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Items: 1 to 50 of 111

1.

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis-inducing molecule RSL3 requires the adaptor protein 14-3-3ε.

Vučković AM, Bosello Travain V, Bordin L, Cozza G, Miotto G, Rossetto M, Toppo S, Venerando R, Zaccarin M, Maiorino M, Ursini F, Roveri A.

FEBS Lett. 2019 Oct 3. doi: 10.1002/1873-3468.13631. [Epub ahead of print]

PMID:
31581313
2.

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1.

Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A, Vučković AM, Bosello Travain V, Zaccarin M, Zennaro L, Maiorino M, Toppo S, Ursini F, Cozza G.

Redox Biol. 2019 Sep 20;28:101328. doi: 10.1016/j.redox.2019.101328. [Epub ahead of print]

3.

Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach.

Di Paolo ML, Cozza G, Milelli A, Zonta F, Sarno S, Minniti E, Ursini F, Rosini M, Minarini A.

FEBS J. 2019 Jul 10. doi: 10.1111/febs.14994. [Epub ahead of print]

PMID:
31291696
4.

Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression.

Kabakci Z, Käppeli S, Cantù C, Jensen LD, König C, Toggweiler J, Gentili C, Ribaudo G, Zagotto G, Basler K, Pinna LA, Cozza G, Ferrari S.

Sci Rep. 2019 Feb 4;9(1):1335. doi: 10.1038/s41598-019-38579-7.

5.

Stealth Iron Oxide Nanoparticles for Organotropic Drug Targeting.

Magro M, Baratella D, Bonaiuto E, de Almeida Roger J, Chemello G, Pasquaroli S, Mancini L, Olivotto I, Zoppellaro G, Ugolotti J, Aparicio C, Fifi AP, Cozza G, Miotto G, Radaelli G, Bertotto D, Zboril R, Vianello F.

Biomacromolecules. 2019 Mar 11;20(3):1375-1384. doi: 10.1021/acs.biomac.8b01750. Epub 2019 Feb 12.

PMID:
30694655
6.

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.

Villella VR, Venerando A, Cozza G, Esposito S, Ferrari E, Monzani R, Spinella MC, Oikonomou V, Renga G, Tosco A, Rossin F, Guido S, Silano M, Garaci E, Chao YK, Grimm C, Luciani A, Romani L, Piacentini M, Raia V, Kroemer G, Maiuri L.

EMBO J. 2019 Jan 15;38(2). pii: e100101. doi: 10.15252/embj.2018100101. Epub 2018 Nov 29.

7.

Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases.

Cozza G, Fortuna M, Meggio F, Sarno S, Kubbutat MHG, Totzke F, Schaechtele C, Pinna LA, Olsufyeva EN, Preobrazhenskaya MN.

Biochemistry (Mosc). 2018 Oct;83(10):1222-1230. doi: 10.1134/S0006297918100073.

PMID:
30472959
8.

The Golgi 'casein kinase' Fam20C is a genuine 'phosvitin kinase' and phosphorylates polyserine stretches devoid of the canonical consensus.

Cozza G, Moro E, Black M, Marin O, Salvi M, Venerando A, Tagliabracci VS, Pinna LA.

FEBS J. 2018 Dec;285(24):4674-4683. doi: 10.1111/febs.14689. Epub 2018 Nov 20.

PMID:
30387551
9.

Development of a yeast-based system to identify new hBRAFV600E functional interactors.

Lubrano S, Comelli L, Piccirilli C, Marranci A, Dapporto F, Tantillo E, Gemignani F, Gutkind JS, Salvetti A, Chiorino G, Cozza G, Chiariello M, Galli A, Poliseno L, Cervelli T.

Oncogene. 2019 Feb;38(8):1355-1366. doi: 10.1038/s41388-018-0496-5. Epub 2018 Sep 20.

PMID:
30237439
10.

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.

Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP.

Sci Signal. 2018 Sep 11;11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147.

11.

TG2 regulates the heat-shock response by the post-translational modification of HSF1.

Rossin F, Villella VR, D'Eletto M, Farrace MG, Esposito S, Ferrari E, Monzani R, Occhigrossi L, Pagliarini V, Sette C, Cozza G, Barlev NA, Falasca L, Fimia GM, Kroemer G, Raia V, Maiuri L, Piacentini M.

EMBO Rep. 2018 Jul;19(7). pii: e45067. doi: 10.15252/embr.201745067. Epub 2018 May 11.

12.

The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131.

