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Items: 1 to 50 of 168

1.

Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.

Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, Lear P, McCullagh J, Cantley J, Cox RD, de Wet H.

Obesity (Silver Spring). 2019 Aug;27(8):1292-1304. doi: 10.1002/oby.22521.

PMID:
31338999
2.

Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis.

Gorvin CM, Loh NY, Stechman MJ, Falcone S, Hannan FM, Ahmad BN, Piret SE, Reed AA, Jeyabalan J, Leo P, Marshall M, Sethi S, Bass P, Roberts I, Sanderson J, Wells S, Hough TA, Bentley L, Christie PT, Simon MM, Mallon AM, Schulz H, Cox RD, Brown MA, Huebner N, Brown SD, Thakker RV.

J Bone Miner Res. 2019 Jul;34(7):1324-1335. doi: 10.1002/jbmr.3695. Epub 2019 Mar 4.

3.

A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways.

Agnew T, Goldsworthy M, Aguilar C, Morgan A, Simon M, Hilton H, Esapa C, Wu Y, Cater H, Bentley L, Scudamore C, Poulton J, Morten KJ, Thompson K, He L, Brown SDM, Taylor RW, Bowl MR, Cox RD.

Cell Rep. 2018 Dec 18;25(12):3315-3328.e6. doi: 10.1016/j.celrep.2018.11.080.

4.

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice.

Gorvin CM, Ahmad BN, Stechman MJ, Loh NY, Hough TA, Leo P, Marshall M, Sethi S, Bentley L, Piret SE, Reed A, Jeyabalan J, Christie PT, Wells S, Simon MM, Mallon AM, Schulz H, Huebner N, Brown MA, Cox RD, Brown SD, Thakker RV.

J Bone Miner Res. 2019 Mar;34(3):497-507. doi: 10.1002/jbmr.3624. Epub 2018 Dec 14.

5.

Interactive effects of severe drought and grazing on the life history cycle of a bioindicator species.

Fritts SR, Grisham BA, Cox RD, Boal CW, Haukos DA, McDaniel P, Hagen CA, Greene DU.

Ecol Evol. 2018 Sep 1;8(18):9550-9562. doi: 10.1002/ece3.4432. eCollection 2018 Sep.

6.

An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion.

Esapa CT, Piret SE, Nesbit MA, Thomas GP, Coulton LA, Gallagher OM, Simon MM, Kumar S, Mallon AM, Bellantuono I, Brown MA, Croucher PI, Potter PK, Brown SD, Cox RD, Thakker RV.

JBMR Plus. 2018 Mar 8;2(3):154-163. doi: 10.1002/jbm4.10033. eCollection 2018 May.

7.

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.

Chakera AJ, Hurst PS, Spyer G, Ogunnowo-Bada EO, Marsh WJ, Riches CH, Yueh CY, Markkula SP, Dalley JW, Cox RD, Macdonald IA, Amiel SA, MacLeod KM, Heisler LK, Hattersley AT, Evans ML.

Mol Metab. 2018 Nov;17:17-27. doi: 10.1016/j.molmet.2018.08.001. Epub 2018 Aug 13.

8.

Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Vinuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI.

Nat Genet. 2018 Sep;50(9):1342. doi: 10.1038/s41588-018-0180-2.

PMID:
30087441
9.

Bone matrix development in steroid-induced osteoporosis is associated with a consistently reduced fibrillar stiffness linked to altered bone mineral quality.

Xi L, De Falco P, Barbieri E, Karunaratne A, Bentley L, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Davis GR, Pugno NM, Thakker RV, Gupta HS.

Acta Biomater. 2018 Aug;76:295-307. doi: 10.1016/j.actbio.2018.05.053. Epub 2018 Jun 15.

10.

Misidentification of copperhead and cottonmouth snakes following snakebites.

Cox RD, Parker CS, Cox ECE, Marlin MB, Galli RL.

Clin Toxicol (Phila). 2018 Dec;56(12):1195-1199. doi: 10.1080/15563650.2018.1473583. Epub 2018 May 24.

PMID:
29792342
11.

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI.

