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Immune phenotype predicts new onset diabetes after kidney transplantation.

Ducloux D, Courivaud C, Bamoulid J, Crepin T, Gaiffe E, Laheurte C, Vauchy C, Rebibou JM, Saas P, Borot S.

Hum Immunol. 2019 Sep 9. pii: S0198-8859(19)30284-8. doi: 10.1016/j.humimm.2019.08.006. [Epub ahead of print]


Trisodium citrate 4% versus heparin as a catheter lock for non-tunneled hemodialysis catheters in critically ill patients: a multicenter, randomized clinical trial.

Quenot JP, Helms J, Bourredjem A, Dargent A, Meziani F, Badie J, Blasco G, Piton G, Capellier G, Mezher C, Rebibou JM, Nadji A, Crepin T, Barbar SD, Fleck C, Cransac A, Boulin M, Binquet C, Soudry-Faure A, Bruyère R; VERROU-REA Trial Investigators and the CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis).

Ann Intensive Care. 2019 Jul 1;9(1):75. doi: 10.1186/s13613-019-0553-4.


PRODIG (Prevention of new onset diabetes after transplantation by a short term treatment of Vildagliptin in the early renal post-transplant period) study: study protocol for a randomized controlled study.

Gaiffe E, Crepin T, Bamoulid J, Courivaud C, Büchler M, Cassuto E, Albano L, Chemouny JM, Choukroun G, Hazzan M, Kessler L, Legendre C, Le Meur Y, Ouali N, Thierry A, Anota A, Nerich V, Limat S, Bonnetain F, Vernerey D, Ducloux D.

Trials. 2019 Jun 21;20(1):375. doi: 10.1186/s13063-019-3392-6.


Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.

Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crépin T, Naffakh N.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10968-10977. doi: 10.1073/pnas.1901214116. Epub 2019 May 10.


The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAIL for nuclear transport.

Donchet A, Oliva J, Labaronne A, Tengo L, Miloudi M, C A Gerard F, Mas C, Schoehn G, W H Ruigrok R, Ducatez M, Crépin T.

Sci Rep. 2019 Jan 24;9(1):600. doi: 10.1038/s41598-018-37306-y.


Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients.

Crépin T, Legendre M, Carron C, Vachey C, Courivaud C, Rebibou JM, Ferrand C, Laheurte C, Vauchy C, Gaiffe E, Saas P, Ducloux D, Bamoulid J.

Nephrol Dial Transplant. 2018 Sep 6. doi: 10.1093/ndt/gfy276. [Epub ahead of print]


ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications.

Ducloux D, Legendre M, Bamoulid J, Rebibou JM, Saas P, Courivaud C, Crepin T.

Immun Ageing. 2018 Jul 17;15:16. doi: 10.1186/s12979-018-0121-z. eCollection 2018.


Structural analysis of the complex between influenza B nucleoprotein and human importin-α.

Labaronne A, Milles S, Donchet A, Jensen MR, Blackledge M, Bourhis JM, Ruigrok RWH, Crépin T.

Sci Rep. 2017 Dec 7;7(1):17164. doi: 10.1038/s41598-017-17458-z.


Posttransplant Immune Activation: Innocent Bystander or Insidious Culprit of Posttransplant Accelerated Atherosclerosis.

Ducloux D, Bamoulid J, Crepin T, Rebibou JM, Courivaud C, Saas P.

Cell Transplant. 2017 Sep;26(9):1601-1609. doi: 10.1177/0963689717735404. Review.


A comparison of TAFRO syndrome between Japanese and non-Japanese cases: a case report and literature review.

Coutier F, Meaux Ruault N, Crepin T, Bouiller K, Gil H, Humbert S, Bedgedjian I, Magy-Bertrand N.

Ann Hematol. 2018 Mar;97(3):401-407. doi: 10.1007/s00277-017-3138-z. Epub 2017 Sep 27. Review.


Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins.

Bamoulid J, Crepin T, Gaiffe E, Laheurte C, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Rebibou JM, Saas P, Courivaud C, Ducloux D.

