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Items: 1 to 50 of 102

1.

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.

Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP.

Sci Signal. 2018 Sep 11;11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147.

PMID:
30206138
2.

TG2 regulates the heat-shock response by the post-translational modification of HSF1.

Rossin F, Villella VR, D'Eletto M, Farrace MG, Esposito S, Ferrari E, Monzani R, Occhigrossi L, Pagliarini V, Sette C, Cozza G, Barlev NA, Falasca L, Fimia GM, Kroemer G, Raia V, Maiuri L, Piacentini M.

EMBO Rep. 2018 Jul;19(7). pii: e45067. doi: 10.15252/embr.201745067. Epub 2018 May 11.

PMID:
29752334
3.

The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131.

Vilardell J, Girardi C, Marin O, Cozza G, Pinna LA, Ruzzene M.

PLoS One. 2018 Mar 1;13(3):e0193479. doi: 10.1371/journal.pone.0193479. eCollection 2018.

4.

The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition.

Cozza G, Salvi M.

Curr Protein Pept Sci. 2018;19(8):728-745. doi: 10.2174/1389203719666180124095405.

PMID:
29366414
5.

Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review.

Palleria C, Cozza G, Khengar R, Libri V, De Sarro G.

Curr Pharm Des. 2017;23(37):5606-5624. doi: 10.2174/1381612823666170809115429.

PMID:
28799510
6.

Covalently bound DNA on naked iron oxide nanoparticles: Intelligent colloidal nano-vector for cell transfection.

Magro M, Martinello T, Bonaiuto E, Gomiero C, Baratella D, Zoppellaro G, Cozza G, Patruno M, Zboril R, Vianello F.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2802-2810. doi: 10.1016/j.bbagen.2017.07.025. Epub 2017 Aug 2.

PMID:
28778487
7.

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center.

Cozza G, Rossetto M, Bosello-Travain V, Maiorino M, Roveri A, Toppo S, Zaccarin M, Zennaro L, Ursini F.

Free Radic Biol Med. 2017 Nov;112:1-11. doi: 10.1016/j.freeradbiomed.2017.07.010. Epub 2017 Jul 12.

PMID:
28709976
8.

Cervical carcinogenesis, bacterial vaginosis, HPV-mRNA test and relapse of CIN2+ after loop electrosurgical excision procedure (LEEP).

Frega A, Lavini G, Guarino A, Giovanale V, Lukic A, Bianchi P, Cozza G, Marziani R, D'Ambrosio A, French D, Caserta D.

Eur Rev Med Pharmacol Sci. 2017 May;21(10):2504-2511.

9.

Comparative effectiveness and impact on health-related quality of life of hysterectomy vs. levonorgestrel intra-uterine system for abnormal uterine bleeding.

Cozza G, Pinto A, Giovanale V, Bianchi P, Guarino A, Marziani R, Frega A, Caserta D.

Eur Rev Med Pharmacol Sci. 2017 May;21(9):2255-2260.

10.

The landscape of BRAF transcript and protein variants in human cancer.

Marranci A, Jiang Z, Vitiello M, Guzzolino E, Comelli L, Sarti S, Lubrano S, Franchin C, Echevarría-Vargas I, Tuccoli A, Mercatanti A, Evangelista M, Sportoletti P, Cozza G, Luzi E, Capobianco E, Villanueva J, Arrigoni G, Signore G, Rocchiccioli S, Pitto L, Tsinoremas N, Poliseno L.

Mol Cancer. 2017 Apr 28;16(1):85. doi: 10.1186/s12943-017-0645-4.

11.

Fam20C is under the control of sphingolipid signaling in human cell lines.

Cozza G, Salvi M, Tagliabracci VS, Pinna LA.

FEBS J. 2017 Apr;284(8):1246-1257. doi: 10.1111/febs.14052. Epub 2017 Mar 22.

12.

The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design.

Cozza G.

Pharmaceuticals (Basel). 2017 Feb 20;10(1). pii: E26. doi: 10.3390/ph10010026. Review.

13.

Expression of E6/E7 HPV-DNA, HPV-mRNA and colposcopic features in management of CIN2/3 during pregnancy.

