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Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single-institution experience.

Ji MS, Eldred BSC, Liu R, Pianka ST, Molaie D, Kevan B, Pan S, Lai TJ, Nguyen NT, Chow FE, Yong WH, Cox CD, Reeh DN, Li T, Liau LM, Nghiemphu PL, Cloughesy TF, Li G, Lai A.

Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa009. doi: 10.1093/noajnl/vdaa009. Epub 2020 Jan 29.


Membrane stiffness is one of the key determinants of E. coli MscS channel mechanosensitivity.

Xue F, Cox CD, Bavi N, Rohde PR, Nakayama Y, Martinac B.

Biochim Biophys Acta Biomembr. 2020 May 1;1862(5):183203. doi: 10.1016/j.bbamem.2020.183203. Epub 2020 Jan 22.


Amphipathic molecules modulate PIEZO1 activity.

Cox CD, Gottlieb PA.

Biochem Soc Trans. 2019 Dec 20;47(6):1833-1842. doi: 10.1042/BST20190372. Review.


Mammalian TRP ion channels are insensitive to membrane stretch.

Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, Vásquez V, Laver DR, Martinac B.

J Cell Sci. 2019 Dec 10;132(23). pii: jcs238360. doi: 10.1242/jcs.238360.


Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction.

Cox CD, Bavi N, Martinac B.

Cell Rep. 2019 Oct 1;29(1):1-12. doi: 10.1016/j.celrep.2019.08.075. Review.


A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability.

Seese RR, Le AA, Wang K, Cox CD, Lynch G, Gall CM.

Neurobiol Dis. 2020 Feb;134:104604. doi: 10.1016/j.nbd.2019.104604. Epub 2019 Sep 5.


Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.

Lauterborn JC, Cox CD, Chan SW, Vanderklish PW, Lynch G, Gall CM.

Brain Pathol. 2020 Mar;30(2):319-331. doi: 10.1111/bpa.12779. Epub 2019 Sep 8.


Acquisition of temporal order requires an intact CA3 commissural/associational (C/A) feedback system in mice.

Cox BM, Cox CD, Gunn BG, Le AA, Inshishian VC, Gall CM, Lynch G.

Commun Biol. 2019 Jul 3;2:251. doi: 10.1038/s42003-019-0494-3. eCollection 2019.


SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation.

Liu F, Cox CD, Chowdhury R, Dovek L, Nguyen H, Li T, Li S, Ozer B, Chou A, Nguyen N, Wei B, Antonios J, Soto H, Kornblum H, Liau L, Prins R, Nghiemphu PL, Yong W, Cloughesy T, Lai A.

J Neurooncol. 2019 May;142(3):423-434. doi: 10.1007/s11060-019-03126-x. Epub 2019 Mar 5.


Inviting articles for and on the Wisdom of Experience.

Janke KK, Cox CD, Lucas C.

Curr Pharm Teach Learn. 2018 Sep;10(9):1155-1159. doi: 10.1016/j.cptl.2017.06.008. Epub 2017 Aug 21. No abstract available.


Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus.

Wang W, Le AA, Hou B, Lauterborn JC, Cox CD, Levin ER, Lynch G, Gall CM.

J Neurosci. 2018 Sep 12;38(37):7935-7951. doi: 10.1523/JNEUROSCI.0801-18.2018. Epub 2018 Aug 1.


Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk.

Nikolova-Krstevski V, Wagner S, Yu ZY, Cox CD, Cvetkovska J, Hill AP, Huttner IG, Benson V, Werdich AA, MacRae C, Feneley MP, Friedrich O, Martinac B, Fatkin D.

JACC Basic Transl Sci. 2017 Oct 30;2(5):575-590. doi: 10.1016/j.jacbts.2017.05.006. eCollection 2017 Oct.


A Preceptor competency framework for pharmacists. Part 2 of a 3-part series.

Walter S, Mulherin K, Cox CD.

Curr Pharm Teach Learn. 2018 Mar;10(3):402-410. doi: 10.1016/j.cptl.2017.11.018. Epub 2017 Dec 18. Review.


National preceptor development program (PDP) prototype. The third of a 3-part series.

Cox CD, Mulherin K, Walter S.

Curr Pharm Teach Learn. 2018 Mar;10(3):298-306. doi: 10.1016/j.cptl.2017.12.003. Epub 2018 Jan 17.


National preceptor development program (PDP): Influential evidence and theory. The first of a 3-part series.

Mulherin K, Walter S, Cox CD.

Curr Pharm Teach Learn. 2018 Mar;10(3):255-266. doi: 10.1016/j.cptl.2017.12.002. Epub 2018 Apr 9.


Is There a Role for Genes in Exercise-Induced Atrial Cardiomyopathy?

Fatkin D, Cox CD, Huttner IG, Martinac B.

Heart Lung Circ. 2018 Sep;27(9):1093-1098. doi: 10.1016/j.hlc.2018.03.028. Epub 2018 Apr 9. Review.


D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.

