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Uncovering the ART of antimalarial resistance.

Marapana D, Cowman AF.

Science. 2020 Jan 3;367(6473):22-23. doi: 10.1126/science.aba0445. No abstract available.


Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes.

Jennison C, Lucantoni L, O'Neill MT, McConville R, Erickson SM, Cowman AF, Sleebs BE, Avery VM, Boddey JA.

Cell Rep. 2019 Dec 17;29(12):3796-3806.e4. doi: 10.1016/j.celrep.2019.11.073.


The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum.

Dumont L, Richardson MB, van der Peet P, Marapana DS, Triglia T, Dixon MWA, Cowman AF, Williams SJ, Tilley L, McConville MJ, Cobbold SA.

mBio. 2019 Dec 10;10(6). pii: e02060-19. doi: 10.1128/mBio.02060-19.


Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes.

Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ.

mBio. 2019 Oct 8;10(5). pii: e01972-19. doi: 10.1128/mBio.01972-19.


A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.

Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM.

Sci Rep. 2019 Jul 16;9(1):10292. doi: 10.1038/s41598-019-46500-5.


Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes.

Healer J, Wong W, Thompson JK, He W, Birkinshaw RW, Miura K, Long CA, Soroka V, Søgaard TMM, Jørgensen T, de Jongh WA, Weir C, Svahn E, Czabotar PE, Tham WH, Mueller I, Barlow PN, Cowman AF.

Cell Microbiol. 2019 Jul;21(7):e13030. doi: 10.1111/cmi.13030. Epub 2019 Apr 24.


Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites.

Schloetel JG, Heine J, Cowman AF, Pasternak M.

Sci Rep. 2019 Mar 18;9(1):4674. doi: 10.1038/s41598-019-40718-z.


Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.

Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar.


Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF.

Nature. 2019 Jan;565(7737):118-121. doi: 10.1038/s41586-018-0779-6. Epub 2018 Dec 12.


Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte.

Marapana DS, Dagley LF, Sandow JJ, Nebl T, Triglia T, Pasternak M, Dickerman BK, Crabb BS, Gilson PR, Webb AI, Boddey JA, Cowman AF.

Nat Microbiol. 2018 Sep;3(9):1010-1022. doi: 10.1038/s41564-018-0219-2. Epub 2018 Aug 20.


A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial.

Pawliw R, Farrow R, Sekuloski S, Jennings H, Healer J, Phuong T, Sathe P, Pasay C, Evans K, Cowman AF, Schofield L, Chen N, McCarthy J, Trenholme K.

Malar J. 2018 Aug 6;17(1):283. doi: 10.1186/s12936-018-2435-x.


Cryo-EM structure of an essential Plasmodium vivax invasion complex.

Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH.

Nature. 2018 Jul;559(7712):135-139. doi: 10.1038/s41586-018-0249-1. Epub 2018 Jun 27.


Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics.

Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE.

Eur J Med Chem. 2018 Jun 25;154:182-198. doi: 10.1016/j.ejmech.2018.05.022. Epub 2018 May 18.


Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries.

Hallée S, Boddey JA, Cowman AF, Richard D.

mSphere. 2018 Jan 3;3(1). pii: e00551-17. doi: 10.1128/mSphere.00551-17. eCollection 2018 Jan-Feb.


Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.

França CT, White MT, He WQ, Hostetler JB, Brewster J, Frato G, Malhotra I, Gruszczyk J, Huon C, Lin E, Kiniboro B, Yadava A, Siba P, Galinski MR, Healer J, Chitnis C, Cowman AF, Takashima E, Tsuboi T, Tham WH, Fairhurst RM, Rayner JC, King CL, Mueller I.

Elife. 2017 Sep 26;6. pii: e28673. doi: 10.7554/eLife.28673.


The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.

Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT.

Cell Host Microbe. 2017 Aug 9;22(2):232-245. doi: 10.1016/j.chom.2017.07.003. Review.


Vaccines to Accelerate Malaria Elimination and Eventual Eradication.

Healer J, Cowman AF, Kaslow DC, Birkett AJ.

Cold Spring Harb Perspect Med. 2017 Sep 1;7(9). pii: a025627. doi: 10.1101/cshperspect.a025627. Review.


Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites.

Kennedy AT, Wijeyewickrema LC, Huglo A, Lin C, Pike R, Cowman AF, Tham WH.

J Immunol. 2017 Jun 15;198(12):4728-4737. doi: 10.4049/jimmunol.1700067. Epub 2017 May 8.


Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J.

Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31.


Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion.

Sisquella X, Nebl T, Thompson JK, Whitehead L, Malpede BM, Salinas ND, Rogers K, Tolia NH, Fleig A, O'Neill J, Tham WH, David Horgen F, Cowman AF.

