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Items: 1 to 50 of 261

1.

Wasf3 deficiency reveals involvement in metastasis in a mouse model of breast cancer.

Qin H, Lu S, Thangaraju M, Cowell JK.

Am J Pathol. 2019 Sep 19. pii: S0002-9440(19)30716-3. doi: 10.1016/j.ajpath.2019.08.012. [Epub ahead of print]

PMID:
31542393
2.

Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome.

Chong Y, Liu Y, Lu S, Cai B, Qin H, Chang CS, Ren M, Cowell JK, Hu T.

Int J Cancer. 2019 Sep 16. doi: 10.1002/ijc.32665. [Epub ahead of print]

PMID:
31525277
3.

Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance pathways.

Silva J, Hawthorn L, Cowell JK.

Genomics. 2019 Jul 2. pii: S0888-7543(19)30015-1. doi: 10.1016/j.ygeno.2019.07.001. [Epub ahead of print]

PMID:
31276752
4.

RAC1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome.

Hu T, Chong Y, Lu S, McGuinness M, Williams DA, Cowell JK.

Haematologica. 2019 Jun 20. pii: haematol.2018.208058. doi: 10.3324/haematol.2018.208058. [Epub ahead of print]

5.

Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.

Lee E, Ouzounova M, Piranlioglu R, Ma MT, Guzel M, Marasco D, Chadli A, Gestwicki JE, Cowell JK, Wicha MS, Hassan KA, Korkaya H.

Oncogene. 2019 Jul;38(28):5749. doi: 10.1038/s41388-019-0838-y.

PMID:
31197211
6.

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model.

Piranlioglu R, Lee E, Ouzounova M, Bollag RJ, Vinyard AH, Arbab AS, Marasco D, Guzel M, Cowell JK, Thangaraju M, Chadli A, Hassan KA, Wicha MS, Celis E, Korkaya H.

Nat Commun. 2019 Mar 29;10(1):1430. doi: 10.1038/s41467-019-09015-1.

7.

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.

Eisa NH, Jilani Y, Kainth K, Redd P, Lu S, Bougrine O, Abdul Sater H, Patwardhan CA, Shull A, Shi H, Liu K, Elsherbiny NM, Eissa LA, El-Shishtawy MM, Horuzsko A, Bollag R, Maihle N, Roig J, Korkaya H, Cowell JK, Chadli A.

J Biol Chem. 2019 Apr 5;294(14):5246-5260. doi: 10.1074/jbc.RA118.006597. Epub 2019 Feb 8.

PMID:
30737284
8.

Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice.

Silva J, Qin H, Cowell JK.

Genesis. 2019 Feb;57(2):e23268. doi: 10.1002/dvg.23268. Epub 2018 Dec 24.

PMID:
30489685
9.

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome.

Silva J, Chang CS, Hu T, Qin H, Kitamura E, Hawthorn L, Ren M, Cowell JK.

Genomics. 2018 Nov 12. pii: S0888-7543(18)30273-8. doi: 10.1016/j.ygeno.2018.10.015. [Epub ahead of print]

PMID:
30439482
10.

Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in Mice.

Hu T, Chong Y, Lu S, Qin H, Ren M, Savage NM, Chang CS, Cowell JK.

Cancer Res. 2019 Jan 1;79(1):114-124. doi: 10.1158/0008-5472.CAN-18-1889. Epub 2018 Nov 9.

PMID:
30413411
11.

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.

Lee E, Ouzounova M, Piranlioglu R, Ma MT, Guzel M, Marasco D, Chadli A, Gestwicki JE, Cowell JK, Wicha MS, Hassan KA, Korkaya H.

Oncogene. 2019 Jan;38(4):469-482. doi: 10.1038/s41388-018-0472-0. Epub 2018 Aug 30. Erratum in: Oncogene. 2019 Jun 13;:.

12.

miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes.

Hu T, Chong Y, Lu S, Wang R, Qin H, Silva J, Kitamura E, Chang CS, Hawthorn L, Cowell JK.

Cancer Res. 2018 Jul 1;78(13):3522-3531. doi: 10.1158/0008-5472.CAN-17-4049. Epub 2018 May 7.

13.

FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome.

Hu T, Wu Q, Chong Y, Qin H, Poole CJ, van Riggelen J, Ren M, Cowell JK.

Leukemia. 2018 Nov;32(11):2363-2373. doi: 10.1038/s41375-018-0124-y. Epub 2018 Apr 2.

14.

Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.

Zhou L, Zhou L, Su LD, Cao SL, Xie YJ, Wang N, Shao CY, Wang YN, Zhou JH, Cowell JK, Shen Y.

J Neurosci. 2018 Mar 28;38(13):3346-3357. doi: 10.1523/JNEUROSCI.3245-17.2018. Epub 2018 Feb 28.

