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Items: 38


Breast Cancer Stem Cells.

Crabtree JS, Miele L.

Biomedicines. 2018 Jul 17;6(3). pii: E77. doi: 10.3390/biomedicines6030077. Review.


Clinical and Preclinical Advances in Gastroenteropancreatic Neuroendocrine Tumor Therapy.

Crabtree JS.

Front Endocrinol (Lausanne). 2017 Dec 4;8:341. doi: 10.3389/fendo.2017.00341. eCollection 2017. Review.


Acquisition of an oncogenic fusion protein is sufficient to globally alter the landscape of miRNA expression to inhibit myogenic differentiation.

Loupe JM, Miller PJ, Crabtree JS, Zabaleta J, Hollenbach AD.

Oncotarget. 2017 Jul 29;8(50):87054-87072. doi: 10.18632/oncotarget.19693. eCollection 2017 Oct 20.


Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.

Loupe JM, Miller PJ, Bonner BP, Maggi EC, Vijayaraghavan J, Zabaleta J, Taylor CM, Tsien F, Crabtree JS, Hollenbach AD.

Oncotarget. 2016 Sep 27;7(39):62814-62835. doi: 10.18632/oncotarget.11716.


Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.

Maggi EC, Trillo-Tinoco J, Struckhoff AP, Vijayaraghavan J, Del Valle L, Crabtree JS.

Oncogenesis. 2016 Aug 22;5(8):e257. doi: 10.1038/oncsis.2016.58.


Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion.

Loupe JM, Miller PJ, Bonner BP, Maggi EC, Vijayaraghavan J, Crabtree JS, Taylor CM, Zabaleta J, Hollenbach AD.

Oncogenesis. 2016 Jul 25;5(7):e246. doi: 10.1038/oncsis.2016.53.


Notch Signaling in Neuroendocrine Tumors.

Crabtree JS, Singleton CS, Miele L.

Front Oncol. 2016 Apr 14;6:94. doi: 10.3389/fonc.2016.00094. eCollection 2016. Review.


The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth.

McKimpson WM, Yuan Z, Zheng M, Crabtree JS, Libutti SK, Kitsis RN.

PLoS One. 2015 Dec 28;10(12):e0145792. doi: 10.1371/journal.pone.0145792. eCollection 2015.


miR-24 regulates menin in the endocrine pancreas.

Vijayaraghavan J, Maggi EC, Crabtree JS.

Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E84-92. doi: 10.1152/ajpendo.00542.2013. Epub 2014 May 13.


A mouse model of androgenetic alopecia.

Crabtree JS, Kilbourne EJ, Peano BJ, Chippari S, Kenney T, McNally C, Wang W, Harris HA, Winneker RC, Nagpal S, Thompson CC.

Endocrinology. 2010 May;151(5):2373-80. doi: 10.1210/en.2009-1474. Epub 2010 Mar 16.


Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma.

McCampbell AS, Harris HA, Crabtree JS, Winneker RC, Walker CL, Broaddus RR.

Cancer Prev Res (Phila). 2010 Mar;3(3):290-300. doi: 10.1158/1940-6207.CAPR-09-0199. Epub 2010 Feb 23.


Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway.

Crabtree JS, Jelinsky SA, Harris HA, Choe SE, Cotreau MM, Kimberland ML, Wilson E, Saraf KA, Liu W, McCampbell AS, Dave B, Broaddus RR, Brown EL, Kao W, Skotnicki JS, Abou-Gharbia M, Winneker RC, Walker CL.

Cancer Res. 2009 Aug 1;69(15):6171-8. doi: 10.1158/0008-5472.CAN-08-4471. Epub 2009 Jul 21.


Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland.

Peano BJ, Crabtree JS, Komm BS, Winneker RC, Harris HA.

Endocrinology. 2009 Apr;150(4):1897-903. doi: 10.1210/en.2008-1210. Epub 2008 Nov 20.


Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman.

Jelinsky SA, Choe SE, Crabtree JS, Cotreau MM, Wilson E, Saraf K, Dorner AJ, Brown EL, Peano BJ, Zhang X, Winneker RC, Harris HA.

BMC Med Genomics. 2008 Jun 25;1:27. doi: 10.1186/1755-8794-1-27.


Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland.

Crabtree JS, Peano BJ, Zhang X, Komm BS, Winneker RC, Harris HA.

Mol Cell Endocrinol. 2008 Jun 11;287(1-2):40-6. doi: 10.1016/j.mce.2008.01.027. Epub 2008 Feb 12.


A study of 17beta-estradiol-regulated genes in the vagina of postmenopausal women with vaginal atrophy.

Cotreau MM, Chennathukuzhi VM, Harris HA, Han L, Dorner AJ, Apseloff G, Varadarajan U, Hatstat E, Zakaria M, Strahs AL, Crabtree JS, Winneker RC, Jelinsky SA.

Maturitas. 2007 Dec 20;58(4):366-76. Epub 2007 Nov 9.


Development of a mouse model of mammary gland versus uterus tissue selectivity using estrogen- and progesterone-regulated gene markers.

Crabtree JS, Zhang X, Peano BJ, Zhang Z, Winneker RC, Harris HA.

J Steroid Biochem Mol Biol. 2006 Sep;101(1):11-21. Epub 2006 Aug 22.


Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.

Scacheri PC, Crabtree JS, Kennedy AL, Swain GP, Ward JM, Marx SJ, Spiegel AM, Collins FS.

Mamm Genome. 2004 Nov;15(11):872-7.


Molecular pathology of the MEN1 gene.

Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

Ann N Y Acad Sci. 2004 Apr;1014:189-98. Review.


Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism.