Elife. 2017 Feb 22;6. pii: e21083. doi: 10.7554/eLife.21083.


Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA.

Chen L, Xu Y, Wong W, Thompson JK, Healer J, Goddard-Borger ED, Lawrence MC, Cowman AF.

Elife. 2017 Feb 14;6. pii: e21347. doi: 10.7554/eLife.21347.


Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE.

J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26.


Malaria: Biology and Disease.

Cowman AF, Healer J, Marapana D, Marsh K.

Cell. 2016 Oct 20;167(3):610-624. doi: 10.1016/j.cell.2016.07.055. Review.


Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes.

Volz JC, Yap A, Sisquella X, Thompson JK, Lim NT, Whitehead LW, Chen L, Lampe M, Tham WH, Wilson D, Nebl T, Marapana D, Triglia T, Wong W, Rogers KL, Cowman AF.

Cell Host Microbe. 2016 Jul 13;20(1):60-71. doi: 10.1016/j.chom.2016.06.004. Epub 2016 Jun 30.


Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity.

Hill DL, Wilson DW, Sampaio NG, Eriksson EM, Ryg-Cornejo V, Harrison GLA, Uboldi AD, Robinson LJ, Beeson JG, Siba P, Cowman AF, Hansen DS, Mueller I, Schofield L.

Infect Immun. 2016 Jul 21;84(8):2175-2184. doi: 10.1128/IAI.00145-16. Print 2016 Aug.


Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

Gazdik M, Jarman KE, O'Neill MT, Hodder AN, Lowes KN, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE.

Bioorg Med Chem. 2016 May 1;24(9):1993-2010. doi: 10.1016/j.bmc.2016.03.027. Epub 2016 Mar 16.


Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy.

Chiu CY, White MT, Healer J, Thompson JK, Siba PM, Mueller I, Cowman AF, Hansen DS.

J Infect Dis. 2016 Jul 1;214(1):96-104. doi: 10.1093/infdis/jiw119. Epub 2016 Mar 28.


Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

Boddey JA, O'Neill MT, Lopaticki S, Carvalho TG, Hodder AN, Nebl T, Wawra S, van West P, Ebrahimzadeh Z, Richard D, Flemming S, Spielmann T, Przyborski J, Babon JJ, Cowman AF.

Nat Commun. 2016 Feb 1;7:10470. doi: 10.1038/ncomms10470.


Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes.

Lin CS, Uboldi AD, Epp C, Bujard H, Tsuboi T, Czabotar PE, Cowman AF.

J Biol Chem. 2016 Apr 1;291(14):7703-15. doi: 10.1074/jbc.M115.698282. Epub 2016 Jan 28.


Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection.

Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisarn T, Gilson PR, Barlow PN, Crabb BS, Cowman AF, Tham WH.

J Immunol. 2016 Feb 1;196(3):1239-48. doi: 10.4049/jimmunol.1501581. Epub 2015 Dec 23.


Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes.

Tham WH, Lim NT, Weiss GE, Lopaticki S, Ansell BR, Bird M, Lucet I, Dorin-Semblat D, Doerig C, Gilson PR, Crabb BS, Cowman AF.

PLoS Pathog. 2015 Dec 22;11(12):e1005343. doi: 10.1371/journal.ppat.1005343. eCollection 2015 Dec.


Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort.

Dent AE, Malhotra I, Wang X, Babineau D, Yeo KT, Anderson T, Kimmel RJ, Angov E, Lanar DE, Narum D, Dutta S, Richards J, Beeson JG, Crabb BS, Cowman AF, Horii T, Muchiri E, Mungai PL, King CL, Kazura JW.

Clin Vaccine Immunol. 2015 Dec 9;23(2):104-16. doi: 10.1128/CVI.00452-15. Print 2016 Feb.


Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion.

Riglar DT, Whitehead L, Cowman AF, Rogers KL, Baum J.

J Cell Sci. 2016 Jan 1;129(1):228-42. doi: 10.1242/jcs.177741. Epub 2015 Nov 24.


Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction between Plasmodium falciparum Adhesin PfRh4 with Its Erythrocyte Receptor Complement Receptor 1.

Lim NT, Harder MJ, Kennedy AT, Lin CS, Weir C, Cowman AF, Call MJ, Schmidt CQ, Tham WH.

J Biol Chem. 2015 Oct 16;290(42):25307-21. doi: 10.1074/jbc.M115.657171. Epub 2015 Aug 31.


Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF.

Nat Struct Mol Biol. 2015 Aug;22(8):590-6. doi: 10.1038/nsmb.3061. Epub 2015 Jul 27.


Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes.