15.

The miR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase.

Hu T, Chong Y, Qin H, Kitamura E, Chang CS, Silva J, Ren M, Cowell JK.

Oncogene. 2018 Apr;37(14):1926-1938. doi: 10.1038/s41388-017-0091-1. Epub 2018 Jan 25.

16.

Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex.

Cowell JK, Teng Y, Bendzunas NG, Ara R, Arbab AS, Kennedy EJ.

Cancer Growth Metastasis. 2017 Jun 19;10:1179064417713197. doi: 10.1177/1179064417713197. eCollection 2017.

17.

Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas.

Cowell JK, Qin H, Hu T, Wu Q, Bhole A, Ren M.

Int J Cancer. 2017 Nov 1;141(9):1822-1829. doi: 10.1002/ijc.30848. Epub 2017 Jul 28.

18.

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade.

Ouzounova M, Lee E, Piranlioglu R, El Andaloussi A, Kolhe R, Demirci MF, Marasco D, Asm I, Chadli A, Hassan KA, Thangaraju M, Zhou G, Arbab AS, Cowell JK, Korkaya H.

Nat Commun. 2017 Apr 6;8:14979. doi: 10.1038/ncomms14979.

19.

Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene.

Teng Y, Ngoka L, Cowell JK.

Genes Chromosomes Cancer. 2017 Jun;56(6):493-500. doi: 10.1002/gcc.22453. Epub 2017 Mar 31.

20.

A model of BCR-FGFR1 driven human AML in immunocompromised mice.

Cowell JK, Qin H, Chang CS, Kitamura E, Ren M.

Br J Haematol. 2016 Nov;175(3):542-545. doi: 10.1111/bjh.13877. Epub 2015 Dec 21. No abstract available.

21.

Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model.

Qin H, Malek S, Cowell JK, Ren M.

Oncogene. 2016 Oct 27;35(43):5686-5691. doi: 10.1038/onc.2016.118. Epub 2016 Apr 11.

22.

The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis.

Teng Y, Qin H, Bahassan A, Bendzunas NG, Kennedy EJ, Cowell JK.

Cancer Res. 2016 Sep 1;76(17):5133-42. doi: 10.1158/0008-5472.CAN-16-0562. Epub 2016 Jul 18.

23.

SCLLTargeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models.

Wu Q, Bhole A, Qin H, Karp J, Malek S, Cowell JK, Ren M.

Oncotarget. 2016 Aug 2;7(31):49733-49742. doi: 10.18632/oncotarget.10438.

24.

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice.

Ren M, Qin H, Wu Q, Savage NM, George TI, Cowell JK.

Int J Cancer. 2016 Aug 15;139(4):836-40. doi: 10.1002/ijc.30100. Epub 2016 May 4.

25.

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.

Zhou HM, Fang YY, Weinberger PM, Ding LL, Cowell JK, Hudson FZ, Ren M, Lee JR, Chen QK, Su H, Dynan WS, Lin Y.

BMC Cancer. 2016 Feb 4;16:55. doi: 10.1186/s12885-016-2105-8.

26.

WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling.

Teng Y, Pi W, Wang Y, Cowell JK.

Oncogene. 2016 Sep 1;35(35):4633-40. doi: 10.1038/onc.2015.527. Epub 2016 Jan 25.

27.

Targeting the WASF3-CYFIP1 Complex Using Stapled Peptides Suppresses Cancer Cell Invasion.

Teng Y, Bahassan A, Dong D, Hanold LE, Ren X, Kennedy EJ, Cowell JK.

Cancer Res. 2016 Feb 15;76(4):965-73. doi: 10.1158/0008-5472.CAN-15-1680. Epub 2015 Dec 16.

28.

FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model.

Qin H, Wu Q, Cowell JK, Ren M.

Haematologica. 2016 Mar;101(3):e91-4. doi: 10.3324/haematol.2015.137695. Epub 2015 Nov 20. No abstract available.

29.

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.

Wang Z, Kim J, Teng Y, Ding HF, Zhang J, Hai T, Cowell JK, Yan C.

Oncogene. 2016 Jul 7;35(27):3555-64. doi: 10.1038/onc.2015.417. Epub 2015 Nov 2.

30.

The promise of zebrafish as a chemical screening tool in cancer therapy.

Xie X, Ross JL, Cowell JK, Teng Y.

Future Med Chem. 2015;7(11):1395-405. doi: 10.4155/fmc.15.73. Review.

PMID:
26230879
31.

Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein.

Teng Y, Ren X, Li H, Shull A, Kim J, Cowell JK.

Oncogene. 2016 Jan 21;35(3):333-43. doi: 10.1038/onc.2015.86. Epub 2015 Mar 30.

32.

Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum.

