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Items: 1 to 50 of 170

1.

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.

Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan FR, Minkah NK, Dadonaite B, Diouf A, Galaway F, Silk SE, Jamwal A, Marshall JM, Miura K, Foquet L, Elias SC, Labbé GM, Douglas AD, Jin J, Payne RO, Illingworth JJ, Pattinson DJ, Pulido D, Williams BG, de Jongh WA, Wright GJ, Kappe SHI, Robinson CV, Long CA, Crabb BS, Gilson PR, Higgins MK, Draper SJ.

Cell. 2019 Jun 11. pii: S0092-8674(19)30553-7. doi: 10.1016/j.cell.2019.05.025. [Epub ahead of print]

2.

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.

Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar.

PMID:
30559138
3.

The N-terminus of EXP2 forms the membrane-associated pore of the protein exporting translocon PTEX in Plasmodium falciparum.

Sanders PR, Dickerman BK, Charnaud SC, Ramsland PA, Crabb BS, Gilson PR.

J Biochem. 2019 Mar 1;165(3):239-248. doi: 10.1093/jb/mvy099.

PMID:
30476118
4.

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export.

Charnaud SC, Kumarasingha R, Bullen HE, Crabb BS, Gilson PR.

PLoS One. 2018 Nov 15;13(11):e0204785. doi: 10.1371/journal.pone.0204785. eCollection 2018.

5.

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte.

Marapana DS, Dagley LF, Sandow JJ, Nebl T, Triglia T, Pasternak M, Dickerman BK, Crabb BS, Gilson PR, Webb AI, Boddey JA, Cowman AF.

Nat Microbiol. 2018 Sep;3(9):1010-1022. doi: 10.1038/s41564-018-0219-2. Epub 2018 Aug 20.

PMID:
30127496
6.

Spatial organization of protein export in malaria parasite blood stages.

Charnaud SC, Jonsdottir TK, Sanders PR, Bullen HE, Dickerman BK, Kouskousis B, Palmer CS, Pietrzak HM, Laumaea AE, Erazo AB, McHugh E, Tilley L, Crabb BS, Gilson PR.

Traffic. 2018 Aug;19(8):605-623. doi: 10.1111/tra.12577. Epub 2018 May 23.

7.

Functional Conservation of the AMA1 Host-Cell Invasion Ligand Between P. falciparum and P. vivax: A Novel Platform to Accelerate Vaccine and Drug Development.

Drew DR, Sanders PR, Weiss G, Gilson PR, Crabb BS, Beeson JG.

J Infect Dis. 2018 Jan 17;217(3):498-507. doi: 10.1093/infdis/jix583.

PMID:
29165651
8.

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR.

J Immunol. 2017 Dec 15;199(12):4165-4179. doi: 10.4049/jimmunol.1700186. Epub 2017 Oct 30.

9.

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.

Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR.

PLoS One. 2017 Jul 21;12(7):e0181656. doi: 10.1371/journal.pone.0181656. eCollection 2017.

10.

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate.

Counihan NA, Chisholm SA, Bullen HE, Srivastava A, Sanders PR, Jonsdottir TK, Weiss GE, Ghosh S, Crabb BS, Creek DJ, Gilson PR, de Koning-Ward TF.

Elife. 2017 Mar 2;6. pii: e23217. doi: 10.7554/eLife.23217.

11.

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE.

J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26.

PMID:
28080063
12.

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum.

Dickerman BK, Elsworth B, Cobbold SA, Nie CQ, McConville MJ, Crabb BS, Gilson PR.

Sci Rep. 2016 Nov 22;6:37502. doi: 10.1038/srep37502.

13.

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.

McCallum FJ, Persson KE, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG.

J Leukoc Biol. 2017 Apr;101(4):913-925. doi: 10.1189/jlb.5MA0716-294R. Epub 2016 Nov 11.

14.

Trafficking of the exported P. falciparum chaperone PfHsp70x.

