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Items: 50

1.

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison.

Cowell IG, Ling EM, Swan RL, Brooks MLW, Austin CA.

Mol Pharmacol. 2019 Nov;96(5):562-572. doi: 10.1124/mol.119.117390. Epub 2019 Sep 12.

PMID:
31515282
2.

Mutations in topoisomerase IIβ result in a B cell immunodeficiency.

Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM.

Nat Commun. 2019 Aug 13;10(1):3644. doi: 10.1038/s41467-019-11570-6.

3.

Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations.

Atwal M, Swan RL, Rowe C, Lee KC, Lee DC, Armstrong L, Cowell IG, Austin CA.

Mol Pharmacol. 2019 Oct;96(4):475-484. doi: 10.1124/mol.119.117259. Epub 2019 Aug 9.

PMID:
31399497
4.

TOP2B: The First Thirty Years.

Austin CA, Lee KC, Swan RL, Khazeem MM, Manville CM, Cridland P, Treumann A, Porter A, Morris NJ, Cowell IG.

Int J Mol Sci. 2018 Sep 14;19(9). pii: E2765. doi: 10.3390/ijms19092765. Review.

5.

Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes.

Lee KC, Swan RL, Sondka Z, Padget K, Cowell IG, Austin CA.

Int J Mol Sci. 2018 Jul 14;19(7). pii: E2056. doi: 10.3390/ijms19072056.

6.

Visualization and Quantification of Topoisomerase-DNA Covalent Complexes Using the Trapped in Agarose Immunostaining (TARDIS) Assay.

Cowell IG, Austin CA.

Methods Mol Biol. 2018;1703:301-316. doi: 10.1007/978-1-4939-7459-7_21.

PMID:
29177750
7.

Topoisomerase II Chromatin Immunoprecipitation.

Smith KA, Cowell IG, Austin CA.

Methods Mol Biol. 2018;1703:183-189. doi: 10.1007/978-1-4939-7459-7_14.

PMID:
29177743
8.

Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy.

Atwal M, Lishman EL, Austin CA, Cowell IG.

Mol Pharmacol. 2017 Jan;91(1):49-57. Epub 2016 Nov 10.

9.

Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II.

Lee KC, Bramley RL, Cowell IG, Jackson GH, Austin CA.

Biochem Pharmacol. 2016 Mar 1;103:29-39. doi: 10.1016/j.bcp.2015.12.015. Epub 2016 Jan 12.

10.

Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells.

Manville CM, Smith K, Sondka Z, Rance H, Cockell S, Cowell IG, Lee KC, Morris NJ, Padget K, Jackson GH, Austin CA.

Biol Open. 2015 Oct 12;4(11):1436-47. doi: 10.1242/bio.014308.

11.

Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.

Ben-David U, Cowell IG, Austin CA, Benvenisty N.

Stem Cells. 2015 Mar;33(3):1013-9. doi: 10.1002/stem.1888.

12.

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons.

Best A, James K, Dalgliesh C, Hong E, Kheirolahi-Kouhestani M, Curk T, Xu Y, Danilenko M, Hussain R, Keavney B, Wipat A, Klinck R, Cowell IG, Cheong Lee K, Austin CA, Venables JP, Chabot B, Santibanez Koref M, Tyson-Capper A, Elliott DJ.

Nat Commun. 2014 Sep 11;5:4760. doi: 10.1038/ncomms5760.

13.

The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1.

Smith KA, Cowell IG, Zhang Y, Sondka Z, Austin CA.

Genes Chromosomes Cancer. 2014 Feb;53(2):117-28. doi: 10.1002/gcc.22124. Epub 2013 Nov 5.

14.

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.

Lee KC, Padget K, Curtis H, Cowell IG, Moiani D, Sondka Z, Morris NJ, Jackson GH, Cockell SJ, Tainer JA, Austin CA.

Biol Open. 2012 Sep 15;1(9):863-73. doi: 10.1242/bio.20121834. Epub 2012 Jul 11.