Xie YJ, Zhou L, Jiang N, Zhang N, Zou N, Zhou L, Wang Y, Cowell JK, Shen Y.

Sci Rep. 2015 Jan 16;5:7827. doi: 10.1038/srep07827.

33.

Homozygous Deletion of the LGI1 Gene in Mice Leads to Developmental Abnormalities Resulting in Cortical Dysplasia.

Silva J, Sharma S, Cowell JK.

Brain Pathol. 2015 Sep;25(5):587-97. doi: 10.1111/bpa.12225. Epub 2014 Dec 1.

PMID:
25346110
34.

LGI1: from zebrafish to human epilepsy.

Cowell JK.

Prog Brain Res. 2014;213:159-79. doi: 10.1016/B978-0-444-63326-2.00009-0. Review.

PMID:
25194489
35.

The involvement of JAK-STAT3 in cell motility, invasion, and metastasis.

Teng Y, Ross JL, Cowell JK.

JAKSTAT. 2014 Jan 1;3(1):e28086. doi: 10.4161/jkst.28086. Epub 2014 Feb 20. Review.

36.

Sepantronium is a DNA damaging agent that synergizes with PLK1 inhibitor volasertib.

Hong M, Ren M, Silva J, Kennedy T, Choi J, Cowell JK, Hao Z.

Am J Cancer Res. 2014 Mar 1;4(2):135-47. eCollection 2014.

37.

Evaluating human cancer cell metastasis in zebrafish.

Teng Y, Xie X, Walker S, White DT, Mumm JS, Cowell JK.

BMC Cancer. 2013 Oct 4;13:453. doi: 10.1186/1471-2407-13-453.

38.

Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.

Ren M, Qin H, Kitamura E, Cowell JK.

Blood. 2013 Aug 8;122(6):1007-16. doi: 10.1182/blood-2013-03-489823. Epub 2013 Jun 18.

39.

Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility.

Teng Y, Ghoshal P, Ngoka L, Mei Y, Cowell JK.

Carcinogenesis. 2013 Sep;34(9):1994-9. doi: 10.1093/carcin/bgt167. Epub 2013 May 14.

40.

Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma.

Weiss GA, Rossi MR, Khushalani NI, Lo K, Gibbs JF, Bharthuar A, Cowell JK, Iyer R.

J Gastrointest Oncol. 2013 Mar;4(1):20-9. doi: 10.3978/j.issn.2078-6891.2012.012.

41.

WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells.

Teng Y, Mei Y, Hawthorn L, Cowell JK.

Oncogene. 2014 Jan 9;33(2):203-11. doi: 10.1038/onc.2012.565. Epub 2013 Jan 14.

42.

Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities.

Ren M, Qin H, Ren R, Cowell JK.

Leukemia. 2013 Jan;27(1):32-40. doi: 10.1038/leu.2012.188. Epub 2012 Jul 11.

43.

Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage.

Ren M, Tidwell JA, Sharma S, Cowell JK.

PLoS One. 2012;7(6):e38265. doi: 10.1371/journal.pone.0038265. Epub 2012 Jun 6.

44.

New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.

Palma-Cerda F, Auger C, Crawford DJ, Hodgson AC, Reynolds SJ, Cowell JK, Swift KA, Cais O, Vyklicky L, Corrie JE, Ogden D.

Neuropharmacology. 2012 Sep;63(4):624-34. doi: 10.1016/j.neuropharm.2012.05.010. Epub 2012 May 17. Erratum in: Neuropharmacology. 2013 Feb;65:245.

PMID:
22609535
45.

HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions.

Ghoshal P, Teng Y, Lesoon LA, Cowell JK.

Int J Cancer. 2012 Sep 15;131(6):E905-15. doi: 10.1002/ijc.27631. Epub 2012 May 30.

46.

HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein.

Teng Y, Ngoka L, Mei Y, Lesoon L, Cowell JK.

J Biol Chem. 2012 Mar 23;287(13):10051-9. doi: 10.1074/jbc.M111.335000. Epub 2012 Feb 7.

47.

Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior.

Teng Y, Xie X, Walker S, Saxena M, Kozlowski DJ, Mumm JS, Cowell JK.

PLoS One. 2011;6(9):e24596. doi: 10.1371/journal.pone.0024596. Epub 2011 Sep 16.

48.

Src activation plays an important key role in lymphomagenesis induced by FGFR1 fusion kinases.

Ren M, Qin H, Ren R, Tidwell J, Cowell JK.

Cancer Res. 2011 Dec 1;71(23):7312-22. doi: 10.1158/0008-5472.CAN-11-1109. Epub 2011 Sep 21.

49.
50.

Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells.

Teng Y, Liu M, Cowell JK.

Int J Cancer. 2011 Dec 15;129(12):2825-35. doi: 10.1002/ijc.25964. Epub 2011 May 5.

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