Li T, Cox CD, Ozer BH, Nguyen NT, Nguyen HN, Lai TJ, Li S, Liu F, Kornblum HI, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A.

Mol Cancer Res. 2018 Jun;16(6):947-960. doi: 10.1158/1541-7786.MCR-17-0367. Epub 2018 Mar 15.


Interprofessional objective structured teaching exercise (iOSTE) to train preceptors.

McCutcheon LRM, Whitcomb K, Cox CD, Klein MS, Burley H, Youngblood T, Raehl C.

Curr Pharm Teach Learn. 2017 Jul;9(4):605-615. doi: 10.1016/j.cptl.2017.03.023. Epub 2017 Jun 1.


Bacterial Mechanosensors.

Cox CD, Bavi N, Martinac B.

Annu Rev Physiol. 2018 Feb 10;80:71-93. doi: 10.1146/annurev-physiol-021317-121351. Epub 2017 Dec 1. Review.


Treating a novel plasticity defect rescues episodic memory in Fragile X model mice.

Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G.

Mol Psychiatry. 2018 Aug;23(8):1798-1806. doi: 10.1038/mp.2017.221. Epub 2017 Nov 14.


The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.

Forster AB, Abeywickrema P, Bunda J, Cox CD, Cabalu TD, Egbertson M, Fay J, Getty K, Hall D, Kornienko M, Lu J, Parthasarathy G, Reid J, Sharma S, Shipe WD, Smith SM, Soisson S, Stachel SJ, Su HP, Wang D, Berger R.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5167-5171. doi: 10.1016/j.bmcl.2017.10.054. Epub 2017 Oct 23.


Experiential learning in rodents: past experience enables rapid learning and localized encoding in hippocampus.

Cox CD, Palmer LC, Pham DT, Trieu BH, Gall CM, Lynch G.

Learn Mem. 2017 Oct 16;24(11):569-579. doi: 10.1101/lm.045559.117. Print 2017 Nov.


Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels.

Cox CD, Bavi N, Martinac B.

Curr Top Membr. 2017;79:59-96. doi: 10.1016/bs.ctm.2016.09.001. Epub 2016 Oct 19. Review.


The LacI family protein GlyR3 co-regulates the celC operon and manB in Clostridium thermocellum.

Choi J, Klingeman DM, Brown SD, Cox CD.

Biotechnol Biofuels. 2017 Jun 24;10:163. doi: 10.1186/s13068-017-0849-2. eCollection 2017.


Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus.

Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G.

Cereb Cortex. 2018 Jul 1;28(7):2253-2266. doi: 10.1093/cercor/bhx126.


The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus.

Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G.

Cereb Cortex. 2017 Aug 1;27(8):4182-4198. doi: 10.1093/cercor/bhx103.


Use of Entertainment Elements in an Online Video Mini-Series to Train Pharmacy Preceptors.

Cox CD, Cheon J, Crooks SM, Lee J, Curtis JD.

Am J Pharm Educ. 2017 Feb 25;81(1):12. doi: 10.5688/ajpe81112.


Piezo1 Channels Are Inherently Mechanosensitive.

Syeda R, Florendo MN, Cox CD, Kefauver JM, Santos JS, Martinac B, Patapoutian A.

Cell Rep. 2016 Nov 8;17(7):1739-1746. doi: 10.1016/j.celrep.2016.10.033.


Toward a structural blueprint for bilayer-mediated channel mechanosensitivity.

Bavi N, Cox CD, Perozo E, Martinac B.

Channels (Austin). 2017 Mar 4;11(2):91-93. doi: 10.1080/19336950.2016.1224624. Epub 2016 Aug 17. No abstract available.


The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.

Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B.

Nat Commun. 2016 Jun 22;7:11984. doi: 10.1038/ncomms11984.


Quantity vs Quality in Experiential Education.

Cox CD.

Am J Pharm Educ. 2016 Apr 25;80(3):36. doi: 10.5688/ajpe80336. No abstract available.


Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus.

Lauterborn JC, Kramár EA, Rice JD, Babayan AH, Cox CD, Karsten CA, Gall CM, Lynch G.

Cereb Cortex. 2017 Apr 1;27(4):2640-2651. doi: 10.1093/cercor/bhw088.


Influence of Global and Local Membrane Curvature on Mechanosensitive Ion Channels: A Finite Element Approach.

Bavi O, Cox CD, Vossoughi M, Naghdabadi R, Jamali Y, Martinac B.

Membranes (Basel). 2016 Feb 5;6(1). pii: E14. doi: 10.3390/membranes6010014.


Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats.

Lauterborn JC, Palmer LC, Jia Y, Pham DT, Hou B, Wang W, Trieu BH, Cox CD, Kantorovich S, Gall CM, Lynch G.

J Neurosci. 2016 Feb 3;36(5):1636-46. doi: 10.1523/JNEUROSCI.3157-15.2016.


Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension.

Cox CD, Bae C, Ziegler L, Hartley S, Nikolova-Krstevski V, Rohde PR, Ng CA, Sachs F, Gottlieb PA, Martinac B.

