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Items: 1 to 50 of 187

1.

Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways.

Tumelty KE, Higginson-Scott N, Fan X, Bajaj P, Knowlton KM, Shamashkin M, Coyle AJ, Lu W, Berasi SP.

J Biol Chem. 2018 Mar 2;293(9):3039-3055. doi: 10.1074/jbc.M117.804021. Epub 2018 Jan 9.

2.

SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion.

Fan X, Yang H, Kumar S, Tumelty KE, Pisarek-Horowitz A, Rasouly HM, Sharma R, Chan S, Tyminski E, Shamashkin M, Belghasem M, Henderson JM, Coyle AJ, Salant DJ, Berasi SP, Lu W.

JCI Insight. 2016 Nov 17;1(19):e86934. doi: 10.1172/jci.insight.86934.

3.

Correlation of cutaneous disease activity with type 1 interferon gene signature and interferon β in dermatomyositis.

Huard C, Gullà SV, Bennett DV, Coyle AJ, Vleugels RA, Greenberg SA.

Br J Dermatol. 2017 May;176(5):1224-1230. doi: 10.1111/bjd.15006. Epub 2017 Mar 14.

PMID:
27564228
4.

Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis.

David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR.

Sci Transl Med. 2016 Aug 24;8(353):353ra112. doi: 10.1126/scitranslmed.aaf4331.

PMID:
27559095
5.

Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease.

Delaney TA, Morehouse C, Brohawn PZ, Groves C, Colonna M, Yao Y, Sanjuan M, Coyle AJ.

J Immunol. 2016 Jul 1;197(1):42-50. doi: 10.4049/jimmunol.1502190. Epub 2016 May 25.

6.

Characterization of Tiki, a New Family of Wnt-specific Metalloproteases.

Zhang X, MacDonald BT, Gao H, Shamashkin M, Coyle AJ, Martinez RV, He X.

J Biol Chem. 2016 Jan 29;291(5):2435-43. doi: 10.1074/jbc.M115.677807. Epub 2015 Dec 2.

7.

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC.

Nat Struct Mol Biol. 2015 Dec;22(12):983-90. doi: 10.1038/nsmb.3117. Epub 2015 Nov 9.

8.

Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1.

Lemaire R, Burwell T, Sun H, Delaney T, Bakken J, Cheng L, Rebelatto MC, Czapiga M, de-Mendez I, Coyle AJ, Herbst R, Lafyatis R, Connor J.

Arthritis Rheumatol. 2016 Feb;68(2):473-83. doi: 10.1002/art.39443.

9.

Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature.

Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder WB, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC.

Mol Cancer Ther. 2015 Aug;14(8):1868-76. doi: 10.1158/1535-7163.MCT-15-0188. Epub 2015 Jun 18.

10.

Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6.

Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton KM, Tyminski E, Paradis T, Zhang Y, Jones JE, von Schack D, Brown CT, Milos PM, Coyle AJ, Tremblay F, Martinez RV.

PLoS One. 2014 Mar 21;9(3):e92608. doi: 10.1371/journal.pone.0092608. eCollection 2014.

11.

A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.

Llop-Guevara A, Chu DK, Walker TD, Goncharova S, Fattouh R, Silver JS, Moore CL, Xie JL, O'Byrne PM, Coyle AJ, Kolbeck R, Humbles AA, Stämpfli MR, Jordana M.

PLoS One. 2014 Feb 14;9(2):e88714. doi: 10.1371/journal.pone.0088714. eCollection 2014.

12.

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E.

J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep 30. Erratum in: J Exp Med. 2014 May 5;211(5):1001.

13.

Building a new biomedical ecosystem: Pfizer's Centers for Therapeutic Innovation.

Patel AC, Coyle AJ.

Clin Pharmacol Ther. 2013 Sep;94(3):314-6. doi: 10.1038/clpt.2013.89. Epub 2013 May 3. No abstract available.

PMID:
23645247
14.

Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.

Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA.

Immunity. 2012 Dec 14;37(6):986-997. doi: 10.1016/j.immuni.2012.09.014. Epub 2012 Dec 6.

15.

Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk.

Tortola L, Rosenwald E, Abel B, Blumberg H, Schäfer M, Coyle AJ, Renauld JC, Werner S, Kisielow J, Kopf M.

