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A 5'-to-3' strand exchange polarity is intrinsic to RecA nucleoprotein filaments in the absence of ATP hydrolysis.

Lin YH, Chu CC, Fan HF, Wang PY, Cox MM, Li HW.

Nucleic Acids Res. 2019 Jun 4;47(10):5126-5140. doi: 10.1093/nar/gkz189.


Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy.

Minkoff BB, Bruckbauer ST, Sabat G, Cox MM, Sussman MR.

Radiat Res. 2019 May;191(5):447-459. doi: 10.1667/RR15288.1. Epub 2019 Mar 8.


Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response.

Ghodke H, Paudel BP, Lewis JS, Jergic S, Gopal K, Romero ZJ, Wood EA, Woodgate R, Cox MM, van Oijen AM.

Elife. 2019 Feb 5;8. pii: e42761. doi: 10.7554/eLife.42761.


Conformational regulation of Escherichia coli DNA polymerase V by RecA and ATP.

Jaszczur MM, Vo DD, Stanciauskas R, Bertram JG, Sikand A, Cox MM, Woodgate R, Mak CH, Pinaud F, Goodman MF.

PLoS Genet. 2019 Feb 4;15(2):e1007956. doi: 10.1371/journal.pgen.1007956. eCollection 2019 Feb.


Experimental Evolution of Extreme Resistance to Ionizing Radiation in Escherichia coli after 50 Cycles of Selection.

Bruckbauer ST, Trimarco JD, Martin J, Bushnell B, Senn KA, Schackwitz W, Lipzen A, Blow M, Wood EA, Culberson WS, Pennacchio C, Cox MM.

J Bacteriol. 2019 Mar 26;201(8). pii: e00784-18. doi: 10.1128/JB.00784-18. Print 2019 Apr 15.


A variant of the Escherichia coli anaerobic transcription factor FNR exhibiting diminished promoter activation function enhances ionizing radiation resistance.

Bruckbauer ST, Trimarco JD, Henry C, Wood EA, Battista JR, Cox MM.

PLoS One. 2019 Jan 23;14(1):e0199482. doi: 10.1371/journal.pone.0199482. eCollection 2019.


RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli.

Henrikus SS, Henry C, Ghodke H, Wood EA, Mbele N, Saxena R, Basu U, van Oijen AM, Cox MM, Robinson A.

Nucleic Acids Res. 2019 Apr 8;47(6):2946-2965. doi: 10.1093/nar/gkz003.


Glycobiotechnology of the Insect Cell-Baculovirus Expression System Technology.

Palomares LA, Srivastava IK, Ramírez OT, Cox MMJ.

Adv Biochem Eng Biotechnol. 2018 Jun 10. doi: 10.1007/10_2018_61. [Epub ahead of print]


Vaccine Technology VI: Innovative and integrated approaches in vaccine development.

Palomares LA, Mukhopadhyay TK, Genzel Y, Lua LHL, Cox MMJ.

Vaccine. 2018 May 24;36(22):3061-3063. doi: 10.1016/j.vaccine.2018.03.077. Epub 2018 Apr 11. No abstract available.


DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli.

Henrikus SS, Wood EA, McDonald JP, Cox MM, Woodgate R, Goodman MF, van Oijen AM, Robinson A.

PLoS Genet. 2018 Jan 19;14(1):e1007161. doi: 10.1371/journal.pgen.1007161. eCollection 2018 Jan.


Vaccination with a Recombinant H7 Hemagglutinin-Based Influenza Virus Vaccine Induces Broadly Reactive Antibodies in Humans.

Stadlbauer D, Rajabhathor A, Amanat F, Kaplan D, Masud A, Treanor JJ, Izikson R, Cox MM, Nachbagauer R, Krammer F.

mSphere. 2017 Dec 13;2(6). pii: e00502-17. doi: 10.1128/mSphere.00502-17. eCollection 2017 Nov-Dec.


Randomized Comparison of Immunogenicity and Safety of Quadrivalent Recombinant Versus Inactivated Influenza Vaccine in Healthy Adults 18-49 Years of Age.

Dunkle LM, Izikson R, Patriarca PA, Goldenthal KL, Muse D, Cox MMJ.