Vilardell J, Girardi C, Marin O, Cozza G, Pinna LA, Ruzzene M.

PLoS One. 2018 Mar 1;13(3):e0193479. doi: 10.1371/journal.pone.0193479. eCollection 2018.

13.

The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition.

Cozza G, Salvi M.

Curr Protein Pept Sci. 2018;19(8):728-745. doi: 10.2174/1389203719666180124095405. Review.

PMID:
29366414
14.

Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review.

Palleria C, Cozza G, Khengar R, Libri V, De Sarro G.

Curr Pharm Des. 2017;23(37):5606-5624. doi: 10.2174/1381612823666170809115429. Review.

PMID:
28799510
15.

Covalently bound DNA on naked iron oxide nanoparticles: Intelligent colloidal nano-vector for cell transfection.

Magro M, Martinello T, Bonaiuto E, Gomiero C, Baratella D, Zoppellaro G, Cozza G, Patruno M, Zboril R, Vianello F.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2802-2810. doi: 10.1016/j.bbagen.2017.07.025. Epub 2017 Aug 2.

PMID:
28778487
16.

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center.

Cozza G, Rossetto M, Bosello-Travain V, Maiorino M, Roveri A, Toppo S, Zaccarin M, Zennaro L, Ursini F.

Free Radic Biol Med. 2017 Nov;112:1-11. doi: 10.1016/j.freeradbiomed.2017.07.010. Epub 2017 Jul 12.

PMID:
28709976
17.

Cervical carcinogenesis, bacterial vaginosis, HPV-mRNA test and relapse of CIN2+ after loop electrosurgical excision procedure (LEEP).

Frega A, Lavini G, Guarino A, Giovanale V, Lukic A, Bianchi P, Cozza G, Marziani R, D'Ambrosio A, French D, Caserta D.

Eur Rev Med Pharmacol Sci. 2017 May;21(10):2504-2511.

18.

Comparative effectiveness and impact on health-related quality of life of hysterectomy vs. levonorgestrel intra-uterine system for abnormal uterine bleeding.

Cozza G, Pinto A, Giovanale V, Bianchi P, Guarino A, Marziani R, Frega A, Caserta D.

Eur Rev Med Pharmacol Sci. 2017 May;21(9):2255-2260.

19.

The landscape of BRAF transcript and protein variants in human cancer.

Marranci A, Jiang Z, Vitiello M, Guzzolino E, Comelli L, Sarti S, Lubrano S, Franchin C, Echevarría-Vargas I, Tuccoli A, Mercatanti A, Evangelista M, Sportoletti P, Cozza G, Luzi E, Capobianco E, Villanueva J, Arrigoni G, Signore G, Rocchiccioli S, Pitto L, Tsinoremas N, Poliseno L.

Mol Cancer. 2017 Apr 28;16(1):85. doi: 10.1186/s12943-017-0645-4.

20.

Fam20C is under the control of sphingolipid signaling in human cell lines.

Cozza G, Salvi M, Tagliabracci VS, Pinna LA.

FEBS J. 2017 Apr;284(8):1246-1257. doi: 10.1111/febs.14052. Epub 2017 Mar 22.

21.

The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design.

Cozza G.

Pharmaceuticals (Basel). 2017 Feb 20;10(1). pii: E26. doi: 10.3390/ph10010026. Review.

22.

Expression of E6/E7 HPV-DNA, HPV-mRNA and colposcopic features in management of CIN2/3 during pregnancy.

Frega A, Verrone A, Manzara F, Schimberni M, Catalano A, Milazzo GN, Marziani R, Cozza G, Bianchi P, French D, Sesti F, Caserta D.

Eur Rev Med Pharmacol Sci. 2016 Oct;20(20):4236-4242.

23.

Human papilloma virus infection and cervical cytomorphological changing among intrauterine contraception users.

Frega A, Manzara F, Schimberni M, Guarino A, Catalano A, Bianchi P, Marziani R, Cozza G, Milazzo GN, French D, Caserta D.

Eur Rev Med Pharmacol Sci. 2016 Sep;20(17):3528-34.

24.

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.

Borthwick LA, Kerbiriou M, Taylor CJ, Cozza G, Lascu I, Postel EH, Cassidy D, Trouvé P, Mehta A, Robson L, Muimo R.

PLoS One. 2016 Mar 7;11(3):e0149097. doi: 10.1371/journal.pone.0149097. eCollection 2016.

25.

Casein kinases as potential therapeutic targets.