Nat Genet. 2018 Apr;50(4):572-580. doi: 10.1038/s41588-018-0088-x. Epub 2018 Apr 9. Erratum in: Nat Genet. 2018 Sep;50(9):1342.

12.

N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice.

Gorvin CM, Rogers A, Stewart M, Paudyal A, Hough TA, Teboul L, Wells S, Brown SD, Cox RD, Thakker RV.

JBMR Plus. 2017 May 2;1(1):3-15. doi: 10.1002/jbm4.10001.

13.

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.

Sachse G, Church C, Stewart M, Cater H, Teboul L, Cox RD, Ashcroft FM.

Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):843-850. doi: 10.1016/j.bbadis.2017.11.027. Epub 2017 Dec 2. No abstract available.

14.

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.

Moir L, Bochukova EG, Dumbell R, Banks G, Bains RS, Nolan PM, Scudamore C, Simon M, Watson KA, Keogh J, Henning E, Hendricks A, O'Rahilly S, Barroso I; UK10K consortium, Sullivan AE, Bersten DC, Whitelaw ML, Kirsch S, Bentley E, Farooqi IS, Cox RD.

Mol Metab. 2017 Nov;6(11):1419-1428. doi: 10.1016/j.molmet.2017.08.006. Epub 2017 Aug 24.

15.

Air Ambulance Delivery and Administration of Four-factor Prothrombin Complex Concentrate Is Feasible and Decreases Time to Anticoagulation Reversal.

Vines C, Tesseneer SJ, Cox RD, Darsey DA, Carbrey K, Puskarich MA.

Acad Emerg Med. 2018 Jan;25(1):33-40. doi: 10.1111/acem.13338. Epub 2017 Nov 13.

16.

Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.

Howles SA, Hannan FM, Gorvin CM, Piret SE, Paudyal A, Stewart M, Hough TA, Nesbit MA, Wells S, Brown SD, Cox RD, Thakker RV.

JCI Insight. 2017 Oct 19;2(20). pii: 96540. doi: 10.1172/jci.insight.96540.

17.

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.

Babinsky VN, Hannan FM, Ramracheya RD, Zhang Q, Nesbit MA, Hugill A, Bentley L, Hough TA, Joynson E, Stewart M, Aggarwal A, Prinz-Wohlgenannt M, Gorvin CM, Kallay E, Wells S, Cox RD, Richards D, Rorsman P, Thakker RV.

Endocrinology. 2017 Aug 1;158(8):2486-2502. doi: 10.1210/en.2017-00111.

18.

A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress.

Piret SE, Olinger E, Reed AAC, Nesbit MA, Hough TA, Bentley L, Devuyst O, Cox RD, Thakker RV.

Dis Model Mech. 2017 Jun 1;10(6):773-786. doi: 10.1242/dmm.029488. Epub 2017 Mar 21.

19.

Mouse Models of Human GWAS Hits for Obesity and Diabetes in the Post Genomic Era: Time for Reevaluation.

Laber S, Cox RD.

Front Endocrinol (Lausanne). 2017 Feb 7;8:11. doi: 10.3389/fendo.2017.00011. eCollection 2017. No abstract available.

20.

Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

Gorvin CM, Hannan FM, Howles SA, Babinsky VN, Piret SE, Rogers A, Freidin AJ, Stewart M, Paudyal A, Hough TA, Nesbit MA, Wells S, Vincent TL, Brown SD, Cox RD, Thakker RV.

JCI Insight. 2017 Feb 9;2(3):e91103. doi: 10.1172/jci.insight.91103.

21.

Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway.

Esapa CT, Piret SE, Nesbit MA, Loh NY, Thomas G, Croucher PI, Brown MA, Brown SD, Cox RD, Thakker RV.

PLoS One. 2016 Dec 13;11(12):e0167916. doi: 10.1371/journal.pone.0167916. eCollection 2016.

22.

Euglycemic Diabetic Ketoacidosis with Elevated Acetone in a Patient Taking a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor.

Andrews TJ, Cox RD, Parker C, Kolb J.

J Emerg Med. 2017 Feb;52(2):223-226. doi: 10.1016/j.jemermed.2016.07.082. Epub 2016 Oct 4.

PMID:
27717592
23.

Islet Insulin Secretion Measurements in the Mouse.

