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NOX2-derived reactive oxygen species in immune cells exacerbates salt-sensitive hypertension.

Abais-Battad JM, Lund H, Dasinger JH, Fehrenbach DJ, Cowley AW Jr, Mattson DL.

Free Radic Biol Med. 2019 Nov 12. pii: S0891-5849(19)31603-X. doi: 10.1016/j.freeradbiomed.2019.11.014. [Epub ahead of print]


Progression of diabetic kidney disease in T2DN rats.

Palygin O, Spires D, Levchenko V, Bohovyk R, Fedoriuk M, Klemens CA, Sykes O, Bukowy JD, Cowley AW Jr, Lazar J, Ilatovskaya DV, Staruschenko A.

Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1450-F1461. doi: 10.1152/ajprenal.00246.2019. Epub 2019 Sep 30.


Dietary Effects on Dahl Salt-Sensitive Hypertension, Renal Damage, and the T Lymphocyte Transcriptome.

Abais-Battad JM, Alsheikh AJ, Pan X, Fehrenbach DJ, Dasinger JH, Lund H, Roberts ML, Kriegel AJ, Cowley AW Jr, Kidambi S, Kotchen TA, Liu P, Liang M, Mattson DL.

Hypertension. 2019 Oct;74(4):854-863. doi: 10.1161/HYPERTENSIONAHA.119.12927. Epub 2019 Sep 3.


Voltage gated proton channels modulate mitochondrial reactive oxygen species production by complex I in renal medullary thick ascending limb.

Patel B, Zheleznova NN, Ray SC, Sun J, Cowley AW Jr, O'Connor PM.

Redox Biol. 2019 Oct;27:101191. doi: 10.1016/j.redox.2019.101191. Epub 2019 Apr 16.


A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production.

Tomar N, Sadri S, Cowley AW Jr, Yang C, Quryshi N, Pannala VR, Audi SH, Dash RK.

Free Radic Biol Med. 2019 Apr;134:581-597. doi: 10.1016/j.freeradbiomed.2019.02.003. Epub 2019 Feb 13.


Therapeutic Suppression of mTOR (Mammalian Target of Rapamycin) Signaling Prevents and Reverses Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats.

Kumar V, Evans LC, Kurth T, Yang C, Wollner C, Nasci V, Zheleznova NN, Bukowy J, Dayton A, Cowley AW Jr.

Hypertension. 2019 Mar;73(3):630-639. doi: 10.1161/HYPERTENSIONAHA.118.12378.


Chrm3 Gene and M3 Muscarinic Receptors Contribute to Salt-Sensitive Hypertension.

Cowley AW Jr.

Hypertension. 2018 Sep;72(3):588-591. doi: 10.1161/HYPERTENSIONAHA.118.11494. No abstract available.


Do computers dream of electric glomeruli?

Bukowy JD, Dayton A, Cloutier D, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.

Kidney Int. 2018 Sep;94(3):635. doi: 10.1016/j.kint.2018.02.011. No abstract available.


Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections.

Bukowy JD, Dayton A, Cloutier D, Manis AD, Staruschenko A, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.

J Am Soc Nephrol. 2018 Aug;29(8):2081-2088. doi: 10.1681/ASN.2017111210. Epub 2018 Jun 19.


A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.

Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A.

J Am Soc Nephrol. 2018 Jul;29(7):1917-1927. doi: 10.1681/ASN.2018030280. Epub 2018 May 23.


Stability of global methylation profiles of whole blood and extracted DNA under different storage durations and conditions.

Li Y, Pan X, Roberts ML, Liu P, Kotchen TA, Cowley AW Jr, Mattson DL, Liu Y, Liang M, Kidambi S.

Epigenomics. 2018 Jun;10(6):797-811. doi: 10.2217/epi-2018-0025. Epub 2018 Apr 23.


Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats.

Evans LC, Dayton A, Yang C, Liu P, Kurth T, Ahn KW, Komas S, Stingo FC, Laud PW, Vannucci M, Liang M, Cowley AW Jr.

Physiol Genomics. 2018 Jun 1;50(6):440-447. doi: 10.1152/physiolgenomics.00034.2018. Epub 2018 Mar 30.


A comprehensive evaluation of alignment software for reduced representation bisulfite sequencing data.

Sun X, Han Y, Zhou L, Chen E, Lu B, Liu Y, Pan X, Cowley AW Jr, Liang M, Wu Q, Lu Y, Liu P.

Bioinformatics. 2018 Aug 15;34(16):2715-2723. doi: 10.1093/bioinformatics/bty174.


Acute In Vivo Analysis of ATP Release in Rat Kidneys in Response to Changes of Renal Perfusion Pressure.

Palygin O, Evans LC, Cowley AW Jr, Staruschenko A.

J Am Heart Assoc. 2017 Sep 12;6(9). pii: e006658. doi: 10.1161/JAHA.117.006658.


Inhibition of Mammalian Target of Rapamycin Complex 1 Attenuates Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats.

Kumar V, Wollner C, Kurth T, Bukowy JD, Cowley AW Jr.