Libutti SK, Crabtree JS, Lorang D, Burns AL, Mazzanti C, Hewitt SM, O'Connor S, Ward JM, Emmert-Buck MR, Remaley A, Miller M, Turner E, Alexander HR, Arnold A, Marx SJ, Collins FS, Spiegel AM.

Cancer Res. 2003 Nov 15;63(22):8022-8.


Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.

Agarwal SK, Novotny EA, Crabtree JS, Weitzman JB, Yaniv M, Burns AL, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10770-5. Epub 2003 Sep 5.


Of mice and MEN1: Insulinomas in a conditional mouse knockout.

Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS.

Mol Cell Biol. 2003 Sep;23(17):6075-85.


The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.

Sukhodolets KE, Hickman AB, Agarwal SK, Sukhodolets MV, Obungu VH, Novotny EA, Crabtree JS, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, Marx SJ.

Mol Cell Biol. 2003 Jan;23(2):493-509.


Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice.

Scacheri PC, Crabtree JS, Novotny EA, Garrett-Beal L, Chen A, Edgemon KA, Marx SJ, Spiegel AM, Chandrasekharappa SC, Collins FS.

Genesis. 2001 Aug;30(4):259-63.


A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

Crabtree JS, Scacheri PC, Ward JM, Garrett-Beal L, Emmert-Buck MR, Edgemon KA, Lorang D, Libutti SK, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23.


The gene for multiple endocrine neoplasia type 1: recent findings.

Marx SJ, Agarwal SK, Heppner C, Kim YS, Kester MB, Goldsmith PK, Skarulis MC, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree JS, Collins FS, Chandrasekharappa SC.

Bone. 1999 Jul;25(1):119-22. Review.


Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene.

Guru SC, Crabtree JS, Brown KD, Dunn KJ, Manickam P, Prasad NB, Wangsa D, Burns AL, Spiegel AM, Marx SJ, Pavan WJ, Collins FS, Chandrasekharappa SC.

Mamm Genome. 1999 Jun;10(6):592-6.


Identification and characterization of the multiple endocrine neoplasia type 1 (MEN1) gene.

Guru SC, Manickam P, Crabtree JS, Olufemi SE, Agarwal SK, Debelenko LV.

J Intern Med. 1998 Jun;243(6):433-9.


Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families.

Agarwal SK, Debelenko LV, Kester MB, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Heppner C, Crabtree JS, Lubensky IA, Zhuang Z, Kim YS, Chandrasekharappa SC, Collins FS, Liotta LA, Spiegel AM, Burns AL, Emmert-Buck MR, Marx SJ.

Hum Mutat. 1998;12(2):75-82.


Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung.

Debelenko LV, Brambilla E, Agarwal SK, Swalwell JI, Kester MB, Lubensky IA, Zhuang Z, Guru SC, Manickam P, Olufemi SE, Chandrasekharappa SC, Crabtree JS, Kim YS, Heppner C, Burns AL, Spiegel AM, Marx SJ, Liotta LA, Collins FS, Travis WD, Emmert-Buck MR.

Hum Mol Genet. 1997 Dec;6(13):2285-90.


Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region.

Manickam P, Guru SC, Debelenko LV, Agarwal SK, Olufemi SE, Weisemann JM, Boguski MS, Crabtree JS, Wang Y, Roe BA, Lubensky IA, Zhuang Z, Kester MB, Burns AL, Spiegel AM, Marx SJ, Liotta LA, Emmert-Buck MR, Collins FS, Chandrasekharappa SC.

Hum Genet. 1997 Nov;101(1):102-8.


Mutations of the MEN1 tumor suppressor gene in pituitary tumors.

Zhuang Z, Ezzat SZ, Vortmeyer AO, Weil R, Oldfield EH, Park WS, Pack S, Huang S, Agarwal SK, Guru SC, Manickam P, Debelenko LV, Kester MB, Olufemi SE, Heppner C, Crabtree JS, Burns AL, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Emmert-Buck MR, Liotta LA, Asa SL, Lubensky IA.

Cancer Res. 1997 Dec 15;57(24):5446-51.


Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.

Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Agarwal SK, Debelenko LV, Kester M, Guru SC, Manickam P, Olufemi SE, Yu F, Heppner C, Crabtree JS, Skarulis MC, Venzon DJ, Emmert-Buck MR, Spiegel AM, Chandrasekharappa SC, Collins FS, Burns AL, Marx SJ, Lubensky IA, et al.

Cancer Res. 1997 Nov 1;57(21):4682-6.


A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC.

Genome Res. 1997 Jul;7(7):725-35.


A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13.

Guru SC, Olufemi SE, Manickam P, Cummings C, Gieser LM, Pike BL, Bittner ML, Jiang Y, Chinault AC, Nowak NJ, Brzozowska A, Crabtree JS, Wang Y, Roe BA, Weisemann JM, Boguski MS, Agarwal SK, Burns AL, Spiegel AM, Marx SJ, Flejter WL, de Jong PJ, Collins FS, Chandrasekharappa SC.

Genomics. 1997 Jun 15;42(3):436-45.


Positional cloning of the gene for multiple endocrine neoplasia-type 1.

Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ.

Science. 1997 Apr 18;276(5311):404-7.


Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog.

Wu X, Robinson CE, Fong HW, Crabtree JS, Rodriguez BR, Roe BA, Gimble JM.

Biochem Biophys Res Commun. 1995 Nov 2;216(1):78-83.


The complete nucleotide sequences of the SacBII Kan domain of the P1 pAD10-SacBII cloning vector and three cosmid cloning vectors: pTCF, svPHEP, and LAWRIST16.

Pan HQ, Wang YP, Chissoe SL, Bodenteich A, Wang Z, Iyer K, Clifton SW, Crabtree JS, Roe BA.

Genet Anal Tech Appl. 1994;11(5-6):181-6.


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