Hugill A, Shimomura K, Cox RD.

Curr Protoc Mouse Biol. 2016 Sep 1;6(3):256-71. doi: 10.1002/cpmo.14.

PMID:
27584553
24.

Comprehensive Energy Balance Measurements in Mice.

Moir L, Bentley L, Cox RD.

Curr Protoc Mouse Biol. 2016 Sep 1;6(3):211-22. doi: 10.1002/cpmo.13.

PMID:
27584551
25.

Longitudinal Trends in the Prevalence of Diabetes Mellitus in an Urban Emergency Department.

Sterling SA, Jones AE, Cox RD.

South Med J. 2016 Apr;109(4):222-7. doi: 10.14423/SMJ.0000000000000447.

26.

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.

Goldsworthy M, Bai Y, Li CM, Ge H, Lamas E, Hilton H, Esapa CT, Baker D, Baron W, Juan T, Véniant MM, Lloyd DJ, Cox RD.

Diabetes. 2016 May;65(5):1434-46. doi: 10.2337/db15-1276. Epub 2016 Feb 11.

27.

Multiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis.

Karunaratne A, Xi L, Bentley L, Sykes D, Boyde A, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Thakker RV, Gupta HS.

Bone. 2016 Mar;84:15-24. doi: 10.1016/j.bone.2015.11.019. Epub 2015 Dec 2.

28.

Commentary: FTO obesity variant circuitry and adipocyte browning in humans.

Laber S, Cox RD.

Front Genet. 2015 Oct 23;6:318. doi: 10.3389/fgene.2015.00318. eCollection 2015. No abstract available.

29.

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.

Hugill AJ, Stewart ME, Yon MA, Probert F, Cox IJ, Hough TA, Scudamore CL, Bentley L, Wall G, Wells SE, Cox RD.

Biol Open. 2015 Oct 2;4(11):1367-75. doi: 10.1242/bio.013342.

30.

The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).

Hannan FM, Walls GV, Babinsky VN, Nesbit MA, Kallay E, Hough TA, Fraser WD, Cox RD, Hu J, Spiegel AM, Thakker RV.

Endocrinology. 2015 Sep;156(9):3114-21. doi: 10.1210/en.2015-1269. Epub 2015 Jun 8.

31.

Prospective study of recovery from copperhead snake envenomation: an observational study.

Lavonas EJ, Gerardo CJ; Copperhead Snakebite Recovery Outcome Group.

BMC Emerg Med. 2015 May 15;15:9. doi: 10.1186/s12873-015-0033-6.

32.

FTO influences adipogenesis by regulating mitotic clonal expansion.

Merkestein M, Laber S, McMurray F, Andrew D, Sachse G, Sanderson J, Li M, Usher S, Sellayah D, Ashcroft FM, Cox RD.

Nat Commun. 2015 Apr 17;6:6792. doi: 10.1038/ncomms7792.

33.

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.

Esapa CT, Hannan FM, Babinsky VN, Potter P, Thomas GP, Croucher PI, Brown MA, Brown SD, Cox RD, Thakker RV.

PLoS One. 2015 Apr 10;10(4):e0122650. doi: 10.1371/journal.pone.0122650. eCollection 2015.

34.

Pharmacological inhibition of FTO.

McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD.

PLoS One. 2015 Apr 1;10(4):e0121829. doi: 10.1371/journal.pone.0121829. eCollection 2015.

35.

The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity.

Possamai LA, McPhail MJ, Khamri W, Wu B, Concas D, Harrison M, Williams R, Cox RD, Cox IJ, Anstee QM, Thursz MR.

Liver Int. 2015 Mar;35(3):764-73. doi: 10.1111/liv.12689. Epub 2014 Oct 8.

36.

Introduction to mammalian genome special issue: metabolism.

Cox RD.

Mamm Genome. 2014 Oct;25(9-10):375-6. doi: 10.1007/s00335-014-9542-y. No abstract available.

PMID:
25178883
37.

On the evolutionary origins of obesity: a new hypothesis.

Sellayah D, Cagampang FR, Cox RD.

Endocrinology. 2014 May;155(5):1573-88. doi: 10.1210/en.2013-2103. Epub 2014 Feb 26. Review.

