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RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.

Booth HDE, Wessely F, Connor-Robson N, Rinaldi F, Vowles J, Browne C, Evetts SG, Hu MT, Cowley SA, Webber C, Wade-Martins R.

Neurobiol Dis. 2019 May 11;129:56-66. doi: 10.1016/j.nbd.2019.05.006. [Epub ahead of print]


An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.

Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, Cowley SA, Bolam P, Hirst W, Wade-Martins R.

Neurobiol Dis. 2019 Apr 5;127:512-526. doi: 10.1016/j.nbd.2019.04.005. [Epub ahead of print]


Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription.

Barnes CE, English DM, Cowley SM.

Essays Biochem. 2019 Apr 23;63(1):97-107. doi: 10.1042/EBC20180061. Print 2019 Apr 23. Review.


Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.

Jarosz-Griffiths HH, Corbett NJ, Rowland HA, Fisher K, Jones AC, Baron J, Howell GJ, Cowley SA, Chintawar S, Cader MZ, Kellett KAB, Hooper NM.

J Biol Chem. 2019 Apr 26;294(17):7085-7097. doi: 10.1074/jbc.RA118.005364. Epub 2019 Mar 14.


Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R.

Hum Mol Genet. 2019 Jun 15;28(12):2001-2013. doi: 10.1093/hmg/ddz038.


Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets.

Nizami S, Hall-Roberts H, Warrier S, Cowley SA, Di Daniel E.

Br J Pharmacol. 2019 Feb 10. doi: 10.1111/bph.14618. [Epub ahead of print] Review.


Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.

Adams GE, Chandru A, Cowley SM.

Biochem J. 2018 Dec 14;475(24):3921-3932. doi: 10.1042/BCJ20170314. Review.


Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.

Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R.

Cell Stem Cell. 2019 Jan 3;24(1):93-106.e6. doi: 10.1016/j.stem.2018.10.023. Epub 2018 Nov 29.


Saturn's magnetic field revealed by the Cassini Grand Finale.

Dougherty MK, Cao H, Khurana KK, Hunt GJ, Provan G, Kellock S, Burton ME, Burk TA, Bunce EJ, Cowley SWH, Kivelson MG, Russell CT, Southwood DJ.

Science. 2018 Oct 5;362(6410). pii: eaat5434. doi: 10.1126/science.aat5434. Erratum in: Science. 2018 Oct 12;362(6411):.


Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain.

Chandru A, Bate N, Vuister GW, Cowley SM.

Sci Rep. 2018 Oct 2;8(1):14689. doi: 10.1038/s41598-018-32942-w.


Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.

Kelly RDW, Chandru A, Watson PJ, Song Y, Blades M, Robertson NS, Jamieson AG, Schwabe JWR, Cowley SM.

Sci Rep. 2018 Oct 2;8(1):14690. doi: 10.1038/s41598-018-32927-9.


RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.

Buchrieser J, Oliva-Martin MJ, Moore MD, Long JCD, Cowley SA, Perez-Simón JA, James W, Venero JL.

Cell Death Dis. 2018 Sep 24;9(10):973. doi: 10.1038/s41419-018-1053-4.


Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Wong MMK, Hoekstra SD, Vowles J, Watson LM, Fuller G, Németh AH, Cowley SA, Ansorge O, Talbot K, Becker EBE.

Acta Neuropathol Commun. 2018 Sep 24;6(1):99. doi: 10.1186/s40478-018-0600-7.


Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.

Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA.

Nature. 2018 Oct;562(7728):E24. doi: 10.1038/s41586-018-0487-2.


Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism.

Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, König I, Klein C.

Mov Disord. 2018 Jul;33(7):1108-1118. doi: 10.1002/mds.27441.


FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

Künzel U, Grieve AG, Meng Y, Sieber B, Cowley SA, Freeman M.

Elife. 2018 Jun 13;7. pii: e35012. doi: 10.7554/eLife.35012.


LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.

Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG.

EMBO J. 2018 Jun 15;37(12). pii: e98694. doi: 10.15252/embj.201798694. Epub 2018 May 22.


HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.

Thambyrajah R, Fadlullah MZH, Proffitt M, Patel R, Cowley SM, Kouskoff V, Lacaud G.

Stem Cell Reports. 2018 Apr 10;10(4):1369-1383. doi: 10.1016/j.stemcr.2018.03.011.


Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1.

