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Items: 1 to 50 of 229

1.

Unique roles of iron and zinc binding to the yeast Fe-S cluster scaffold assembly protein "Isu1".

Lewis BE, Mason Z, Rodrigues AV, Nuth M, Dizin E, Cowan JA, Stemmler TL.

Metallomics. 2019 Sep 18. doi: 10.1039/c9mt00172g. [Epub ahead of print]

PMID:
31532427
2.

Reconstitution, characterization, and [2Fe-2S] cluster exchange reactivity of a holo human BOLA3 homodimer.

Wachnowsky C, Rao B, Sen S, Fries B, Howard CJ, Ottesen JJ, Cowan JA.

J Biol Inorg Chem. 2019 Sep 5. doi: 10.1007/s00775-019-01713-x. [Epub ahead of print]

PMID:
31486956
3.

Understanding the Mechanism of [4Fe-4S] Cluster Assembly on Eukaryotic Mitochondrial and Cytosolic Aconitase.

Wachnowsky C, Hendricks AL, Wesley NA, Ferguson C, Fidai I, Cowan JA.

Inorg Chem. 2019 Aug 22. doi: 10.1021/acs.inorgchem.9b01278. [Epub ahead of print]

PMID:
31436962
4.

Rapid Telomere Reduction in Cancer Cells Induced by G-Quadruplex-Targeting Copper Complexes.

Yu Z, Fenk KD, Huang D, Sen S, Cowan JA.

J Med Chem. 2019 May 23;62(10):5040-5048. doi: 10.1021/acs.jmedchem.9b00215. Epub 2019 May 9.

PMID:
31026396
5.

Cu-ATCUN Derivatives of Sub5 Exhibit Enhanced Antimicrobial Activity via Multiple Modes of Action.

Alexander JL, Thompson Z, Yu Z, Cowan JA.

ACS Chem Biol. 2019 Mar 15;14(3):449-458. doi: 10.1021/acschembio.8b01087. Epub 2019 Feb 20.

PMID:
30742402
6.

Genotypic variation in phenological plasticity: Reciprocal common gardens reveal adaptive responses to warmer springs but not to fall frost.

Cooper HF, Grady KC, Cowan JA, Best RJ, Allan GJ, Whitham TG.

Glob Chang Biol. 2019 Jan;25(1):187-200. doi: 10.1111/gcb.14494. Epub 2018 Nov 14.

PMID:
30346108
7.

Broad-spectrum catalytic metallopeptide inactivators of Zika and West Nile virus NS2B/NS3 proteases.

Pinkham AM, Yu Z, Cowan JA.

Chem Commun (Camb). 2018 Oct 30;54(87):12357-12360. doi: 10.1039/c8cc07448h.

PMID:
30324214
8.

Cluster exchange reactivity of [2Fe-2S] cluster-bridged complexes of BOLA3 with monothiol glutaredoxins.

Sen S, Rao B, Wachnowsky C, Cowan JA.

Metallomics. 2018 Sep 19;10(9):1282-1290. doi: 10.1039/c8mt00128f.

9.

Role of the HSPA9/HSC20 chaperone pair in promoting directional human iron-sulfur cluster exchange involving monothiol glutaredoxin 5.

Olive JA, Cowan JA.

J Inorg Biochem. 2018 Jul;184:100-107. doi: 10.1016/j.jinorgbio.2018.04.007. Epub 2018 Apr 11.

10.

Antimicrobial Metallopeptides.

Alexander JL, Thompson Z, Cowan JA.

ACS Chem Biol. 2018 Apr 20;13(4):844-853. doi: 10.1021/acschembio.7b00989. Epub 2018 Feb 13. Review.

PMID:
29390186
11.

Attenuation of West Nile Virus NS2B/NS3 Protease by Amino Terminal Copper and Nickel Binding (ATCUN) Peptides.

Pinkham AM, Yu Z, Cowan JA.

J Med Chem. 2018 Feb 8;61(3):980-988. doi: 10.1021/acs.jmedchem.7b01409. Epub 2018 Jan 25.

PMID:
29301071
12.

Investigation of glutathione-derived electrostatic and hydrogen-bonding interactions and their role in defining Grx5 [2Fe-2S] cluster optical spectra and transfer chemistry.

Sen S, Bonfio C, Mansy SS, Cowan JA.

J Biol Inorg Chem. 2018 Mar;23(2):241-252. doi: 10.1007/s00775-017-1525-5. Epub 2017 Dec 20.

PMID:
29264659
13.

Regulation of human Nfu activity in Fe-S cluster delivery-characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex.

Wachnowsky C, Liu Y, Yoon T, Cowan JA.

FEBS J. 2018 Jan;285(2):391-410. doi: 10.1111/febs.14353. Epub 2017 Dec 29.

14.

Amino Terminal Copper and Nickel Binding Motif Derivatives of Ovispirin-3 Display Increased Antimicrobial Activity via Lipid Oxidation.

Alexander JL, Yu Z, Cowan JA.