15.

Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?

Cowell IG, Austin CA.

Cell Cycle. 2012 Sep 1;11(17):3143-4. doi: 10.4161/cc.21477. Epub 2012 Aug 16. No abstract available.

16.

Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.

Cowell IG, Austin CA.

Int J Environ Res Public Health. 2012 Jun;9(6):2075-91. doi: 10.3390/ijerph9062075. Epub 2012 May 31. Review.

17.

Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity.

Cowell IG, Sondka Z, Smith K, Lee KC, Manville CM, Sidorczuk-Lesthuruge M, Rance HA, Padget K, Jackson GH, Adachi N, Austin CA.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8989-94. doi: 10.1073/pnas.1204406109. Epub 2012 May 21.

18.

Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin.

Cowell IG, Papageorgiou N, Padget K, Watters GP, Austin CA.

Nucleus. 2011 Jan-Feb;2(1):61-71. doi: 10.4161/nucl.2.1.14194.

19.

An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay.

Cowell IG, Tilby MJ, Austin CA.

Mutagenesis. 2011 Mar;26(2):253-60. doi: 10.1093/mutage/geq094. Epub 2010 Nov 10. Review.

PMID:
21068206
20.

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide.

Sunter NJ, Cowell IG, Willmore E, Watters GP, Austin CA.

J Nucleic Acids. 2010 Aug 19;2010. pii: 710589. doi: 10.4061/2010/710589.

21.

NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.

Toyoda E, Kagaya S, Cowell IG, Kurosawa A, Kamoshita K, Nishikawa K, Iiizumi S, Koyama H, Austin CA, Adachi N.

J Biol Chem. 2008 Aug 29;283(35):23711-20. doi: 10.1074/jbc.M803936200. Epub 2008 Jul 2.

22.

DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

Willmore E, Elliott SL, Mainou-Fowler T, Summerfield GP, Jackson GH, O'Neill F, Lowe C, Carter A, Harris R, Pettitt AR, Cano-Soumillac C, Griffin RJ, Cowell IG, Austin CA, Durkacz BW.

Clin Cancer Res. 2008 Jun 15;14(12):3984-92. doi: 10.1158/1078-0432.CCR-07-5158.

23.

gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

Cowell IG, Sunter NJ, Singh PB, Austin CA, Durkacz BW, Tilby MJ.

PLoS One. 2007 Oct 24;2(10):e1057.

24.

Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure.

Leontiou C, Watters GP, Gilroy KL, Heslop P, Cowell IG, Craig K, Lightowlers RN, Lakey JH, Austin CA.

Mol Pharmacol. 2007 Apr;71(4):1006-14. Epub 2007 Jan 5.

PMID:
17209120
25.

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

Zhao Y, Thomas HD, Batey MA, Cowell IG, Richardson CJ, Griffin RJ, Calvert AH, Newell DR, Smith GC, Curtin NJ.

Cancer Res. 2006 May 15;66(10):5354-62.

26.
27.
28.

E4BP4/NFIL3, a PAR-related bZIP factor with many roles.

Cowell IG.

Bioessays. 2002 Nov;24(11):1023-9. Review.

PMID:
12386933
29.

Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals.

Cowell IG, Aucott R, Mahadevaiah SK, Burgoyne PS, Huskisson N, Bongiorni S, Prantera G, Fanti L, Pimpinelli S, Wu R, Gilbert DM, Shi W, Fundele R, Morrison H, Jeppesen P, Singh PB.

Chromosoma. 2002 Mar;111(1):22-36.

PMID:
12068920
30.

Loss of heterochromatin protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death.

Filesi I, Cardinale A, van der Sar S, Cowell IG, Singh PB, Biocca S.

J Cell Sci. 2002 May 1;115(Pt 9):1803-13.

31.

The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure.

Scholzen T, Endl E, Wohlenberg C, van der Sar S, Cowell IG, Gerdes J, Singh PB.

