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Chromatin regulators mediate anthracycline sensitivity in breast cancer.

Seoane JA, Kirkland JG, Caswell-Jin JL, Crabtree GR, Curtis C.

Nat Med. 2019 Nov;25(11):1721-1727. doi: 10.1038/s41591-019-0638-5. Epub 2019 Nov 7.


Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome.

Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR.

Mol Cell. 2019 Jan 3;73(1):61-72.e3. doi: 10.1016/j.molcel.2018.10.028. Epub 2018 Nov 21.


Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. 1989. 246: 1617-1620.

Emmel EA, Verweij CL, Durand DB, Higgins KM, Lacy E, Crabtree GR.

J Immunol. 2018 Dec 1;201(11):3149-3152. No abstract available.


Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.

Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC.

Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. Epub 2018 Sep 6.


Chemically induced proximity in biology and medicine.

Stanton BZ, Chory EJ, Crabtree GR.

Science. 2018 Mar 9;359(6380). pii: eaao5902. doi: 10.1126/science.aao5902. Review.


Rapid chromatin repression by Aire provides precise control of immune tolerance.

Koh AS, Miller EL, Buenrostro JD, Moskowitz DM, Wang J, Greenleaf WJ, Chang HY, Crabtree GR.

Nat Immunol. 2018 Feb;19(2):162-172. doi: 10.1038/s41590-017-0032-8. Epub 2018 Jan 15.


Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.

Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR.

Nat Struct Mol Biol. 2018 Jan;25(1):61-72. doi: 10.1038/s41594-017-0007-3. Epub 2017 Dec 11.


Rapid and reversible epigenome editing by endogenous chromatin regulators.

Braun SMG, Kirkland JG, Chory EJ, Husmann D, Calarco JP, Crabtree GR.

Nat Commun. 2017 Sep 15;8(1):560. doi: 10.1038/s41467-017-00644-y.


DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

Morrison EA, Sanchez JC, Ronan JL, Farrell DP, Varzavand K, Johnson JK, Gu BX, Crabtree GR, Musselman CA.

Nat Commun. 2017 Jul 14;8:16080. doi: 10.1038/ncomms16080.


Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.

Ren J, Hathaway NA, Crabtree GR, Muegge K.

Epigenetics. 2018;13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6.


Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.

Platt RJ, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J, Desai M, Sood S, Kempton HR, Crabtree GR, Feng G, Zhang F.

Cell Rep. 2017 Apr 11;19(2):335-350. doi: 10.1016/j.celrep.2017.03.052.


A General Non-Radioactive ATPase Assay for Chromatin Remodeling Complexes.

Stanton BZ, Hodges C, Crabtree GR, Zhao K.

Curr Protoc Chem Biol. 2017 Mar 2;9(1):1-10. doi: 10.1002/cpch.16.


TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin.

Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR.

Nat Struct Mol Biol. 2017 Apr;24(4):344-352. doi: 10.1038/nsmb.3384. Epub 2017 Feb 27.


Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states.

Kadoch C, Williams RT, Calarco JP, Miller EL, Weber CM, Braun SM, Pulice JL, Chory EJ, Crabtree GR.

Nat Genet. 2017 Feb;49(2):213-222. doi: 10.1038/ng.3734. Epub 2016 Dec 12.


Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin.

Stanton BZ, Hodges C, Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR.

Nat Genet. 2017 Feb;49(2):282-288. doi: 10.1038/ng.3735. Epub 2016 Dec 12.


The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance.

Krasteva V, Crabtree GR, Lessard JA.

Exp Hematol. 2017 Apr;48:58-71.e15. doi: 10.1016/j.exphem.2016.11.008. Epub 2016 Dec 5.


The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer.

Hodges C, Kirkland JG, Crabtree GR.

Cold Spring Harb Perspect Med. 2016 Aug 1;6(8). pii: a026930. doi: 10.1101/cshperspect.a026930. Review.


Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

Kadoch C, Crabtree GR.

Sci Adv. 2015 Jun 12;1(5):e1500447. doi: 10.1126/sciadv.1500447. eCollection 2015 Jun. Review.


Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities.

Zhan X, Cao M, Yoo AS, Zhang Z, Chen L, Crabtree GR, Wu JI.

Genesis. 2015 Jul;53(7):440-8. doi: 10.1002/dvg.22866. Epub 2015 Jun 23.


The role of BAF (mSWI/SNF) complexes in mammalian neural development.

Son EY, Crabtree GR.

Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):333-49. doi: 10.1002/ajmg.c.31416. Epub 2014 Sep 5.


Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.

Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA.

Blood. 2014 Mar 13;123(11):1720-8. doi: 10.1182/blood-2013-02-483495. Epub 2014 Jan 29.


Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains.

Takebayashi S, Lei I, Ryba T, Sasaki T, Dileep V, Battaglia D, Gao X, Fang P, Fan Y, Esteban MA, Tang J, Crabtree GR, Wang Z, Gilbert DM.

Epigenetics Chromatin. 2013 Dec 13;6(1):42. doi: 10.1186/1756-8935-6-42.


Creating a neural specific chromatin landscape by npBAF and nBAF complexes.

Staahl BT, Crabtree GR.

Curr Opin Neurobiol. 2013 Dec;23(6):903-13. doi: 10.1016/j.conb.2013.09.003. Epub 2013 Oct 1. Review.


Reprogramming human fibroblasts to neurons by recapitulating an essential microRNA-chromatin switch.

Tang J, Yoo AS, Crabtree GR.

Curr Opin Genet Dev. 2013 Oct;23(5):591-8. doi: 10.1016/j.gde.2013.07.001.


Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.

Staahl BT, Tang J, Wu W, Sun A, Gitler AD, Yoo AS, Crabtree GR.

J Neurosci. 2013 Jun 19;33(25):10348-61. doi: 10.1523/JNEUROSCI.1258-13.2013.


Exome sequencing to identify de novo mutations in sporadic ALS trios.

Chesi A, Staahl BT, Jovičić A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD.

Nat Neurosci. 2013 Jul;16(7):851-5. doi: 10.1038/nn.3412. Epub 2013 May 26.


BAF complexes facilitate decatenation of DNA by topoisomerase IIα.

Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR.

Nature. 2013 May 30;497(7451):624-7. doi: 10.1038/nature12146. Epub 2013 May 22.


Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR.

Nat Genet. 2013 Jun;45(6):592-601. doi: 10.1038/ng.2628. Epub 2013 May 5.


From neural development to cognition: unexpected roles for chromatin.

Ronan JL, Wu W, Crabtree GR.

Nat Rev Genet. 2013 May;14(5):347-59. doi: 10.1038/nrg3413. Epub 2013 Apr 9. Review. Erratum in: Nat Rev Genet. 2013 Jun;14(6):440.


Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma.

Kadoch C, Crabtree GR.

Cell. 2013 Mar 28;153(1):71-85. doi: 10.1016/j.cell.2013.02.036.


The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.

Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA.

Nat Neurosci. 2013 May;16(5):552-61. doi: 10.1038/nn.3359. Epub 2013 Mar 24.


Rethinking our intellectual origins: response to Kalinka et al.

Crabtree GR.

Trends Genet. 2013 Mar;29(3):127-9. doi: 10.1016/j.tig.2013.01.013. Epub 2013 Feb 17. No abstract available.


ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.

Bao X, Tang J, Lopez-Pajares V, Tao S, Qu K, Crabtree GR, Khavari PA.

Cell Stem Cell. 2013 Feb 7;12(2):193-203. doi: 10.1016/j.stem.2012.12.014.


MicroRNAs: regulators of neuronal fate.

Sun AX, Crabtree GR, Yoo AS.