Transpl Immunol. 2017 Dec;45:48-52. doi: 10.1016/j.trim.2017.09.002. Epub 2017 Sep 20.


Antithymocyte globulins in renal transplantation-from lymphocyte depletion to lymphocyte activation: The doubled-edged sword.

Bamoulid J, Crépin T, Courivaud C, Rebibou JM, Saas P, Ducloux D.

Transplant Rev (Orlando). 2017 Jul;31(3):180-187. doi: 10.1016/j.trre.2017.02.004. Epub 2017 Feb 17. Review.


Anti-thymocyte globulins in kidney transplantation: focus on current indications and long-term immunological side effects.

Bamoulid J, Staeck O, Crépin T, Halleck F, Saas P, Brakemeier S, Ducloux D, Budde K.

Nephrol Dial Transplant. 2017 Oct 1;32(10):1601-1608. doi: 10.1093/ndt/gfw368. Review.


Binding of RNA by the Nucleoproteins of Influenza Viruses A and B.

Labaronne A, Swale C, Monod A, Schoehn G, Crépin T, Ruigrok RW.

Viruses. 2016 Sep 13;8(9). pii: E247. doi: 10.3390/v8090247.


Late Persistent Positive EBV Viral Load and Risk of Solid Cancer in Kidney Transplant Patients.

Bamoulid J, Courivaud C, Coaquette A, Crépin T, Carron C, Gaiffe E, Roubiou C, Rebibou JM, Ducloux D.

Transplantation. 2017 Jun;101(6):1473-1478. doi: 10.1097/TP.0000000000001280.


Reversible Fluindione-Induced Chronic Interstitial Nephritis.

Crepin T, Bamoulid J, Courivaud C, Dahmani O, Felix S, Ducloux D.

Case Rep Nephrol. 2016;2016:9818195. doi: 10.1155/2016/9818195. Epub 2016 Apr 5.


Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.

Swale C, Monod A, Tengo L, Labaronne A, Garzoni F, Bourhis JM, Cusack S, Schoehn G, Berger I, Ruigrok RW, Crépin T.

Sci Rep. 2016 Apr 20;6:24727. doi: 10.1038/srep24727.


Pretransplant thymic function predicts acute rejection in antithymocyte globulin-treated renal transplant recipients.

Bamoulid J, Courivaud C, Crepin T, Carron C, Gaiffe E, Roubiou C, Laheurte C, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Rebibou JM, Saas P, Ducloux D.

Kidney Int. 2016 May;89(5):1136-1143. doi: 10.1016/j.kint.2015.12.044. Epub 2016 Mar 2.


Pre-transplant end-stage renal disease-related immune risk profile in kidney transplant recipients predicts post-transplant infections.

Crepin T, Gaiffe E, Courivaud C, Roubiou C, Laheurte C, Moulin B, Frimat L, Rieu P, Mousson C, Durrbach A, Heng AE, Saas P, Bamoulid J, Ducloux D.

Transpl Infect Dis. 2016 Jun;18(3):415-22. doi: 10.1111/tid.12534. Epub 2016 May 21.


In Vitro/In Vivo Production of tRNA for X-Ray Studies.

Dégut C, Monod A, Brachet F, Crépin T, Tisné C.

Methods Mol Biol. 2016;1320:37-57. doi: 10.1007/978-1-4939-2763-0_4.


[Clinical consequences of immunosenescence in chronic kidney diseases].

Bamoulid J, Carron C, Crépin T, Saas P, Ducloux D.

Med Sci (Paris). 2015 May;31(5):484-6. doi: 10.1051/medsci/20153105008. Epub 2015 Jun 9. French. No abstract available.


Polyproteins in structural biology.

Crépin T, Swale C, Monod A, Garzoni F, Chaillet M, Berger I.

Curr Opin Struct Biol. 2015 Jun;32:139-46. doi: 10.1016/ Epub 2015 May 18. Review.


Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza.