Frega A, Verrone A, Manzara F, Schimberni M, Catalano A, Milazzo GN, Marziani R, Cozza G, Bianchi P, French D, Sesti F, Caserta D.

Eur Rev Med Pharmacol Sci. 2016 Oct;20(20):4236-4242.

14.

Human papilloma virus infection and cervical cytomorphological changing among intrauterine contraception users.

Frega A, Manzara F, Schimberni M, Guarino A, Catalano A, Bianchi P, Marziani R, Cozza G, Milazzo GN, French D, Caserta D.

Eur Rev Med Pharmacol Sci. 2016 Sep;20(17):3528-34.

15.

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.

Borthwick LA, Kerbiriou M, Taylor CJ, Cozza G, Lascu I, Postel EH, Cassidy D, Trouvé P, Mehta A, Robson L, Muimo R.

PLoS One. 2016 Mar 7;11(3):e0149097. doi: 10.1371/journal.pone.0149097. eCollection 2016.

16.

Casein kinases as potential therapeutic targets.

Cozza G, Pinna LA.

Expert Opin Ther Targets. 2016;20(3):319-40. doi: 10.1517/14728222.2016.1091883. Epub 2015 Nov 13. Review.

PMID:
26565594
17.

The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.

Cozza G, Venerando A, Sarno S, Pinna LA.

Biomed Res Int. 2015;2015:734127. doi: 10.1155/2015/734127. Epub 2015 Oct 19.

18.

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.

Cozza G, Zanin S, Sarno S, Costa E, Girardi C, Ribaudo G, Salvi M, Zagotto G, Ruzzene M, Pinna LA.

Biochem J. 2015 Nov 1;471(3):415-30. doi: 10.1042/BJ20141127. Epub 2015 Sep 8.

PMID:
26349539
19.

Feasibility of office CO2 laser surgery in patients affected by benign pathologies and congenital malformations of female lower genital tract.

Frega A, Verrone A, Schimberni M, Manzara F, Ralli E, Catalano A, Schimberni M, Torcia F, Cozza G, Bianchi P, Marziani R, Lukic A.

Eur Rev Med Pharmacol Sci. 2015;19(14):2528-36.

20.

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.

Kalathur M, Toso A, Chen J, Revandkar A, Danzer-Baltzer C, Guccini I, Alajati A, Sarti M, Pinton S, Brambilla L, Di Mitri D, Carbone G, Garcia-Escudero R, Padova A, Magnoni L, Tarditi A, Maccari L, Malusa F, Kalathur RK, A Pinna L, Cozza G, Ruzzene M, Delaleu N, Catapano CV, Frew IJ, Alimonti A.

Nat Commun. 2015 Jun 18;6:7227. doi: 10.1038/ncomms8227.

PMID:
26085373
21.

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins.

Cozza G, Salvi M, Banerjee S, Tibaldi E, Tagliabracci VS, Dixon JE, Pinna LA.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1718-26. doi: 10.1016/j.bbapap.2015.04.023. Epub 2015 Apr 30.

PMID:
25936777
22.

Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects.

Zanin S, Sandre M, Cozza G, Ottaviani D, Marin O, Pinna LA, Ruzzene M.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1694-707. doi: 10.1016/j.bbapap.2015.04.026. Epub 2015 Apr 30.

PMID:
25936516
23.

ALK kinase domain mutations in primary anaplastic large cell lymphoma: consequences on NPM-ALK activity and sensitivity to tyrosine kinase inhibitors.

Lovisa F, Cozza G, Cristiani A, Cuzzolin A, Albiero A, Mussolin L, Pillon M, Moro S, Basso G, Rosolen A, Bonvini P.

PLoS One. 2015 Apr 13;10(4):e0121378. doi: 10.1371/journal.pone.0121378. eCollection 2015.

24.

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.

Herhaus L, Perez-Oliva AB, Cozza G, Gourlay R, Weidlich S, Campbell DG, Pinna LA, Sapkota GP.

Sci Signal. 2015 Apr 14;8(372):ra35. doi: 10.1126/scisignal.aaa0441.

25.

Understanding mammalian glutathione peroxidase 7 in the light of its homologs.

Maiorino M, Bosello-Travain V, Cozza G, Miotto G, Roveri A, Toppo S, Zaccarin M, Ursini F.