Curr Opin Cell Biol. 2013 Apr;25(2):215-21. doi: 10.1016/ Epub 2013 Jan 29. Review.


Our fragile intellect. Part II.

Crabtree GR.

Trends Genet. 2013 Jan;29(1):3-5. doi: 10.1016/j.tig.2012.10.003. Epub 2012 Nov 12.


Our fragile intellect. Part I.

Crabtree GR.

Trends Genet. 2013 Jan;29(1):1-3. doi: 10.1016/j.tig.2012.10.002. Epub 2012 Nov 12.


The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function.

Krasteva V, Buscarlet M, Diaz-Tellez A, Bernard MA, Crabtree GR, Lessard JA.

Blood. 2012 Dec 6;120(24):4720-32. doi: 10.1182/blood-2012-04-427047. Epub 2012 Sep 26.


Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation.

Dykhuizen EC, Carmody LC, Tolliday N, Crabtree GR, Palmer MA.

J Biomol Screen. 2012 Oct;17(9):1221-30. Epub 2012 Aug 1.


Dynamics of inherently bounded histone modification domains.

Hodges C, Crabtree GR.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13296-301. doi: 10.1073/pnas.1211172109. Epub 2012 Jul 30.


Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.

Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, Ramos AH, Ross MG, Russ C, Shefler E, Sivachenko A, Sogoloff B, Stojanov P, Tamayo P, Mesirov JP, Amani V, Teider N, Sengupta S, Francois JP, Northcott PA, Taylor MD, Yu F, Crabtree GR, Kautzman AG, Gabriel SB, Getz G, Jäger N, Jones DT, Lichter P, Pfister SM, Roberts TM, Meyerson M, Pomeroy SL, Cho YJ.

Nature. 2012 Aug 2;488(7409):106-10. doi: 10.1038/nature11329.


Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.

Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK.

Dev Cell. 2012 Jul 17;23(1):21-34. doi: 10.1016/j.devcel.2012.05.014.


Dynamics and memory of heterochromatin in living cells.

Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR.

Cell. 2012 Jun 22;149(7):1447-60. doi: 10.1016/j.cell.2012.03.052. Epub 2012 Jun 14.


esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function.

Ho L, Miller EL, Ronan JL, Ho WQ, Jothi R, Crabtree GR.

Nat Cell Biol. 2011 Jul 24;13(8):903-13. doi: 10.1038/ncb2285.


MicroRNA-mediated conversion of human fibroblasts to neurons.

Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR.

Nature. 2011 Jul 13;476(7359):228-31. doi: 10.1038/nature10323.


Engineering the ABA plant stress pathway for regulation of induced proximity.

Liang FS, Ho WQ, Crabtree GR.

Sci Signal. 2011 Mar 15;4(164):rs2. doi: 10.1126/scisignal.2001449.


ATP-dependent chromatin remodeling: genetics, genomics and mechanisms.

Hargreaves DC, Crabtree GR.

Cell Res. 2011 Mar;21(3):396-420. doi: 10.1038/cr.2011.32. Epub 2011 Mar 1. Review.


Identification of a putative regulator of early T cell activation genes. Science. 1988. 241: 202-205.

Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR.

J Immunol. 2010 Nov 1;185(9):4972-5. No abstract available.


Chromatin regulatory mechanisms in pluripotency.

Lessard JA, Crabtree GR.

Annu Rev Cell Dev Biol. 2010;26:503-32. doi: 10.1146/annurev-cellbio-051809-102012. Review.


Chromatin remodelling during development.

Ho L, Crabtree GR.

Nature. 2010 Jan 28;463(7280):474-84. doi: 10.1038/nature08911. Review.


SnapShot: Ca2+-calcineurin-NFAT signaling.

Crabtree GR, Schreiber SL.

Cell. 2009 Jul 10;138(1):210, 210.e1. doi: 10.1016/j.cell.2009.06.026. No abstract available.

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