J Clin Invest. 2012 Nov;122(11):3965-76. doi: 10.1172/JCI63451. Epub 2012 Oct 15.

16.

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.

Chu DK, Llop-Guevara A, Walker TD, Flader K, Goncharova S, Boudreau JE, Moore CL, Seunghyun In T, Waserman S, Coyle AJ, Kolbeck R, Humbles AA, Jordana M.

J Allergy Clin Immunol. 2013 Jan;131(1):187-200.e1-8. doi: 10.1016/j.jaci.2012.08.002. Epub 2012 Sep 21.

PMID:
23006545
17.

Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis.

Krausz S, Garcia S, Ambarus CA, de Launay D, Foster M, Naiman B, Iverson W, Connor JR, Sleeman MA, Coyle AJ, Hamann J, Baeten D, Tak PP, Reedquist KA.

Ann Rheum Dis. 2012 Aug;71(8):1402-10. doi: 10.1136/annrheumdis-2011-200718. Epub 2012 Jun 22.

PMID:
22730375
18.

Role of YKL-40 in bronchial smooth muscle remodeling in asthma.

Bara I, Ozier A, Girodet PO, Carvalho G, Cattiaux J, Begueret H, Thumerel M, Ousova O, Kolbeck R, Coyle AJ, Woods J, Tunon de Lara JM, Marthan R, Berger P.

Am J Respir Crit Care Med. 2012 Apr 1;185(7):715-22. doi: 10.1164/rccm.201105-0915OC. Epub 2012 Jan 26.

PMID:
22281830
19.

Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection.

Miller AL, Sims GP, Brewah YA, Rebelatto MC, Kearley J, Benjamin E, Keller AE, Brohawn P, Herbst R, Coyle AJ, Humbles AA, Kolbeck R.

J Infect Dis. 2012 Apr 15;205(8):1311-20. doi: 10.1093/infdis/jir826. Epub 2012 Jan 18.

20.

Shifting of immune responsiveness to house dust mite by influenza A infection: genomic insights.

Al-Garawi A, Husain M, Ilieva D, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

J Immunol. 2012 Jan 15;188(2):832-43. doi: 10.4049/jimmunol.1102349. Epub 2011 Dec 14.

21.

IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.

Botelho FM, Bauer CM, Finch D, Nikota JK, Zavitz CC, Kelly A, Lambert KN, Piper S, Foster ML, Goldring JJ, Wedzicha JA, Bassett J, Bramson J, Iwakura Y, Sleeman M, Kolbeck R, Coyle AJ, Humbles AA, Stämpfli MR.

PLoS One. 2011;6(12):e28457. doi: 10.1371/journal.pone.0028457. Epub 2011 Dec 6.

22.

A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo.

Ward E, Mittereder N, Kuta E, Sims GP, Bowen MA, Dall'Acqua W, Tedder T, Kiener P, Coyle AJ, Wu H, Jallal B, Herbst R.

Br J Haematol. 2011 Nov;155(4):426-37. doi: 10.1111/j.1365-2141.2011.08857.x. Epub 2011 Sep 9.

PMID:
21902688
23.

Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood.

Al-Garawi A, Fattouh R, Botelho F, Walker TD, Goncharova S, Moore CL, Mori M, Erjefalt JS, Chu DK, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

Mucosal Immunol. 2011 Nov;4(6):682-94. doi: 10.1038/mi.2011.35. Epub 2011 Aug 31.

PMID:
21881572
24.

Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation.

Karnell JL, Karnell FG 3rd, Stephens GL, Rajan B, Morehouse C, Li Y, Swerdlow B, Wilson M, Goldbach-Mansky R, Groves C, Coyle AJ, Herbst R, Ettinger R.

J Immunol. 2011 Oct 1;187(7):3603-12. doi: 10.4049/jimmunol.1003319. Epub 2011 Aug 26.

25.

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.

Arias K, Chu DK, Flader K, Botelho F, Walker T, Arias N, Humbles AA, Coyle AJ, Oettgen HC, Chang HD, Van Rooijen N, Waserman S, Jordana M.

J Allergy Clin Immunol. 2011 Jun;127(6):1552-61.e1. doi: 10.1016/j.jaci.2011.03.044.

PMID:
21624619
26.

Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation.

