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Items: 31


Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription.

Barnes CE, English DM, Cowley SM.

Essays Biochem. 2019 Apr 23;63(1):97-107. doi: 10.1042/EBC20180061. Print 2019 Apr 23. Review.


Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.

Adams GE, Chandru A, Cowley SM.

Biochem J. 2018 Dec 14;475(24):3921-3932. doi: 10.1042/BCJ20170314. Review.


Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain.

Chandru A, Bate N, Vuister GW, Cowley SM.

Sci Rep. 2018 Oct 2;8(1):14689. doi: 10.1038/s41598-018-32942-w.


Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.

Kelly RDW, Chandru A, Watson PJ, Song Y, Blades M, Robertson NS, Jamieson AG, Schwabe JWR, Cowley SM.

Sci Rep. 2018 Oct 2;8(1):14690. doi: 10.1038/s41598-018-32927-9.


Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.

Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA.

Nature. 2018 Oct;562(7728):E24. doi: 10.1038/s41586-018-0487-2.


HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.

Thambyrajah R, Fadlullah MZH, Proffitt M, Patel R, Cowley SM, Kouskoff V, Lacaud G.

Stem Cell Reports. 2018 Apr 10;10(4):1369-1383. doi: 10.1016/j.stemcr.2018.03.011.


OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.

Simandi Z, Horvath A, Wright LC, Cuaranta-Monroy I, De Luca I, Karolyi K, Sauer S, Deleuze JF, Gudas LJ, Cowley SM, Nagy L.

Mol Cell. 2016 Aug 18;63(4):647-661. doi: 10.1016/j.molcel.2016.06.039. Epub 2016 Aug 4.


Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.

Watson PJ, Millard CJ, Riley AM, Robertson NS, Wright LC, Godage HY, Cowley SM, Jamieson AG, Potter BV, Schwabe JW.

Nat Commun. 2016 Apr 25;7:11262. doi: 10.1038/ncomms11262.


Differential requirements of singleplex and multiplex recombineering of large DNA constructs.

Reddy TR, Kelsall EJ, Fevat LM, Munson SE, Cowley SM.

PLoS One. 2015 May 8;10(5):e0125533. doi: 10.1371/journal.pone.0125533. eCollection 2015.


Lambda red mediated gap repair utilizes a novel replicative intermediate in Escherichia coli.

Reddy TR, Fevat LM, Munson SE, Stewart AF, Cowley SM.

PLoS One. 2015 Mar 24;10(3):e0120681. doi: 10.1371/journal.pone.0120681. eCollection 2015.


Subcloning plus insertion (SPI)--a novel recombineering method for the rapid construction of gene targeting vectors.

Reddy TR, Kelsall EJ, Fevat LM, Munson SE, Cowley SM.

J Vis Exp. 2015 Jan 8;(95):e52155. doi: 10.3791/52155.


Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach.

Portolano N, Watson PJ, Fairall L, Millard CJ, Milano CP, Song Y, Cowley SM, Schwabe JW.

J Vis Exp. 2014 Oct 16;(92):e51897. doi: 10.3791/51897.


Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.

Jamaladdin S, Kelly RD, O'Regan L, Dovey OM, Hodson GE, Millard CJ, Portolano N, Fry AM, Schwabe JW, Cowley SM.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9840-5. doi: 10.1073/pnas.1321330111. Epub 2014 Jun 23.


Class I HDACs share a common mechanism of regulation by inositol phosphates.

Millard CJ, Watson PJ, Celardo I, Gordiyenko Y, Cowley SM, Robinson CV, Fairall L, Schwabe JW.

Mol Cell. 2013 Jul 11;51(1):57-67. doi: 10.1016/j.molcel.2013.05.020. Epub 2013 Jun 20.


The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts.

Kelly RD, Cowley SM.

Biochem Soc Trans. 2013 Jun;41(3):741-9. doi: 10.1042/BST20130010. Review.


Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.

Dovey OM, Foster CT, Conte N, Edwards SA, Edwards JM, Singh R, Vassiliou G, Bradley A, Cowley SM.

Blood. 2013 Feb 21;121(8):1335-44. doi: 10.1182/blood-2012-07-441949. Epub 2013 Jan 3.


Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.

Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA.

Nature. 2012 Feb 1;482(7384):221-5. doi: 10.1038/nature10805. Erratum in: Nature. 2018 Oct;562(7728):E24.


Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability.

Foster CT, Dovey OM, Lezina L, Luo JL, Gant TW, Barlev N, Bradley A, Cowley SM.

Mol Cell Biol. 2010 Oct;30(20):4851-63. doi: 10.1128/MCB.00521-10. Epub 2010 Aug 16.


Emphasizing the positive: A role for histone deacetylases in transcriptional activation.

Dovey OM, Foster CT, Cowley SM.

Cell Cycle. 2010 Jul 15;9(14):2700-1. Epub 2010 Jul 10. No abstract available.


Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.

Dovey OM, Foster CT, Cowley SM.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8242-7. doi: 10.1073/pnas.1000478107. Epub 2010 Apr 19.


The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.

Cowley SM, Iritani BM, Mendrysa SM, Xu T, Cheng PF, Yada J, Liggitt HD, Eisenman RN.

Mol Cell Biol. 2005 Aug;25(16):6990-7004.


HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations.

Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I.

Nat Struct Mol Biol. 2004 Aug;11(8):738-46. Epub 2004 Jul 4.


Functional analysis of the Mad1-mSin3A repressor-corepressor interaction reveals determinants of specificity, affinity, and transcriptional response.

Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN.

Mol Cell Biol. 2004 Apr;24(7):2698-709.


Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.

Orian A, van Steensel B, Delrow J, Bussemaker HJ, Li L, Sawado T, Williams E, Loo LW, Cowley SM, Yost C, Pierce S, Edgar BA, Parkhurst SM, Eisenman RN.

Genes Dev. 2003 May 1;17(9):1101-14. Epub 2003 Apr 14.


Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.

Hook SS, Orian A, Cowley SM, Eisenman RN.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13425-30. Epub 2002 Sep 27.


Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex.

Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I.

Cell. 2000 Nov 10;103(4):655-65.


Function of Estrogen Receptors in Breast Cancer.

Parker MG, Cowley SM, Heery D, Henttu P, Kalkhoven E, Sjoberg M, Valentine JE, White R.

Breast Cancer. 1997 Dec 25;4(4):204-208. No abstract available.


The Myc/Max/Mad network and the transcriptional control of cell behavior.

Grandori C, Cowley SM, James LP, Eisenman RN.

Annu Rev Cell Dev Biol. 2000;16:653-99. Review.


A comparison of transcriptional activation by ER alpha and ER beta.

Cowley SM, Parker MG.

J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):165-75.


Estrogen receptors alpha and beta form heterodimers on DNA.

Cowley SM, Hoare S, Mosselman S, Parker MG.

J Biol Chem. 1997 Aug 8;272(32):19858-62.


Nursing and cardiovascular clinical trial research: collaborating for successful outcomes.

Cowley SM, Somelofski C, Hill MN, Smith J, Buchwald H.

Cardiovasc Nurs. 1988 Sep-Oct;24(5):25-30. No abstract available.


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