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Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice.

Mukai J, Cannavò E, Crabtree GW, Sun Z, Diamantopoulou A, Thakur P, Chang CY, Cai Y, Lomvardas S, Takata A, Xu B, Gogos JA.

Neuron. 2019 Oct 1. pii: S0896-6273(19)30787-1. doi: 10.1016/j.neuron.2019.09.014. [Epub ahead of print]


Addressing the challenge of carbon-free energy.

Eisenberg R, Gray HB, Crabtree GW.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201821674. doi: 10.1073/pnas.1821674116. [Epub ahead of print]


The abiding relevance of mouse models of rare mutations to psychiatric neuroscience and therapeutics.

Gogos JA, Crabtree G, Diamantopoulou A.

Schizophr Res. 2019 Apr 12. pii: S0920-9964(19)30112-4. doi: 10.1016/j.schres.2019.03.018. [Epub ahead of print]


Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome.

Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR.

Mol Cell. 2019 Jan 3;73(1):61-72.e3. doi: 10.1016/j.molcel.2018.10.028. Epub 2018 Nov 21.


Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. 1989. 246: 1617-1620.

Emmel EA, Verweij CL, Durand DB, Higgins KM, Lacy E, Crabtree GR.

J Immunol. 2018 Dec 1;201(11):3149-3152. No abstract available.


Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.

Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC.

Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. Epub 2018 Sep 6.


Role of Endogenous Metabolite Alterations in Neuropsychiatric Disease.

Crabtree GW, Gogos JA.

ACS Chem Neurosci. 2018 Sep 19;9(9):2101-2113. doi: 10.1021/acschemneuro.8b00145. Epub 2018 Aug 31.



Onishi SM, Crabtree GS, Marks SJ, Wilson T, Shields CL.

Retin Cases Brief Rep. 2018 Jul 17. doi: 10.1097/ICB.0000000000000755. [Epub ahead of print]


Chemically induced proximity in biology and medicine.

Stanton BZ, Chory EJ, Crabtree GR.

Science. 2018 Mar 9;359(6380). pii: eaao5902. doi: 10.1126/science.aao5902. Review.


Rapid chromatin repression by Aire provides precise control of immune tolerance.

Koh AS, Miller EL, Buenrostro JD, Moskowitz DM, Wang J, Greenleaf WJ, Chang HY, Crabtree GR.

Nat Immunol. 2018 Feb;19(2):162-172. doi: 10.1038/s41590-017-0032-8. Epub 2018 Jan 15.


Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.

Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR.

Nat Struct Mol Biol. 2018 Jan;25(1):61-72. doi: 10.1038/s41594-017-0007-3. Epub 2017 Dec 11.


Parallel magnetic field suppresses dissipation in superconducting nanostrips.

Wang YL, Glatz A, Kimmel GJ, Aranson IS, Thoutam LR, Xiao ZL, Berdiyorov GR, Peeters FM, Crabtree GW, Kwok WK.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10274-E10280. doi: 10.1073/pnas.1619550114. Epub 2017 Nov 13.


Rapid and reversible epigenome editing by endogenous chromatin regulators.

Braun SMG, Kirkland JG, Chory EJ, Husmann D, Calarco JP, Crabtree GR.

Nat Commun. 2017 Sep 15;8(1):560. doi: 10.1038/s41467-017-00644-y.


DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

Morrison EA, Sanchez JC, Ronan JL, Farrell DP, Varzavand K, Johnson JK, Gu BX, Crabtree GR, Musselman CA.

Nat Commun. 2017 Jul 14;8:16080. doi: 10.1038/ncomms16080.


Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.

Ren J, Hathaway NA, Crabtree GR, Muegge K.

Epigenetics. 2018;13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6.


Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.

Platt RJ, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J, Desai M, Sood S, Kempton HR, Crabtree GR, Feng G, Zhang F.

Cell Rep. 2017 Apr 11;19(2):335-350. doi: 10.1016/j.celrep.2017.03.052.


Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.

Crabtree GW, Sun Z, Kvajo M, Broek JA, Fénelon K, McKellar H, Xiao L, Xu B, Bahn S, O'Donnell JM, Gogos JA.

J Neurosci. 2017 Apr 12;37(15):4158-4180. doi: 10.1523/JNEUROSCI.4345-15.2017. Epub 2017 Mar 10.


A General Non-Radioactive ATPase Assay for Chromatin Remodeling Complexes.

Stanton BZ, Hodges C, Crabtree GR, Zhao K.