J Pathol. 2002 Feb;196(2):135-44.

PMID:
11793364
32.

The gene and pseudogenes of Cbx3/mHP1 gamma.

Jones DO, Mattei MG, Horsley D, Cowell IG, Singh PB.

DNA Seq. 2001;12(3):147-60.

PMID:
11762190
33.

Dynamic associations of heterochromatin protein 1 with the nuclear envelope.

Kourmouli N, Theodoropoulos PA, Dialynas G, Bakou A, Politou AS, Cowell IG, Singh PB, Georgatos SD.

EMBO J. 2000 Dec 1;19(23):6558-68.

34.

Conservation of heterochromatin protein 1 function.

Wang G, Ma A, Chow CM, Horsley D, Brown NR, Cowell IG, Singh PB.

Mol Cell Biol. 2000 Sep;20(18):6970-83.

35.

Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.

Cowell IG, Okorokov AL, Cutts SA, Padget K, Bell M, Milner J, Austin CA.

Exp Cell Res. 2000 Feb 25;255(1):86-94.

PMID:
10666337
36.

Mammalian chromodomain proteins: their role in genome organisation and expression.

Jones DO, Cowell IG, Singh PB.

Bioessays. 2000 Feb;22(2):124-37. Review.

PMID:
10655032
37.

Nuclear distribution of human DNA topoisomerase IIbeta: a nuclear targeting signal resides in the 116-residue C-terminal tail.

Cowell IG, Willmore E, Chalton D, Marsh KL, Jazrawi E, Fisher LM, Austin CA.

Exp Cell Res. 1998 Sep 15;243(2):232-40.

PMID:
9743583
38.

Self-association of chromo domain peptides.

Cowell IG, Austin CA.

Biochim Biophys Acta. 1997 Feb 8;1337(2):198-206.

PMID:
9048896
39.

Yeast two-hybrid library screening.

Cowell IG.

Methods Mol Biol. 1997;69:185-202. No abstract available.

PMID:
9116853
40.
41.
42.
43.

Repression versus activation in the control of gene transcription.

Cowell IG.

Trends Biochem Sci. 1994 Jan;19(1):38-42. Review.

PMID:
8140620
44.

Cloning DNA binding proteins from cDNA expression libraries using oligonucleotide binding site probes.

Cowell IG, Hurst HC.

Methods Mol Biol. 1994;31:363-70. Review. No abstract available.

PMID:
7921033
45.

The human mitochondrial NADH: ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase P1-1 gene on chromosome 11q13.

Spencer SR, Taylor JB, Cowell IG, Xia CL, Pemble SE, Ketterer B.

Genomics. 1992 Dec;14(4):1116-8. No abstract available.

PMID:
1478657
46.

Transcriptional repression by a novel member of the bZIP family of transcription factors.

Cowell IG, Skinner A, Hurst HC.

Mol Cell Biol. 1992 Jul;12(7):3070-7.

47.

Glutathione transferase pi its minimal promoter and downstream cis-acting element.

Xia CL, Cowell IG, Dixon KH, Pemble SE, Ketterer B, Taylor JB.

Biochem Biophys Res Commun. 1991 Apr 15;176(1):233-40.

PMID:
1850260
48.

Control of expression of the human glutathione S-transferase pi gene differs from its rat orthologue.

Dixon KH, Cowell IG, Xia CL, Pemble SE, Ketterer B, Taylor JB.

Biochem Biophys Res Commun. 1989 Sep 15;163(2):815-22.

PMID:
2783123
49.

The structure of the human glutathione S-transferase pi gene.

Cowell IG, Dixon KH, Pemble SE, Ketterer B, Taylor JB.

Biochem J. 1988 Oct 1;255(1):79-83.

50.

Molecular biology of glutathione transferases.

Taylor JB, Pemble SE, Cowell IG, Dixon KH, Ketterer B.

Biochem Soc Trans. 1987 Aug;15(4):578-81. No abstract available.

PMID:
3678579

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