Free Radic Biol Med. 2015 Jun;83:352-60. doi: 10.1016/j.freeradbiomed.2015.02.017. Epub 2015 Feb 25. Review.

PMID:
25724691
26.

Diagnostic accuracy of sonohysterography vs hysteroscopy in benign uterine endocavitary findings.

Zinna M, Gentile M, Torcia F, Bianchi P, Cozza G, Marziani R, Milazzo GN, Catalano A, Di Properzio M, Manzara F, Schimberni M, Caserta D, Frega A.

Eur Rev Med Pharmacol Sci. 2015;19(3):365-71.

27.

Adjuvant topical treatment with imiquimod 5% after excisional surgery for VIN 2/3.

Gentile M, Bianchi P, Sesti F, Sopracordevole F, Biamonti A, Scirpa P, Schimberni M, Cozza G, Marziani R, Di Martino G, Catalano A, Milazzo GN, Zinna M, Caserta D, Frega A.

Eur Rev Med Pharmacol Sci. 2014 Oct;18(19):2949-52.

28.

Ultrasound-guided dilatation and curettage in life-threatening cesarean scar ectopic pregnancy.

Bianchi P, Cozza G, Salvatori MM, Giovanale V, Vitali M.

Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:252. doi: 10.1016/j.ejogrb.2014.03.015. Epub 2014 Mar 28. No abstract available.

PMID:
24857309
29.

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

Cozza G, Zanin S, Determann R, Ruzzene M, Kunick C, Pinna LA.

PLoS One. 2014 Feb 24;9(2):e89176. doi: 10.1371/journal.pone.0089176. eCollection 2014.

30.

The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.

Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R, Izpisua Belmonte JC, Pinna LA, Sarno S.

Biochim Biophys Acta. 2014 Apr;1844(4):722-9. doi: 10.1016/j.bbapap.2014.01.014. Epub 2014 Jan 31.

PMID:
24486797
31.

Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential.

Cozza G, Girardi C, Ranchio A, Lolli G, Sarno S, Orzeszko A, Kazimierczuk Z, Battistutta R, Ruzzene M, Pinna LA.

Cell Mol Life Sci. 2014 Aug;71(16):3173-85. doi: 10.1007/s00018-013-1552-5. Epub 2014 Jan 18.

PMID:
24442476
32.

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.

Bonaiuto E, Milelli A, Cozza G, Tumiatti V, Marchetti C, Agostinelli E, Fimognari C, Hrelia P, Minarini A, Di Paolo ML.

Eur J Med Chem. 2013;70:88-101. doi: 10.1016/j.ejmech.2013.07.005. Epub 2013 Oct 1.

PMID:
24140951
33.

Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation.

Venerando A, Franchin C, Cant N, Cozza G, Pagano MA, Tosoni K, Al-Zahrani A, Arrigoni G, Ford RC, Mehta A, Pinna LA.

PLoS One. 2013 Sep 18;8(9):e74232. doi: 10.1371/journal.pone.0074232. eCollection 2013.

34.

An atypical presentation of sporadic ovarian Burkitt's lymphoma: case report and review of the literature.

Bianchi P, Torcia F, Vitali M, Cozza G, Matteoli M, Giovanale V.

J Ovarian Res. 2013 Jul 4;6(1):46. doi: 10.1186/1757-2215-6-46.

35.

Imiquimod 5% cream versus cold knife excision for treatment of VIN 2/3: a five-year follow-up.

Frega A, Sesti F, Sopracordevole F, Biamonti A, Scirpa P, Milazzo GN, Catalano A, Assorgi C, Lombardi D, Gentile M, Maniglio P, Ricciardi E, Cozza G, Marziani R, Moscarini M.

Eur Rev Med Pharmacol Sci. 2013 Apr;17(7):936-40.

36.

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M, Roveri A, Toppo S, Ursini F, Zaccarin M, Maiorino M.

Biochim Biophys Acta. 2013 Jun;1830(6):3846-57. doi: 10.1016/j.bbagen.2013.02.017. Epub 2013 Feb 27.

PMID:
23454490
37.

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.

Cozza G, Sarno S, Ruzzene M, Girardi C, Orzeszko A, Kazimierczuk Z, Zagotto G, Bonaiuto E, Di Paolo ML, Pinna LA.

