Sort by
Items per page

Send to

Choose Destination

Search results

Items: 44


Correction: HIF-2α is essential for carotid body development and function.

Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson R.

Elife. 2018 Jun 4;7. pii: e38781. doi: 10.7554/eLife.38781. No abstract available.


HIF-2α is essential for carotid body development and function.

Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson RS.

Elife. 2018 Apr 19;7. pii: e34681. doi: 10.7554/eLife.34681. Erratum in: Elife. 2018 Jun 04;7:.


The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.

Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, Johnson RS.

Cell Metab. 2018 Apr 3;27(4):898-913.e7. doi: 10.1016/j.cmet.2018.02.020.


Cardiovascular adaptation to hypoxia and the role of peripheral resistance.

Cowburn AS, Macias D, Summers C, Chilvers ER, Johnson RS.

Elife. 2017 Oct 19;6. pii: e28755. doi: 10.7554/eLife.28755.


Human Cytomegalovirus Delays Neutrophil Apoptosis and Stimulates the Release of a Prosurvival Secretome.

Pocock JM, Storisteanu DML, Reeves MB, Juss JK, Wills MR, Cowburn AS, Chilvers ER.

Front Immunol. 2017 Sep 25;8:1185. doi: 10.3389/fimmu.2017.01185. eCollection 2017.


Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.


Hypoxia causes IL-8 secretion, Charcot Leyden crystal formation, and suppression of corticosteroid-induced apoptosis in human eosinophils.

Porter LM, Cowburn AS, Farahi N, Deighton J, Farrow SN, Fiddler CA, Juss JK, Condliffe AM, Chilvers ER.

Clin Exp Allergy. 2017 Jun;47(6):770-784. doi: 10.1111/cea.12877. Epub 2017 Feb 3.


Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens.

Storisteanu DM, Pocock JM, Cowburn AS, Juss JK, Nadesalingam A, Nizet V, Chilvers ER.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):423-431. doi: 10.1165/rcmb.2016-0193PS. Review.


Cutaneous exposure to hypoxia does not affect skin perfusion in humans.

Siebenmann C, Keramidas ME, Rundqvist H, Mijwel S, Cowburn AS, Johnson RS, Eiken O.

Acta Physiol (Oxf). 2017 Jul;220(3):361-369. doi: 10.1111/apha.12825. Epub 2016 Nov 30.


The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion.

Fiddler CA, Parfrey H, Cowburn AS, Luo D, Nash GB, Murphy G, Chilvers ER.

PLoS One. 2016 Jul 28;11(7):e0160108. doi: 10.1371/journal.pone.0160108. eCollection 2016.


HIF2α-arginase axis is essential for the development of pulmonary hypertension.

Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8801-6. doi: 10.1073/pnas.1602978113. Epub 2016 Jul 18.


HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.

Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.

Nat Commun. 2016 May 18;7:11635. doi: 10.1038/ncomms11635.


Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism.

Ashmore T, Roberts LD, Morash AJ, Kotwica AO, Finnerty J, West JA, Murfitt SA, Fernandez BO, Branco C, Cowburn AS, Clarke K, Johnson RS, Feelisch M, Griffin JL, Murray AJ.

BMC Biol. 2015 Dec 22;13:110. doi: 10.1186/s12915-015-0221-6.


Caveolae protect endothelial cells from membrane rupture during increased cardiac output.

Cheng JP, Mendoza-Topaz C, Howard G, Chadwick J, Shvets E, Cowburn AS, Dunmore BJ, Crosby A, Morrell NW, Nichols BJ.

J Cell Biol. 2015 Oct 12;211(1):53-61. doi: 10.1083/jcb.201504042.


Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart.

Ashmore T, Fernandez BO, Branco-Price C, West JA, Cowburn AS, Heather LC, Griffin JL, Johnson RS, Feelisch M, Murray AJ.

J Physiol. 2014 Nov 1;592(21):4715-31. doi: 10.1113/jphysiol.2014.275263. Epub 2014 Aug 28.


HIF isoforms in the skin differentially regulate systemic arterial pressure.

Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17570-5. doi: 10.1073/pnas.1306942110. Epub 2013 Oct 7.


Epidermal deletion of HIF-2α stimulates wound closure.

Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS.

J Invest Dermatol. 2014 Mar;134(3):801-808. doi: 10.1038/jid.2013.395. Epub 2013 Sep 13.


Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.

Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H Jr, Johnson RS, Broide DH, Nizet V.

J Mol Med (Berl). 2013 May;91(5):637-44. doi: 10.1007/s00109-012-0986-9. Epub 2012 Dec 19.


Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival.

Juss JK, Hayhoe RP, Owen CE, Bruce I, Walmsley SR, Cowburn AS, Kulkarni S, Boyle KB, Stephens L, Hawkins PT, Chilvers ER, Condliffe AM.

PLoS One. 2012;7(9):e45933. doi: 10.1371/journal.pone.0045933. Epub 2012 Sep 24.


Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.

Farahi N, Uller L, Juss JK, Langton AJ, Cowburn AS, Gibson A, Foster MR, Farrow SN, Marco-Casanova P, Sobolewski A, Condliffe AM, Chilvers ER.

Clin Exp Allergy. 2011 May;41(5):673-87. doi: 10.1111/j.1365-2222.2010.03680.x. Epub 2011 Jan 24.


Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.

McGovern NN, Cowburn AS, Porter L, Walmsley SR, Summers C, Thompson AAR, Anwar S, Willcocks LC, Whyte MKB, Condliffe AM, Chilvers ER.

J Immunol. 2011 Jan 1;186(1):453-463. doi: 10.4049/jimmunol.1002213. Epub 2010 Dec 6.


Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils.

