 10.1093/nar/gku402. Epub 2014 May 16.

11.

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity.

Mussolino C, Alzubi J, Fine EJ, Morbitzer R, Cradick TJ, Lahaye T, Bao G, Cathomen T.

Nucleic Acids Res. 2014 Jun;42(10):6762-73. doi: 10.1093/nar/gku305. Epub 2014 May 3.

12.

Identification of off-target cleavage sites of zinc finger nucleases and TAL effector nucleases using predictive models.

Fine EJ, Cradick TJ, Bao G.

Methods Mol Biol. 2014;1114:371-83. doi: 10.1007/978-1-62703-761-7_24.

PMID:
24557916
13.

High-throughput cellular screening of engineered nuclease activity using the single-strand annealing assay and luciferase reporter.

Cradick TJ, Antico CJ, Bao G.

Methods Mol Biol. 2014;1114:339-52. doi: 10.1007/978-1-62703-761-7_22.

PMID:
24557914
14.

Designing and testing the activities of TAL effector nucleases.

Lin Y, Cradick TJ, Bao G.

Methods Mol Biol. 2014;1114:203-19. doi: 10.1007/978-1-62703-761-7_13.

PMID:
24557905
15.

SAPTA: a new design tool for improving TALE nuclease activity.

Lin Y, Fine EJ, Zheng Z, Antico CJ, Voit RA, Porteus MH, Cradick TJ, Bao G.

Nucleic Acids Res. 2014 Apr;42(6):e47. doi: 10.1093/nar/gkt1363. Epub 2014 Jan 16.

16.

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage.

Fine EJ, Cradick TJ, Zhao CL, Lin Y, Bao G.

Nucleic Acids Res. 2014 Apr;42(6):e42. doi: 10.1093/nar/gkt1326. Epub 2013 Dec 30.

17.

Nanomedicine: tiny particles and machines give huge gains.

Tong S, Fine EJ, Lin Y, Cradick TJ, Bao G.

Ann Biomed Eng. 2014 Feb;42(2):243-59. doi: 10.1007/s10439-013-0952-x. Epub 2013 Dec 3. Review.

18.

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity.

Cradick TJ, Fine EJ, Antico CJ, Bao G.

Nucleic Acids Res. 2013 Nov;41(20):9584-92. doi: 10.1093/nar/gkt714. Epub 2013 Aug 11.

19.

DNA targeting specificity of RNA-guided Cas9 nucleases.

Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F.

Nat Biotechnol. 2013 Sep;31(9):827-32. doi: 10.1038/nbt.2647. Epub 2013 Jul 21.

20.

Engineering imaging probes and molecular machines for nanomedicine.

Tong S, Cradick TJ, Ma Y, Dai Z, Bao G.

Sci China Life Sci. 2012 Oct;55(10):843-61. doi: 10.1007/s11427-012-4380-1. Epub 2012 Oct 31. Review.

PMID:
23108862
21.

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects.

Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK.

Nucleic Acids Res. 2012 Jul;40(12):5560-8. doi: 10.1093/nar/gks179. Epub 2012 Feb 28.

22.

ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites.

Cradick TJ, Ambrosini G, Iseli C, Bucher P, McCaffrey AP.

BMC Bioinformatics. 2011 May 13;12:152. doi: 10.1186/1471-2105-12-152.

23.

Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs.

Cradick TJ, Keck K, Bradshaw S, Jamieson AC, McCaffrey AP.

Mol Ther. 2010 May;18(5):947-54. doi: 10.1038/mt.2010.20. Epub 2010 Feb 16.

24.

Controlling gene expression in Drosophila using engineered zinc finger protein transcription factors.

Jamieson AC, Guan B, Cradick TJ, Xiao H, Holmes MC, Gregory PD, Carroll PM.

Biochem Biophys Res Commun. 2006 Sep 29;348(3):873-9. Epub 2006 Jul 31.

PMID:
16899226
25.

Defining critical residues in the epitope for a HIV-neutralizing monoclonal antibody using phage display and peptide array technologies.

Jellis CL, Cradick TJ, Rennert P, Salinas P, Boyd J, Amirault T, Gray GS.

Gene. 1993 Dec 27;137(1):63-8.

PMID:
7506691

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