Weiss GE, Gilson PR, Taechalertpaisarn T, Tham WH, de Jong NW, Harvey KL, Fowkes FJ, Barlow PN, Rayner JC, Wright GJ, Cowman AF, Crabb BS.

PLoS Pathog. 2015 Feb 27;11(2):e1004670. doi: 10.1371/journal.ppat.1004670. eCollection 2015 Feb.


Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria.

Chiu CY, Hodder AN, Lin CS, Hill DL, Li Wai Suen CS, Schofield L, Siba PM, Mueller I, Cowman AF, Hansen DS.

J Infect Dis. 2015 Aug 1;212(3):406-15. doi: 10.1093/infdis/jiv057. Epub 2015 Feb 2.


Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes.

Chen L, Xu Y, Healer J, Thompson JK, Smith BJ, Lawrence MC, Cowman AF.

Elife. 2014 Oct 8;3. doi: 10.7554/eLife.04187. No abstract available.


Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, Lowes K, Smith BJ, Cowman AF, Boddey JA.

J Med Chem. 2014 Sep 25;57(18):7644-62. doi: 10.1021/jm500797g. Epub 2014 Sep 11.


Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

Harvey KL, Yap A, Gilson PR, Cowman AF, Crabb BS.

Int J Parasitol. 2014 Oct 15;44(12):853-7. doi: 10.1016/j.ijpara.2014.08.001. Epub 2014 Aug 23.


Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton.

Rug M, Cyrklaff M, Mikkonen A, Lemgruber L, Kuelzer S, Sanchez CP, Thompson J, Hanssen E, O'Neill M, Langer C, Lanzer M, Frischknecht F, Maier AG, Cowman AF.

Blood. 2014 Nov 27;124(23):3459-68. doi: 10.1182/blood-2014-06-583054. Epub 2014 Aug 19.


The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum.

Lin CS, Uboldi AD, Marapana D, Czabotar PE, Epp C, Bujard H, Taylor NL, Perugini MA, Hodder AN, Cowman AF.

J Biol Chem. 2014 Sep 12;289(37):25655-69. doi: 10.1074/jbc.M114.586495. Epub 2014 Jul 29.


Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria.

Chiu CY, Healer J, Thompson JK, Chen L, Kaul A, Savergave L, Raghuwanshi A, Li Wai Suen CS, Siba PM, Schofield L, Mueller I, Cowman AF, Hansen DS.

Front Microbiol. 2014 Jun 30;5:314. doi: 10.3389/fmicb.2014.00314. eCollection 2014.


Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Günther S, Whitehead LW, Lowes KN, Barfod L, Hviid L, Shaw PJ, Hodder AN, Smith BJ, Cowman AF, Boddey JA.

PLoS Biol. 2014 Jul 1;12(7):e1001897. doi: 10.1371/journal.pbio.1001897. eCollection 2014 Jul.


Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites.

Yap A, Azevedo MF, Gilson PR, Weiss GE, O'Neill MT, Wilson DW, Crabb BS, Cowman AF.

Cell Microbiol. 2014 May;16(5):642-56. doi: 10.1111/cmi.12287. Epub 2014 Mar 27.


Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity.

Macrae JI, Lopaticki S, Maier AG, Rupasinghe T, Nahid A, Cowman AF, McConville MJ.

Mol Microbiol. 2014 Feb;91(4):762-76. doi: 10.1111/mmi.12496. Epub 2014 Jan 16.


Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor.

Park HJ, Guariento M, Maciejewski M, Hauhart R, Tham WH, Cowman AF, Schmidt CQ, Mertens HD, Liszewski MK, Hourcade DE, Barlow PN, Atkinson JP.

J Biol Chem. 2014 Jan 3;289(1):450-63. doi: 10.1074/jbc.M113.520346. Epub 2013 Nov 8.


Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum.

Cobbold SA, Vaughan AM, Lewis IA, Painter HJ, Camargo N, Perlman DH, Fishbaugher M, Healer J, Cowman AF, Kappe SH, Llinás M.

J Biol Chem. 2013 Dec 20;288(51):36338-50. doi: 10.1074/jbc.M113.503557. Epub 2013 Oct 25.


Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum.

Healer J, Thompson JK, Riglar DT, Wilson DW, Chiu YH, Miura K, Chen L, Hodder AN, Long CA, Hansen DS, Baum J, Cowman AF.

PLoS One. 2013 Sep 10;8(9):e72504. doi: 10.1371/journal.pone.0072504. eCollection 2013.


Plasmodium nesting: remaking the erythrocyte from the inside out.

Boddey JA, Cowman AF.

Annu Rev Microbiol. 2013;67:243-69. doi: 10.1146/annurev-micro-092412-155730. Epub 2013 Jun 26. Review.


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