Brode S, Farahi N, Cowburn AS, Juss JK, Condliffe AM, Chilvers ER.

Thorax. 2010 Dec;65(12):1116-7. doi: 10.1136/thx.2009.124909. Epub 2010 Aug 30. No abstract available.


Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.

Cowburn AS, Summers C, Dunmore BJ, Farahi N, Hayhoe RP, Print CG, Cook SJ, Chilvers ER.

Am J Respir Cell Mol Biol. 2011 Jun;44(6):879-87. doi: 10.1165/rcmb.2010-0101OC. Epub 2010 Aug 12.


Changes in helper lymphocyte chemokine receptor expression and elevation of IP-10 during acute respiratory syncytial virus infection in infants.

Roe MF, Bloxham DM, Cowburn AS, O'Donnell DR.

Pediatr Allergy Immunol. 2011 Mar;22(2):229-34. doi: 10.1111/j.1399-3038.2010.01032.x.


Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation.

McKeon DJ, Cadwallader KA, Idris S, Cowburn AS, Pasteur MC, Barker H, Haworth CS, Bilton D, Chilvers ER, Condliffe AM.

Eur Respir J. 2010 Jun;35(6):1264-72. doi: 10.1183/09031936.00089709. Epub 2009 Oct 19.


Advances in neutrophil biology: clinical implications.

Cowburn AS, Condliffe AM, Farahi N, Summers C, Chilvers ER.

Chest. 2008 Sep;134(3):606-612. doi: 10.1378/chest.08-0422. Review.


Prolonged survival of neutrophils from patients with Delta F508 CFTR mutations.

McKeon DJ, Condliffe AM, Cowburn AS, Cadwallader KC, Farahi N, Bilton D, Chilvers ER.

Thorax. 2008 Jul;63(7):660-1. doi: 10.1136/thx.2008.096834. No abstract available.


Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells.

Farahi N, Cowburn AS, Upton PD, Deighton J, Sobolewski A, Gherardi E, Morrell NW, Chilvers ER.

J Immunol. 2007 Jul 15;179(2):1264-73.


Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis.

Walmsley SR, Cowburn AS, Clatworthy MR, Morrell NW, Roper EC, Singleton V, Maxwell P, Whyte MK, Chilvers ER.

Blood. 2006 Nov 1;108(9):3176-8. Epub 2006 Jun 29.


Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils.

Cowburn AS, Sobolewski A, Reed BJ, Deighton J, Murray J, Cadwallader KA, Bradley JR, Chilvers ER.

J Biol Chem. 2006 May 5;281(18):12458-67. Epub 2006 Mar 13.


Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.

Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER.

J Exp Med. 2005 Jan 3;201(1):105-15.


z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species.

Cowburn AS, White JF, Deighton J, Walmsley SR, Chilvers ER.

Blood. 2005 Apr 1;105(7):2970-2. Epub 2004 Nov 30.


Eating their way out of trouble: selective uptake of apoptotic eosinophils by bronchial epithelial cells.

Farahi N, Cowburn AS, Rossi AG, Chilvers ER.

Clin Exp Allergy. 2004 Oct;34(10):1503-6. No abstract available.


Effect of priming on activation and localization of phospholipase D-1 in human neutrophils.

Cadwallader KA, Uddin M, Condliffe AM, Cowburn AS, White JF, Skepper JN, Ktistakis NT, Chilvers ER.

Eur J Biochem. 2004 Jul;271(13):2755-64.


The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release.

Cowburn AS, Deighton J, Walmsley SR, Chilvers ER.

Eur J Immunol. 2004 Jun;34(6):1733-43.


Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.

Walmsley SR, Cowburn AS, Sobolewski A, Murray J, Farahi N, Sabroe I, Chilvers ER.

Biochem Soc Trans. 2004 Jun;32(Pt3):456-60.


Hypoxic regulation of neutrophil apoptosis role: of reactive oxygen intermediates in constitutive and tumor necrosis factor alpha-induced cell death.

Murray J, Walmsley SR, Mecklenburgh KI, Cowburn AS, White JF, Rossi AG, Chilvers ER.

Ann N Y Acad Sci. 2003 Dec;1010:417-25.


Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis.

Mecklenburgh KI, Walmsley SR, Cowburn AS, Wiesener M, Reed BJ, Upton PD, Deighton J, Greening AP, Chilvers ER.

Blood. 2002 Oct 15;100(8):3008-16.


Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival.

Cowburn AS, Cadwallader KA, Reed BJ, Farahi N, Chilvers ER.

Blood. 2002 Oct 1;100(7):2607-16.


Are cysteinyl leukotrienes involved in allergic responses in human skin?

Church MK, Griffiths TJ, Jeffery S, Ravell LC, Cowburn AS, Sampson AP, Clough GF.

Clin Exp Allergy. 2002 Jul;32(7):1013-9.


Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells.

Condliffe AM, Cadwallader KA, Walker TR, Rintoul RC, Cowburn AS, Chilvers ER.

Respir Res. 2000;1(1):24-9. Epub 2000 Jun 8.


Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

Cowburn AS, Sladek K, Soja J, Adamek L, Nizankowska E, Szczeklik A, Lam BK, Penrose JF, Austen FK, Holgate ST, Sampson AP.

J Clin Invest. 1998 Feb 15;101(4):834-46.


Profound overexpression of leukotriene C4 synthase in bronchial biopsies from aspirin-intolerant asthmatic patients.

Sampson AP, Cowburn AS, Sladek K, Adamek L, Nizankowska E, Szczeklik A, Lam BK, Penrose JF, Austen KF, Holgate ST.

Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):355-7. No abstract available.


Supplemental Content

Loading ...
Support Center