Nat Commun. 2016 Jan 20;7:10366. doi: 10.1038/ncomms10366.


Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.

Raheem IT, Schreier JD, Fuerst J, Gantert L, Hostetler ED, Huszar S, Joshi A, Kandebo M, Kim SH, Li J, Ma B, McGaughey G, Sharma S, Shipe WD, Uslaner J, Vandeveer GH, Yan Y, Renger JJ, Smith SM, Coleman PJ, Cox CD.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):126-32. doi: 10.1016/j.bmcl.2015.11.013. Epub 2015 Nov 10.


Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193.

Hostetler ED, Fan H, Joshi AD, Zeng Z, Eng W, Gantert L, Holahan M, Meng X, Miller P, O'Malley S, Purcell M, Riffel K, Salinas C, Williams M, Ma B, Buist N, Smith SM, Coleman PJ, Cox CD, Flores BA, Raheem IT, Cook JJ, Evelhoch JL.

Mol Imaging Biol. 2016 Aug;18(4):579-87. doi: 10.1007/s11307-015-0910-0.


Endocannabinoid signaling mediates oxytocin-driven social reward.

Wei D, Lee D, Cox CD, Karsten CA, Peñagarikano O, Geschwind DH, Gall CM, Piomelli D.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14084-9. doi: 10.1073/pnas.1509795112. Epub 2015 Oct 26.


The Low Noise Limit in Gene Expression.

Dar RD, Razooky BS, Weinberger LS, Cox CD, Simpson ML.

PLoS One. 2015 Oct 21;10(10):e0140969. doi: 10.1371/journal.pone.0140969. eCollection 2015.


Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines.

Abdulkareem ZA, Gee JM, Cox CD, Wann KT.

Br J Pharmacol. 2016 Jan;173(1):177-90. doi: 10.1111/bph.13357. Epub 2015 Dec 5.


Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.

Shipe WD, Sharik SS, Barrow JC, McGaughey GB, Theberge CR, Uslaner JM, Yan Y, Renger JJ, Smith SM, Coleman PJ, Cox CD.

J Med Chem. 2015 Oct 8;58(19):7888-94. doi: 10.1021/acs.jmedchem.5b00983. Epub 2015 Sep 25.


Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.

Roecker AJ, Cox CD, Coleman PJ.

J Med Chem. 2016 Jan 28;59(2):504-30. doi: 10.1021/acs.jmedchem.5b00832. Epub 2015 Sep 15. Review.


Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes.

Nomura T, Cox CD, Bavi N, Sokabe M, Martinac B.

FASEB J. 2015 Oct;29(10):4334-45. doi: 10.1096/fj.15-275198. Epub 2015 Jun 26.


Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.

Cox CD, Hostetler ED, Flores BA, Evelhoch JL, Fan H, Gantert L, Holahan M, Eng W, Joshi A, McGaughey G, Meng X, Purcell M, Raheem IT, Riffel K, Yan Y, Renger JJ, Smith SM, Coleman PJ.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4893-4898. doi: 10.1016/j.bmcl.2015.05.080. Epub 2015 Jun 1.


Pronounced differences in signal processing and synaptic plasticity between piriform-hippocampal network stages: a prominent role for adenosine.

Trieu BH, Kramár EA, Cox CD, Jia Y, Wang W, Gall CM, Lynch G.

J Physiol. 2015 Jul 1;593(13):2889-907. doi: 10.1113/JP270398. Epub 2015 May 20.


Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.

Raheem IT, Breslin MJ, Bruno J, Cabalu TD, Cooke A, Cox CD, Cui D, Garson S, Gotter AL, Fox SV, Harrell CM, Kuduk SD, Lemaire W, Prueksaritanont T, Renger JJ, Stump C, Tannenbaum PL, Williams PD, Winrow CJ, Coleman PJ.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):444-50. doi: 10.1016/j.bmcl.2014.12.056. Epub 2014 Dec 23.


Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

Roecker AJ, Reger TS, Mattern MC, Mercer SP, Bergman JM, Schreier JD, Cube RV, Cox CD, Li D, Lemaire W, Bruno JG, Harrell CM, Garson SL, Gotter AL, Fox SV, Stevens J, Tannenbaum PL, Prueksaritanont T, Cabalu TD, Cui D, Stellabott J, Hartman GD, Young SD, Winrow CJ, Renger JJ, Coleman PJ.

Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90. doi: 10.1016/j.bmcl.2014.08.041. Epub 2014 Aug 26.


Biophysical implications of lipid bilayer rheometry for mechanosensitive channels.

Bavi N, Nakayama Y, Bavi O, Cox CD, Qin QH, Martinac B.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13864-9. doi: 10.1073/pnas.1409011111. Epub 2014 Sep 8.


Pharmacological enhancement of memory or cognition in normal subjects.

Lynch G, Cox CD, Gall CM.

Front Syst Neurosci. 2014 May 20;8:90. doi: 10.3389/fnsys.2014.00090. eCollection 2014. Review.

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