Hypertension. 2017 Oct;70(4):813-821. doi: 10.1161/HYPERTENSIONAHA.117.09456. Epub 2017 Aug 21.


MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4.

Chuppa S, Liang M, Liu P, Liu Y, Casati MC, Cowley AW, Patullo L, Kriegel AJ.

Kidney Int. 2018 Feb;93(2):375-389. doi: 10.1016/j.kint.2017.05.014. Epub 2017 Jul 29.


How can precision medicine be applied to temporomandibular disorders and its comorbidities?

Wilentz JB, Cowley AW Jr.

Mol Pain. 2017 Jan-Dec;13:1744806917710094. doi: 10.1177/1744806917710094.


Increased Perfusion Pressure Drives Renal T-Cell Infiltration in the Dahl Salt-Sensitive Rat.

Evans LC, Petrova G, Kurth T, Yang C, Bukowy JD, Mattson DL, Cowley AW Jr.

Hypertension. 2017 Sep;70(3):543-551. doi: 10.1161/HYPERTENSIONAHA.117.09208. Epub 2017 Jul 10.


Renal Delivery of Anti-microRNA Oligonucleotides in Rats.

Usa KS, Liu Y, Kurth T, Kriegel AJ, Mattson DL, Cowley AW Jr, Liang M.

Methods Mol Biol. 2017;1527:409-419. doi: 10.1007/978-1-4939-6625-7_31.


Breaking the Cycle: Estrous Variation Does Not Require Increased Sample Size in the Study of Female Rats.

Dayton A, Exner EC, Bukowy JD, Stodola TJ, Kurth T, Skelton M, Greene AS, Cowley AW Jr.

Hypertension. 2016 Nov;68(5):1139-1144. Epub 2016 Sep 26.


Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats.

Zheleznova NN, Yang C, Cowley AW Jr.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F450-8. doi: 10.1152/ajprenal.00187.2016. Epub 2016 Jun 8.


p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A.

J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.


Introduction to the American Heart Association's Hypertension Strategically Focused Research Network.

Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW Jr, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM.

Hypertension. 2016 Apr;67(4):674-80. doi: 10.1161/HYPERTENSIONAHA.115.06433. Epub 2016 Feb 22. Review. No abstract available.


Ushering Hypertension Into a New Era of Precision Medicine.

Kotchen TA, Cowley AW Jr, Liang M.

JAMA. 2016 Jan 26;315(4):343-4. doi: 10.1001/jama.2015.18359. No abstract available.


Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.

Cowley AW Jr, Yang C, Zheleznova NN, Staruschenko A, Kurth T, Rein L, Kumar V, Sadovnikov K, Dayton A, Hoffman M, Ryan RP, Skelton MM, Salehpour F, Ranji M, Geurts A.

Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.


Pappa2 is linked to salt-sensitive hypertension in Dahl S rats.

Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M.

Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3.


Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney.

Palygin O, Levchenko V, Evans LC, Blass G, Cowley AW Jr, Staruschenko A.

J Vis Exp. 2015 Oct 12;(104). doi: 10.3791/53059.


Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes.

Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AW Jr, Liang M.

Hypertension. 2015 Oct;66(4):793-9. doi: 10.1161/HYPERTENSIONAHA.115.05645. Epub 2015 Aug 17.


Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.

Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M.

Kidney Int. 2015 Oct;88(4):796-803. doi: 10.1038/ki.2015.176. Epub 2015 Jun 24.


deGPS is a powerful tool for detecting differential expression in RNA-sequencing studies.

Chu C, Fang Z, Hua X, Yang Y, Chen E, Cowley AW Jr, Liang M, Liu P, Lu Y.

BMC Genomics. 2015 Jun 13;16:455. doi: 10.1186/s12864-015-1676-0.


Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: optical fluorescence 3-D cryoimaging.

Salehpour F, Ghanian Z, Yang C, Zheleznova NN, Kurth T, Dash RK, Cowley AW Jr, Ranji M.

Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F377-82. doi: 10.1152/ajprenal.00098.2015. Epub 2015 Jun 10.


Genetic, epigenetic, and mechanistic studies of temporomandibular disorders and overlapping pain conditions.

Munzenmaier DH, Wilentz J, Cowley AW Jr.

Mol Pain. 2014 Dec 15;10:72. doi: 10.1186/1744-8069-10-72.


Null mutation of the nicotinamide adenine dinucleotide phosphate-oxidase subunit p67phox protects the Dahl-S rat from salt-induced reductions in medullary blood flow and glomerular filtration rate.

Evans LC, Ryan RP, Broadway E, Skelton MM, Kurth T, Cowley AW Jr.

Hypertension. 2015 Mar;65(3):561-8. doi: 10.1161/HYPERTENSIONAHA.114.04468. Epub 2014 Dec 8.


Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr.

Hypertension. 2015 Feb;65(2):447-55. doi: 10.1161/HYPERTENSIONAHA.114.04179. Epub 2014 Dec 1.