Nikota JK, Botelho FM, Bauer CM, Jordana M, Coyle AJ, Humbles AA, Stampfli MR.

Respir Res. 2011 Apr 7;12:39. doi: 10.1186/1465-9921-12-39.

27.

A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke.

Botelho FM, Nikota JK, Bauer C, Davis NH, Cohen ES, Anderson IK, Coyle AJ, Kolbeck R, Humbles AA, Stämpfli MR, Sleeman MA.

Eur Respir J. 2011 Aug;38(2):285-94. doi: 10.1183/09031936.00076210. Epub 2011 Mar 24.

28.

IL-9 is a Th17-derived cytokine that limits pathogenic activity in organ-specific autoimmune disease.

Stephens GL, Swerdlow B, Benjamin E, Coyle AJ, Humbles A, Kolbeck R, Fung M.

Eur J Immunol. 2011 Apr;41(4):952-62. doi: 10.1002/eji.201040879. Epub 2011 Feb 24.

29.

RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity.

Telcian AG, Laza-Stanca V, Edwards MR, Harker JA, Wang H, Bartlett NW, Mallia P, Zdrenghea MT, Kebadze T, Coyle AJ, Openshaw PJ, Stanciu LA, Johnston SL.

J Infect Dis. 2011 Jan 1;203(1):85-94. doi: 10.1093/infdis/jiq020. Erratum in: J Infect Dis. 2012 Apr;205(7):1180.

30.

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.

Kearley J, Erjefalt JS, Andersson C, Benjamin E, Jones CP, Robichaud A, Pegorier S, Brewah Y, Burwell TJ, Bjermer L, Kiener PA, Kolbeck R, Lloyd CM, Coyle AJ, Humbles AA.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):865-75. doi: 10.1164/rccm.200909-1462OC. Epub 2010 Oct 22.

31.

Angiopoietin-2-driven vascular remodeling in airway inflammation.

Tabruyn SP, Colton K, Morisada T, Fuxe J, Wiegand SJ, Thurston G, Coyle AJ, Connor J, McDonald DM.

Am J Pathol. 2010 Dec;177(6):3233-43. doi: 10.2353/ajpath.2010.100059. Epub 2010 Oct 15.

32.

Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease.

Fattouh R, Al-Garawi A, Fattouh M, Arias K, Walker TD, Goncharova S, Coyle AJ, Humbles AA, Jordana M.

Am J Respir Crit Care Med. 2011 Jan 15;183(2):179-88. doi: 10.1164/rccm.200905-0736OC. Epub 2010 Aug 23.

PMID:
20732990
33.

B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.

Herbst R, Wang Y, Gallagher S, Mittereder N, Kuta E, Damschroder M, Woods R, Rowe DC, Cheng L, Cook K, Evans K, Sims GP, Pfarr DS, Bowen MA, Dall'Acqua W, Shlomchik M, Tedder TF, Kiener P, Jallal B, Wu H, Coyle AJ.

J Pharmacol Exp Ther. 2010 Oct;335(1):213-22. doi: 10.1124/jpet.110.168062. Epub 2010 Jul 6. Erratum in: J Pharmacol Exp Ther. 2011 Jan;336(1):294. Dall'Aqua, William [corrected to Dall'Acqua, William].

PMID:
20605905
34.

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.

Kolbeck R, Kozhich A, Koike M, Peng L, Andersson CK, Damschroder MM, Reed JL, Woods R, Dall'acqua WW, Stephens GL, Erjefalt JS, Bjermer L, Humbles AA, Gossage D, Wu H, Kiener PA, Spitalny GL, Mackay CR, Molfino NA, Coyle AJ.

J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2. doi: 10.1016/j.jaci.2010.04.004.

PMID:
20513525
35.

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma.

Busse WW, Katial R, Gossage D, Sari S, Wang B, Kolbeck R, Coyle AJ, Koike M, Spitalny GL, Kiener PA, Geba GP, Molfino NA.

J Allergy Clin Immunol. 2010 Jun;125(6):1237-1244.e2. doi: 10.1016/j.jaci.2010.04.005.

PMID:
20513521
36.

HMGB1 and RAGE in inflammation and cancer.

Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ.

Annu Rev Immunol. 2010;28:367-88. doi: 10.1146/annurev.immunol.021908.132603. Review.