Cozza G, Pinna LA.

Expert Opin Ther Targets. 2016;20(3):319-40. doi: 10.1517/14728222.2016.1091883. Epub 2015 Nov 13. Review.

PMID:
26565594
26.

The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.

Cozza G, Venerando A, Sarno S, Pinna LA.

Biomed Res Int. 2015;2015:734127. doi: 10.1155/2015/734127. Epub 2015 Oct 19.

27.

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.

Cozza G, Zanin S, Sarno S, Costa E, Girardi C, Ribaudo G, Salvi M, Zagotto G, Ruzzene M, Pinna LA.

Biochem J. 2015 Nov 1;471(3):415-30. doi: 10.1042/BJ20141127. Epub 2015 Sep 8.

PMID:
26349539
28.

Feasibility of office CO2 laser surgery in patients affected by benign pathologies and congenital malformations of female lower genital tract.

Frega A, Verrone A, Schimberni M, Manzara F, Ralli E, Catalano A, Schimberni M, Torcia F, Cozza G, Bianchi P, Marziani R, Lukic A.

Eur Rev Med Pharmacol Sci. 2015;19(14):2528-36.

29.

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.

Kalathur M, Toso A, Chen J, Revandkar A, Danzer-Baltzer C, Guccini I, Alajati A, Sarti M, Pinton S, Brambilla L, Di Mitri D, Carbone G, Garcia-Escudero R, Padova A, Magnoni L, Tarditi A, Maccari L, Malusa F, Kalathur RK, A Pinna L, Cozza G, Ruzzene M, Delaleu N, Catapano CV, Frew IJ, Alimonti A.

Nat Commun. 2015 Jun 18;6:7227. doi: 10.1038/ncomms8227.

PMID:
26085373
30.

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins.

Cozza G, Salvi M, Banerjee S, Tibaldi E, Tagliabracci VS, Dixon JE, Pinna LA.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1718-26. doi: 10.1016/j.bbapap.2015.04.023. Epub 2015 Apr 30.

PMID:
25936777
31.

Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects.

Zanin S, Sandre M, Cozza G, Ottaviani D, Marin O, Pinna LA, Ruzzene M.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1694-707. doi: 10.1016/j.bbapap.2015.04.026. Epub 2015 Apr 30.

PMID:
25936516
32.

ALK kinase domain mutations in primary anaplastic large cell lymphoma: consequences on NPM-ALK activity and sensitivity to tyrosine kinase inhibitors.

Lovisa F, Cozza G, Cristiani A, Cuzzolin A, Albiero A, Mussolin L, Pillon M, Moro S, Basso G, Rosolen A, Bonvini P.

PLoS One. 2015 Apr 13;10(4):e0121378. doi: 10.1371/journal.pone.0121378. eCollection 2015.

33.

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.

Herhaus L, Perez-Oliva AB, Cozza G, Gourlay R, Weidlich S, Campbell DG, Pinna LA, Sapkota GP.

Sci Signal. 2015 Apr 14;8(372):ra35. doi: 10.1126/scisignal.aaa0441.

34.

Understanding mammalian glutathione peroxidase 7 in the light of its homologs.

Maiorino M, Bosello-Travain V, Cozza G, Miotto G, Roveri A, Toppo S, Zaccarin M, Ursini F.

Free Radic Biol Med. 2015 Jun;83:352-60. doi: 10.1016/j.freeradbiomed.2015.02.017. Epub 2015 Feb 25. Review.

PMID:
25724691
35.

Diagnostic accuracy of sonohysterography vs hysteroscopy in benign uterine endocavitary findings.

Zinna M, Gentile M, Torcia F, Bianchi P, Cozza G, Marziani R, Milazzo GN, Catalano A, Di Properzio M, Manzara F, Schimberni M, Caserta D, Frega A.

Eur Rev Med Pharmacol Sci. 2015;19(3):365-71.

36.

Adjuvant topical treatment with imiquimod 5% after excisional surgery for VIN 2/3.

Gentile M, Bianchi P, Sesti F, Sopracordevole F, Biamonti A, Scirpa P, Schimberni M, Cozza G, Marziani R, Di Martino G, Catalano A, Milazzo GN, Zinna M, Caserta D, Frega A.

Eur Rev Med Pharmacol Sci. 2014 Oct;18(19):2949-52.

37.

Ultrasound-guided dilatation and curettage in life-threatening cesarean scar ectopic pregnancy.