J Infect Dis. 2017 Dec 5;216(10):1219-1226. doi: 10.1093/infdis/jix478.


Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older.

Dunkle LM, Izikson R, Patriarca P, Goldenthal KL, Muse D, Callahan J, Cox MMJ; PSC12 Study Team.

N Engl J Med. 2017 Jun 22;376(25):2427-2436. doi: 10.1056/NEJMoa1608862.


Single-molecule visualization of fast polymerase turnover in the bacterial replisome.

Lewis JS, Spenkelink LM, Jergic S, Wood EA, Monachino E, Horan NP, Duderstadt KE, Cox MM, Robinson A, Dixon NE, van Oijen AM.

Elife. 2017 Apr 22;6. pii: e23932. doi: 10.7554/eLife.23932.


Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine.

Honda-Okubo Y, Rajapaksha H, Sajkov D, Gordon D, Cox MMJ, Petrovsky N.

Hum Vaccin Immunother. 2017 Jun 3;13(6):1-11. doi: 10.1080/21645515.2017.1279765. Epub 2017 Feb 14.


DNA flap creation by the RarA/MgsA protein of Escherichia coli.

Stanage TH, Page AN, Cox MM.

Nucleic Acids Res. 2017 Mar 17;45(5):2724-2735. doi: 10.1093/nar/gkw1322.


Escherichia coli RadD Protein Functionally Interacts with the Single-stranded DNA-binding Protein.

Chen SH, Byrne-Nash RT, Cox MM.

J Biol Chem. 2016 Sep 23;291(39):20779-86. doi: 10.1074/jbc.M116.736223. Epub 2016 Aug 12.


Structural and Functional Studies of H. seropedicae RecA Protein - Insights into the Polymerization of RecA Protein as Nucleoprotein Filament.

Leite WC, Galvão CW, Saab SC, Iulek J, Etto RM, Steffens MB, Chitteni-Pattu S, Stanage T, Keck JL, Cox MM.

PLoS One. 2016 Jul 22;11(7):e0159871. doi: 10.1371/journal.pone.0159871. eCollection 2016.


DNA Metabolism in Balance: Rapid Loss of a RecA-Based Hyperrec Phenotype.

Bakhlanova IV, Dudkina AV, Wood EA, Lanzov VA, Cox MM, Baitin DM.

PLoS One. 2016 Apr 28;11(4):e0154137. doi: 10.1371/journal.pone.0154137. eCollection 2016.


Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword.

Jaszczur M, Bertram JG, Robinson A, van Oijen AM, Woodgate R, Cox MM, Goodman MF.

Biochemistry. 2016 Apr 26;55(16):2309-18. doi: 10.1021/acs.biochem.6b00117. Epub 2016 Apr 12. Review.



Cox MM, Andrews B.

Crit Rev Biochem Mol Biol. 2016;51(2):73. doi: 10.3109/10409238.2016.1147998. Epub 2016 Mar 9. No abstract available.


Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans.

Nachbagauer R, Choi A, Izikson R, Cox MM, Palese P, Krammer F.

MBio. 2016 Jan 19;7(1):e01996-15. doi: 10.1128/mBio.01996-15.


P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality.

Ronayne EA, Wan YC, Boudreau BA, Landick R, Cox MM.

PLoS Genet. 2016 Jan 14;12(1):e1005797. doi: 10.1371/journal.pgen.1005797. eCollection 2016 Jan.


Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age.

Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM.

Vaccine. 2015 Nov 27;33(48):6622-8. doi: 10.1016/j.vaccine.2015.10.097. Epub 2015 Nov 1.


Anionic Phospholipids Stabilize RecA Filament Bundles in Escherichia coli.

Rajendram M, Zhang L, Reynolds BJ, Auer GK, Tuson HH, Ngo KV, Cox MM, Yethiraj A, Cui Q, Weibel DB.

Mol Cell. 2015 Nov 5;60(3):374-84. doi: 10.1016/j.molcel.2015.09.009. Epub 2015 Oct 17.


Safety, efficacy, and immunogenicity of Flublok in the prevention of seasonal influenza in adults.

