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Items: 41


Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations.

Bueren-Calabuig JA, G Bage M, Cowling VH, Pisliakov AV.

Nucleic Acids Res. 2019 Jul 22. pii: gkz613. doi: 10.1093/nar/gkz613. [Epub ahead of print]


Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells.

Dunn S, Lombardi O, Lukoszek R, Cowling VH.

Open Biol. 2019 Apr 26;9(4):190052. doi: 10.1098/rsob.190052.


CAPAM: The mRNA Cap Adenosine N6-Methyltransferase.

Cowling VH.

Trends Biochem Sci. 2019 Mar;44(3):183-185. doi: 10.1016/j.tibs.2019.01.002. Epub 2019 Jan 21.


mRNA cap regulation in mammalian cell function and fate.

Galloway A, Cowling VH.

Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):270-279. doi: 10.1016/j.bbagrm.2018.09.011. Epub 2018 Oct 9. Review.


DHX15 regulates CMTR1-dependent gene expression and cell proliferation.

Inesta-Vaquera F, Chaugule VK, Galloway A, Chandler L, Rojas-Fernandez A, Weidlich S, Peggie M, Cowling VH.

Life Sci Alliance. 2018 Jun 18;1(3):e201800092. doi: 10.26508/lsa.201800092.


The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.

Kelner A, Tinti M, Guther MLS, Foth BJ, Chappell L, Berriman M, Cowling VH, Ferguson MAJ.

PLoS One. 2018 Jul 24;13(7):e0201263. doi: 10.1371/journal.pone.0201263. eCollection 2018.


mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription.

Varshney D, Lombardi O, Schweikert G, Dunn S, Suska O, Cowling VH.

Cell Rep. 2018 May 1;23(5):1530-1542. doi: 10.1016/j.celrep.2018.04.004.


Regulation and function of CMTR1-dependent mRNA cap methylation.

Inesta-Vaquera F, Cowling VH.

Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1450. Epub 2017 Oct 2. Review.


c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production.

Dunn S, Lombardi O, Cowling VH.

Biochem J. 2017 Feb 1;474(3):377-384. doi: 10.1042/BCJ20160930. Epub 2016 Dec 1.


Regulation of mRNA capping in the cell cycle.

Aregger M, Cowling VH.

RNA Biol. 2017 Jan 2;14(1):11-14. doi: 10.1080/15476286.2016.1251540. Epub 2016 Oct 28. Review.


c-Myc deregulation induces mRNA capping enzyme dependency.

Lombardi O, Varshney D, Phillips NM, Cowling VH.

Oncotarget. 2016 Dec 13;7(50):82273-82288. doi: 10.18632/oncotarget.12701.


Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family.

Young DF, Andrejeva J, Li X, Inesta-Vaquera F, Dong C, Cowling VH, Goodbourn S, Randall RE.

J Virol. 2016 Sep 29;90(20):9446-56. doi: 10.1128/JVI.01056-16. Print 2016 Oct 15.


mRNA Cap Methylation in Pluripotency and Differentiation.

Grasso L, Suska O, Davidson L, Gonatopoulos-Pournatzis T, Williamson R, Wasmus L, Wiedlich S, Peggie M, Stavridis MP, Cowling VH.

Cell Rep. 2016 Aug 2;16(5):1352-1365. doi: 10.1016/j.celrep.2016.06.089. Epub 2016 Jul 21.


Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.

Varshney D, Petit AP, Bueren-Calabuig JA, Jansen C, Fletcher DA, Peggie M, Weidlich S, Scullion P, Pisliakov AV, Cowling VH.

Nucleic Acids Res. 2016 Dec 1;44(21):10423-10436. Epub 2016 Jul 15.


CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription.

Aregger M, Kaskar A, Varshney D, Fernandez-Sanchez ME, Inesta-Vaquera FA, Weidlich S, Cowling VH.

Mol Cell. 2016 Mar 3;61(5):734-746. doi: 10.1016/j.molcel.2016.02.008.


Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.

Preston GC, Sinclair LV, Kaskar A, Hukelmann JL, Navarro MN, Ferrero I, MacDonald HR, Cowling VH, Cantrell DA.

EMBO J. 2015 Aug 4;34(15):2008-24. doi: 10.15252/embj.201490252. Epub 2015 Jul 1.


SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation.

Varshney D, Vavrova-Anderson J, Oler AJ, Cowling VH, Cairns BR, White RJ.

Nat Commun. 2015 Mar 23;6:6569. doi: 10.1038/ncomms7569.