Jonikas M, Madill M, Mathy A, Zekoll T, Zois CE, Wigfield S, Kurzawa-Akanbi M, Browne C, Sims D, Chinnery PF, Cowley SA, Tofaris GK.

Ann Neurol. 2018 May;83(5):915-925. doi: 10.1002/ana.25221. Epub 2018 Apr 25.


Interleukin-18 Is Critical for Mucosa-Associated Invariant T Cell Gamma Interferon Responses to Francisella Species In Vitro but Not In Vivo.

Jesteadt E, Zhang I, Yu H, Meierovics A, Chua Yankelevich WJ, Cowley S.

Infect Immun. 2018 Apr 23;86(5). pii: e00117-18. doi: 10.1128/IAI.00117-18. Print 2018 May.


A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.

Watson LM, Wong MMK, Vowles J, Cowley SA, Becker EBE.

Cerebellum. 2018 Aug;17(4):419-427. doi: 10.1007/s12311-017-0913-2.


Lentiviral gene therapy vector with UCOE stably restores function in iPSC-derived neutrophils of a CDG patient.

Haenseler W, Kuzmenko E, Smalls-Mantey A, Browne C, Seger R, James WS, Cowley SA, Reichenbach J, Siler U.

Matters (Zur). 2018;2018. doi: 10.19185/matters.201805000005. Epub 2018 May 23.


Corrigenda: The Prevalence of Dementia and Cognitive Impairment in our Acute Medical Admissions.

Cowley S, Ghaznain M, Basirat A, Kennelly M, Teresa Donnelly M.

Age Ageing. 2018 May 1;47(3):489. doi: 10.1093/ageing/afx176. No abstract available.


Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.

Heman-Ackah SM, Manzano R, Hoozemans JJM, Scheper W, Flynn R, Haerty W, Cowley SA, Bassett AR, Wood MJA.

Hum Mol Genet. 2017 Nov 15;26(22):4441-4450. doi: 10.1093/hmg/ddx331.


Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA.

Sci Rep. 2017 Aug 21;7(1):9003. doi: 10.1038/s41598-017-09362-3.


MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Beevers JE, Lai MC, Collins E, Booth HDE, Zambon F, Parkkinen L, Vowles J, Cowley SA, Wade-Martins R, Caffrey TM.

Stem Cell Reports. 2017 Aug 8;9(2):587-599. doi: 10.1016/j.stemcr.2017.06.005. Epub 2017 Jul 6.


A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA.

Stem Cell Reports. 2017 Jun 6;8(6):1727-1742. doi: 10.1016/j.stemcr.2017.05.017.


Jupiter's magnetosphere and aurorae observed by the Juno spacecraft during its first polar orbits.

Connerney JEP, Adriani A, Allegrini F, Bagenal F, Bolton SJ, Bonfond B, Cowley SWH, Gerard JC, Gladstone GR, Grodent D, Hospodarsky G, Jorgensen JL, Kurth WS, Levin SM, Mauk B, McComas DJ, Mura A, Paranicas C, Smith EJ, Thorne RM, Valek P, Waite J.

Science. 2017 May 26;356(6340):826-832. doi: 10.1126/science.aam5928.


LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.

Lee H, James WS, Cowley SA.

Biochem Soc Trans. 2017 Feb 8;45(1):131-139. doi: 10.1042/BST20160262. Review.


Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells.

Baud A, Wessely F, Mazzacuva F, McCormick J, Camuzeaux S, Heywood WE, Little D, Vowles J, Tuefferd M, Mosaku O, Lako M, Armstrong L, Webber C, Cader MZ, Peeters P, Gissen P, Cowley SA, Mills K.

Anal Chem. 2017 Feb 21;89(4):2440-2448. doi: 10.1021/acs.analchem.6b04368. Epub 2017 Feb 6.


Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Sandor C, Robertson P, Lang C, Heger A, Booth H, Vowles J, Witty L, Bowden R, Hu M, Cowley SA, Wade-Martins R, Webber C.

Hum Mol Genet. 2017 Feb 1;26(3):552-566. doi: 10.1093/hmg/ddw412.


Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.

Vazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, Sareen D, James W, Wade-Martins R, Cowley SA, Murphy S, O'Reilly D.

Nucleic Acids Res. 2016 Dec 15;44(22):10960-10973. Epub 2016 Aug 17.


OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.

Simandi Z, Horvath A, Wright LC, Cuaranta-Monroy I, De Luca I, Karolyi K, Sauer S, Deleuze JF, Gudas LJ, Cowley SM, Nagy L.