Cox MM, Izikson R, Post P, Dunkle L.

Ther Adv Vaccines. 2015 Jul;3(4):97-108. doi: 10.1177/2051013615595595. Review.


Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate.

Rhodes DG, Holtz K, Robinson P, Wang K, McPherson CE, Cox MM, Srivastava IK.

Vaccine. 2015 Nov 4;33(44):6011-6. doi: 10.1016/j.vaccine.2015.09.029. Epub 2015 Sep 26.


Regulation of Mutagenic DNA Polymerase V Activation in Space and Time.

Robinson A, McDonald JP, Caldas VE, Patel M, Wood EA, Punter CM, Ghodke H, Cox MM, Woodgate R, Goodman MF, van Oijen AM.

PLoS Genet. 2015 Aug 28;11(8):e1005482. doi: 10.1371/journal.pgen.1005482. eCollection 2015 Aug.


Vaccine Technology V: The art of taking vaccines to disease prevention.

Palomares LA, Buckland BC, Genzel Y, Cox MM.

Vaccine. 2015 Aug 20;33(35):4219-20. doi: 10.1016/j.vaccine.2015.06.098. Epub 2015 Jun 29. No abstract available.


Directed Evolution of RecA Variants with Enhanced Capacity for Conjugational Recombination.

Kim T, Chitteni-Pattu S, Cox BL, Wood EA, Sandler SJ, Cox MM.

PLoS Genet. 2015 Jun 5;11(6):e1005278. doi: 10.1371/journal.pgen.1005278. eCollection 2015 Jun.


Dissolved carbon dioxide determines the productivity of a recombinant hemagglutinin component of an influenza vaccine produced by insect cells.

Meghrous J, Khramtsov N, Buckland BC, Cox MM, Palomares LA, Srivastava IK.

Biotechnol Bioeng. 2015 Nov;112(11):2267-75. doi: 10.1002/bit.25634. Epub 2015 Jul 14.


Active displacement of RecA filaments by UvrD translocase activity.

Petrova V, Chen SH, Molzberger ET, Tomko E, Chitteni-Pattu S, Jia H, Ordabayev Y, Lohman TM, Cox MM.

Nucleic Acids Res. 2015 Apr 30;43(8):4133-49. doi: 10.1093/nar/gkv186. Epub 2015 Mar 30.


Decreasing the length of stay in phase I postanesthesia care unit: an evidence-based approach.

McLaren JM, Reynolds JA, Cox MM, Lyall JS, McCarthy M, McNoble EM, Petersen VR.

J Perianesth Nurs. 2015 Apr;30(2):116-23. doi: 10.1016/j.jopan.2014.05.010.


A RecA protein surface required for activation of DNA polymerase V.

Gruber AJ, Erdem AL, Sabat G, Karata K, Jaszczur MM, Vo DD, Olsen TM, Woodgate R, Goodman MF, Cox MM.

PLoS Genet. 2015 Mar 26;11(3):e1005066. doi: 10.1371/journal.pgen.1005066. eCollection 2015 Mar.


Function of the N-terminal segment of the RecA-dependent nuclease Ref.

Gruber AJ, Olsen TM, Dvorak RH, Cox MM.

Nucleic Acids Res. 2015 Feb 18;43(3):1795-803. doi: 10.1093/nar/gku1330. Epub 2015 Jan 23.



Cox MM, Wendler CC, Erdelyi I, Beck A, Zeiss C, Rivkees SA.

Online J Biol Sci. 2014 Jan 1;14(1):49-56.


Biochemical characterization of RecA variants that contribute to extreme resistance to ionizing radiation.

Piechura JR, Tseng TL, Hsu HF, Byrne RT, Windgassen TA, Chitteni-Pattu S, Battista JR, Li HW, Cox MM.

DNA Repair (Amst). 2015 Feb;26:30-43. doi: 10.1016/j.dnarep.2014.12.001. Epub 2014 Dec 9.


Modifications of cysteine residues in the transmembrane and cytoplasmic domains of a recombinant hemagglutinin protein prevent cross-linked multimer formation and potency loss.