Rhiel M, Bittl V, Tribensky A, Charnaud SC, Strecker M, Müller S, Lanzer M, Sanchez C, Schaeffer-Reiss C, Westermann B, Crabb BS, Gilson PR, Külzer S, Przyborski JM.

Sci Rep. 2016 Nov 8;6:36174. doi: 10.1038/srep36174.

15.

Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.

Elsworth B, Sanders PR, Nebl T, Batinovic S, Kalanon M, Nie CQ, Charnaud SC, Bullen HE, de Koning Ward TF, Tilley L, Crabb BS, Gilson PR.

Cell Microbiol. 2016 Nov;18(11):1551-1569. doi: 10.1111/cmi.12596. Epub 2016 May 3.

PMID:
27019089
16.

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR.

Immunity. 2016 Oct 18;45(4):889-902. doi: 10.1016/j.immuni.2016.08.011. Epub 2016 Sep 27.

17.

Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.

Littler DR, Bullen HE, Harvey KL, Beddoe T, Crabb BS, Rossjohn J, Gilson PR.

J Biol Chem. 2016 Dec 2;291(49):25375-25386. Epub 2016 Oct 13.

18.

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites.

Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW.

Sci Rep. 2016 Oct 4;6:34479. doi: 10.1038/srep34479.

19.

Host cell remodelling in malaria parasites: a new pool of potential drug targets.

Gilson PR, Chisholm SA, Crabb BS, de Koning-Ward TF.

Int J Parasitol. 2017 Feb;47(2-3):119-127. doi: 10.1016/j.ijpara.2016.06.001. Epub 2016 Jun 29. Review.

PMID:
27368610
20.

Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum.

Buskes MJ, Harvey KL, Prinz B, Crabb BS, Gilson PR, Wilson DJ, Abbott BM.

Bioorg Med Chem. 2016 Jun 1;24(11):2389-96. doi: 10.1016/j.bmc.2016.03.048. Epub 2016 Mar 28.

PMID:
27112453
21.

Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation.

Buskes MJ, Harvey KL, Richards BJ, Kalhor R, Christoff RM, Gardhi CK, Littler DR, Cope ED, Prinz B, Weiss GE, O'Brien NJ, Crabb BS, Deady LW, Gilson PR, Abbott BM.

Org Biomol Chem. 2016 May 18;14(20):4617-39. doi: 10.1039/c5ob02517f.

PMID:
27105169
22.

Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion.

Weiss GE, Crabb BS, Gilson PR.

Trends Parasitol. 2016 Apr;32(4):284-295. doi: 10.1016/j.pt.2015.12.007. Epub 2016 Jan 7. Review.

PMID:
26778295
23.

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection.

Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisarn T, Gilson PR, Barlow PN, Crabb BS, Cowman AF, Tham WH.

J Immunol. 2016 Feb 1;196(3):1239-48. doi: 10.4049/jimmunol.1501581. Epub 2015 Dec 23.

24.

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes.

Tham WH, Lim NT, Weiss GE, Lopaticki S, Ansell BR, Bird M, Lucet I, Dorin-Semblat D, Doerig C, Gilson PR, Crabb BS, Cowman AF.

PLoS Pathog. 2015 Dec 22;11(12):e1005343. doi: 10.1371/journal.ppat.1005343. eCollection 2015 Dec.

25.

Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort.

Dent AE, Malhotra I, Wang X, Babineau D, Yeo KT, Anderson T, Kimmel RJ, Angov E, Lanar DE, Narum D, Dutta S, Richards J, Beeson JG, Crabb BS, Cowman AF, Horii T, Muchiri E, Mungai PL, King CL, Kazura JW.

Clin Vaccine Immunol. 2015 Dec 9;23(2):104-16. doi: 10.1128/CVI.00452-15. Print 2016 Feb.

26.

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG.

BMC Biol. 2015 Jul 18;13:52. doi: 10.1186/s12915-015-0162-0.

27.

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.