J Med Chem. 2017 Dec 28;60(24):10047-10055. doi: 10.1021/acs.jmedchem.7b01117. Epub 2017 Dec 7.

PMID:
29172482
15.

Metal complexes promoting catalytic cleavage of nucleic acids-biochemical tools and therapeutics.

Yu Z, Cowan JA.

Curr Opin Chem Biol. 2018 Apr;43:37-42. doi: 10.1016/j.cbpa.2017.10.029. Epub 2017 Nov 15. Review.

16.

Iron-sulfur cluster biosynthesis and trafficking - impact on human disease conditions.

Wachnowsky C, Fidai I, Cowan JA.

Metallomics. 2018 Jan 24;10(1):9-29. doi: 10.1039/c7mt00180k. Review.

17.

Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1.

Wesley NA, Wachnowsky C, Fidai I, Cowan JA.

FEBS J. 2017 Nov;284(22):3838-3848. doi: 10.1111/febs.14271. Epub 2017 Oct 12.

18.

Analysis of NFU-1 metallocofactor binding-site substitutions-impacts on iron-sulfur cluster coordination and protein structure and function.

Wesley NA, Wachnowsky C, Fidai I, Cowan JA.

FEBS J. 2017 Nov;284(22):3817-3837. doi: 10.1111/febs.14270. Epub 2017 Oct 16.

19.

In Vitro Studies of Cellular Iron-Sulfur Cluster Biosynthesis, Trafficking, and Transport.

Wachnowsky C, Cowan JA.

Methods Enzymol. 2017;595:55-82. doi: 10.1016/bs.mie.2017.06.045. Epub 2017 Aug 21.

PMID:
28882208
20.

Role of protein-glutathione contacts in defining glutaredoxin-3 [2Fe-2S] cluster chirality, ligand exchange and transfer chemistry.

Sen S, Cowan JA.

J Biol Inorg Chem. 2017 Oct;22(7):1075-1087. doi: 10.1007/s00775-017-1485-9. Epub 2017 Aug 23.

PMID:
28836015
21.

Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics.

Yu Z, Cowan JA.

Chemistry. 2017 Oct 12;23(57):14113-14127. doi: 10.1002/chem.201701714. Epub 2017 Aug 21. Review.

PMID:
28688119
22.

Analysis of Structure-Activity Relationships Based on the Hepatitis C Virus SLIIb Internal Ribosomal Entry Sequence RNA-Targeting GGHYRFK⋅Cu Complex.

Ross MJ, Fidai I, Cowan JA.

Chembiochem. 2017 Sep 5;18(17):1743-1754. doi: 10.1002/cbic.201700228. Epub 2017 Aug 7.

23.
24.

Design of Artificial Glycosidases: Metallopeptides that Remove H Antigen from Human Erythrocytes.

Yu Z, Cowan JA.

Angew Chem Int Ed Engl. 2017 Mar 1;56(10):2763-2766. doi: 10.1002/anie.201612079. Epub 2017 Jan 27.

26.

Cytosolic iron-sulfur cluster transfer-a proposed kinetic pathway for reconstitution of glutaredoxin 3.

Wachnowsky C, Fidai I, Cowan JA.

FEBS Lett. 2016 Dec;590(24):4531-4540. doi: 10.1002/1873-3468.12491. Epub 2016 Dec 1.

27.

Duplications of an iron-sulphur tripeptide leads to the formation of a protoferredoxin.

Scintilla S, Bonfio C, Belmonte L, Forlin M, Rossetto D, Li J, Cowan JA, Galliani A, Arnesano F, Assfalg M, Mansy SS.

Chem Commun (Camb). 2016 Nov 10;52(92):13456-13459.

PMID:
27790655
28.

Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking.

Fidai I, Wachnowsky C, Cowan JA.

J Biol Inorg Chem. 2016 Oct;21(7):887-901. doi: 10.1007/s00775-016-1387-2. Epub 2016 Sep 2.

PMID:
27590019
29.

Iron-sulfur cluster exchange reactions mediated by the human Nfu protein.

Wachnowsky C, Fidai I, Cowan JA.

J Biol Inorg Chem. 2016 Oct;21(7):825-836. doi: 10.1007/s00775-016-1381-8. Epub 2016 Aug 18.

30.

Catalytic metallodrugs based on the LaR2C peptide target HCV SLIV IRES RNA.

Ross MJ, Bradford SS, Cowan JA.

Dalton Trans. 2015 Dec 28;44(48):20972-82. doi: 10.1039/c5dt02837j. Epub 2015 Nov 19.

31.

Glutathione-coordinated [2Fe-2S] cluster is stabilized by intramolecular salt bridges.

Li J, Pearson SA, Fenk KD, Cowan JA.

J Biol Inorg Chem. 2015 Dec;20(8):1221-7. doi: 10.1007/s00775-015-1301-3. Epub 2015 Oct 14.

PMID:
26468125
32.

Glutathione-coordinated [2Fe-2S] cluster: a viable physiological substrate for mitochondrial ABCB7 transport.