Holtz KM, Robinson PS, Matthews EE, Hashimoto Y, McPherson CE, Khramtsov N, Reifler MJ, Meghrous J, Rhodes DG, Cox MM, Srivastava IK.

BMC Biotechnol. 2014 Dec 24;14:111. doi: 10.1186/s12896-014-0111-y.


Escherichia coli radD (yejH) gene: a novel function involved in radiation resistance and double-strand break repair.

Chen SH, Byrne RT, Wood EA, Cox MM.

Mol Microbiol. 2015 Mar;95(5):754-68. doi: 10.1111/mmi.12885. Epub 2015 Jan 16.


Titer on chip: new analytical tool for influenza vaccine potency determination.

Kuck LR, Sorensen M, Matthews E, Srivastava I, Cox MM, Rowlen KL.

PLoS One. 2014 Oct 20;9(10):e109616. doi: 10.1371/journal.pone.0109616. eCollection 2014.


Technology transfer and scale-up of the Flublok recombinant hemagglutinin (HA) influenza vaccine manufacturing process.

Buckland B, Boulanger R, Fino M, Srivastava I, Holtz K, Khramtsov N, McPherson C, Meghrous J, Kubera P, Cox MM.

Vaccine. 2014 Sep 22;32(42):5496-502. doi: 10.1016/j.vaccine.2014.07.074. Epub 2014 Aug 12.


Escherichia coli genes and pathways involved in surviving extreme exposure to ionizing radiation.

Byrne RT, Chen SH, Wood EA, Cabot EL, Cox MM.

J Bacteriol. 2014 Oct;196(20):3534-45. doi: 10.1128/JB.01589-14. Epub 2014 Jul 21.


DNA polymerase V activity is autoregulated by a novel intrinsic DNA-dependent ATPase.

Erdem AL, Jaszczur M, Bertram JG, Woodgate R, Cox MM, Goodman MF.

Elife. 2014 Apr 24;3:e02384. doi: 10.7554/eLife.02384.


Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair.

Byrne RT, Klingele AJ, Cabot EL, Schackwitz WS, Martin JA, Martin J, Wang Z, Wood EA, Pennacchio C, Pennacchio LA, Perna NT, Battista JR, Cox MM.

Elife. 2014 Mar 4;3:e01322. doi: 10.7554/eLife.01322.


RecA-dependent programmable endonuclease Ref cleaves DNA in two distinct steps.

Ronayne EA, Cox MM.

Nucleic Acids Res. 2014 Apr;42(6):3871-83. doi: 10.1093/nar/gkt1342. Epub 2013 Dec 26.


Proteins pinpoint double strand breaks.

Cox MM.

Elife. 2013 Oct 29;2:e01561. doi: 10.7554/eLife.01561.


Foundational concepts and underlying theories for majors in "biochemistry and molecular biology".

Tansey JT, Baird T Jr, Cox MM, Fox KM, Knight J, Sears D, Bell E.

Biochem Mol Biol Educ. 2013 Sep-Oct;41(5):289-96. doi: 10.1002/bmb.20727. Epub 2013 Sep 10.


Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures.

Tham KC, Hermans N, Winterwerp HH, Cox MM, Wyman C, Kanaar R, Lebbink JH.

Mol Cell. 2013 Aug 8;51(3):326-37. doi: 10.1016/j.molcel.2013.07.008.


Regulation of Deinococcus radiodurans RecA protein function via modulation of active and inactive nucleoprotein filament states.

Ngo KV, Molzberger ET, Chitteni-Pattu S, Cox MM.

J Biol Chem. 2013 Jul 19;288(29):21351-66. doi: 10.1074/jbc.M113.459230. Epub 2013 May 31.


The Deinococcus radiodurans DR1245 protein, a DdrB partner homologous to YbjN proteins and reminiscent of type III secretion system chaperones.

Norais C, Servant P, Bouthier-de-la-Tour C, Coureux PD, Ithurbide S, Vannier F, Guerin PP, Dulberger CL, Satyshur KA, Keck JL, Armengaud J, Cox MM, Sommer S.

PLoS One. 2013;8(2):e56558. doi: 10.1371/journal.pone.0056558. Epub 2013 Feb 18.

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