Myc and mRNA capping.

Dunn S, Cowling VH.

Biochim Biophys Acta. 2015 May;1849(5):501-5. doi: 10.1016/j.bbagrm.2014.03.007. Epub 2014 Mar 27. Review.


Cap-binding complex (CBC).

Gonatopoulos-Pournatzis T, Cowling VH.

Biochem J. 2014 Jan 15;457(2):231-42. doi: 10.1042/BJ20131214. Review. Erratum in: Biochem J. 2014 Feb 15;458(1):185.


RAM function is dependent on KapĪ²2-mediated nuclear entry.

Gonatopoulos-Pournatzis T, Cowling VH.

Biochem J. 2014 Feb 1;457(3):473-84. doi: 10.1042/BJ20131359.


The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells.

Preston GC, Feijoo-Carnero C, Schurch N, Cowling VH, Cantrell DA.

PLoS One. 2013 Oct 14;8(10):e77537. doi: 10.1371/journal.pone.0077537. eCollection 2013.


Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis.

Cowling VH, Turner SA, Cole MD.

Oncogene. 2014 Jul 3;33(27):3519-27. doi: 10.1038/onc.2013.338. Epub 2013 Sep 9.


E2F1-dependent methyl cap formation requires RNA pol II phosphorylation.

Aregger M, Cowling VH.

Cell Cycle. 2012 Jun 1;11(11):2146-8. doi: 10.4161/cc.20620. Epub 2012 Jun 1.


RAM/Fam103a1 is required for mRNA cap methylation.

Gonatopoulos-Pournatzis T, Dunn S, Bounds R, Cowling VH.

Mol Cell. 2011 Nov 18;44(4):585-96. doi: 10.1016/j.molcel.2011.08.041.


Myc Regulation of mRNA Cap Methylation.

Cowling VH, Cole MD.

Genes Cancer. 2010 Jun;1(6):576-579.


Myc up-regulates formation of the mRNA methyl cap.

Cowling VH.

Biochem Soc Trans. 2010 Dec;38(6):1598-601. doi: 10.1042/BST0381598.


Regulation of mRNA cap methylation.

Cowling VH.

Biochem J. 2009 Dec 23;425(2):295-302. doi: 10.1042/BJ20091352. Review.


Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformation.

Cowling VH.

Oncogene. 2010 Feb 11;29(6):930-6. doi: 10.1038/onc.2009.368. Epub 2009 Nov 16.


S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation.

Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, Cowling VH.

Mol Cell Biol. 2009 Dec;29(23):6182-91. doi: 10.1128/MCB.00973-09. Epub 2009 Oct 5.


A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response.

Chandriani S, Frengen E, Cowling VH, Pendergrass SA, Perou CM, Whitfield ML, Cole MD.

PLoS One. 2009 Aug 19;4(8):e6693. doi: 10.1371/journal.pone.0006693.


Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors.

Cole MD, Cowling VH.

Oncogene. 2009 Mar 5;28(9):1169-75. doi: 10.1038/onc.2008.463. Epub 2009 Jan 12.


Transcription-independent functions of MYC: regulation of translation and DNA replication.

Cole MD, Cowling VH.

Nat Rev Mol Cell Biol. 2008 Oct;9(10):810-5. doi: 10.1038/nrm2467. Epub 2008 Aug 13. Review.


Turning the tables: Myc activates Wnt in breast cancer.

Cowling VH, Cole MD.

Cell Cycle. 2007 Nov 1;6(21):2625-7. Epub 2007 Aug 13. Review.


c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1.

Cowling VH, D'Cruz CM, Chodosh LA, Cole MD.

Mol Cell Biol. 2007 Jul;27(14):5135-46. Epub 2007 May 7.


HATs off to capping: a new mechanism for Myc.

Cowling VH, Cole MD.

Cell Cycle. 2007 Apr 15;6(8):907-9. Epub 2007 Apr 8.


E-cadherin repression contributes to c-Myc-induced epithelial cell transformation.

Cowling VH, Cole MD.

Oncogene. 2007 May 24;26(24):3582-6. Epub 2006 Dec 4.


Mechanism of transcriptional activation by the Myc oncoproteins.

Cowling VH, Cole MD.

Semin Cancer Biol. 2006 Aug;16(4):242-52. Epub 2006 Aug 4. Review.


A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest.

Cowling VH, Chandriani S, Whitfield ML, Cole MD.

Mol Cell Biol. 2006 Jun;26(11):4226-39. Erratum in: Mol Cell Biol. 2006 Jul;26(13):5201.

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