Li J, Cowan JA.

Chem Commun (Camb). 2015 Feb 11;51(12):2253-5. doi: 10.1039/c4cc09175b.

33.

Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex.

Yu Z, Han M, Cowan JA.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1901-5. doi: 10.1002/anie.201410434. Epub 2014 Dec 11.

34.

Inactivation of sortase A mediated by metal ATCUN complexes.

Fidai I, Hocharoen L, Bradford S, Wachnowsky C, Cowan JA.

J Biol Inorg Chem. 2014 Dec;19(8):1327-39. doi: 10.1007/s00775-014-1190-x. Epub 2014 Sep 9.

PMID:
25217034
35.

Insight into the recognition, binding, and reactivity of catalytic metallodrugs targeting stem loop IIb of hepatitis C IRES RNA.

Bradford SS, Ross MJ, Fidai I, Cowan JA.

ChemMedChem. 2014 Jun;9(6):1275-85. doi: 10.1002/cmdc.201400070. Epub 2014 Apr 22.

36.

Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.

Amick J, Schlanger SE, Wachnowsky C, Moseng MA, Emerson CC, Dare M, Luo WI, Ithychanda SS, Nix JC, Cowan JA, Page RC, Misra S.

Protein Sci. 2014 Jun;23(6):833-42. doi: 10.1002/pro.2466. Epub 2014 Apr 17.

37.

A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters.

Qi W, Li J, Cowan JA.

Chem Commun (Camb). 2014 Apr 14;50(29):3795-8. doi: 10.1039/c3cc48239a.

38.

N- versus C-domain selectivity of catalytic inactivation of human angiotensin converting enzyme by lisinopril-coupled transition metal chelates.

Hocharoen L, Joyner JC, Cowan JA.

J Med Chem. 2013 Dec 27;56(24):9826-36. doi: 10.1021/jm4009345. Epub 2013 Dec 5.

39.

Target-directed catalytic metallodrugs.

Joyner JC, Cowan JA.

Braz J Med Biol Res. 2013 Jun;46(6):465-85. doi: 10.1590/1414-431X20133086. Epub 2013 Jul 2. Review.

40.

Thermodynamic and structural analysis of human NFU conformational chemistry.

Li J, Ding S, Cowan JA.

Biochemistry. 2013 Jul 23;52(29):4904-13. doi: 10.1021/bi400320s. Epub 2013 Jul 15.

41.

Glutathione-complexed iron-sulfur clusters. Reaction intermediates and evidence for a template effect promoting assembly and stability.

Qi W, Li J, Chain CY, Pasquevich GA, Pasquevich AF, Cowan JA.

Chem Commun (Camb). 2013 Jul 18;49(56):6313-5. doi: 10.1039/c3cc43620a.

42.
43.

Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.

Joyner JC, Hodnick WF, Cowan AS, Tamuly D, Boyd R, Cowan JA.

Chem Commun (Camb). 2013 Mar 14;49(21):2118-20. doi: 10.1039/c3cc38977d. Epub 2013 Feb 5.

44.

Human ferredoxin-2 displays a unique conformational change.

Qi W, Li J, Cowan JA.

Dalton Trans. 2013 Mar 7;42(9):3088-91. doi: 10.1039/c2dt32018e. Epub 2012 Dec 3.

45.

Analysis of RNA cleavage by MALDI-TOF mass spectrometry.

Joyner JC, Keuper KD, Cowan JA.

Nucleic Acids Res. 2013 Jan 7;41(1):e2. doi: 10.1093/nar/gks811. Epub 2012 Aug 31.

46.

Glutathione complexed Fe-S centers.

Qi W, Li J, Chain CY, Pasquevich GA, Pasquevich AF, Cowan JA.

J Am Chem Soc. 2012 Jul 4;134(26):10745-8. doi: 10.1021/ja302186j. Epub 2012 Jun 21.

47.

Diet and body composition outcomes of an environmental and educational intervention among men in treatment for substance addiction.

Cowan JA, Devine CM.

J Nutr Educ Behav. 2013 Mar;45(2):154-8. doi: 10.1016/j.jneb.2011.10.011. Epub 2012 May 23.

48.

Process evaluation of an environmental and educational nutrition intervention in residential drug-treatment facilities.

Cowan JA, Devine CM.

Public Health Nutr. 2012 Jul;15(7):1159-67. doi: 10.1017/S1368980012000572. Epub 2012 Apr 4.

PMID:
22475412
49.

DNA nuclease activity of Rev-coupled transition metal chelates.

Joyner JC, Keuper KD, Cowan JA.

Dalton Trans. 2012 Jun 7;41(21):6567-78. doi: 10.1039/c2dt00026a. Epub 2012 Mar 27.

PMID:
22450234
50.

Catalytic metallodrugs targeting HCV IRES RNA.

Bradford S, Cowan JA.

Chem Commun (Camb). 2012 Mar 25;48(25):3118-20. doi: 10.1039/c2cc17377h. Epub 2012 Feb 16.

PMID:
22343977

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