Curr Protoc Chem Biol. 2017 Mar 2;9(1):1-10. doi: 10.1002/cpch.16.


TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin.

Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR.

Nat Struct Mol Biol. 2017 Apr;24(4):344-352. doi: 10.1038/nsmb.3384. Epub 2017 Feb 27.


Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states.

Kadoch C, Williams RT, Calarco JP, Miller EL, Weber CM, Braun SM, Pulice JL, Chory EJ, Crabtree GR.

Nat Genet. 2017 Feb;49(2):213-222. doi: 10.1038/ng.3734. Epub 2016 Dec 12.


Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin.

Stanton BZ, Hodges C, Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR.

Nat Genet. 2017 Feb;49(2):282-288. doi: 10.1038/ng.3735. Epub 2016 Dec 12.


The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance.

Krasteva V, Crabtree GR, Lessard JA.

Exp Hematol. 2017 Apr;48:58-71.e15. doi: 10.1016/j.exphem.2016.11.008. Epub 2016 Dec 5.


Hemifacial spasm in a patient with basilar artery dolichoectasia caused by uncontrolled hypertension.

Crabtree GS, Gish D, Goldberg D.

J Community Hosp Intern Med Perspect. 2016 Oct 26;6(5):32686. doi: 10.3402/jchimp.v6.32686. eCollection 2016.


Impending aortic aneurysm rupture - a case report and review of the warning signs.

Gish DS, Baer JA, Crabtree GS, Shaikh B, Fareedy SB.

J Community Hosp Intern Med Perspect. 2016 Oct 26;6(5):32217. doi: 10.3402/jchimp.v6.32217. eCollection 2016.


Vortices in high-performance high-temperature superconductors.

Kwok WK, Welp U, Glatz A, Koshelev AE, Kihlstrom KJ, Crabtree GW.

Rep Prog Phys. 2016 Nov;79(11):116501. Epub 2016 Sep 21.


Large spin-orbit coupling and helical spin textures in 2D heterostructure [Pb2BiS3][AuTe2].

Fang L, Im J, DeGottardi W, Jia Y, Glatz A, Matveev KA, Kwok WK, Crabtree GW, Kanatzidis MG.

Sci Rep. 2016 Oct 12;6:35313. doi: 10.1038/srep35313.


Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.

Crabtree GW, Park AJ, Gordon JA, Gogos JA.

Cell Rep. 2016 Oct 4;17(2):570-582. doi: 10.1016/j.celrep.2016.09.029.


The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer.

Hodges C, Kirkland JG, Crabtree GR.

Cold Spring Harb Perspect Med. 2016 Aug 1;6(8). pii: a026930. doi: 10.1101/cshperspect.a026930. Review.


Rewritable artificial magnetic charge ice.

Wang YL, Xiao ZL, Snezhko A, Xu J, Ocola LE, Divan R, Pearson JE, Crabtree GW, Kwok WK.

Science. 2016 May 20;352(6288):962-6. doi: 10.1126/science.aad8037.


Toward Superconducting Critical Current by Design.

Sadovskyy IA, Jia Y, Leroux M, Kwon J, Hu H, Fang L, Chaparro C, Zhu S, Welp U, Zuo JM, Zhang Y, Nakasaki R, Selvamanickam V, Crabtree GW, Koshelev AE, Glatz A, Kwok WK.

Adv Mater. 2016 Jun;28(23):4593-600. doi: 10.1002/adma.201600602. Epub 2016 Mar 31.


The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo.

Panamarova M, Cox A, Wicher KB, Butler R, Bulgakova N, Jeon S, Rosen B, Seong RH, Skarnes W, Crabtree G, Zernicka-Goetz M.

Development. 2016 Apr 15;143(8):1271-83. doi: 10.1242/dev.131961. Epub 2016 Mar 7.


Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

Kadoch C, Crabtree GR.

Sci Adv. 2015 Jun 12;1(5):e1500447. doi: 10.1126/sciadv.1500447. eCollection 2015 Jun. Review.


Perspective: The energy-storage revolution.

Crabtree G.

Nature. 2015 Oct 29;526(7575):S92. doi: 10.1038/526S92a. No abstract available.


Temperature-Dependent Three-Dimensional Anisotropy of the Magnetoresistance in WTe_{2}.

Thoutam LR, Wang YL, Xiao ZL, Das S, Luican-Mayer A, Divan R, Crabtree GW, Kwok WK.

Phys Rev Lett. 2015 Jul 24;115(4):046602. Epub 2015 Jul 22.


Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities.

Zhan X, Cao M, Yoo AS, Zhang Z, Chen L, Crabtree GR, Wu JI.

Genesis. 2015 Jul;53(7):440-8. doi: 10.1002/dvg.22866. Epub 2015 Jun 23.


Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia.

Crabtree GW, Gogos JA.

Front Synaptic Neurosci. 2014 Nov 25;6:28. doi: 10.3389/fnsyn.2014.00028. eCollection 2014. Review.


Iris metastasis from systemic cancer in 104 patients: the 2014 Jerry A. Shields Lecture.

Shields CL, Kaliki S, Crabtree GS, Peshtani A, Morton S, Anand RA, Coco G, Shields JA.

Cornea. 2015 Jan;34(1):42-8. doi: 10.1097/ICO.0000000000000285.


Value Driven Outcomes (VDO): a pragmatic, modular, and extensible software framework for understanding and improving health care costs and outcomes.

Kawamoto K, Martin CJ, Williams K, Tu MC, Park CG, Hunter C, Staes CJ, Bray BE, Deshmukh VG, Holbrook RA, Morris SJ, Fedderson MB, Sletta A, Turnbull J, Mulvihill SJ, Crabtree GL, Entwistle DE, McKenna QL, Strong MB, Pendleton RC, Lee VS.

J Am Med Inform Assoc. 2015 Jan;22(1):223-35. doi: 10.1136/amiajnl-2013-002511. Epub 2014 Oct 16.


The role of BAF (mSWI/SNF) complexes in mammalian neural development.

Son EY, Crabtree GR.

Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):333-49. doi: 10.1002/ajmg.c.31416. Epub 2014 Sep 5.


A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab.

Fredericks CA, Kvam KA, Bear J, Crabtree GS, Josephson SA.

Lupus. 2014 Jun;23(7):711-3. doi: 10.1177/0961203314524292. Epub 2014 Feb 14.


Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.

Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA.

Blood. 2014 Mar 13;123(11):1720-8. doi: 10.1182/blood-2013-02-483495. Epub 2014 Jan 29.


Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains.

Takebayashi S, Lei I, Ryba T, Sasaki T, Dileep V, Battaglia D, Gao X, Fang P, Fan Y, Esteban MA, Tang J, Crabtree GR, Wang Z, Gilbert DM.

Epigenetics Chromatin. 2013 Dec 13;6(1):42. doi: 10.1186/1756-8935-6-42.


Huge critical current density and tailored superconducting anisotropy in SmFeAsO₀.₈F₀.₁₅ by low-density columnar-defect incorporation.

Fang L, Jia Y, Mishra V, Chaparro C, Vlasko-Vlasov VK, Koshelev AE, Welp U, Crabtree GW, Zhu S, Zhigadlo ND, Katrych S, Karpinski J, Kwok WK.

Nat Commun. 2013;4:2655. doi: 10.1038/ncomms3655.


Creating a neural specific chromatin landscape by npBAF and nBAF complexes.

Staahl BT, Crabtree GR.

Curr Opin Neurobiol. 2013 Dec;23(6):903-13. doi: 10.1016/j.conb.2013.09.003. Epub 2013 Oct 1. Review.


Reprogramming human fibroblasts to neurons by recapitulating an essential microRNA-chromatin switch.

Tang J, Yoo AS, Crabtree GR.

Curr Opin Genet Dev. 2013 Oct;23(5):591-8. doi: 10.1016/j.gde.2013.07.001.


The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.

Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M.

Cell Stem Cell. 2013 Oct 3;13(4):403-18. doi: 10.1016/j.stem.2013.07.002. Epub 2013 Aug 8.


Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.

Staahl BT, Tang J, Wu W, Sun A, Gitler AD, Yoo AS, Crabtree GR.

J Neurosci. 2013 Jun 19;33(25):10348-61. doi: 10.1523/JNEUROSCI.1258-13.2013.


Exome sequencing to identify de novo mutations in sporadic ALS trios.

Chesi A, Staahl BT, Jovičić A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD.

Nat Neurosci. 2013 Jul;16(7):851-5. doi: 10.1038/nn.3412. Epub 2013 May 26.


BAF complexes facilitate decatenation of DNA by topoisomerase IIα.

Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR.

Nature. 2013 May 30;497(7451):624-7. doi: 10.1038/nature12146. Epub 2013 May 22.


Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR.

Nat Genet. 2013 Jun;45(6):592-601. doi: 10.1038/ng.2628. Epub 2013 May 5.

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