PMID:
20192808
37.

Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease.

Ferhani N, Letuve S, Kozhich A, Thibaudeau O, Grandsaigne M, Maret M, Dombret MC, Sims GP, Kolbeck R, Coyle AJ, Aubier M, Pretolani M.

Am J Respir Crit Care Med. 2010 May 1;181(9):917-27. doi: 10.1164/rccm.200903-0340OC. Epub 2010 Feb 4.

PMID:
20133931
38.

Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.

Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.

Arthritis Rheum. 2010 Mar;62(3):742-52. doi: 10.1002/art.27285.

39.

Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation.

Létuvé S, Kozhich A, Humbles A, Brewah Y, Dombret MC, Grandsaigne M, Adle H, Kolbeck R, Aubier M, Coyle AJ, Pretolani M.

Am J Pathol. 2010 Feb;176(2):638-49. doi: 10.2353/ajpath.2010.090455. Epub 2009 Dec 30.

40.

Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.

Goutagny N, Jiang Z, Tian J, Parroche P, Schickli J, Monks BG, Ulbrandt N, Ji H, Kiener PA, Coyle AJ, Fitzgerald KA.

J Immunol. 2010 Feb 1;184(3):1168-79. doi: 10.4049/jimmunol.0902750. Epub 2009 Dec 30.

41.

RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes.

Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A.

Autoimmunity. 2010 Feb;43(1):103-10. doi: 10.3109/08916930903384591.

42.

Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation.

Perros F, Hoogsteden HC, Coyle AJ, Lambrecht BN, Hammad H.

Allergy. 2009 Jul;64(7):995-1002. doi: 10.1111/j.1398-9995.2009.02095.x.

PMID:
19630858
43.

IL-9 as a mediator of Th17-driven inflammatory disease.

Nowak EC, Weaver CT, Turner H, Begum-Haque S, Becher B, Schreiner B, Coyle AJ, Kasper LH, Noelle RJ.

J Exp Med. 2009 Aug 3;206(8):1653-60. doi: 10.1084/jem.20090246. Epub 2009 Jul 13.

44.

Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus.

Yao Y, Richman L, Higgs BW, Morehouse CA, de los Reyes M, Brohawn P, Zhang J, White B, Coyle AJ, Kiener PA, Jallal B.

Arthritis Rheum. 2009 Jun;60(6):1785-96. doi: 10.1002/art.24557.

45.

The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses.

Nembrini C, Kisielow J, Shamshiev AT, Tortola L, Coyle AJ, Kopf M, Marsland BJ.

J Biol Chem. 2009 Jul 17;284(29):19183-8. doi: 10.1074/jbc.M109.006353. Epub 2009 May 27.

46.

Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice.

Okazaki T, Ni A, Baluk P, Ayeni OA, Kearley J, Coyle AJ, Humbles A, McDonald DM.

Am J Pathol. 2009 Jun;174(6):2388-99. doi: 10.2353/ajpath.2009.080949. Epub 2009 May 14.

47.

Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection.

Reed JL, Welliver TP, Sims GP, McKinney L, Velozo L, Avendano L, Hintz K, Luma J, Coyle AJ, Welliver RC Sr.

J Infect Dis. 2009 Apr 15;199(8):1128-38. doi: 10.1086/597386.

PMID:
19278337
48.

NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.

Yamasaki K, Muto J, Taylor KR, Cogen AL, Audish D, Bertin J, Grant EP, Coyle AJ, Misaghi A, Hoffman HM, Gallo RL.

J Biol Chem. 2009 May 8;284(19):12762-71. doi: 10.1074/jbc.M806084200. Epub 2009 Mar 3.

49.

Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease.

Al-Garawi AA, Fattouh R, Walker TD, Jamula EB, Botelho F, Goncharova S, Reed J, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

J Immunol. 2009 Mar 1;182(5):3095-104. doi: 10.4049/jimmunol.0802837.

50.

Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus.

Yao Y, Higgs BW, Morehouse C, de Los Reyes M, Trigona W, Brohawn P, White W, Zhang J, White B, Coyle AJ, Kiener PA, Jallal B.

Hum Genomics Proteomics. 2009 Nov 17;2009. pii: 374312. doi: 10.4061/2009/374312.

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