Characteristics of long non-coding RNAs in the Brown Norway rat and alterations in the Dahl salt-sensitive rat.

Wang F, Li L, Xu H, Liu Y, Yang C, Cowley AW Jr, Wang N, Liu P, Liang M.

Sci Rep. 2014 Nov 21;4:7146. doi: 10.1038/srep07146.


Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension.

Cowley AW Jr, Abe M, Mori T, O'Connor PM, Ohsaki Y, Zheleznova NN.

Am J Physiol Renal Physiol. 2015 Feb 1;308(3):F179-97. doi: 10.1152/ajprenal.00455.2014. Epub 2014 Oct 29. Review.


Improved rat genome gene prediction by integration of ESTs with RNA-Seq information.

Li L, Chen E, Yang C, Zhu J, Jayaraman P, De Pons J, Kaczorowski CC, Jacob HJ, Greene AS, Hodges MR, Cowley AW Jr, Liang M, Xu H, Liu P, Lu Y.

Bioinformatics. 2015 Jan 1;31(1):25-32. doi: 10.1093/bioinformatics/btu608. Epub 2014 Sep 12.


Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.

Cowley AW Jr, Moreno C, Jacob HJ, Peterson CB, Stingo FC, Ahn KW, Liu P, Vannucci M, Laud PW, Reddy P, Lazar J, Evans L, Yang C, Kurth T, Liang M.

Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8.


Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats.

He X, Liu Y, Usa K, Tian Z, Cowley AW Jr, Liang M.

Am J Physiol Renal Physiol. 2014 May 15;306(10):F1190-7. doi: 10.1152/ajprenal.00073.2014. Epub 2014 Apr 2.


Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence.

Liu Y, Liu P, Yang C, Cowley AW Jr, Liang M.

Hypertension. 2014 Apr;63(4):827-38. doi: 10.1161/HYPERTENSIONAHA.113.02637. Epub 2014 Jan 13.


Effect of P2X4 and P2X7 receptor antagonism on the pressure diuresis relationship in rats.

Menzies RI, Unwin RJ, Dash RK, Beard DA, Cowley AW Jr, Carlson BE, Mullins JJ, Bailey MA.

Front Physiol. 2013 Oct 25;4:305. doi: 10.3389/fphys.2013.00305. eCollection 2013.


Aldosterone secretagogues increase adrenal blood flow in male rats.

Ansurudeen I, Kopf PG, Gauthier KM, Bornstein SR, Cowley AW Jr, Campbell WB.

Endocrinology. 2014 Jan;155(1):127-32. doi: 10.1210/en.2013-1532. Epub 2013 Dec 20.


Epigenomics of hypertension.

Liang M, Cowley AW Jr, Mattson DL, Kotchen TA, Liu Y.

Semin Nephrol. 2013 Jul;33(4):392-9. doi: 10.1016/j.semnephrol.2013.05.011. Review.


CTGF a tubular twist on an old theme.

Cowley AW Jr.

Hypertension. 2013 Oct;62(4):687-8. doi: 10.1161/HYPERTENSIONAHA.113.01955. Epub 2013 Aug 19. No abstract available.


Salt in health and disease--a delicate balance.

Kotchen TA, Cowley AW Jr, Frohlich ED.

N Engl J Med. 2013 Jun 27;368(26):2531-2. doi: 10.1056/NEJMc1305326. No abstract available.


Progression of glomerular filtration rate reduction determined in conscious Dahl salt-sensitive hypertensive rats.

Cowley AW Jr, Ryan RP, Kurth T, Skelton MM, Schock-Kusch D, Gretz N.

Hypertension. 2013 Jul;62(1):85-90. doi: 10.1161/HYPERTENSIONAHA.113.01194. Epub 2013 Apr 29.


Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension.

Pavlov TS, Levchenko V, O'Connor PM, Ilatovskaya DV, Palygin O, Mori T, Mattson DL, Sorokin A, Lombard JH, Cowley AW Jr, Staruschenko A.

J Am Soc Nephrol. 2013 Jun;24(7):1053-62. doi: 10.1681/ASN.2012080839. Epub 2013 Apr 18.


Real-time electrochemical detection of ATP and H₂O₂ release in freshly isolated kidneys.

Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Ryan RP, Cowley AW Jr, Staruschenko A.

Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F134-41. doi: 10.1152/ajprenal.00129.2013. Epub 2013 Apr 17.


Salt in health and disease--a delicate balance.

Kotchen TA, Cowley AW Jr, Frohlich ED.

N Engl J Med. 2013 Mar 28;368(13):1229-37. doi: 10.1056/NEJMra1212606. Review. No abstract available.


Dynamic genetic linkage of intermediate blood pressure phenotypes during postural adaptations in a founder population.

Arenas IA, Tremblay J, Deslauriers B, Sandoval J, Šeda O, Gaudet D, Merlo E, Kotchen T, Cowley AW Jr, Hamet P.

Physiol Genomics. 2013 Feb 15;45(4):138-50. doi: 10.1152/physiolgenomics.00037.2012. Epub 2012 Dec 26.

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