Monod A, Swale C, Tarus B, Tissot A, Delmas B, Ruigrok RW, Crépin T, Slama-Schwok A.

Expert Opin Drug Discov. 2015 Apr;10(4):345-71. doi: 10.1517/17460441.2015.1019859. Review.


ATG-induced accelerated immune senescence: clinical implications in renal transplant recipients.

Crepin T, Carron C, Roubiou C, Gaugler B, Gaiffe E, Simula-Faivre D, Ferrand C, Tiberghien P, Chalopin JM, Moulin B, Frimat L, Rieu P, Saas P, Ducloux D, Bamoulid J.

Am J Transplant. 2015 Apr;15(4):1028-38. doi: 10.1111/ajt.13092. Epub 2015 Mar 10.


Serum immunoglobulin G levels and peritonitis in peritoneal dialysis patients.

Courivaud C, Bardonnet K, Crepin T, Bresson-Vautrin C, Rebibou JM, Ducloux D.

J Nephrol. 2015 Aug;28(4):511-5. doi: 10.1007/s40620-015-0176-2. Epub 2015 Mar 11.


Structural insight into cap-snatching and RNA synthesis by influenza polymerase.

Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crépin T, Hart D, Lunardi T, Nanao M, Ruigrok RW, Cusack S.

Nature. 2014 Dec 18;516(7531):361-6. doi: 10.1038/nature14009. Epub 2014 Nov 19.


Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes.

Crepin T, Shalak VF, Yaremchuk AD, Vlasenko DO, McCarthy A, Negrutskii BS, Tukalo MA, El'skaya AV.

Nucleic Acids Res. 2014 Nov 10;42(20):12939-48. doi: 10.1093/nar/gku974. Epub 2014 Oct 17.


Alloimmune responses and atherosclerotic disease after kidney transplantation.

Ducloux D, Courivaud C, Bamoulid J, Bisaccia V, Roubiou C, Crepin T, Gaugler B, Laheurte C, Rebibou JM, Chalopin JM, Saas P.

Transplantation. 2015 Jan;99(1):220-5. doi: 10.1097/TP.0000000000000346.


Editorial overview: virus structure and function.

Chiu W, Crépin T, Ruigrok RW.

Curr Opin Virol. 2014 Apr;5:viii-ix. doi: 10.1016/j.coviro.2014.03.003. Epub 2014 Apr 13. No abstract available.


Capsid proteins of enveloped viruses as antiviral drug targets.

Klumpp K, Crépin T.

Curr Opin Virol. 2014 Apr;5:63-71. doi: 10.1016/j.coviro.2014.02.002. Epub 2014 Mar 5. Review.


Polyclonal antithymocyte globulin and cardiovascular disease in kidney transplant recipients.

Ducloux D, Courivaud C, Bamoulid J, Crepin T, Chalopin JM, Tiberghien P, Saas P.

J Am Soc Nephrol. 2014 Jun;25(6):1349-56. doi: 10.1681/ASN.2013060663. Epub 2014 Feb 7.


Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains.

Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S.

PLoS One. 2014 Jan 15;9(1):e84973. doi: 10.1371/journal.pone.0084973. eCollection 2014.


Influenza virus nucleoprotein: structure, RNA binding, oligomerization and antiviral drug target.

Chenavas S, Crépin T, Delmas B, Ruigrok RW, Slama-Schwok A.

Future Microbiol. 2013 Dec;8(12):1537-45. doi: 10.2217/fmb.13.128. Review.


Peritoneal dialysis reduces the number of hospitalization days in heart failure patients refractory to diuretics.

Courivaud C, Kazory A, Crépin T, Azar R, Bresson-Vautrin C, Chalopin JM, Ducloux D.

Perit Dial Int. 2014 Jan-Feb;34(1):100-8. doi: 10.3747/pdi.2012.00149. Epub 2013 Sep 1.


Structure of the tetramerization domain of measles virus phosphoprotein.

Communie G, Crépin T, Maurin D, Jensen MR, Blackledge M, Ruigrok RW.