Biochim Biophys Acta. 2013 Jul;1834(7):1402-9. doi: 10.1016/j.bbapap.2013.01.018. Epub 2013 Jan 27.

PMID:
23360763
38.

Kinase CK2 inhibition: an update.

Cozza G, Pinna LA, Moro S.

Curr Med Chem. 2013;20(5):671-93. Review.

PMID:
23210774
39.

Protein kinase CK2 inhibitors: a patent review.

Cozza G, Pinna LA, Moro S.

Expert Opin Ther Pat. 2012 Sep;22(9):1081-97. doi: 10.1517/13543776.2012.717615. Review.

PMID:
22908959
40.

Investigation on PLK2 and PLK3 substrate recognition.

Salvi M, Trashi E, Cozza G, Franchin C, Arrigoni G, Pinna LA.

Biochim Biophys Acta. 2012 Dec;1824(12):1366-73. doi: 10.1016/j.bbapap.2012.07.003. Epub 2012 Jul 21.

PMID:
22828320
41.

Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.

Lolli G, Cozza G, Mazzorana M, Tibaldi E, Cesaro L, Donella-Deana A, Meggio F, Venerando A, Franchin C, Sarno S, Battistutta R, Pinna LA.

Biochemistry. 2012 Aug 7;51(31):6097-107. Epub 2012 Jul 25.

PMID:
22794353
42.

Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases.

Salvi M, Trashi E, Cozza G, Negro A, Hanson PI, Pinna LA.

Biotechniques. 2012 Jul 1;53(1). doi: 10.2144/000113866.

43.

Casein hydrolysate for uterine infection treatment: a patent evaluation (WO2011132191).

Cozza G.

Expert Opin Ther Pat. 2012 May;22(5):575-8. doi: 10.1517/13543776.2012.677437. Epub 2012 Mar 29.

PMID:
22458646
44.

Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors.

Cozza G, Gianoncelli A, Bonvini P, Zorzi E, Pasquale R, Rosolen A, Pinna LA, Meggio F, Zagotto G, Moro S.

ChemMedChem. 2011 Dec 9;6(12):2273-86. doi: 10.1002/cmdc.201100338. Epub 2011 Oct 4.

PMID:
21972104
45.

Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.

Battistutta R, Cozza G, Pierre F, Papinutto E, Lolli G, Sarno S, O'Brien SE, Siddiqui-Jain A, Haddach M, Anderes K, Ryckman DM, Meggio F, Pinna LA.

Biochemistry. 2011 Oct 4;50(39):8478-88. doi: 10.1021/bi2008382. Epub 2011 Sep 7.

PMID:
21870818
46.

Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A.

Sarno S, Mazzorana M, Traynor R, Ruzzene M, Cozza G, Pagano MA, Meggio F, Zagotto G, Battistutta R, Pinna LA.

Cell Mol Life Sci. 2012 Feb;69(3):449-60. doi: 10.1007/s00018-011-0758-7. Epub 2011 Jul 1.

PMID:
21720886
47.

The dark side of protein kinase CK2 inhibition.

Cozza G, Meggio F, Moro S.

Curr Med Chem. 2011;18(19):2867-84. Review.

PMID:
21651492
48.

The role of the N-terminal domain in the regulation of the "constitutively active" conformation of protein kinase CK2α: insight from a molecular dynamics investigation.

Cristiani A, Costa G, Cozza G, Meggio F, Scapozza L, Moro S.

ChemMedChem. 2011 Jul 4;6(7):1207-16. doi: 10.1002/cmdc.201100046. Epub 2011 May 17.

PMID:
21591262
49.

8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment.

Zagotto G, Redaelli M, Pasquale R, D'Avella D, Cozza G, Denaro L, Pizzato F, Mucignat-Caretta C.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2079-82. doi: 10.1016/j.bmcl.2011.02.001. Epub 2011 Feb 24.

PMID:
21353776
50.

Cervical pregnancy.

Bianchi P, Salvatori MM, Torcia F, Cozza G, Mossa B.

Fertil Steril. 2011 May;95(6):2123.e3-4. doi: 10.1016/j.fertnstert.2011.01.016. Epub 2011 Feb 3.

PMID:
21292258

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