PMID:
24605831
38.

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.

Bentley L, Esapa CT, Nesbit MA, Head RA, Evans H, Lath D, Scudamore CL, Hough TA, Podrini C, Hannan FM, Fraser WD, Croucher PI, Brown MA, Brown SD, Cox RD, Thakker RV.

Endocrinology. 2014 Mar;155(3):908-22. doi: 10.1210/en.2013-1247. Epub 2013 Dec 3.

39.

Lead toxicity as an etiology for abdominal pain in the emergency department.

Moriarity RS, Harris JT, Cox RD.

J Emerg Med. 2014 Feb;46(2):e35-8. doi: 10.1016/j.jemermed.2013.08.037. Epub 2013 Oct 7.

PMID:
24113481
40.

Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.

Ulmasov B, Oshima K, Rodriguez MG, Cox RD, Neuschwander-Tetri BA.

Am J Pathol. 2013 Sep;183(3):692-708. doi: 10.1016/j.ajpath.2013.05.020. Epub 2013 Jul 8.

41.

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

Goldsworthy M, Absalom NL, Schröter D, Matthews HC, Bogani D, Moir L, Long A, Church C, Hugill A, Anstee QM, Goldin R, Thursz M, Hollfelder F, Cox RD.

PLoS One. 2013 Jun 24;8(6):e61870. doi: 10.1371/journal.pone.0061870. Print 2013.

42.

Gene Dosage Effects at the Imprinted Gnas Cluster.

Ball ST, Kelly ML, Robson JE, Turner MD, Harrison J, Jones L, Napper D, Beechey CV, Hough T, Plagge A, Cattanach BM, Cox RD, Peters J.

PLoS One. 2013 Jun 18;8(6):e65639. doi: 10.1371/journal.pone.0065639. Print 2013.

43.

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.

Loh NY, Bentley L, Dimke H, Verkaart S, Tammaro P, Gorvin CM, Stechman MJ, Ahmad BN, Hannan FM, Piret SE, Evans H, Bellantuono I, Hough TA, Fraser WD, Hoenderop JG, Ashcroft FM, Brown SD, Bindels RJ, Cox RD, Thakker RV.

PLoS One. 2013;8(1):e55412. doi: 10.1371/journal.pone.0055412. Epub 2013 Jan 30.

44.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.

45.

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

McMurray F, Church CD, Larder R, Nicholson G, Wells S, Teboul L, Tung YC, Rimmington D, Bosch F, Jimenez V, Yeo GS, O'Rahilly S, Ashcroft FM, Coll AP, Cox RD.

PLoS Genet. 2013;9(1):e1003166. doi: 10.1371/journal.pgen.1003166. Epub 2013 Jan 3.

46.

Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone.

Karunaratne A, Boyde A, Esapa CT, Hiller J, Terrill NJ, Brown SD, Cox RD, Thakker RV, Gupta HS.

Bone. 2013 Feb;52(2):689-98. doi: 10.1016/j.bone.2012.10.029. Epub 2012 Nov 3.

PMID:
23128355
47.

From mice to humans.

McMurray F, Moir L, Cox RD.

Curr Diab Rep. 2012 Dec;12(6):651-8. doi: 10.1007/s11892-012-0323-2. Review.

48.

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.

Esapa CT, Head RA, Jeyabalan J, Evans H, Hough TA, Cheeseman MT, McNally EG, Carr AJ, Thomas GP, Brown MA, Croucher PI, Brown SD, Cox RD, Thakker RV.

PLoS One. 2012;7(8):e43205. doi: 10.1371/journal.pone.0043205. Epub 2012 Aug 13.

49.

Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.

Lee AW, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, de Angelis MH, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schäfer MK.

PLoS One. 2012;7(7):e41537. doi: 10.1371/journal.pone.0041537. Epub 2012 Jul 23.

50.

Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development.

Karunaratne A, Davis GR, Hiller J, Esapa CT, Terrill NJ, Brown SD, Cox RD, Thakker RV, Gupta HS.

Bone. 2012 Sep;51(3):553-62. doi: 10.1016/j.bone.2012.04.021. Epub 2012 May 15.

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