J Virol. 2013 Jun;87(12):7166-9. doi: 10.1128/JVI.00487-13. Epub 2013 Apr 10.


Monomeric nucleoprotein of influenza A virus.

Chenavas S, Estrozi LF, Slama-Schwok A, Delmas B, Di Primo C, Baudin F, Li X, Crépin T, Ruigrok RW.

PLoS Pathog. 2013 Mar;9(3):e1003275. doi: 10.1371/journal.ppat.1003275. Epub 2013 Mar 28.


Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ.

Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7.


Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase.

Palencia A, Crépin T, Vu MT, Lincecum TL Jr, Martinis SA, Cusack S.

Nat Struct Mol Biol. 2012 Jun 10;19(7):677-84. doi: 10.1038/nsmb.2317.


Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian translation elongation factor eEF1A2.

Yaremchuk A, Shalak VF, Novosylna OV, Negrutskii BS, Crépin T, El'skaya AV, Tukalo M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Mar 1;68(Pt 3):295-7. doi: 10.1107/S1744309112000243. Epub 2012 Feb 22.


[A rare cause of anemia in a chronic dialyzed patient].

Crépin T, Bamoulid J, Tunda A, Moskovtchenko P, Ducloux D.

Nephrol Ther. 2012 Apr;8(2):110-2. doi: 10.1016/j.nephro.2011.07.404. Epub 2011 Sep 28. French.


Nucleoproteins and nucleocapsids of negative-strand RNA viruses.

Ruigrok RW, Crépin T, Kolakofsky D.

Curr Opin Microbiol. 2011 Aug;14(4):504-10. doi: 10.1016/j.mib.2011.07.011. Epub 2011 Aug 6. Review.


A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase.

Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M.

J Mol Biol. 2011 Jan 28;405(4):1056-69. doi: 10.1016/j.jmb.2010.11.049. Epub 2010 Dec 4.


Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit.

Crépin T, Dias A, Palencia A, Swale C, Cusack S, Ruigrok RW.

J Virol. 2010 Sep;84(18):9096-104. doi: 10.1128/JVI.00995-10. Epub 2010 Jun 30.


Structure of the dimerization domain of the rabies virus phosphoprotein.

Ivanov I, Crépin T, Jamin M, Ruigrok RW.

J Virol. 2010 Apr;84(7):3707-10. doi: 10.1128/JVI.02557-09. Epub 2010 Jan 20.


Towards an atomic resolution understanding of the influenza virus replication machinery.

Ruigrok RW, Crépin T, Hart DJ, Cusack S.

Curr Opin Struct Biol. 2010 Feb;20(1):104-13. doi: 10.1016/ Epub 2010 Jan 12. Review.


Nucleoproteins of negative strand RNA viruses; RNA binding, oligomerisation and binding to polymerase co-factor.

Ruigrok RW, Crépin T.

Viruses. 2010 Jan;2(1):27-32. doi: 10.3390/v2010027. Epub 2010 Jan 7.


A first low-resolution difference Fourier map of phosphorus in a membrane protein from near-edge anomalous diffraction.

Boesecke P, Bois JM, Crépin T, Hunte C, Kahn R, Kao WC, Nauton L, Winther AM, Moller J, Nissen P, Nury H, Olesen C, Pebay-Peyroula E, Vicat J, Stuhrmann H.

J Synchrotron Radiat. 2009 Sep;16(Pt 5):658-65. doi: 10.1107/S0909049509025692. Epub 2009 Jul 8.


Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis.

Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M.

J Med Chem. 2009 Jun 25;52(12):3666-78. doi: 10.1021/jm801609s.


[New strategy for targeting influenza virus replication].

Dias A, Bouvier D, Cusack S, Ruigrok RW, Crépin T.

Med Sci (Paris). 2009 Apr;25(4):352-4. doi: 10.1051/medsci/2009254352. French. No abstract available.


The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit.

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW.

Nature. 2009 Apr 16;458(7240):914-8. doi: 10.1038/nature07745. Epub 2009 Feb 4.


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