Josling GA, Petter M, Oehring SC, Gupta AP, Dietz O, Wilson DW, Schubert T, Längst G, Gilson PR, Crabb BS, Moes S, Jenoe P, Lim SW, Brown GV, Bozdech Z, Voss TS, Duffy MF.

Cell Host Microbe. 2015 Jun 10;17(6):741-51. doi: 10.1016/j.chom.2015.05.009.

28.

Advances in molecular genetic systems in malaria.

de Koning-Ward TF, Gilson PR, Crabb BS.

Nat Rev Microbiol. 2015 Jun;13(6):373-87. doi: 10.1038/nrmicro3450. Review.

PMID:
25978707
29.

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes.

Weiss GE, Gilson PR, Taechalertpaisarn T, Tham WH, de Jong NW, Harvey KL, Fowkes FJ, Barlow PN, Rayner JC, Wright GJ, Cowman AF, Crabb BS.

PLoS Pathog. 2015 Feb 27;11(2):e1004670. doi: 10.1371/journal.ppat.1004670. eCollection 2015 Feb.

30.

Why Australia needs a Medical Research Future Fund.

Cunningham AL, Anderson T, Bennett CC, Crabb BS, Goodier G, Hilton D, Koff E, Trapani J.

Med J Aust. 2015 Feb 16;202(3):123-4. No abstract available.

PMID:
25669464
31.

Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites.

Howard BL, Harvey KL, Stewart RJ, Azevedo MF, Crabb BS, Jennings IG, Sanders PR, Manallack DT, Thompson PE, Tonkin CJ, Gilson PR.

ACS Chem Biol. 2015 Apr 17;10(4):1145-54. doi: 10.1021/cb501004q. Epub 2015 Feb 4.

PMID:
25555060
32.

Plasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitors.

Azevedo MF, Nie CQ, Elsworth B, Charnaud SC, Sanders PR, Crabb BS, Gilson PR.

PLoS One. 2014 Nov 13;9(11):e112571. doi: 10.1371/journal.pone.0112571. eCollection 2014.

33.

Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

Harvey KL, Yap A, Gilson PR, Cowman AF, Crabb BS.

Int J Parasitol. 2014 Oct 15;44(12):853-7. doi: 10.1016/j.ijpara.2014.08.001. Epub 2014 Aug 23.

34.

PTEX is an essential nexus for protein export in malaria parasites.

Elsworth B, Matthews K, Nie CQ, Kalanon M, Charnaud SC, Sanders PR, Chisholm SA, Counihan NA, Shaw PJ, Pino P, Chan JA, Azevedo MF, Rogerson SJ, Beeson JG, Crabb BS, Gilson PR, de Koning-Ward TF.

Nature. 2014 Jul 31;511(7511):587-91. doi: 10.1038/nature13555. Epub 2014 Jul 16.

PMID:
25043043
35.

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

Lau LS, Fernandez-Ruiz D, Mollard V, Sturm A, Neller MA, Cozijnsen A, Gregory JL, Davey GM, Jones CM, Lin YH, Haque A, Engwerda CR, Nie CQ, Hansen DS, Murphy KM, Papenfuss AT, Miles JJ, Burrows SR, de Koning-Ward T, McFadden GI, Carbone FR, Crabb BS, Heath WR.

PLoS Pathog. 2014 May 22;10(5):e1004135. doi: 10.1371/journal.ppat.1004135. eCollection 2014 May.

36.

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites.

Yap A, Azevedo MF, Gilson PR, Weiss GE, O'Neill MT, Wilson DW, Crabb BS, Cowman AF.

Cell Microbiol. 2014 May;16(5):642-56. doi: 10.1111/cmi.12287. Epub 2014 Mar 27.

37.

Protein export in malaria parasites: an update.

Elsworth B, Crabb BS, Gilson PR.

Cell Microbiol. 2014 Mar;16(3):355-63. doi: 10.1111/cmi.12261. Epub 2014 Jan 27. Review.

PMID:
24418476
38.

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth.