Mol Cell. 2016 Aug 18;63(4):647-661. doi: 10.1016/j.molcel.2016.06.039. Epub 2016 Aug 4.


A novel real time imaging platform to quantify macrophage phagocytosis.

Kapellos TS, Taylor L, Lee H, Cowley SA, James WS, Iqbal AJ, Greaves DR.

Biochem Pharmacol. 2016 Sep 15;116:107-19. doi: 10.1016/j.bcp.2016.07.011. Epub 2016 Jul 27.


Health visitor education for today's Britain: Messages from a narrative review of the health visitor literature.

Malone M, Whittaker KA, Cowley S, Ezhova I, Maben J.

Nurse Educ Today. 2016 Sep;44:175-86. doi: 10.1016/j.nedt.2016.04.007. Epub 2016 Apr 28. Review.


Nonlinear Stability and Saturation of Ballooning Modes in Tokamaks.

Ham CJ, Cowley SC, Brochard G, Wilson HR.

Phys Rev Lett. 2016 Jun 10;116(23):235001. doi: 10.1103/PhysRevLett.116.235001. Epub 2016 Jun 9.


Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.

Watson PJ, Millard CJ, Riley AM, Robertson NS, Wright LC, Godage HY, Cowley SM, Jamieson AG, Potter BV, Schwabe JW.

Nat Commun. 2016 Apr 25;7:11262. doi: 10.1038/ncomms11262.


C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Dafinca R, Scaber J, Ababneh N, Lalic T, Weir G, Christian H, Vowles J, Douglas AG, Fletcher-Jones A, Browne C, Nakanishi M, Turner MR, Wade-Martins R, Cowley SA, Talbot K.

Stem Cells. 2016 Aug;34(8):2063-78. doi: 10.1002/stem.2388. Epub 2016 May 4.


ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R.

Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18.


Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics.

Handel AE, Chintawar S, Lalic T, Whiteley E, Vowles J, Giustacchini A, Argoud K, Sopp P, Nakanishi M, Bowden R, Cowley S, Newey S, Akerman C, Ponting CP, Cader MZ.

Hum Mol Genet. 2016 Mar 1;25(5):989-1000. doi: 10.1093/hmg/ddv637. Epub 2016 Jan 5.


GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, Li Y, Lancrin C, Clapes T, Möröy T, Robin C, Miller C, Cowley S, Göttgens B, Kouskoff V, Lacaud G.

Nat Cell Biol. 2016 Jan;18(1):21-32. doi: 10.1038/ncb3276. Epub 2015 Nov 30.


Making a difference for children and families: an appreciative inquiry of health visitor values and why they start and stay in post.

Whittaker KA, Malone M, Cowley S, Grigulis A, Nicholson C, Maben J.

Health Soc Care Community. 2017 Mar;25(2):338-348. doi: 10.1111/hsc.12307. Epub 2015 Nov 19.


How peer-review constrains cognition: on the frontline in the knowledge sector.

Cowley SJ.

Front Psychol. 2015 Nov 3;6:1706. doi: 10.3389/fpsyg.2015.01706. eCollection 2015.


Control of Francisella tularensis Intracellular Growth by Pulmonary Epithelial Cells.

Maggio S, Takeda K, Stark F, Meierovics AI, Yabe I, Cowley SC.

PLoS One. 2015 Sep 17;10(9):e0138565. doi: 10.1371/journal.pone.0138565. eCollection 2015.


Lady in weighting.

Brewerton A, Cowley S.

Community Pract. 2015 Jun;88(6):14-5. No abstract available.


Explosive instability and erupting flux tubes in a magnetized plasma.

Cowley SC, Cowley B, Henneberg SA, Wilson HR.

Proc Math Phys Eng Sci. 2015 Aug 8;471(2180):20140913. Review.


Blending Cr2O3 into a NiO-Ni electrocatalyst for sustained water splitting.

Gong M, Zhou W, Kenney MJ, Kapusta R, Cowley S, Wu Y, Lu B, Lin MC, Wang DY, Yang J, Hwang BJ, Dai H.

Angew Chem Int Ed Engl. 2015 Oct 5;54(41):11989-93. doi: 10.1002/anie.201504815. Epub 2015 Aug 24.


The Current State of Naïve Human Pluripotency.

Dodsworth BT, Flynn R, Cowley SA.

Stem Cells. 2015 Nov;33(11):3181-6. doi: 10.1002/stem.2085. Epub 2015 Jul 14. Review.

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