Bianchi P, Cozza G, Salvatori MM, Giovanale V, Vitali M.

Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:252. doi: 10.1016/j.ejogrb.2014.03.015. Epub 2014 Mar 28. No abstract available.

PMID:
24857309
38.

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

Cozza G, Zanin S, Determann R, Ruzzene M, Kunick C, Pinna LA.

PLoS One. 2014 Feb 24;9(2):e89176. doi: 10.1371/journal.pone.0089176. eCollection 2014.

39.

The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.

Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R, Izpisua Belmonte JC, Pinna LA, Sarno S.

Biochim Biophys Acta. 2014 Apr;1844(4):722-9. doi: 10.1016/j.bbapap.2014.01.014. Epub 2014 Jan 31.

PMID:
24486797
40.

Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential.

Cozza G, Girardi C, Ranchio A, Lolli G, Sarno S, Orzeszko A, Kazimierczuk Z, Battistutta R, Ruzzene M, Pinna LA.

Cell Mol Life Sci. 2014 Aug;71(16):3173-85. doi: 10.1007/s00018-013-1552-5. Epub 2014 Jan 18.

PMID:
24442476
41.

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.

Bonaiuto E, Milelli A, Cozza G, Tumiatti V, Marchetti C, Agostinelli E, Fimognari C, Hrelia P, Minarini A, Di Paolo ML.

Eur J Med Chem. 2013;70:88-101. doi: 10.1016/j.ejmech.2013.07.005. Epub 2013 Oct 1.

PMID:
24140951
42.

Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation.

Venerando A, Franchin C, Cant N, Cozza G, Pagano MA, Tosoni K, Al-Zahrani A, Arrigoni G, Ford RC, Mehta A, Pinna LA.

PLoS One. 2013 Sep 18;8(9):e74232. doi: 10.1371/journal.pone.0074232. eCollection 2013.

43.

An atypical presentation of sporadic ovarian Burkitt's lymphoma: case report and review of the literature.

Bianchi P, Torcia F, Vitali M, Cozza G, Matteoli M, Giovanale V.

J Ovarian Res. 2013 Jul 4;6(1):46. doi: 10.1186/1757-2215-6-46.

44.

Imiquimod 5% cream versus cold knife excision for treatment of VIN 2/3: a five-year follow-up.

Frega A, Sesti F, Sopracordevole F, Biamonti A, Scirpa P, Milazzo GN, Catalano A, Assorgi C, Lombardi D, Gentile M, Maniglio P, Ricciardi E, Cozza G, Marziani R, Moscarini M.

Eur Rev Med Pharmacol Sci. 2013 Apr;17(7):936-40.

45.

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M, Roveri A, Toppo S, Ursini F, Zaccarin M, Maiorino M.

Biochim Biophys Acta. 2013 Jun;1830(6):3846-57. doi: 10.1016/j.bbagen.2013.02.017. Epub 2013 Feb 27.

PMID:
23454490
46.

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.

Cozza G, Sarno S, Ruzzene M, Girardi C, Orzeszko A, Kazimierczuk Z, Zagotto G, Bonaiuto E, Di Paolo ML, Pinna LA.

Biochim Biophys Acta. 2013 Jul;1834(7):1402-9. doi: 10.1016/j.bbapap.2013.01.018. Epub 2013 Jan 27.

PMID:
23360763
47.

Kinase CK2 inhibition: an update.

Cozza G, Pinna LA, Moro S.

Curr Med Chem. 2013;20(5):671-93. Review.

PMID:
23210774
48.

Protein kinase CK2 inhibitors: a patent review.

Cozza G, Pinna LA, Moro S.

Expert Opin Ther Pat. 2012 Sep;22(9):1081-97. doi: 10.1517/13543776.2012.717615. Review.

PMID:
22908959
49.

Investigation on PLK2 and PLK3 substrate recognition.

Salvi M, Trashi E, Cozza G, Franchin C, Arrigoni G, Pinna LA.

Biochim Biophys Acta. 2012 Dec;1824(12):1366-73. doi: 10.1016/j.bbapap.2012.07.003. Epub 2012 Jul 21.

PMID:
22828320
50.

Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.

Lolli G, Cozza G, Mazzorana M, Tibaldi E, Cesaro L, Donella-Deana A, Meggio F, Venerando A, Franchin C, Sarno S, Battistutta R, Pinna LA.

Biochemistry. 2012 Aug 7;51(31):6097-107. Epub 2012 Jul 25.

PMID:
22794353

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