Matthews K, Kalanon M, Chisholm SA, Sturm A, Goodman CD, Dixon MW, Sanders PR, Nebl T, Fraser F, Haase S, McFadden GI, Gilson PR, Crabb BS, de Koning-Ward TF.

Mol Microbiol. 2013 Sep;89(6):1167-86. doi: 10.1111/mmi.12334. Epub 2013 Aug 15.

39.

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.

Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG.

J Immunol. 2013 Jul 15;191(2):795-809. doi: 10.4049/jimmunol.1300778. Epub 2013 Jun 17.

40.

Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development.

Azevedo MF, Sanders PR, Krejany E, Nie CQ, Fu P, Bach LA, Wunderlich G, Crabb BS, Gilson PR.

Biochem J. 2013 Jun 15;452(3):433-41. doi: 10.1042/BJ20130124.

PMID:
23548171
41.

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes.

Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF.

Nat Commun. 2013;4:1415. doi: 10.1038/ncomms2449.

42.

Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites.

Bullen HE, Crabb BS, Gilson PR.

Curr Opin Microbiol. 2012 Dec;15(6):699-704. doi: 10.1016/j.mib.2012.09.008. Epub 2012 Oct 22. Review.

PMID:
23092921
43.

The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.

Reiling L, Richards JS, Fowkes FJ, Wilson DW, Chokejindachai W, Barry AE, Tham WH, Stubbs J, Langer C, Donelson J, Michon P, Tavul L, Crabb BS, Siba PM, Cowman AF, Mueller I, Beeson JG.

PLoS One. 2012;7(9):e45253. doi: 10.1371/journal.pone.0045253. Epub 2012 Sep 20.

44.

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte.

Külzer S, Charnaud S, Dagan T, Riedel J, Mandal P, Pesce ER, Blatch GL, Crabb BS, Gilson PR, Przyborski JM.

Cell Microbiol. 2012 Nov;14(11):1784-95. doi: 10.1111/j.1462-5822.2012.01840.x. Epub 2012 Aug 24.

PMID:
22925632
45.

Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection.

Dent AE, Moormann AM, Yohn CT, Kimmel RJ, Sumba PO, Vulule J, Long CA, Narum DL, Crabb BS, Kazura JW, Tisch DJ.

Malar J. 2012 Aug 21;11:287. doi: 10.1186/1475-2875-11-287.

46.

Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41.

Taechalertpaisarn T, Crosnier C, Bartholdson SJ, Hodder AN, Thompson J, Bustamante LY, Wilson DW, Sanders PR, Wright GJ, Rayner JC, Cowman AF, Gilson PR, Crabb BS.

PLoS One. 2012;7(7):e41937. doi: 10.1371/journal.pone.0041937. Epub 2012 Jul 27.

47.

Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum.

de Azevedo MF, Gilson PR, Gabriel HB, Simões RF, Angrisano F, Baum J, Crabb BS, Wunderlich G.

PLoS One. 2012;7(7):e40981. doi: 10.1371/journal.pone.0040981. Epub 2012 Jul 16.

48.

A model for the progression of receptor-ligand interactions during erythrocyte invasion by Plasmodium falciparum.

Harvey KL, Gilson PR, Crabb BS.

Int J Parasitol. 2012 May 15;42(6):567-73. doi: 10.1016/j.ijpara.2012.02.011. Epub 2012 Mar 21. Review.

PMID:
22710063
49.

NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection.

Ryg-Cornejo V, Nie CQ, Bernard NJ, Lundie RJ, Evans KJ, Crabb BS, Schofield L, Hansen DS.

Immunobiology. 2013 Feb;218(2):263-71. doi: 10.1016/j.imbio.2012.05.018. Epub 2012 May 23.

PMID:
22704523
50.

Perspectives: The missing pieces.

Crabb BS, Beeson JG, Amino R, Ménard R, Waters A, Winzeler EA, Wahlgren M, Fidock DA, Nwaka S.

Nature. 2012 Apr 25;484(7395):S22-3. doi: 10.1038/484S22a. No abstract available.

PMID:
22534528

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