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Items: 19

1.

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity.

Cozier GE, Schwager SL, Sharma RK, Chibale K, Sturrock ED, Acharya KR.

FEBS J. 2018 Apr;285(8):1477-1490. doi: 10.1111/febs.14421. Epub 2018 Mar 8.

2.

Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme.

Abrie JA, Moolman WJA, Cozier GE, Schwager SL, Acharya KR, Sturrock ED.

Mol Pharmacol. 2018 Apr;93(4):344-354. doi: 10.1124/mol.117.110866. Epub 2018 Jan 25. Erratum in: Mol Pharmacol. 2018 May;93(5):416.

PMID:
29371233
3.

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme.

Fienberg S, Cozier GE, Acharya KR, Chibale K, Sturrock ED.

J Med Chem. 2018 Jan 11;61(1):344-359. doi: 10.1021/acs.jmedchem.7b01478. Epub 2017 Dec 21.

PMID:
29206036
4.

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae.

Abu Hasan Z', Williams H, Ismail NM, Othman H, Cozier GE, Acharya KR, Isaac RE.

Sci Rep. 2017 Mar 27;7:45409. doi: 10.1038/srep45409.

5.

Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.

Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR.

FEBS J. 2016 Dec;283(23):4357-4369. doi: 10.1111/febs.13928. Epub 2016 Nov 6.

6.

Chimeric microtubule disruptors.

Leese MP, Jourdan F, Kimberley MR, Cozier GE, Thiyagarajan N, Stengel C, Regis-Lydi S, Foster PA, Newman SP, Acharya KR, Ferrandis E, Purohit A, Reed MJ, Potter BV.

Chem Commun (Camb). 2010 May 7;46(17):2907-9. doi: 10.1039/c002558e. Epub 2010 Mar 20.

PMID:
20386818
7.

Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.

Cozier GE, Leese MP, Lloyd MD, Baker MD, Thiyagarajan N, Acharya KR, Potter BV.

Biochemistry. 2010 Apr 27;49(16):3464-76. doi: 10.1021/bi902178w.

PMID:
20297840
8.

Studying the spatial and temporal regulation of Ras GTPase-activating proteins.

Kupzig S, Bouyoucef D, Cozier GE, Cullen PJ.

Methods Enzymol. 2006;407:64-82.

PMID:
16757315
9.

GFP fusion proteins to study signaling in live cells.

Walker SA, Cozier GE, Cullen PJ.

Methods Mol Biol. 2004;273:407-20. No abstract available.

PMID:
15308815
10.

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.

Walker SA, Kupzig S, Bouyoucef D, Davies LC, Tsuboi T, Bivona TG, Cozier GE, Lockyer PJ, Buckler A, Rutter GA, Allen MJ, Philips MR, Cullen PJ.

EMBO J. 2004 Apr 21;23(8):1749-60. Epub 2004 Apr 1.

11.

Membrane targeting by pleckstrin homology domains.

Cozier GE, Carlton J, Bouyoucef D, Cullen PJ.

Curr Top Microbiol Immunol. 2004;282:49-88. Review.

PMID:
14594214
12.

Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain.

Cozier GE, Bouyoucef D, Cullen PJ.

J Biol Chem. 2003 Oct 10;278(41):39489-96. Epub 2003 Jul 28.

13.
14.

Modular phosphoinositide-binding domains--their role in signalling and membrane trafficking.

Cullen PJ, Cozier GE, Banting G, Mellor H.

Curr Biol. 2001 Oct 30;11(21):R882-93. Review.

15.

GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association.

Cozier GE, Lockyer PJ, Reynolds JS, Kupzig S, Bottomley JR, Millard TH, Banting G, Cullen PJ.

J Biol Chem. 2000 Sep 8;275(36):28261-8.

17.

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